Marilia Cascalho

Marilia Cascalho is a Professor and Vice Chair for Research at the Department of Pathology, Case Western Reserve University School of Medicine. She also serves as a Member of the Immune Oncology Program at the Case Comprehensive Cancer Center. Her academic journey includes MD and PhD degrees from the University of Lisbon and UCSF, respectively, followed by postdoctoral training at the Hagedorn Research Institute and UCSF.

• Key Appointments: Vice Chair for Research (2024), Richard J. Fasenmyer Professor (2024)
• Prior Institutions: Mayo Clinic (1999-2008), University of Michigan (2008-2024)

Research Interests focus on

• Immunobiology of organ transplantation
• Genetic susceptibility in immune-mediated diseases
• Development of mutable vaccines against viral evolution
• C3d-based immunotherapies for cancer
• TACI/TNFRSF13B polymorphisms in immunity

Article Trends reveal contributions to transplantation science, B cell immunology, and cancer immunotherapy. Her work spans antibody-mediated immunity, adaptive immune responses, and somatic hypermutation mechanisms, with recent emphasis on piRNA biomarkers in transplant monitoring and metabolic reprogramming for graft survival.

Scientific Awards include:

• Science Magazine Prize for Young Investigators (1999)
• NIH Grant Support (multiple awards)
• Gates Foundation Grant
• US-Israel Bi-National Science Foundation
• NIH Study Section Memberships

Patents and Innovation highlight her inventions in

• Soluble C3d immunotherapies
• Mutable vaccine technology
• B cell repertoire analysis methods
• T cell diversity modulation

Laboratory Focus integrates immunology, genetics, and bioengineering to develop therapies for transplant rejection, autoimmune diseases, and incurable cancers like multiple myeloma.