Carolin Wichmann

Prof. Carolin Wichmann is a Professor at the University Medical Center Göttingen (UMG), leading the Wichmann group within the Institute for Auditory Neuroscience. Her research focuses on the molecular and structural basis of synapse function, particularly at sensory synapses in the inner ear. Using advanced techniques like electron tomography, high-pressure freezing, and optogenetics, her group investigates how synapse architecture relates to functional properties in hearing mechanisms.

Research Interests:

• Electron microscopy-based 3D structural analysis of synapses
• Optogenetic stimulation of inner hair cells
• Role of otoferlin and other synaptic proteins in hearing
• Calcium channel regulation in auditory synapses
• Developmental maturation of synaptic structures

Funding & Projects:

• Recipient of REACT-EU/ERDF funding (2022-2023) for acquiring advanced STEM tomography equipment
• Led the ETomoH&H project studying ultrastructural changes in neurological and cardiological diseases

Advising & Team:

• Current lab members: Julius Bahr, Ruchi Modgekar
• Prominent former members include Dr. Rituparna Chakrabarti and Dr. Jana Kroll
• Collaborates with multiple groups (e.g., Cretu, Goßler labs) on auditory neuroscience projects

Labs & Facilities:

• Specializes in ultrastructural imaging with state-of-the-art microscopy
• Develops SynapseNet deep learning tools for synapse analysis
• Manages the Otoferlin and CABP2 registries for genetic deafness research