Charlotte Hellmich

Charlotte Hellmich is an NIHR Clinical Lecturer at Norwich Medical School, University of East Anglia, actively engaged in research at the intersection of hematology, aging, and immunometabolism. Her work is supported by major funding bodies including the National Institute for Health and Care Research (NIHR), Wellcome Trust, and the Academy of Medical Sciences.

Research Interests: Her research focuses on the role of cellular senescence, metabolic regulation, and immune cell dysfunction in aging and disease. She investigates how age-related changes in hematopoietic stem cells and macrophages contribute to conditions such as myelodysplasia, MGUS progression to myeloma, and liver-gut axis dysfunction. Her work integrates molecular biology, metabolism, and translational approaches to understand disease mechanisms and improve therapeutic outcomes.

Publication Trends: Her most recent articles (2023–2024) reveal a strong emphasis on senescence pathways (e.g., p16INK4A), metabolic reprogramming (e.g., glutamine synthetase, mTOR/autophagy), and clonal dynamics in hematopoiesis. These studies are published in high-impact journals such as Blood Advances, Genome Biology, and Communications Biology, reflecting interdisciplinary and clinically relevant science.

Scientific Awards:

• No specific awards are listed in the provided text.

Grants and Advising: Charlotte Hellmich is a Co-Investigator on multiple funded projects, including a Wellcome Trust collaboration with UCAM and an NIHR Clinical Lectureship. While no direct advisees are listed, her role in research projects and publications with junior researchers suggests involvement in mentorship and team leadership within the hematology and aging research community at UEA.

Labs and Teams: She is part of a collaborative research network at Norwich Medical School, working closely with Prof. Stuart Rushworth, Prof. Kristian Bowles, and Dr. Nadja Beraza. Her work is embedded in the Cancer Studies and Metabolic Health research themes, contributing to interdisciplinary efforts in understanding hematological and inflammatory diseases.