جست‌وجوی استاد و پژوهشگر

• Polyene Macrolide Biosynthesis
• Antibiotic Engineering
• Genetic Manipulation of Secondary Metabolism
• +۴ مورد دیگر

Dr. Patrick Caffrey serves as an Assistant Professor in the School of Biomolecular and Biomedical Science at University College Dublin, with a continuous academic appointment since July 1995. His research focuses on engineering polyene macrolide antibiotics, particularly amphotericin B analogues, through genetic manipulation of Streptomyces nodosus and related bacteria. His research interests center on biosynthesis of polyene antibiotics derived from bacterial and fungal natural products, with emphasis on genetic manipulation of secondary metabolic pathways. Caffrey's work targets engineered biosynthesis of less toxic polyene analogues through polyketide synthase modification, glycosylation engineering, and late-stage oxidative modifications. Key projects include development of 16-descarboxyl-16-methyl amphotericin B and disaccharide-modified polyenes with improved therapeutic indices. Analysis of recent publications reveals consistent innovation in polyene engineering, with 2022-2024 work focusing on structural characterization of biosynthetic enzymes, biomimetic purification methods, and glycoengineering of novel analogues. His research combines structural biology, synthetic biology, and pharmaceutical chemistry to address toxicity limitations in antifungal therapy. Scholarship (2003-2006) Caffrey actively mentors through module coordination in Microbial Physiology, Molecular Genetics and Biotechnology, and Natural Product Synthesis. His research program has secured grants supporting metabolic engineering of antibiotic-producing bacteria. Current work involves optimizing polyene glycosylation and developing biomimetic polymers for analogue purification, with applications against fungal infections, leishmaniasis, and prion diseases. His laboratory maintains focus on Streptomyces genetics and polyketide biochemistry, collaborating with structural biologists and pharmaceutical chemists to translate engineered biosynthesis into therapeutic candidates.

• Analytical Chemistry
• Mass Spectrometry
• Bioanalysis
• +۴ مورد دیگر

Dr. Javier Sastre Torano is an Assistant Professor in the Department of Chemical Biology and Drug Discovery at Utrecht University's Faculty of Science. He leads the Analytical Glycoscience Group and specializes in advanced analytical techniques for glycan analysis. His research focuses on addressing key challenges in glycomics, particularly the accurate determination of glycan structures and their quantification. Dr. Sastre Torano completed his doctoral studies at Utrecht University, defending his thesis "Analysis of Glycans by Electrophoretic Approaches: Highly Sensitive Capillary Electrophoretic Separation and Ion Mobility-Mass Spectrometric Structure Assignment" in 2020. His academic background is in analytical chemistry, with a strong focus on developing innovative methodologies for complex biomolecule analysis. His research interests span multiple areas of analytical science with emphasis on glycomics . Dr. Sastre Torano specializes in: Advanced glycan structural analysis Ion mobility spectrometry applications Mass spectrometry for biomolecular characterization Capillary electrophoresis techniques Pharmaceutical and bioanalytical method development His publication record demonstrates a consistent focus on developing and applying cutting-edge analytical techniques for glycan characterization. His work particularly emphasizes the integration of ion mobility with mass spectrometry to solve challenging problems in glycomics, including isomer differentiation and structural assignment of complex carbohydrates. Recent publications show increasing sophistication in analytical approaches for glycan analysis, with applications spanning pharmaceutical development, disease biomarker discovery, and fundamental glycoscience. Dr. Sastre Torano is actively involved in teaching within the College of Pharmaceutical Sciences, contributing to both bachelor's and master's programs in Pharmacy and Drug Innovation. He leads the Analytical Glycoscience Group, which focuses on developing novel analytical methodologies for glycan characterization. The group's work bridges analytical chemistry, biochemistry, and pharmaceutical sciences, with applications in drug development and disease biomarker discovery.

• Glycomics
• Protein Glycosylation
• Post-translational Modifications
• +۳ مورد دیگر

Jarkko Juhani Lackman is a Researcher at the Department of Cellular and Molecular Medicine within the Faculty of Health and Medical Sciences at the University of Copenhagen. His work focuses on protein glycosylation mechanisms in human physiology and disease, with contact details including phone +4535337951 and email jajl@sund.ku.dk. Research Focus: Post-translational modifications and protein glycosylation Integration of protein biology, glycoscience, and biomedicine Structural/functional impact of glycosylation in disease contexts Advanced methodologies: gene engineering, mass spectrometry, biophysical analysis Recent publications demonstrate consistent exploration of glycosylation's role in receptor function across cardiovascular and immune systems. Key findings include 'glyco-sulfo barcodes' regulating chemokine receptors (2023) and O-glycosylation modulating adrenergic receptor activity (2025), highlighting translational potential for disease treatment. Laboratory Affiliation: Member of the Schjoldager Group at University of Copenhagen Utilizes animal/cell models to dissect molecular protein functions

Ian Van Altenaمشاهده پروفایل

مدرس

• Chemical Ecology
• Natural Products Chemistry
• Marine Chemistry
• +۳ مورد دیگر

Dr. Ian Van Altena is an Honorary Lecturer in the School of Medicine and Public Health and a Lecturer in the School of Environmental and Life Sciences at the University of Newcastle. He holds a PhD in Chemistry from the University of Alberta (Canada) and has extensive postdoctoral and academic experience, including roles at the University of Adelaide and University of British Columbia. His research focuses on natural products chemistry, chemical ecology, and marine algae, with a particular emphasis on bioactive compounds from marine organisms and their applications in cancer research. Dr. Van Altena has supervised over a dozen PhD and Master’s students in areas such as marine natural products, anticancer agents, and phytochemical analysis. He has secured grants totaling AUD $202,778 for research infrastructure and natural product studies. His work bridges chemistry, biology, and environmental science, contributing to drug discovery and sustainable resource utilization. Education: BSc (James Cook University, 1972), BSc (Hons) under Prof. John Coll (1975), PhD (University of Alberta, 1976). Postdoctoral research at the University of British Columbia (1982–1984) on dinoflagellates. Professional memberships include the Royal Society of Chemistry and American Chemical Society. Research interests include isolation and characterization of bioactive metabolites from marine and terrestrial organisms, chemical ecology of algae, and development of extraction techniques for phytochemicals. His publications span natural products chemistry, pharmacology, and analytical methods, with a focus on compounds with pharmaceutical potential. Dr. Van Altena collaborates internationally, contributing to projects on pancreatic cancer therapies and traditional medicine analyses. Grants include AUD $190,000 for high-field NMR facilities (1994) and AUD $4,778 for teaching innovations (1995). His supervision spans marine natural products, anticancer agents, and chemotaxonomy. Notable contributions include studies on Cystophora spp. metabolites and bioactive compounds from Vietnamese medicinal plants.

Megan Bennettمشاهده پروفایل

پژوهشگر

• Structural Biology
• Biochemistry
• Enzymology
• +۴ مورد دیگر

Dr Megan Bennett is a Postdoctoral Research Associate in the Department of Chemistry at the University of York, working within Professor Gideon Davies' group. Her research focuses on carbohydrate-based enzymes, structural characterization, and biochemical analysis using X-ray crystallography and cryo-EM. Education: PhD in Chemistry (University of York), supervised by Professor Gideon Grogan MBioChem (University of York), studied under Professor Keith Wilson Research Interests: Structural and biochemical analysis of carbohydrate enzymes Activity-based probes for glycosidase enzyme studies Biocatalyst engineering for pharmaceutical chiral amines Labs & Teams: Member of Professor Gideon Davies' research group

Isabelle Auzanneauمشاهده پروفایل

استاد

• Carbohydrate Chemistry
• Organic Synthesis
• Immunology
• +۳ مورد دیگر

France-Isabelle Auzanneau is a Professor in the Department of Chemistry at the University of Guelph. Her research focuses on the synthesis and conformational analysis of carbohydrate-based antigens, particularly those associated with tumor cells and bacterial infections. She investigates how these antigens interact with the immune system, aiming to develop immunotherapeutics. Educational Background: B.Sc., Paris-Sud Orsay University (1985) M.Sc., Paris-Sud Orsay University (1986) Ph.D., Paris-Sud Orsay University (1989) Her work involves advanced techniques such as nuclear magnetic resonance (NMR) spectroscopy, molecular dynamics simulations, and organic synthesis for glycosylation reactions. She studies Lewis blood group antigens and their analogues, exploring their roles in immune responses and potential applications in vaccine design. Recent publications highlight her contributions to understanding glycan stability, self-assembly of carbohydrate networks, and the development of dimeric antigen fragments. Her lab at the University of Guelph (MACN 226/239) is equipped with modern instrumentation for chromatography, molecular modeling, and biointerface studies. She has mentored numerous graduate students and postdoctoral researchers, fostering expertise in carbohydrate chemistry and immunological applications. Her collaborations span disciplines, including food science and microbiology, reflecting a broad impact in glycosciences.

• Glycobiology
• Heparan Sulfate
• Drug Discovery
• +۴ مورد دیگر

Professor Jeremy Turnbull is Professor of Glycosciences at Keele University's School of Life Sciences with additional part-time appointments as Professor of Proteoglycans and Extracellular Matrix at the University of Copenhagen, Adjunct Professor at Ferrier Institute (New Zealand), and Visiting Professor at Imperial College London. His research focuses on structure-function relationships of heparan sulfate polysaccharides in biological processes and disease, particularly in cancer, neurodegenerative disorders, and viral infections like COVID-19. His laboratory has developed innovative glycomics strategies including saccharide sequencing techniques, synthetic libraries, and microarrays. This work has led to next-generation heparin drugs and the founding of spin-out company IntelliHep. His research has secured over £19M in funding and resulted in 153 publications with an H-index of 55. Major awards and honors: Fellow of the Royal Society of Chemistry (2012) Fellow of the Royal Society for Biology (2011)

Gideon Daviesمشاهده پروفایل

استاد پژوهشی

• Structural Enzymology
• Chemical Biology
• Glycoscience
• +۴ مورد دیگر

Professor Gideon Davies is a Royal Society Ken Murray Research Professor in the Department of Chemistry at the University of York. His research focuses on structural enzymology and chemical biology, particularly in glycoscience, exploring the roles of glycans in health and disease. He holds degrees from the University of Bristol and has held postdoctoral positions at EMBL Hamburg and CNRS Grenoble. PhD: University of Bristol (1990) Royal Society University Research Fellowship (1996) Fellowships: Royal Society (2010), Academy of Medical Sciences (2014) Research interests include enzyme mechanisms of carbohydrate-active proteins, development of activity-based probes, and applications in cancer biology, neurodegeneration, and microbiota studies. His work has led to advancements in understanding glycan biosynthesis and degradation pathways. Key awards include the 2024 Centenary Award (Biochemical Society), 2020 Rita and Cornforth Award (Royal Society of Chemistry), and the 2015 Davy Medal (Royal Society). He currently serves on the Royal Society Council.

Yuan Guoمشاهده پروفایل

استاد

• Glycobiology
• Multivalency
• Receptor Recognition
• +۷ مورد دیگر

Professor Yuan Guo is a faculty member at the University of Leeds, serving as Professor of Glycoscience within the School of Food Science and Nutrition. Her research is conducted in the Chemistry Faculty Environment, with a focus on glycan-mediated immune regulation and receptor signaling. She leads a multidisciplinary research program integrating carbohydrate chemistry, molecular biology, and immunology to understand how cell surface lectins translate extracellular glycan binding into intracellular immune signals. Research Interests: Professor Guo's work centers on glycobiology , particularly the mechanisms of multivalent interactions between glycan-binding receptors (C-type lectins) and their ligands. She investigates how receptor clustering induced by multivalent glycans regulates dendritic cell function and immune responses. Her research has significant implications for understanding immune evasion by pathogens and cancer, and for developing novel therapeutics. Her research program includes three major strands: (1) elucidating thermodynamic and kinetic principles of high-affinity multivalent lectin-glycan binding using glycan-nanoparticles; (2) uncovering how multivalent glycan binding modulates dendritic cell signaling, cytokine production, and antigen presentation; and (3) exploring therapeutic applications of glycan-nanoparticles in allergy and autoimmune diseases. These studies combine synthetic glycobiology, protein biochemistry, biophysics, and cell-based assays. No scientific awards or prizes were mentioned in the provided text. Professor Guo collaborates with clinical researchers to evaluate the therapeutic potential of glycan-nanoparticles using patient-derived samples. She has not listed any advisees or grant funding details. Her laboratory utilizes advanced nanoparticle platforms to mimic viral glycan structures and dissect immune cell activation mechanisms.

GIOVANNIMARIA PICCINIمشاهده پروفایل

دانشیار

• Physical Chemistry
• Computational Chemistry
• Molecular Dynamics Simulations
• +۵ مورد دیگر

Giovannimaria Piccini serves as an Associate Professor in the Department of Chemical and Geological Sciences at the University of Modena and Reggio Emilia (UNIMORE). His academic profile centers on advanced computational approaches to physical chemistry problems, with a particular focus on molecular dynamics simulations and free energy calculations applied to catalytic systems. His current teaching responsibilities include Physical Chemistry I, Physical Chemistry of Natural Systems, and Physical Chemistry of Catalysis for undergraduate and graduate programs in Chemistry and Chemical Sciences. Dr. Piccini's research interests span multiple sophisticated areas of computational chemistry, with emphasis on supramolecular catalysis , enzyme mechanisms , and molecular dynamics simulations . His work demonstrates particular expertise in developing and applying advanced computational methodologies for studying complex chemical systems. His research bridges theoretical chemistry with practical applications in biocatalysis, materials science, and drug development. A distinctive feature of his approach involves the development of innovative computational protocols that achieve high accuracy while maintaining computational feasibility, as evidenced by his work on free energy calculations and enhanced sampling techniques. Analysis of his recent publications (2022-2025) reveals a strong research trajectory focused on supramolecular systems, particularly molecular capsules and their catalytic applications. His work demonstrates increasing sophistication in computational methods while maintaining relevance to pressing environmental and biomedical challenges, such as plastic degradation and drug permeation. The interdisciplinary nature of his research connects physical chemistry with biochemistry, materials science, and organic synthesis, highlighting his ability to bridge theoretical and applied domains. Dr. Piccini has established productive collaborations with researchers across multiple institutions, as evidenced by his extensive publication record with international co-authors. His work frequently appears in high-impact journals, demonstrating recognition within the computational chemistry community. His ORCID identifier (0000-0002-3511-4281) documents his substantial scholarly output spanning from fundamental methodological developments to applied studies in catalysis and biophysics.

Kirk Bergstromمشاهده پروفایل

استادیار

• Host-microbiota interactions
• Glycobiology
• Mucin glycosylation
• +۳ مورد دیگر

Kirk Bergstrom is an Assistant Professor in the Department of Biology at the University of British Columbia's Okanagan campus, Faculty of Science. His research focuses on the complex relationship between host organisms and their microbial communities, with particular emphasis on the role of glycobiology in intestinal health. Based in ASC 373, he teaches undergraduate courses including BIOL420 Functional Glycoscience and BIOL314 Medical Microbiology, contributing to the education of future scientists in microbiology and related fields. Education: BSc from University of Northern British Columbia PhD from University of British Columbia Dr. Bergstrom's research centers on the intestinal mucus system and how defects in this system contribute to susceptibility to infections, inflammatory bowel disease (IBD), and colon cancer. His work specifically investigates how the intestine utilizes key glycosyltransferases (Core-1 and Core-3 synthases) to decorate mucin proteins with sugars (glycans), promoting optimal mucus function that keeps microbes at a healthy distance from the gut lining. His laboratory employs advanced techniques including functional analysis of mucins and glycan biology, gut ecology, and state-of-the-art imaging and genetic modeling to probe host-microbiota interactions at multiple biological levels. Analysis of his recent publications reveals a consistent research trajectory focused on mucin-type O-glycosylation and its critical role in maintaining gut homeostasis. His work spans from fundamental mechanisms of mucus barrier function to clinical implications for inflammatory bowel diseases and cancer. A significant trend in his research involves the development of non-invasive diagnostic approaches using fecal material to assess mucus barrier integrity in health and disease. Scientific recognition includes: The Bhagirath Singh Early Career Award in Infection and Immunity (2024) While Dr. Bergstrom serves as a graduate student supervisor, he is not currently accepting new graduate students. His research program has generated numerous high-impact publications in prestigious journals including Science, Nature Medicine, and Journal of Experimental Medicine. His work often involves collaborative efforts with researchers across multiple institutions, reflecting the interdisciplinary nature of microbiome research. Dr. Bergstrom's laboratory focuses on understanding how mucin-type O-glycans regulate formation and function of the intestinal mucus system, with goals aimed at increasing knowledge of fundamental roles of mucins in gut health and developing novel interventions for IBD and cancer patients.

Jamie Blazaمشاهده پروفایل

استاد

• Bioenergetics
• Cryo-EM
• Bacteriology
• +۷ مورد دیگر

Professor Jamie Blaza is a UKRI Future Leader Fellow and head of the York Bioenergetics Lab at the University of York. His research explores the structural and functional dynamics of bioenergetic systems, focusing on cryo-EM analysis of mitochondrial and bacterial respiratory complexes, carbon fixation mechanisms, and antibiotic transport. Education: Undergraduate in Microbiology (University of Leeds, National University of Singapore); PhD in Mitochondrial Biophysics (University of Cambridge). Research Interests: The lab employs interdisciplinary approaches at the intersection of biology, chemistry, and physics to unravel molecular mechanisms in bioenergetics. Key areas include: Structural analysis of mitochondrial complex I using cryo-EM Bacterial antibiotic resistance and transporter mechanisms Carbon fixation in eukaryotic green lineage through collaboration Glycoscience and energy metabolism in tuberculosis pathogens Article Trends: Recent publications highlight advancements in cryo-EM structures of respiratory complexes, transmembrane acyltransferases, and ribosome hibernation factors, with applications in microbiology, structural biology, and metabolic engineering. Scientific Awards: UKRI Future Leader Fellowship (2021) Advising & Grants: Jamie mentors students at the interface of biological and physical sciences. His projects are funded by UKRI, BBSRC, and EPSRC, including grants for Energy metabolism and antibiotic action in tuberculosis and Synthetic pyrenoid engineering for enhanced crops . Labs: Leads the York Bioenergetics Lab within the York Structural Biology Laboratory, focusing on structural insights into bioenergetic systems and collaborative projects.

Francisco Vilaplanaمشاهده پروفایل

دانشیار

• Structural analysis of plant biomass
• Food raw materials
• Biopolymers and assemblies
• +۳ مورد دیگر

Francisco Vilaplana is an Associate Professor and Head of the Division of Glycoscience at KTH Royal Institute of Technology in Stockholm, Sweden. He also serves as Coordinator of the Research Environment for Healthy and Sustainable Food Systems and is a member of the Food Core Group at LINXS, where he leads the Structure of Food Raw Materials initiative. Focuses on structural characterization of plant biomass and food raw materials Develops chemo-enzymatic processes for food waste valorization Works on sustainable food systems and nutrition improvement His leadership in Glycoscience and contributions to transforming food waste streams into functional food products highlight his interdisciplinary approach at the intersection of biotechnology, food science, and sustainability.

• Bioengineering
• Systems Glycobiology
• Glycosciences
• +۶ مورد دیگر

Neelamegham Sriram is UB Distinguished Professor in the Department of Chemical and Biological Engineering , with joint appointments in Biomedical Engineering and Medicine at the University at Buffalo, State University of New York . Since 1997 he has progressed from Assistant Professor to his current distinguished rank, leading an interdisciplinary laboratory that integrates molecular, cellular and computational approaches to solve problems in human health and disease. Education PhD, Chemical/Biomedical Engineering, Rice University, 1996 B.Tech, Chemical Engineering, Indian Institute of Technology, Delhi, 1991 Post-doctoral training, Baylor College of Medicine, 1995–1997 Research Interests Prof. Neelamegham’s work is anchored in Bioengineering and Systems Glycobiology . His group deciphers how complex cell-surface glycans modulate leukocyte and platelet adhesion under fluid shear, with implications for inflammation , thrombosis , cancer metastasis and viral infection . Using high-throughput glycomics, CRISPR screens, microfluidics and machine-learning models, the lab develops: Novel glycosylation inhibitors and glycoengineered stem-cell targeting strategies. Mechanistic insights into von Willebrand factor (VWF) self-association under shear. Open-source bioinformatics tools (e.g., GNAT, DrawGlycan-SNFG) for systems glycobiology. Publications & Impact Across 140+ peer-reviewed articles, patents and book chapters, recent work (2020-2025) emphasizes AI-driven glycan structure prediction, SARS-CoV-2 glycobiology, cancer glycocalyx disruption, and next-generation VLP/mRNA delivery systems, positioning the lab at the forefront of translational glyco-engineering. Scientific Awards & Honors NIH Independent Scientist Award SUNY Chancellor’s Award for Excellence in Scholarship and Creative Activities (2015) Schoellkopf Medal, Western New York ACS (2018) Fellow, AIMBE (2012) Fellow, BMES (2019) Advising & Grant Leadership The lab hosts post-doctoral researchers, graduate students, research technicians and undergraduates, supported by multiple NIH R01 and NSF awards. Active recruitment is advertised for post-doctoral associates and full- or part-time research technicians. Laboratory & Collaborations Located in 906 Furnas Hall, the Neelamegham Laboratory operates core facilities for glycomics, microfluidic shear devices, and computational modeling. Collaborations extend across UB’s Clinical and Translational Research Center, Roswell Park Comprehensive Cancer Center, and national consortia including NCBI-glycans (SNFG standards).

• Glycoscience
• Infectious Diseases
• Cancer
• +۵ مورد دیگر

Mark von Itzstein is a Distinguished Professor at Griffith University's Institute for Biomedicine and Glycomics, where he founded and directed the Institute for Glycomics (2000-2024). His research focuses on glycoscience and drug discovery, particularly in anti-infective therapeutics. He is an NHMRC Investigator since 2021 with current projects targeting influenza, parainfluenza, drug-resistant bacteria, and cancer. His landmark achievement includes leading the team that developed the anti-influenza drug Relenza®, approved worldwide since 1999. Research spans: Carbohydrate-based drug discovery Antiviral therapeutic development Glycotherapeutic platforms Cancer glycobiology Publications reveal strong emphasis on viral pathogenesis mechanisms (55%), glycoconjugate synthesis (20%), cancer glycobiology (15%), and analytical glycomics (10%). Recent work utilizes advanced structural biology and glycoanalytics to develop novel therapeutics. Honors include: Fellow of Australian Academy of Science (2003) Fellow of Australian Academy of Health & Medical Sciences (2015) Officer of the Order of Australia (2019) Australia Prize for Health (1996) He has supervised 51+ graduate students across doctoral and master's projects in virology, glycobiology, and diagnostics. Currently leads 12 doctoral candidates in projects including universal vaccines, nanobody diagnostics, and cancer glycomics. Research infrastructure includes the ACRF International Centre for Cancer Glycomics and receives funding from NHMRC, industry partners, and philanthropic organizations totaling $10M+.