معرفی
John V. Brigande is an Associate Professor at the Oregon Hearing Research Center, Oregon Health & Science University. He began his academic career at Boston College where he earned his B.S. (1987), M.S. (1991), and Ph.D. (1997) in neuroscience and developmental neurobiology. His postdoctoral training included developmental genetics at the University of Texas at Austin (1998) and auditory development at Purdue University (2003). He joined the Oregon Hearing Research Center as an Assistant Professor in 2003 and was promoted to Associate Professor in 2009. Since 2011, he has been a key contributor to the Hearing Health Foundation's Hearing Restoration Project.
Education:
- B.S., Boston College, 1987
- M.S., Boston College, 1991
- Ph.D., Boston College, 1997
- Postdoctoral Fellowship, University of Texas at Austin, 1998
- Postdoctoral Fellowship, Purdue University, 2003
Brigande's research focuses on mammalian inner ear development, employing experimental embryology, surgical techniques, and gene transfer methods to study developmental processes in vivo. His lab investigates cell fate decisions in otic progenitors using retroviral lineage analysis and develops fetal gene/drug therapies for congenital deafness. A major focus is translating developmental mechanisms into gene and cell therapies for hearing loss and balance disorders, with particular emphasis on hair cell regeneration strategies.
His publications demonstrate a strong focus on translational approaches to hearing restoration, including gene therapy (CRISPR/Cas9, AAV vectors), antisense oligonucleotides for congenital disorders, and optimization of diagnostic techniques. Recent work explores primate models of Usher syndrome, fetal pharmacotherapy, and mitochondrial genetics, reflecting interdisciplinary collaboration across genetics, audiology, and developmental biology.
Brigande leads a research laboratory within the Hearing Health Foundation's Hearing Restoration Project consortium, focused on developing mouse model systems to validate hair cell regeneration candidates. The lab utilizes techniques including transuterine microinjection, in vivo electroporation, and single-cell transcriptomics to advance therapeutic strategies for inner ear disorders.
