معرفی
Dr. Mirosław Cygler is a Professor at the University of Saskatchewan's Department of Biochemistry, Microbiology & Immunology, where he leads research in structural biology and host-pathogen interactions. He holds an MSc in Physics and PhD in Chemistry from the University of Lodz, Poland. Previously, he served as Principal Research Officer at NRC's Biotechnology Research Institute (Montreal) and maintains adjunct roles at McGill University. His work focuses on bacterial virulence mechanisms, glycosaminoglycan metabolism, and high-throughput structural biology pipelines.
Research interests center on:
- Automated structural determination of protein complexes
- Molecular mechanisms of bacterial O-antigen synthesis and export
- Enzymatic pathways in glycosaminoglycan degradation
- Legionella/Salmonella effector proteins and host cell manipulation
Recent publications (2015–2025) reveal strong emphasis on:
- Bacterial pathogenesis (Salmonella/Legionella effector systems)
- Structural virology (SARS-CoV-2 spike dynamics)
- Enzyme mechanisms in cancer and metabolism
- Innovative techniques in protein crystallography
Awards include the NRC Outstanding Research Achievement Award for establishing a medium-throughput structural biology pipeline.
He directs a laboratory specializing in structural analysis of pathogenicity systems and collaborates with the Protein Crystallography Beamline Design Team at Canadian Light Source. His team integrates biochemical, microbiological, and computational approaches to study macromolecular interactions.
