معرفی
Kristian Bowles is Professor of Haematology and Dean of Norwich Medical School at the University of East Anglia. He is a member of the Cancer Studies department and an active Consultant Haematologist at Norfolk and Norwich University Hospital. His academic leadership and research are central to the medical school's mission in advancing haematological science and clinical practice.
- University: University of East Anglia
- School: Norwich Medical School
- Department: Cancer Studies
- Academic Rank: Professor
He earned his medical degree from Guy's and St Thomas' Hospitals Medical School, London, completed specialist training in haematology in Cambridge and Norwich, and obtained his PhD from the University of Cambridge, focusing on haematopoietic stem cell self-renewal.
His research interests lie at the intersection of haematology, cancer biology, and ageing. He investigates the metabolic and mitochondrial regulation of haematopoietic stem cells, senescence in the bone marrow niche, and the progression of pre-malignant conditions like MGUS to myeloma. His work integrates molecular biology, genomics, and immunology to understand blood cancers and stem cell dynamics.
His recent publications (2023–2024) reveal a strong focus on mitochondrial fate, metabolic reprogramming, and immune interactions in haematological malignancies. Key themes include BCL2 regulation in AML, mtDAMP-mediated macrophage activation in myeloma, and the role of fatty acid oxidation in stem cell function. These studies are published in leading journals such as Blood, Genome Biology, and Blood Advances.
Kristian Bowles leads multiple funded research projects, including those supported by the Medical Research Council, Royal Society, and Academy of Medical Sciences. These projects explore glutamine synthetase in aged stem cells, NAMPT in myeloma progression, and the health impacts of climate change.
- Investigating the role of NAMPT and age-related macrophage changes in MGUS-to-myeloma progression (British Society of Haematology)
- Role of glutamine synthetase in aged haematopoietic stem cells (Academy of Medical Sciences)
- Comprehensive assessment of climate change health risks (Royal Society)
- Mitochondrial fate in normal and malignant haematopoiesis (Medical Research Council)
He collaborates extensively with Dr. Stuart Rushworth and other researchers, supervises students, and leads a dynamic research group. His lab, referenced at www.rushworthlab.com, is a hub for innovation in haematological research.
