معرفی
Saaid Safieddine is a Permanent Researcher (DR2 CNRS) at the Institut Pasteur in Paris, where he co-leads the Auditory Cognition and Communication team. His research focuses on developing translational gene therapies for hereditary and acquired hearing loss, particularly targeting genetic deafness such as DFNB9 caused by otoferlin mutations. He works within a multidisciplinary team that includes engineers, researchers, and ENT surgeons, aiming to bridge molecular discoveries with clinical applications through robotic delivery systems.
His primary research interests include:
- Molecular physiology of hearing and auditory synapses
- Gene therapy for inner ear abnormalities
- Adeno-associated virus (AAV) vector design and tropism
- Otoferlin gene expression and regulation
- Translational neuroscience and preclinical modeling
- Cell-specific targeting in the inner ear
His recent publications (2019–2025) demonstrate a consistent and impactful research trajectory in gene therapy for deafness. The work shows a progression from foundational studies on synaptic mechanisms to advanced preclinical models and clinical translation. Key themes include the development of dual-AAV systems for otoferlin delivery, in vivo tropism studies across developmental stages, restoration of auditory processing, and expanding therapeutic time windows in Usher syndrome models. His research increasingly integrates developmental biology, viral engineering, and behavioral neuroscience to address the full spectrum of hearing restoration.
Saaid Safieddine has not been noted to have received specific scientific awards in the provided texts. However, his leadership in high-impact projects such as the ANR "Robocop" initiative and collaborations with clinical centers (Pitié-Salpêtrière and Necker Hospitals) indicate significant research funding and institutional support. He supervises PhD students and postdoctoral researchers, contributing to the training of next-generation scientists in auditory neuroscience and gene therapy.
He is involved in multidisciplinary research teams and collaborative projects that integrate:
- The Auditory Cognition and Communication team at Institut Pasteur
- The RobOtol robotic surgery project for otological interventions
- Clinical ENT departments at Pitié-Salpêtrière and Necker University Hospitals
- The Hearing Institute for translational development
- ANR-funded projects like "Robocop" for active cochlear implants
