جست‌وجوی استاد و پژوهشگر

Kathy Fange Liuمشاهده پروفایل

دانشیار

• RNA Biochemistry
• Cancer Biology
• Epitranscriptomics
• +۳ مورد دیگر

Kathy Fange Liu, Ph.D., is an Associate Professor with tenure at the University of Pennsylvania Perelman School of Medicine. She serves as Co-Director of the Penn Center for Genome Integrity and Group Lead at the Penn Institute for RNA Innovation. The lab combines deep mechanistic studies with innovative therapeutic development across four major research directions: X-Y paired homologous proteins, cancer fusion proteins, ribosome biology, and cross-RNA modification coregulation. Research highlights include pioneering the concept of RNA modification coregulation (DOI:10.1073/pnas.1913448117), where enzyme-mediated modifications across RNA species demonstrate interconnected networks. Current projects investigate rRNA-modifying enzymes' dual roles in ribosome assembly and genome organization, while developing targeted therapies for fusion oncoproteins like TRIM24-ERG (US patent 63/797,545). 2025 Damon Runyon-Rachleff Innovator Award Stage 2 2024 St. Baldrick's Research Grant 2023 Linda Pechenik Montague Investigator 2022 Damon Runyon & ACS Scholar awards 2019 NIH MIRA R35 award Lab members include 6 postdocs (Praneeth Bommisetti, Yanze Jian, Sarai Mendoza, Yulia Gonskikh, Hyojeong Hwang, Sheetal Tushir) and 3 graduate trainees. Former lab members Hui Shen (now professor at China Pharmaceutical University), Julian Stoute (Ph.D. 2023), and Jordan Ontiveros (Ph.D. 2022) received multiple fellowships during their tenure. Key grants include NIH/NHLBI R01 (2022), CZI Multi-Institutional Collaboration (2024), and continuous support from private foundations like CURE Childhood Cancer and Alex's Lemonade Stand. The lab actively develops technologies for RNA modification analysis while maintaining strong collaborative ties across Penn's epigenetics and structural biology programs.

Matthew A. Mulveyمشاهده پروفایل

استاد

• Bacterial Pathogenesis
• Innate Immunity
• Antibiotic Resistance
• +۶ مورد دیگر

Matthew A. Mulvey is a Professor of Biological Sciences at the University of Utah, where he leads the Mulvey Laboratory within the Molecular Biology Program. His work integrates microbiology, genetics, cell biology, and bioinformatics to understand how pathogenic E. coli strains colonize hosts, evade immune responses, and develop antibiotic resistance. Education: B.S. in Biological Sciences – University of Texas, Austin Ph.D. – University of Texas, Austin Research Interests: Dr. Mulvey’s laboratory focuses on the molecular mechanisms underlying bacterial pathogenesis, with a particular emphasis on Extraintestinal Pathogenic Escherichia coli (ExPEC). His team investigates how genetic diversity and environmental pressures shape virulence, using zebrafish, mouse, and cell culture models. Key areas include urinary tract infections, sepsis, antibiotic resistance, and the role of the microbiota in disease outcomes. His lab employs cutting-edge techniques such as high-throughput screening, advanced microscopy, genomics, and bioinformatics to dissect host-pathogen interactions. They also collaborate closely with clinicians to translate findings into therapeutic strategies. Scientific Publications Overview: Mulvey’s recent publications span a broad range of topics including antibiotic resistance gene networks, plant-derived antimicrobials, bacterial adhesion mechanisms, and the use of zebrafish as infection models. His work consistently bridges basic science with translational applications, addressing urgent challenges in infectious disease management. Teaching & Mentorship: Dr. Mulvey teaches undergraduate and graduate courses including BIOL 2020: Principles of Cell Biology , BIOL 5210: Cell Structure and Function , and DENT 7135: Host and Defense, Bacterial Pathogenesis . His lab is actively involved in training the next generation of scientists. Laboratory & Collaborations: The Mulvey Lab is part of the University of Utah’s robust bioscience research community. It collaborates with bioinformaticians, clinicians, and core facilities to advance understanding of bacterial pathogenesis and develop novel therapeutic interventions.

• Time-resolved spectroscopy
• White-light spectroscopy
• Luminescence microscopy
• +۵ مورد دیگر

Prof. Dr. Marina Gerhard leads the Semiconductor Spectroscopy Group at Philipps University of Marburg's Department of Experimental Semiconductor Physics. Her research focuses on time-resolved spectroscopy , white-light spectroscopy , and luminescence microscopy of organic and organic/inorganic semiconductor systems. Philipps University of Marburg Department 13 - Physics Experimental Semiconductor Physics Key research areas include: Optical and electronic properties of semiconductor nanostructures Magnetic semiconductors Organic-inorganic hybrid systems Her recent publications span drug design , biochemical interactions , and structural biology , with emphasis on kinase targeting , tRNA-Guanine transglycosylase inhibition, and ligand-receptor interactions . While no specific scientific awards were mentioned in the provided data, her group maintains active research collaborations and training programs. Current doctoral and master's students include: Nico Hofeditz Dominik Muth Alexander Schauerte Anton Krüger Johannes Röder Pranav Elango Luise Rost For detailed information about research projects, publications, and team activities, please consult the group's intranet resources.

Lei Leiمشاهده پروفایل

استاد

• Origin of Life
• Evolution of the Genetic Code
• Transcriptional Regulation
• +۵ مورد دیگر

Professor Lei Lei is a faculty member at the University of New England's Graduate School of Biomedical Science and Engineering since 2010. He specializes in teaching undergraduate courses such as Cell and Molecular Biology and Developmental Neurobiology, earning the Debra J. Summers Memorial Award for Teaching Excellence in 2018. His research focuses on two core areas: transcriptional regulation in neural development and the evolutionary origins of life and genetic code. Lei holds a Ph.D. in Biochemistry from Michigan State University (1998) and a B.S. in Biology from Wuhan University (1991). He completed postdoctoral training in Developmental Biology at UT Southwestern Medical Center. His work has been supported by grants including NIH R01 awards and the COBRE interdisciplinary center for Pain and Sensory Function studies. Lei’s research integrates evolutionary biology with molecular mechanisms, exploring how genetic code evolution intersects with modern developmental biology. His lab investigates transcriptional networks controlling sensory neuron development and axon regeneration, with a focus on Sox11 and Klf7 transcription factors. He has presented at major conferences like the Society for Developmental Biology and the Gordon Research Conference on Neurotrophic Factors. Grants: NIH R01 (2020), COBRE P20GM103643 (2015), and multiple institutional partnerships. Labs/Teams: Collaborates across institutions including Mayo Clinic Arizona and Barrow Neurological Institute. Future Work: Expanding studies on genetic code evolution and neurotrophic factor pathways in chronic pain.

Ashutosh Shuklaمشاهده پروفایل

پژوهشگر

• Microbiology
• Genetics
• Chromatin Biology
• +۶ مورد دیگر

Ashutosh Shukla, Ph.D., is a Researcher and Instructor in the Department of Internal Medicine at UT Southwestern Medical Center, affiliated with the Division of Digestive and Liver Diseases. He holds a master's in biochemistry from the University of Hyderabad and a doctorate in chromatin/transcription biology from the Center for Cellular and Molecular Biology (CCMB), Hyderabad. After completing a postdoctoral fellowship under Ivan D'Orso at UT Southwestern (2018–2023), he joined the faculty in 2023. His research focuses on chromatin biology, transcriptional regulation, and their roles in diseases such as cancer and viral infections. Key areas include microbiome-driven colorectal polyposis prediction, oncogenic transcription programs, and HIV latency mechanisms. He employs yeast and mammalian systems to study RNA polymerase III dynamics, epigenetic modifications, and host-pathogen interactions. Shukla’s work bridges basic molecular mechanisms with clinical applications, particularly in gastrointestinal and liver diseases. His recent studies highlight microbiota-metabolite interactions, viral genome engineering, and chromatin remodeling pathways. Despite no listed awards or grants, his publications underscore contributions to understanding transcriptional regulation in health and disease.

• Mitochondrial Medicine
• Genetics
• Neurology
• +۳ مورد دیگر

Dr Aurora Gomez Duran is a researcher at Newcastle University's Institute of Genetic Medicine within the Faculty of Medical Sciences. Her work focuses on mitochondrial genetics, immunology, and pharmacogenomics with an emphasis on understanding mitochondrial dysfunction in human diseases. She collaborates extensively with experts in neurology, biochemistry, and clinical genetics. Her research investigates how mitochondrial DNA mutations influence disease severity, immune responses, and therapeutic outcomes. Notable studies include exploring cysteine supplementation for mitochondrial translation deficiencies and the role of mitochondrial haplogroups in disease susceptibility. She has contributed to translational studies using cybrid models to simulate neurodegenerative conditions like multiple sclerosis. Key research themes include mitochondrial immune interactions, genetic modifiers of disease, and personalized medicine approaches for mitochondrial disorders. Her work has advanced understanding of mitochondrial contributions to common late-onset diseases and antibiotic efficacy modulation by genetic background. Dr Gomez Duran's research frequently involves collaborations across disciplines, with notable projects addressing RNA metabolism defects in motor neuron disorders and mitochondrial involvement in liver failure. Her team explores both basic science mechanisms and clinical applications, including novel therapeutic strategies targeting mitochondrial pathways.

• RNA modification
• Ribosome profiling
• tRNA modification
• +۶ مورد دیگر

Sebastian Leidel is a Full Professor for RNA Biochemistry at the Department of Chemistry and Biochemistry, University of Bern, Switzerland, since 2018. He has held significant roles including Max Planck Research Group Leader at the Max Planck Institute for Molecular Biomedicine (2010-2019), Lecturer at ETH Zurich (2008-2010), and Postdoctoral Researcher at ETH Zurich (2005-2008). His research focuses on the in vivo roles of tRNA modifications in development and disease, making him a leading figure in this field in Europe. Current affiliation: University of Bern Previous affiliations: Max Planck Institute for Molecular Biomedicine, ETH Zurich His research explores how natural chemical tRNA modifications regulate local translation rates and protein aggregation, particularly in metastable proteins, as demonstrated by his groundbreaking work on tRNA modification mutants. He has contributed to European scientific networks such as COST actions and ERA networks. Scientific Awards: James Heineman Research Award (2016) ERC Starting Grant (2012) UBS Promedica Fellowship (2009) He advocates for non-tenured researchers through roles in the Young Academy of Europe (board member since 2015, treasurer 2016-2018) and the Max Planck Leadnet steering committee.

• Protein Phosphorylation
• Phosphoproteomics
• Synthetic Biology
• +۳ مورد دیگر

Dr. Jesse Rinehart is an Associate Professor in the Department of Cellular & Molecular Physiology at Yale School of Medicine, with a joint appointment in the Systems Biology Institute. His research focuses on decoding protein phosphorylation mechanisms using innovative phosphoproteomics and synthetic biology approaches. He developed a groundbreaking E. coli-based technology enabling site-specific phosphoserine incorporation into human proteins, advancing studies of phosphorylation networks. Education: PhD in Molecular Biophysics and Biochemistry, Yale University School of Medicine (2004) MS, Yale University (1999) BA, Kalamazoo College (1998) Research Interests: Dr. Rinehart’s work integrates systems biology with molecular physiology, emphasizing phosphorylation’s role in disease mechanisms such as cancer and hypertension. His lab explores how phosphorylation regulates ion transporters, signaling pathways, and metabolic processes. Recent breakthroughs include engineering genomically recoded organisms and identifying therapeutic targets for glioblastoma and kidney diseases. Key Contributions: Structural studies of sodium-chloride cotransporters and their inhibition by diuretics Development of phosphoserine resource tools for proteome-wide analysis Identification of PKM2’s role in gene regulation via G-quadruplex interactions Collaborations with neuro-oncology and diabetes research groups Labs & Teams: The Rinehart Lab at Yale West Campus employs interdisciplinary approaches, combining biochemistry, genetics, and computational modeling. Collaborations extend across departments including Biophysics, Pharmacology, and the Cancer Center.

Dieter Söllمشاهده پروفایل

استاد پژوهشی

• Molecular Biology
• Biochemistry
• Genetics
• +۴ مورد دیگر

Dieter Söll is a Sterling Professor Emeritus and Research Professor in Molecular Biophysics and Biochemistry at Yale University, also holding an Emeritus title in Chemistry. He received his PhD in Chemistry from the Technische Hochschule Stuttgart (1962) and conducted postdoctoral research under H.G. Khorana at the University of Wisconsin, contributing to the elucidation of the genetic code. Since 1967, he has led a research group at Yale, mentoring over 250 trainees. His work focuses on transfer RNA (tRNA), aminoacyl-tRNA synthetases, and the genetic code, with groundbreaking contributions to selenocysteine and pyrrolysine research. Söll co-founded Nucleic Acids Research and pioneered educational initiatives like a summer program for underrepresented students. He is a member of prestigious academies and has been honored with awards such as the Humboldt Research Award and Guggenheim Fellowship. Research interests span genetics, molecular biology, and synthetic biology, emphasizing tRNA's role in protein biosynthesis and genetic code expansion. Recent studies explore selenocysteine's therapeutic applications and archaeal genetic innovations. His legacy includes over 665 papers and foundational contributions to understanding life's molecular machinery. Awards: Sterling Professorship (2006), US National Academy of Sciences membership, honorary doctorate from Uppsala University. Education Initiatives: Creator of a model summer research program, recipient of Bouchet Leadership Award for mentoring. Labs/Teams: Dynamic research lab at Yale focused on tRNA synthetases and genetic code engineering.

• Tetrapyrroles
• Bacterial Resistance Mechanisms
• Lipid Modification
• +۳ مورد دیگر

Dr. Jürgen Moser is a Senior Academic Councillor/Group Leader at the Institute of Microbiology, Technical University of Braunschweig, within the Faculty of Life Sciences. His group focuses on tetrapyrrole biosynthesis, bacterial lipid modification mechanisms, and microbial natural products. He holds a PhD in organic chemistry and has led research on antibiotic resistance, chlorophyll synthesis, and violacein production. Education: 1991–1996: Studied Chemistry at Albert Ludwig University of Freiburg 1996–1997: Diploma thesis at Freiburg’s Department of Organic Chemistry (topic: phospholipase C structure) 1997–2000: PhD at Freiburg under Prof. D. Jahn (topic: glutamyl-tRNA reductase mechanism) Research Interests: Enzymatic mechanisms of tetrapyrrole biosynthesis tRNA-dependent lipid modifications (e.g., alanyl- and lysyl-phosphatidylglycerol) Antibiotic resistance pathways in Pseudomonas aeruginosa and Acinetobacter baumannii Chlorophyll and bacteriochlorophyll synthesis in photosynthetic bacteria Biosynthesis of antimicrobial natural products like violacein Publications: Recent work includes studies on carnitine degradation pathways in pathogens, lipid homeostasis in biofilms, and structural biology of nitrogenase-like enzymes. His research bridges microbiology, enzymology, and structural biology to uncover molecular mechanisms of bacterial adaptation and survival. Lab/Team: The Moser Group investigates microbial metabolism and resistance mechanisms, with ongoing projects in the MINAS consortium for microbial natural products. Collaborations include structural biology (e.g., crystallography) and biophysical methods.

Claus-Peter Witteمشاهده پروفایل

استاد

• Central nucleotide metabolism
• Nucleotide catabolism
• Urea catabolism
• +۷ مورد دیگر

Prof. Dr. Claus-Peter Witte is a full Professor and Executive Director at the Institute of Plant Nutrition, Leibniz University Hannover, within the Faculty of Natural Sciences. He leads research in molecular nutrition and plant biochemistry, focusing on nucleotide and nitrogen metabolism. He also serves on multiple academic committees, including the Faculty Council, Curriculum and Teaching Committee, and the Admissions Board for MSc Plant Biotechnology. Studied biotechnology at TU Braunschweig (1991–1997) Diploma thesis at University of Córdoba, Spain (1996–1997) PhD at Scottish Crop Research Institute, UK (1997–2001), supported by DAAD and Marie Curie scholarships Postdoctoral fellow at Max Planck Institute for Plant Breeding Research (2001–2004), EMBO fellow University Assistant at Free University of Berlin (2005–2009) Group leader of German-Chinese junior research group (2009–2014) Habilitation in Botany, Free University of Berlin (2012) Appointed W3 Professor at Leibniz University Hannover (2014) His research centers on central nucleotide metabolism, including purine and pyrimidine catabolism, urea and ureide degradation, and nucleoside salvage pathways in plants. He investigates metabolic analytics and the role of nucleotide metabolites in plant development and stress responses. His work integrates biochemistry, molecular biology, and metabolomics. Analysis of his recent publications (2021–2025) reveals a consistent focus on nucleotide metabolism in plants, particularly enzymes involved in purine and pyrimidine catabolism, nucleoside phosphorylation, and salvage pathways. His studies employ structural biology, metabolomics, and genetic approaches, often in Arabidopsis thaliana and crop plants, contributing to understanding metabolic regulation, genome stability, and plant nutrition. Prof. Witte has held prestigious fellowships, including DAAD, Marie Curie, and EMBO, reflecting his international research recognition. While no specific awards are listed, these fellowships underscore his scientific excellence. He advises students and collaborates widely, with frequent co-authorship with researchers such as Herde, Straube, and Medina-Escobar. He has contributed to methodological advances in nucleotide analysis and protein purification. His research is supported by institutional and likely external funding, though specific grants are not detailed. Prof. Witte leads the Institute of Plant Nutrition, overseeing research and education in plant nutrition and biochemistry. His team investigates metabolic pathways critical for plant growth, nutrient use efficiency, and stress adaptation, with potential applications in agriculture and biotechnology.

Didier Mazelمشاهده پروفایل

پژوهشگر

• Bacterial Genome Plasticity
• Antibiotic Resistance
• Integrons
• +۱۲ مورد دیگر

Didier Mazel is a Researcher and Head of the Plasticity of the Bacterial Genome unit at the Institut Pasteur in Paris, France, within the Genomes and Genetics Department. He leads a research team investigating bacterial genome dynamics, particularly in the context of antibiotic resistance and evolution. His research focuses on integrons—natural genetic systems that capture and express genes, notably those conferring antibiotic resistance—and the unique two-chromosome genome of Vibrio cholerae . His team employs genetic and post-genomic approaches to study gene recombination, stress responses, and chromosome maintenance. Key research areas include the molecular mechanisms of integron recombination, the impact of sub-inhibitory antibiotic concentrations on bacterial stress responses, and the coordination of dual chromosome replication in Vibrio species. They have also developed novel antimicrobial technologies targeting resistant pathogens. Dr. Mazel’s recent publications (2024–2025) reveal significant insights into integron function as biobanks of antiphage defense systems, the mechanical regulation of recombination efficiency, toxin-antitoxin control of gene cassette dynamics, and tRNA modifications linked to antibiotic tolerance. His work bridges fundamental molecular biology with applied antimicrobial strategies. He is actively involved in teaching, contributing to the Pasteur Institute’s genome analysis course and a MOOC on antibacterial resistance. He mentors several PhD students and postdoctoral researchers and leads multiple research projects, including Definbank, Chromintevol, and studies on Vibrio genome plasticity. His research is supported by institutional and national funding, and he collaborates within interdisciplinary programs such as Labex IBEID and INCEPTION, focusing on emerging infectious diseases and integrative biology. His laboratory is equipped with advanced imaging and molecular analysis tools.

• Medicinal Chemistry
• Organic Chemistry
• Autoimmune Diseases
• +۵ مورد دیگر

Dr. John Southern is an Assistant Professor in the Department of Chemistry at Trinity College Dublin (TCD), where he conducts research at the intersection of organic, medicinal, and chemical biology. His work focuses on the synthesis of novel nucleobase analogs and small molecules with therapeutic potential for autoimmune and neuroinflammatory diseases. Assistant Professor, Department of Chemistry, Trinity College Dublin Visiting Professor, Louvain-la-Neuve University, Belgium (2006) His research interests include medicinal chemistry, tRNA modification, autoimmune disease modulation, and synthetic methodology development. He has pioneered work on artificial nucleobase incorporation into tRNA, demonstrating disease remission in animal models of multiple sclerosis. His group designs bioactive heterocycles, including thiophenes, pyrrolidines, and piperidines, with applications in immunology and neuroscience. The recent publications highlight a strong trend toward developing novel agents for autoimmune conditions such as rheumatoid arthritis and multiple sclerosis. These studies combine synthetic organic chemistry with biological evaluation, focusing on cytokine regulation (e.g., IL-6), tRNA modification enzymes, and neuroinflammatory pathways. The work bridges chemical synthesis and translational medicine, aiming to deliver new therapeutic strategies through nucleic acid and small molecule interventions. Scientific Awards and Honors: Visiting Professor, University of Louvain-la-Neuve, Belgium (Jan–Apr 2006) Dr. Southern has advised several graduate students and postdoctoral researchers, though specific names are not listed in the source material. His research has been supported by peer-reviewed grants, particularly in the areas of autoimmune disease therapeutics and nucleic acid chemistry, although grant details are not specified. He collaborates closely with researchers such as Prof. Stephen J. Connon and Prof. Vincent P. Kelly. While no dedicated laboratory name is mentioned, his research group operates within the School of Chemistry at TCD, contributing to the institution’s strengths in pharmaceutical and synthetic chemistry. The team employs techniques in organic synthesis, enzymology, and molecular biology to explore novel biochemical interventions.

Laura Hartmannمشاهده پروفایل

استاد

• Glycobiology
• Chemical Biology
• Macromolecular Chemistry
• +۱۲ مورد دیگر

Professor Dr. Laura Hartmann is a faculty member in the Department of Macromolecular Chemistry at the Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf (HHU). She has held this position since March 1, 2023, and leads an active research group at the interface of chemistry and biology, with a focus on glycobiology and disease mechanisms. Her research interests include: Chemical Glycobiology Aberrant Protein Glycosylation Congenital Disorders of Glycosylation (CDG) NGLY1 Deficiency and the Nrf1 Pathway Bioorthogonal Chemistry and Glycoanalysis Development of Molecular Tools for Biomolecule Analysis The recent publications of Prof. Hartmann and her team reveal a strong trend in developing chemical tools for glycoprotein analysis, understanding rare genetic diseases like CDGs, and exploring therapeutic strategies for cancers such as multiple myeloma through modulation of the NGLY1/Nrf1 axis. Her work combines synthetic chemistry, biochemical analysis, and disease modeling. Scientific awards and recognitions include: ERC Consolidator Grant (2022) Honored for contribution to the Wolf Prize 2022 special issue of the Israel Journal of Chemistry Prof. Hartmann actively mentors and advises students, including PhD candidates Simon Walber, Georgia Partalidou, and Frauke Stoelting, as well as Master's and Bachelor's students. Her research is supported by competitive grants, including the ERC Consolidator Grant, and she collaborates with national and international researchers, such as Prof. Nicole Snyder and Dr. Jonathan Lim. She is also involved in academic outreach through initiatives like the Dr. Manfred Jäger Lecture series. She leads a research laboratory focused on chemical glycobiology, where her team develops and applies bioorthogonal probes and investigates the molecular basis of glycosylation-related diseases. The lab is part of the broader Institute of Organic Chemistry and Macromolecular Chemistry at HHU and participates in research consortia such as GlycoPathogens.

• Phage Therapy
• Biocontainment
• Molecular Biology
• +۳ مورد دیگر

Pamela Tsoumbris serves as an Academic Casual staff member in the School of Natural Sciences, Faculty of Science and Engineering at Macquarie University, concurrently pursuing her Doctor of Philosophy (PhD) candidacy as indicated by her HDR email address. Educational background: Doctor of Philosophy (PhD) candidate at Macquarie University Research Interests: Ms. Tsoumbris specializes in developing safety mechanisms for bacteriophage-based therapies through molecular engineering. Her expertise spans: Design of genetic biocontainment systems using amber suppressor tRNA Engineering of therapeutic bacteriophages with controlled replication Integration of synthetic biology principles for viral vector safety Translational approaches to overcome clinical barriers in phage therapy Molecular characterization of phage-host interactions Development of fail-safe mechanisms for environmental release Publication Trends: Her 2021-2024 publications demonstrate a focused research trajectory in creating clinically viable phage therapies through precision genetic modifications. The work bridges fundamental virology with practical therapeutic applications, emphasizing safety engineering as a prerequisite for regulatory approval and clinical adoption. Scientific Recognition: No formal awards or fellowships were documented in the source materials. Mentorship and Funding: As a PhD candidate in a part-time academic role, there is no evidence of independent grant acquisition or formal student supervision responsibilities. Her scholarly contributions center on collaborative research publications within her doctoral program. Research Environment: Ms. Tsoumbris operates within Macquarie University's School of Natural Sciences research ecosystem, likely collaborating with molecular virology and synthetic biology laboratories focused on antimicrobial alternatives and genetic engineering applications.