Stuart Rushworth

Professor Stuart Rushworth is a faculty member at Norwich Medical School, University of East Anglia, where he serves as the scientific group leader for molecular haematology research. His work focuses on the tumour microenvironment in haematological malignancies, particularly Acute Myeloid Leukaemia and Multiple Myeloma, and the impact of infection and ageing on haematopoietic stem cells.

Education:

• Bachelor's Degree – University of Sunderland
• PhD in Immunology – University of Cambridge
• Post-doctoral Training – University of Cambridge and University of East Anglia

His research explores metabolic reprogramming, mitochondrial transfer, and stromal interactions in cancer. He has made significant contributions to understanding how leukaemia cells exploit the bone marrow microenvironment for survival and proliferation. His studies have identified key mechanisms such as fatty acid release from adipocytes and intercellular mitochondrial transfer via tunnelling nanotubes. His work bridges basic science and clinical translation, with implications for drug resistance and novel therapeutic strategies.

The most recent articles highlight trends in immunometabolism, infection-induced haematopoietic stress responses, and metabolic crosstalk in cancer. Key themes include mitochondrial dynamics, metabolic adaptation, and innate immune signaling pathways like STING. His publications appear in high-impact journals such as Cell Reports, Nature Communications, and Blood.

He is actively funded by major research bodies including the British Heart Foundation, The Big C Appeal, Academy of Medical Sciences, and BBSRC. While no formal scientific awards are listed in the provided text, his research has led to clinical trials involving BTK inhibitors in myeloma patients.

Professor Rushworth mentors several PhD researchers, including Dominic Fowler-Shorten, E. E. Wojtowicz, A. Jibril, J. A. Moore, and J. Mistry. He leads the Rushworth Group, which is part of the Metabolic Health Research Centre at UEA, focusing on metabolic processes in the tumour microenvironment.