معرفی
David Corey is the Bertarelli Professor of Translational Medical Science at Harvard Medical School, leading the Corey Lab in the Department of Neurobiology. His work focuses on auditory neuroscience and ion channel biology, particularly the molecular mechanisms of hearing and deafness. The lab investigates hair cell mechanotransduction, gene therapy approaches for hereditary deafness (e.g., Usher syndrome), and the structural biology of transduction channels. Key techniques include electrophysiology, electron microscopy, and CRISPR-based gene editing.
Research emphasizes translating discoveries into therapies, such as AAV-based gene delivery systems and protein-engineered variants for hearing restoration. The lab is based at 220 Longwood Avenue, Boston, with collaborations in neurobiology and biomedical engineering. Corey’s work bridges basic science and clinical applications, aiming to address sensory disorders through molecular insights and innovative treatments.
Publications highlight advancements in mechanotransduction channel function, deafness gene therapy strategies, and protein design for inner-ear applications. Ongoing projects target Usher syndrome type 1F and DFNB1 deafness, with a focus on dual-AAV vectors and mini-PCDH15 proteins.
