جست‌وجوی استاد و پژوهشگر

• Musculoskeletal Sciences
• Inflammatory Fibrosis
• Tendinopathy
• +۳ مورد دیگر

Stephanie Dakin is a tenured Full Professor of Musculoskeletal Sciences at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, and a Senior Research Fellow at Green Templeton College. Her research focuses on identifying mechanisms of chronic inflammatory fibrosis in soft tissue joint diseases including tendinopathy, frozen shoulder, and knee arthrofibrosis to develop novel therapeutic strategies for fibrosis resolution. Her educational background includes: BVetMed from the Royal Veterinary College (RVC), University of London (2003) PhD from the RVC (completed 2012) PGCert in Teaching & Learning in Higher Education (2020) Professor Dakin's research centers on the cellular and molecular basis of soft tissue joint diseases, investigating how tissue-resident cells including fibroblasts and macrophages drive chronic inflammation and fibrosis. Her work spans from equine orthopaedics to human translational research, with particular emphasis on identifying resolution pathways in inflammatory fibrosis to develop targeted therapies for conditions like frozen shoulder and tendinopathy. Her publication record (2015-2025) shows a clear evolution from foundational studies on inflammation in tendon disease toward advanced single-cell and transcriptomic analyses of fibrosis mechanisms. Recent work leverages cutting-edge techniques to model soft-tissue diseases in vitro and identify precision therapeutic targets, with growing emphasis on stem cell dynamics and resolution biology in chronic conditions. Her scientific recognition includes: Versus Arthritis Foundation Fellowship Oxford-UCB Prize Fellowship in Biomedical Sciences Versus Arthritis Career Development Fellowship Fellow of the Higher Education Academy Professor Dakin has supervised multiple research students including Alejandro Gomez, Alexis Pointdexter, and Jiachen Lou, and served as Director of Postgraduate Taught Studies for the MSc in Musculoskeletal Sciences for eight years. Her research is funded by major grants from Versus Arthritis, NIBR Global Scholars program, Oxford-BMS, The Rosetrees Trust, NC3Rs, and UKRI. She leads the Dakin Group (Soft Tissue Joint Disease) at NDORMS, collaborating closely with Professors Andrew Carr, Christopher Buckley, and Mark Coles on translational research aimed at reducing the global burden of soft tissue joint diseases.

Matthew Murrayمشاهده پروفایل

استاد

• Germ Cell Tumours
• Paediatric Oncology
• Molecular Pathology
• +۶ مورد دیگر

Professor Matthew Murray is a Professor in the Department of Pathology at the University of Cambridge, leading the Murray Group within the Division of Cellular and Molecular Pathology. He concurrently serves as an Honorary Consultant Paediatric Oncologist at Addenbrooke's Hospital. His research centers on childhood solid tumours, with groundbreaking work on germ cell tumours (GCTs) establishing microRNA clusters miR-371~373 and miR-302/367 as universal biomarkers for malignant GCTs. Current projects investigate clonal dynamics of tumour evolution, tumour microenvironment interactions through extracellular vesicles, therapeutic targeting of microRNA pathways including the LIN28/let-7 axis, and clinical translation of serum microRNA assays for diagnosis and relapse monitoring in international trials. Professor Murray mentors PhD student Zachary Scurlock and visiting student Jessica Balls. His laboratory, embedded within the Department of Pathology on Tennis Court Road, actively contributes to prospective clinical trials for biomarker validation in germ cell tumours and neuroblastoma.

Thomas G. Blanchardمشاهده پروفایل

استاد

• Immunology
• Mucosal Immunology
• Vaccine Development
• +۳ مورد دیگر

Dr. Thomas G. Blanchard is a Professor in the Department of Pediatrics at the University of Maryland School of Medicine. He serves as the Director of the University of Maryland Brain and Tissue Bank (UMBTB) and has held this position since 2007. His academic journey includes a PhD in Immunology from the University of Massachusetts (1991) and a JD from Case Western Reserve University (2002). Education: University of Massachusetts, B.S., Biology, 1985 University of Massachusetts, Ph.D., Immunology, 1985-1991 Case Western Reserve University, J.D., 2002 Dr. Blanchard specializes in immunology, particularly mucosal immunology, focusing on the host response to Helicobacter pylori (H. pylori) infections. His work has elucidated mechanisms of immune evasion by H. pylori and pioneered vaccine development strategies, including neonatal vaccination and systemic/mucosal delivery. Notably, he has demonstrated the roles of IL-10, Treg cells, dendritic cells, and Th17/Th1 responses in immunity. Recent research explores andrographolide (AGP) in colon cancer therapy, revealing its capacity to induce ER stress, upregulate tumor suppressor genes (PTEN, RASSF1A), and trigger apoptosis. His publications span topics like H. pylori genomics, IRAK-M signaling, and lymphoid follicle formation, reflecting interdisciplinary expertise in immunology, microbiology, and oncology. Leadership Roles: Director, University of Maryland Brain and Tissue Bank (2007–present)

Sara O. Vargasمشاهده پروفایل

دانشیار

• Pediatric Pathology
• Pulmonary Pathology
• Interstitial Lung Disease
• +۴ مورد دیگر

Sara O. Vargas is an Associate Professor at Harvard Medical School and a practicing pediatric pathologist at Boston Children's Hospital. She holds an MD from University of Vermont College of Medicine and completed fellowships in Pediatric Pathology and Anatomic/Clinical Pathology. Harvard University (Undergraduate) University of Vermont College of Medicine (Medical School) Boston Children's Hospital (Pediatric Pathology Fellowship) Brigham and Women's Hospital (Anatomic/Clinical Pathology Fellowship) Her research focuses on pediatric pulmonary pathology, interstitial lung disease, and genetic determinants of congenital disorders. She has contributed extensively to understanding pulmonary hypertension mechanisms and imaging protocols for developmental lung conditions. Her recent publications address topics like genetic variants in interstitial lung disease, vascular remodeling in pulmonary hypertension, and multiomic analyses of sudden infant death. She serves as Director of Quality and Patient Safety in the Department of Pathology, which processes over 12,000 surgical pathology cases annually. Dr. Vargas specializes in the intersection of pathology, radiology, and clinical genetics, with particular expertise in: Pediatric pulmonary hypertension Congenital lung malformations Genetic lung disease Post-transplant pathology Interstitial lung disease Pediatric oncologic pathology

Andrew Barbourمشاهده پروفایل

استاد

• Surgical Oncology
• Cancer Genomics
• Translational Research
• +۳ مورد دیگر

Professor Andrew Barbour is an academic general surgeon and translational researcher at The University of Queensland , specifically affiliated with the School of Medicine under the Faculty of Health, Medicine and Behavioural Sciences . He specializes in upper gastrointestinal, pancreatic, melanoma, and sarcoma surgery , with expertise in robotic and laparoscopic procedures for conditions like oesophageal cancer and soft tissue tumours. Doctor of Philosophy, The University of Queensland Faculty of Anaesthetists, Royal Australasian College of Surgeons His research integrates genomic, epigenomic, and transcriptomic data to advance precision medicine in cancer , focusing on biomarker discovery for therapy response and recurrence prediction. Key contributions include the DOCTOR trial (first PET-guided personalized therapy for oesophageal cancer) and the GAP Trial (establishing preoperative chemotherapy for pancreatic cancer). Recent publications emphasize spatial transcriptomics for thin melanoma mortality prediction, multi-omic profiling of oesophageal adenocarcinoma, and radiomics for immune signature analysis in melanoma. His work also explores small extracellular vesicle heterogeneity and genomic catastrophes as drivers in cancer. Queensland Advancing Clinical Research Fellowship for melanoma recurrence prediction Key roles in NHMRC-funded trials and MRFF MASTERPLAN trial As Chair of the AGITG Upper GI working party , he leads national cancer research initiatives. His Surgical Oncology Lab at TRI operates the Cancer Evolution Biobank , linking tumour biology with clinical outcomes.

Jan Lammerdingمشاهده پروفایل

استاد

• Cell nucleus mechanobiology
• Mechanotransduction
• Cancer cell migration and metastasis
• +۵ مورد دیگر

Jan Lammerding is a Professor at Cornell University's Meinig School of Biomedical Engineering and the Weill Institute for Cell and Molecular Biology. His research focuses on nuclear mechanobiology, investigating how mechanical forces affect nuclear structure and function in cancer metastasis and muscular dystrophies. He has developed microfluidic platforms to study nuclear deformation and holds fellowships from BMES, AIMBE, and ASCB. Education: Diplom Ingenieur (RWTH Aachen), B.E. (Dartmouth), Ph.D. (MIT) Leadership: Director of Graduate Studies (2011-2024), Associate Director of Meinig School (2024-) Research spans nuclear envelope rupture in cancer cells, mechanotransduction pathways, and Ledercq Foundation-funded projects on laminopathies. His lab has produced 15+ articles (2023-2025) covering topics like microtubule-induced nuclear damage , 3D hydrogel migration , and mechanical stress epigenetic effects . Awards include Keith Porter Medal , NSF CAREER , and Cornell Teaching Excellence honors.

Alan N. Engelmanمشاهده پروفایل

استاد

• HIV-1 Integration
• Virology
• Molecular Biology
• +۳ مورد دیگر

Alan N. Engelman, Ph.D. , is a Professor of Medicine at Harvard Medical School and Principal Investigator at Engelman Laboratory. He has held appointments in Pathology (1995-2009) and Medicine (2009-present) at Harvard, with concurrent roles at Dana-Farber Cancer Institute and Beth Israel Deaconess Medical Center. Education: B.S.Ch.E., Tufts University (1981) M.S., Tufts University (1985) Ph.D., Tufts University School of Medicine (1990) His research focuses on HIV-1 integration mechanisms , targeting capsid-host interactions and nuclear entry pathways . Recent studies investigate phase separation dynamics, nucleoporin engagement, and structural modeling of viral core transport. Scientific Awards: 1995: R-AXIS Golden Crystal Award 2010: NIH MERIT Award 2012: Harvard Honoris Causa MA 2014: AAAS Fellow 2016: American Academy of Microbiology Fellow Engelman has mentored numerous researchers in retrovirology, including Sooin Jang , Satya Singh , and Zachary Ingram . His work spans collaborations with institutions like Dana-Farber Cancer Institute and Beth Israel Deaconess Medical Center, focusing on structural and mechanistic aspects of HIV-1 replication.

Xin Geمشاهده پروفایل

دانشیار

• Biologics Development
• Monoclonal Antibody Engineering
• T-cell Receptor Research
• +۷ مورد دیگر

Xin Ge is an Associate Professor at the MD Anderson-UTHealth Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, specializing in molecular medicine. He holds the Kay & Ben Fortson Distinguished Chair in Neurodegenerative Disease Research and is an adjunct faculty member in the Department of Neurobiology and Anatomy at McGovern Medical School. Ph.D. in Chemical Engineering, McMaster University M.S. in Chemical and Biochemical Engineering, Tsinghua University B.S. in Chemical Engineering, Tsinghua University Dr. Ge’s research focuses on developing biologics like monoclonal antibodies (mAbs), T-cell receptors (TCRs), and therapeutic enzymes. His lab engineers technologies such as synthetic antibody libraries, mammalian cell display, and functional selection to overcome limitations in protease inhibition and immunotherapy development. Current projects target MMP-9 for diabetic neuropathy, stroke, and SARS-CoV-2, alongside Fc engineering for enhanced immune receptor affinity. His recent publications emphasize mammalian cell-based directed evolution, protease inhibitory antibody mechanisms, and immunotherapy applications for cancer, infections, and metabolic disorders. Topics include FcγR affinity optimization, CAR-T development, and MMP-14/MMP-9 targeting for pain and disease. Maximizing Investigators’ Research Award (R35), NIGMS, 2021 NSF CAREER Award, 2015 NSERC Postdoctoral Fellowship, 2008 Dr. Ge has graduated 7 PhD and 7 MS students while mentoring 11 postdocs and 5 research scientists. His lab employs structure-aided design, repertoire deep sequencing, and recombinase-mediated transgene integration systems to engineer next-generation biologics for clinical translation.

Marilia Cascalhoمشاهده پروفایل

استاد

• Transplantation Immunobiology
• Genetic Susceptibility in Immunopathogenesis
• Novel Immunotherapies
• +۶ مورد دیگر

Marilia Cascalho is a Professor and Vice Chair for Research at the Department of Pathology, Case Western Reserve University School of Medicine. She also serves as a Member of the Immune Oncology Program at the Case Comprehensive Cancer Center. Her academic journey includes MD and PhD degrees from the University of Lisbon and UCSF, respectively, followed by postdoctoral training at the Hagedorn Research Institute and UCSF. Key Appointments : Vice Chair for Research (2024), Richard J. Fasenmyer Professor (2024) Prior Institutions : Mayo Clinic (1999-2008), University of Michigan (2008-2024) Research Interests focus on Immunobiology of organ transplantation Genetic susceptibility in immune-mediated diseases Development of mutable vaccines against viral evolution C3d-based immunotherapies for cancer TACI/TNFRSF13B polymorphisms in immunity Article Trends reveal contributions to transplantation science, B cell immunology, and cancer immunotherapy. Her work spans antibody-mediated immunity , adaptive immune responses , and somatic hypermutation mechanisms , with recent emphasis on piRNA biomarkers in transplant monitoring and metabolic reprogramming for graft survival . Scientific Awards include: Science Magazine Prize for Young Investigators (1999) NIH Grant Support (multiple awards) Gates Foundation Grant US-Israel Bi-National Science Foundation NIH Study Section Memberships Patents and Innovation highlight her inventions in Soluble C3d immunotherapies Mutable vaccine technology B cell repertoire analysis methods T cell diversity modulation Laboratory Focus integrates immunology, genetics, and bioengineering to develop therapies for transplant rejection, autoimmune diseases, and incurable cancers like multiple myeloma.

David Samolsمشاهده پروفایل

استاد

• Acute Phase Response
• C-Reactive Protein (CRP) Biology
• Cytokine Signaling
• +۳ مورد دیگر

Professor David Samols is a leading researcher in the Department of Biochemistry at Case Western Reserve University School of Medicine. With a PhD in Cell Biology from the University of Chicago and postdoctoral training at Roche Institute of Molecular Biology and University of Oregon's Institute of Molecular Biology, his work focuses on the acute phase response and C-reactive protein (CRP) biology. Key research areas: CRP transcriptional regulation, cytokine signaling pathways, transcription factor interactions, inflammatory disease models Methodologies: Transgenic mouse models, Hep3B cell studies, molecular cloning, protein biochemistry Publications demonstrate expertise in CRP's anti-inflammatory properties across septic shock, pulmonary inflammation, and antigen-induced arthritis models. Collaborations with Dr. Irwin Kushner have produced seminal works on CRP's clinical significance and transcriptional mechanisms. Scientific contributions include: Elucidating C/EBPβ's critical role in cytokine responsiveness Discovering indirect NFκB (rel proteins) activation pathways Establishing CRP's in vivo anti-inflammatory effects Advancing understanding of evolutionary conserved biotin enzymes

• neurodevelopment
• mental disorders
• brain aneurysms
• +۸ مورد دیگر

Ketu Mishra-Gorur is an Associate Professor in the Department of Neurosurgery at Yale School of Medicine. With a strong background in cell biology and molecular genetics, Dr. Mishra-Gorur has established a significant research program focused on understanding the cellular and molecular mechanisms of brain tumors and vascular disorders. Dr. Mishra-Gorur's educational journey includes: PhD in Cell, Molecular & Developmental Biology from Tufts University MS in Genetics from Purdue University MSc in Microbiology from University of Bombay Postdoctoral Fellowship in Cell Biology at Harvard Medical School/MGH Cancer Center Dr. Mishra-Gorur's research spans multiple areas within neuroscience and oncology, with particular expertise in neurodevelopment and associated disorders, brain aneurysms and tumors, vascular diseases, cancer biology, and therapeutic approaches including drug research and oncolytic viruses. Their work utilizes a variety of in vitro and in vivo approaches, ranging from biochemical and cell-based assays to studying neural development in model organisms and in vivo modeling of tumor growth and metastasis. The research portfolio demonstrates a strong focus on meningioma genomics, with particular interest in TRAF7 mutations, skull-base meningiomas, and genomic variations across racial and ethnic groups. Additional significant work explores brain angiogenesis, intracranial aneurysms, and genetic factors in neurodevelopmental disorders. Dr. Mishra-Gorur has established productive collaborations with several prominent researchers at Yale including: Murat Günel, MD (24 joint publications) Zeynep Erson Omay, PhD (17 joint publications) Kaya Bilguvar, MD, PhD (13 joint publications) Katsuhito Yasuno, PhD (12 joint publications) Sacit Bulent Omay, MD (11 joint publications) Declan McGuone, MD (10 joint publications) Dr. Mishra-Gorur's work has been published in high-impact journals including Nature, Proceedings of the National Academy of Sciences, and Neuro-Oncology, demonstrating the significance and quality of their research contributions to the field of neurosurgery and neuroscience.

Rahul Kohliمشاهده پروفایل

دانشیار

• DNA Modifying Enzymes
• Epigenetics
• Antibiotic Resistance
• +۶ مورد دیگر

Rahul Kohli, M.D., Ph.D. is Associate Professor of Medicine and Biochemistry & Biophysics at the University of Pennsylvania's Perelman School of Medicine, Department of Medicine. His laboratory is located in Johnson Pavilion at 3610 Hamilton Walk, Philadelphia, PA. Dr. Kohli's research focuses on DNA modifying enzymes that add complexity to the genome through purposeful mutation and nucleobase modification. His work spans two primary areas: (1) enzymatic deamination, oxidation and methylation of cytosine bases with emphasis on AID/APOBEC DNA deaminases and TET oxygenases; and (2) targeting pathogen pathways that promote evolution and antibiotic resistance, particularly the LexA/RecA axis governing the bacterial SOS response. His lab employs biochemical characterization of enzyme mechanisms, chemical synthesis of enzyme probes, and biological assays spanning bacteriology, immunology, and virology. Analysis of Dr. Kohli's recent publications reveals a strong emphasis on developing novel epigenetic sequencing technologies, understanding TET enzyme mechanisms in cancer and development, engineering hyperactive DNA modifying enzymes for genome editing applications, and targeting bacterial stress responses to combat antibiotic resistance. His work bridges chemical biology, epigenetics, and infectious disease research. Scientific Awards: Benjamin Franklin Medal in Chemistry (2017) Dr. Kohli mentors a robust research team with 15 lab members including graduate students and undergraduate researchers. His work has been supported by multiple grants focused on DNA modification enzymes and their applications in epigenetics and antimicrobial resistance. His research has significant implications for cancer therapy, genome editing technologies, and novel antibiotic development strategies. The Kohli laboratory maintains active collaborations across multiple disciplines, particularly in immunology and cancer research, as evidenced by publications related to CAR-T cell therapy where TET2 disruption enhances therapeutic efficacy.

Mary Lauren Bentonمشاهده پروفایل

استادیار

• Computational Biology
• Gene Regulation
• Biomedical Informatics
• +۳ مورد دیگر

Dr. Mary Lauren Benton is an Assistant Professor in the Department of Computer Science at Baylor University's College of Engineering and Computer Science. She holds a Ph.D. and M.S. in Biomedical Informatics from Vanderbilt University (2020, 2018) and a B.S.I. in Bioinformatics from Baylor University (2015). Education: Ph.D. (Vanderbilt, 2020), M.S. (Vanderbilt, 2018), B.S.I. (Baylor, 2015) Her research focuses on computational biology and gene regulation, particularly how DNA sequences influence genome function and human disease risk through integrated datasets. Recent work explores enhancer-gene interactions, epigenetic mechanisms, and the application of graph neural networks to genomic problems. Selected publications highlight interdisciplinary trends across genomics (e.g., Cis-regulatory landscapes , CTCF motif accessibility ) and computer science (e.g., Dynamic graph attention , Node classification ).

Rosalyn Fergusonمشاهده پروفایل

مدرس

• Medical Education
• Anatomy and Physiology Education
• Genomic Medicine Education
• +۳ مورد دیگر

Rosalyn Ferguson is a University Teacher at the School of Allied Health Professions, Nursing and Midwifery, University of Sheffield, where she has taught Anatomy, Physiology, and Cell Biology across health-related programs since 2020. Her role encompasses curriculum leadership and pedagogical innovation in nursing and allied health education. Her academic credentials include: BSc Microbiology (Hons), University of Edinburgh MSc Clinical Medicine (Haematology), Queen’s University Belfast PhD in Cell Biology, Queen’s University Belfast Postgraduate Certificate in Education (PGCE), Queen’s University Belfast Dr. Ferguson's research centers on medical education pedagogy, with current projects standardizing Anatomy and Physiology teaching for nursing students and developing digital genomic medicine resources. She pioneers interactive software and online platforms to create flexible, cross-program educational materials that address critical gaps in allied health training. Her publication trajectory reveals a strategic shift from cancer biology (2010-2013), where she investigated metabolic disorder-cancer links through molecular mechanisms, to contemporary educational scholarship focused on quality assurance frameworks like the SAFE-A&P database. This evolution underscores her commitment to transforming healthcare education through evidence-based teaching standardization.

Gaurav Bhardwajمشاهده پروفایل

استادیار

• Computational Peptide Design
• Drug Discovery
• Structural Biology
• +۴ مورد دیگر

Gaurav Bhardwaj is an Assistant Professor in the Department of Medicinal Chemistry at the University of Washington School of Pharmacy. He is affiliated with the Institute for Protein Design and leads the Bhardwaj Lab, focusing on computational and experimental tools for peptide-based therapeutics. Education: B.Tech in Biotechnology, GGS Indraprastha University, Delhi PhD in Integrative Biosciences, Pennsylvania State University Postdoctoral work at University of California, Davis and University of Washington, Seattle His research spans computational peptide design , structural biology , and drug discovery , targeting challenges in membrane permeability , oral bioavailability , and blood-brain barrier traversal . Current projects address antibiotic resistance, chronic pain, and neurodegenerative disorders. Recent publications highlight de novo macrocycle design , AlphaFold-based modeling , and cyclic peptide libraries , emphasizing computational methods and deep learning applications in drug design. His work integrates molecular biophysics and structural validation to enhance therapeutic efficacy. The Bhardwaj Lab promotes diversity and offers opportunities for undergraduate researchers, graduate students, postdoctoral fellows, and technicians, with a focus on interdisciplinary collaboration at the interface of chemistry, biology, and computational sciences.