جست‌وجوی استاد و پژوهشگر

• Evolutionary Biology
• Microbiology
• Genomics
• +۸ مورد دیگر

Joseph J. Gillespie is an Assistant Professor at the University of Maryland School of Medicine in the Department of Microbiology and Immunology . His research focuses on the evolutionary biology of obligate intracellular pathogens, particularly Rickettsia and Orientia species, and their interactions with arthropod vectors. Education : BS in Biology (Widener University, 1998), MS in Entomology/Applied Ecology (University of Delaware, 2001), PhD in Entomology (Texas A&M University, 2005), Postdoc & Senior Research Associate (Virginia Bioinformatics Institute, 2006-2013) Dr. Gillespie employs phylogenetics, comparative genomics, and bioinformatics to investigate three core research areas: 1) Virulence Factors (e.g., RalF, RARP-2, Risk1 effectors), 2) Host-Dependent Metabolism (amino sugar scavenging, metabolic network reconstruction), and 3) Reproductive Parasitism (Wolbachia-like toxin-antidote systems in Rickettsiales). His work is NIH-funded with grants exploring lipid A variation, RAGE-mediated gene transfer, and rickettsial secretome dynamics. He serves on multiple committees at UMB, including the Awards Committee and Curriculum Committee . Dr. Gillespie also contributes to science communication, appearing in the Netflix series '72 Dangerous Animals: Latin America' and maintaining active roles in editorial boards ( PeerJ , PLoS NTD ). Scientific Awards & Service : Editorial Board, PeerJ (2017-present) Editorial Board, PLoS Neglected Tropical Diseases (2020-present) Research Advisory Board, Johns Hopkins Temporal Bone Histopathology (2024) NIH Study Section Reviewer (Bacterial Pathogenesis, Prokaryotic Cell Biology) Collaborations : University of Cambridge (Dr. Jeanne Salje) Auburn University (Dr. John Beckmann) University of Maryland Dental School (Dr. Bob Ernst) University of Maryland (Dr. Alan Cross) University of Victoria (Dr. Dave Goodlett) Washington State University (Dr. Viveka Vadyvaloo, Dr. Anders Omsland)

• Bacterial pathogenesis
• Gastrointestinal microbiology
• DNA supercoiling and gene regulation
• +۷ مورد دیگر

Associate Professor Tadhg Ó'Cróinín is a microbiologist based at the School of Biomolecular and Biomedical Science , University College Dublin (UCD) . Since 2008 he has held academic appointments rising to Associate Professor in June 2023. He served as Head of Microbiology (2016-2022) and Associate Dean for Study Abroad (2011-2016) and currently chairs the UCD Student Finance Committee . Education BA (Moderatorship) in Microbiology, Trinity College Dublin (1995) PhD in Paediatrics, University College Dublin (1999) Professional Diploma in University Teaching & Learning, University College Dublin Research Interests Dr Ó’Cróinín’s group investigates the molecular basis of bacterial virulence, focusing on gastrointestinal pathogens such as Campylobacter jejuni , Salmonella enterica and Helicobacter pylori , as well as biofilm-forming pathogens on medical devices including Staphylococcus aureus and Pseudomonas aeruginosa . A unifying theme is the role of DNA supercoiling as a global regulator of virulence gene expression, biofilm formation and antibiotic resistance. The laboratory employs in vitro cell-culture models, 3-D intestinal spheroids, in vivo infection models, high-content imaging and genome-scale analyses to dissect these processes. Publication Themes Recent publications (2024-2025) reveal three major strands of work: (i) elucidating how DNA-relaxation in C. jejuni triggers an invasive phenotype and tight-junction disruption; (ii) developing antifouling and antimicrobial bioresorbable coatings for orthopaedic titanium implants to combat MRSA and P. aeruginosa biofilms; and (iii) genomic and phenotypic characterisation of novel yeast species from Irish soils. Earlier seminal studies established the role of DNA supercoiling and nucleoid-associated proteins (Fis, HU, Lrp) in regulating motility, invasion and intracellular survival across Salmonella , E. coli and Bordetella . Honours & Awards College of Science Teaching Award (2018) College of Science Teaching Award (2024) Chair, Professional Development Committee, Microbiology Society (2018-2021) Council Member, Microbiology Society (2018-2021) Grants & Supervision Since 2008 Dr Ó’Cróinín has been PI or Co-PI on >12 competitively funded grants from Science Foundation Ireland, EMBO, NIH, and industry partners, totalling in excess of €1.5 M. He has successfully supervised 7 PhD and 3 Master’s research students , mentoring them through projects spanning bacterial pathogenesis, antibiotic resistance and biofilm biology. Laboratory & Collaborations Research is conducted within the Microbiology Research Laboratory at UCD’s Health Sciences Centre. The group maintains active collaborations with clinical (Our Lady’s Children’s Hospital), materials-science (AMBER, CRANN) and international partners (NIH Bethesda, VU Amsterdam) to translate insights into infection control and biomaterial innovation.

• Structural biology
• Protein biochemistry
• Protein crystallography
• +۳ مورد دیگر

Hartmut Niemann is a Professor for Structural Biochemistry at Bielefeld University since 2013, affiliated with the Faculty of Chemistry under the Biochemistry IV department. He previously held a Junior Professorship there from 2007 to 2013. His research focuses on structural and protein biochemistry , particularly protein crystallography , with applications in studying virulence factors of human pathogenic bacteria , Type III secretion systems , flavin-dependent halogenases , and pharmacological chaperones for multiple sulfatase deficiency . Doctoral scholarship of the Boehringer Ingelheim Fund (1999-2001) Scholarship of the German National Academic Foundation (1996-1997) Scholarship for particularly gifted students of the Free State of Bavaria (1992-1997) He has held leadership roles in scientific communities, including Contact person of the Society for Biochemistry and Molecular Biology (GBM) since 2020 and Spokesperson of the Working Group on Biological Structures, German Society for Crystallography (DGK) (2017-2020).

• Microbiology
• Virology
• Molecular Biology
• +۵ مورد دیگر

Colin Tittes is a researcher at the University of Groningen , affiliated with the Faculty of Science and Engineering and Molecular Microbiology department. His work focuses on archaeal virology and host-pathogen interactions. Current affiliation: University of Groningen Academic rank: Researcher Research interests span archaeal genetics, viral hijacking mechanisms, and microbial physiology. His recent publications highlight studies on: Haloarchaeal virus-host systems Surface structure interactions Genetic tool development Bartonella infection mechanisms Collaborations include researchers from multiple institutions across Europe. His 2024 thesis Salty Genetics establishes a comprehensive framework for haloarchaeal research.

• Structural Biology
• Host-Pathogen Interactions
• Glycosaminoglycan Metabolism
• +۳ مورد دیگر

Dr. Mirosław Cygler is a Professor at the University of Saskatchewan's Department of Biochemistry, Microbiology & Immunology, where he leads research in structural biology and host-pathogen interactions. He holds an MSc in Physics and PhD in Chemistry from the University of Lodz, Poland. Previously, he served as Principal Research Officer at NRC's Biotechnology Research Institute (Montreal) and maintains adjunct roles at McGill University. His work focuses on bacterial virulence mechanisms, glycosaminoglycan metabolism, and high-throughput structural biology pipelines. Research interests center on: Automated structural determination of protein complexes Molecular mechanisms of bacterial O-antigen synthesis and export Enzymatic pathways in glycosaminoglycan degradation Legionella/Salmonella effector proteins and host cell manipulation Recent publications (2015–2025) reveal strong emphasis on: Bacterial pathogenesis (Salmonella/Legionella effector systems) Structural virology (SARS-CoV-2 spike dynamics) Enzyme mechanisms in cancer and metabolism Innovative techniques in protein crystallography Awards include the NRC Outstanding Research Achievement Award for establishing a medium-throughput structural biology pipeline. He directs a laboratory specializing in structural analysis of pathogenicity systems and collaborates with the Protein Crystallography Beamline Design Team at Canadian Light Source. His team integrates biochemical, microbiological, and computational approaches to study macromolecular interactions.

Samuel Wagnerمشاهده پروفایل

استاد

• Bacterial Secretion Systems
• Anti-Infective Development
• Molecular Microbiology
• +۳ مورد دیگر

Samuel Wagner is a Full Professor of Infection Biology at the University of Tübingen and heads the Section for Cellular and Molecular Microbiology at the Institute for Medical Microbiology and Hygiene, University Hospital Tübingen. He serves as Director of Graduate Studies for the Interfaculty Graduate School of Infection Biology and Microbiology (IGIM), Deputy Director of the Interfaculty Institute for Microbiology and Infection Medicine Tübingen (IMIT), and member of the Cluster of Excellence "Controlling Microbes to Fight Infections" (CMFI) Board. He also co-coordinates the DZIF's TTU Gastrointestinal Infections. Education: Human Biology (Marburg), Biomedicine (Karolinska Institute), Biochemistry PhD (Karolinska, 2008) Research focuses on anti-infective strategies targeting bacterial virulence mechanisms , particularly structural and functional analysis of Salmonella 's Type III Secretion System (T3SS) and Legionella 's Type IV Secretion System (T4SS). His work spans molecular microbiology, infection biology, and therapeutic development, with emphasis on pathogen-host interactions and secretion system inhibition. Recent publications show trends in secretion system architecture , effector protein targeting , and anti-virulence compound discovery . Collaborations include EMBO, HFSP, DZIF, and CMFI initiatives. Scientific Awards EMBO Long-Term Fellowship (2008) Human Frontier Science Program Fellowship (2009) Sofja Kovalevskaja Award (2012) Capital Junge Elite 4x40 under 40 (2014) DGHM Förderpreis (2016) Active in academic leadership as Vice Dean for Digitalization and Young Scientists (Faculty of Medicine, 2020-present) and member of multiple expert commissions. Collaborates with German Center for Infection Research (DZIF) and European research networks.

Irina Saraiva Francoمشاهده پروفایل

استادیار

• Microbiology
• Infection Biology
• Cellular Microbiology
• +۳ مورد دیگر

Irina Saraiva Franco serves as an Assistant Professor in the Department of Life Sciences at the Faculty of Science and Technology, NOVA University Lisbon. Her office is located in Cabinet 303 with extension 11107, and she maintains active research leadership through the Infection Biology Lab. Her research centers on intracellular bacterial pathogens, specifically Legionella pneumophila and Chlamydia trachomatis , investigating how effector proteins subvert host cell processes to establish replicative niches. Ongoing projects focus on L. pneumophila effectors involved in actin dynamics and nuclear targeting, alongside C. trachomatis Golgi-associated proteins. This multidisciplinary work combines subcellular localization studies, eukaryotic target identification, and biochemical characterization to unravel pathogen survival mechanisms. Analysis of her publication record reveals consistent contributions to bacterial pathogenesis, with emphasis on effector protein functions, cytoskeletal manipulation, and host-pathogen molecular interactions. Her work spans experimental studies, methodological developments, and comprehensive reviews that contextualize bacterial secretion systems within cellular microbiology. Dr. Franco leads the Infection Biology Lab with dual affiliations at FCT NOVA and UCIBIO (Applied Molecular Biosciences Unit), maintaining active research Twitter presence. Her laboratory bridges fundamental molecular mechanisms with translational infection biology through collaborative projects across Portuguese and international institutions.

Jaime Motaمشاهده پروفایل

دانشیار

• Microbiology
• Infectious Diseases
• Bacterial Pathogenesis
• +۴ مورد دیگر

Jaime Mota is an Associate Professor at the Department of Life Sciences, NOVA School of Science and Technology (NOVA FCT), NOVA University Lisbon. His research focuses on understanding the molecular and cellular mechanisms by which bacterial pathogens modify the normal functioning of animal host cells, with the goal of developing specific strategies to combat infectious diseases. Dr. Mota's research interests center on bacterial pathogenesis, particularly studying intracellular pathogens including Chlamydia trachomatis (which causes sexually transmitted diseases and ocular infections), Legionella pneumophila (causing Legionnaire's Disease), and Salmonella enterica (responsible for gastrointestinal and systemic diseases). His laboratory investigates how these bacteria inject effector proteins into host cells through specialized type III or type IV secretion systems, and how these molecular mechanisms contribute to bacterial intracellular growth and virulence. His work bridges microbiology, cellular biology, and infectious disease research, exploring how microbial pathogens manipulate host cell processes including cytokinesis, centrosome positioning, Golgi distribution, and lipid droplet dynamics. Analysis of Dr. Mota's recent publications (2013-2024) reveals a consistent research trajectory focused on effector proteins of intracellular bacterial pathogens, particularly Chlamydia trachomatis . His work demonstrates expertise in identifying and characterizing bacterial effector proteins, understanding their molecular mechanisms, and determining how they manipulate host cell processes. The research spans multiple model systems including Chlamydia , Legionella , and Salmonella , with particular emphasis on type III secretion systems and the proteins they deliver into host cells. Dr. Mota leads the Infection Biology laboratory, which is hosted at the Department of Life Sciences of FCT NOVA and is part of the Molecular Microbiology & Genomics Research Group of the R&D unit UCIBIO. His laboratory employs a range of cellular and molecular techniques to study host-pathogen interactions, with the ultimate goal of translating fundamental knowledge into strategies for combating infectious diseases.

J SIVARAMANمشاهده پروفایل

استاد

• Macromolecular Structure
• Protein Function
• Infectious Diseases
• +۱۰ مورد دیگر

J SIVARAMAN is a Professor in the Department of Biological Sciences at the National University of Singapore (NUS), where he leads the Macromolecular Structure and Function Laboratory. His research program focuses on structural and functional studies of protein targets related to infectious diseases and cancers, employing X-ray crystallography to determine three-dimensional structures and understand functional roles in disease mechanisms. The lab investigates host-pathogen interactions with particular emphasis on bacterial and viral pathogenesis. Professor Sivaraman's research interests center on macromolecular structure and function, with specific focus on proteins involved in infectious diseases and cancer. His laboratory investigates molecular mechanisms of bacterial pathogenesis, particularly studying type III secretion system (T3SS) and type VI secretion systems (T6SS) in Gram-negative bacteria, as well as viral pathogenesis mechanisms of hepatitis E virus (HEV). Additionally, his group studies structural basis for mechanisms of action of cancer-related proteins and their interactions within signal transduction pathways. The long-term goal of his research is to provide new avenues for drug design and development through understanding host-pathogen interactions and cancer mechanisms. His publication record shows a strong focus on structural biology of pathogenic mechanisms, with significant contributions in understanding viral capsid structures, bacterial secretion systems, antibiotic resistance mechanisms, and cancer-related protein interactions. The research spans multiple pathogens and disease mechanisms, demonstrating a comprehensive approach to structural biology with therapeutic applications. Publications appear in high-impact journals including Cell Research, Nature Communications, PNAS, and EMBO Journal. Scientific Recognition: Faculty of 1000 (F1000) recommended his 2011 paper in Nature Protocols as one of the most important articles in biology and medical research Professor Sivaraman's laboratory investigates structural and functional aspects of proteins critical to disease processes, combining structural approaches with in vitro and in vivo functional assays to identify molecular determinants involved in disease mechanisms. His work bridges basic structural biology with potential therapeutic applications, particularly in the areas of infectious disease and cancer. The research has implications for drug design and development targeting specific protein mechanisms in pathogens and cancer cells. The Macromolecular Structure and Function Laboratory is located in Block S3, Level 3, Department of Biological Sciences at NUS (14 Science Drive 4, Singapore 117543), with laboratory contact number 6516 1163 and office number 6779 2486. The lab continues to be active as evidenced by the website being updated as recently as January 25, 2021.

Sara Blumer-Schuetteمشاهده پروفایل

دانشیار

• Microbial Physiology
• Microbial Genomics
• Extremophiles
• +۳ مورد دیگر

Sara Blumer-Schuette is an Associate Professor in the Department of Biological Sciences at Oakland University in Rochester, MI. She holds a Ph.D. and maintains her laboratory in MSC 330, with office space in MSC 331. Her research focuses on extremophilic microorganisms and their applications in biotechnology, particularly studying non-model environmental microorganisms living at the extremes of life. Professor Blumer-Schuette's research interests center around microbial physiology and genomics of extremophiles, with specific focus on mechanisms used by thermophilic microbes to interact with energy substrates. Her work explores microbial attachment mechanisms, environmental implications of energy harvesting processes, and identifying targets for rational design of commercially relevant microbes. She also investigates transport systems used to secrete large enzymes (some over 200 kDa) by monoderm bacteria and methods to optimize secretion efficiency. Analysis of her publication record reveals a consistent focus on thermophilic bacteria from the genus Caldicellulosiruptor, with research spanning microbial physiology, genomics, and biotechnology applications. Her work bridges fundamental microbiology with practical applications in biofuel production and industrial biotechnology, demonstrating expertise in anaerobic and aerobic microbiology, functional genomics, microbial genetics, and biochemistry. Professor Blumer-Schuette actively mentors students in research, with multiple undergraduate and graduate students presenting their work at academic conferences including the Biology Research Day Symposium at Oakland University and the Annual Michigan Branch of the American Society for Microbiology meeting. Her laboratory provides hands-on research experience for students interested in cutting-edge microbiological techniques and extremophile research. She teaches several courses including BIO 1200 Biology I, BIO 3500 General Microbiology, BIO 4511 Microbial Biotechnology, and specialized courses in Microbial Physiology and Genomics. Her laboratory continues to welcome new students for summer research projects and thesis work, maintaining an active research program in extremophile physiology and genomics.