معرفی
J SIVARAMAN is a Professor in the Department of Biological Sciences at the National University of Singapore (NUS), where he leads the Macromolecular Structure and Function Laboratory. His research program focuses on structural and functional studies of protein targets related to infectious diseases and cancers, employing X-ray crystallography to determine three-dimensional structures and understand functional roles in disease mechanisms. The lab investigates host-pathogen interactions with particular emphasis on bacterial and viral pathogenesis.
Professor Sivaraman's research interests center on macromolecular structure and function, with specific focus on proteins involved in infectious diseases and cancer. His laboratory investigates molecular mechanisms of bacterial pathogenesis, particularly studying type III secretion system (T3SS) and type VI secretion systems (T6SS) in Gram-negative bacteria, as well as viral pathogenesis mechanisms of hepatitis E virus (HEV). Additionally, his group studies structural basis for mechanisms of action of cancer-related proteins and their interactions within signal transduction pathways. The long-term goal of his research is to provide new avenues for drug design and development through understanding host-pathogen interactions and cancer mechanisms.
His publication record shows a strong focus on structural biology of pathogenic mechanisms, with significant contributions in understanding viral capsid structures, bacterial secretion systems, antibiotic resistance mechanisms, and cancer-related protein interactions. The research spans multiple pathogens and disease mechanisms, demonstrating a comprehensive approach to structural biology with therapeutic applications. Publications appear in high-impact journals including Cell Research, Nature Communications, PNAS, and EMBO Journal.
Scientific Recognition:
- Faculty of 1000 (F1000) recommended his 2011 paper in Nature Protocols as one of the most important articles in biology and medical research
Professor Sivaraman's laboratory investigates structural and functional aspects of proteins critical to disease processes, combining structural approaches with in vitro and in vivo functional assays to identify molecular determinants involved in disease mechanisms. His work bridges basic structural biology with potential therapeutic applications, particularly in the areas of infectious disease and cancer. The research has implications for drug design and development targeting specific protein mechanisms in pathogens and cancer cells.
The Macromolecular Structure and Function Laboratory is located in Block S3, Level 3, Department of Biological Sciences at NUS (14 Science Drive 4, Singapore 117543), with laboratory contact number 6516 1163 and office number 6779 2486. The lab continues to be active as evidenced by the website being updated as recently as January 25, 2021.
