معرفی
Professor Yuan Guo is a faculty member at the University of Leeds, serving as Professor of Glycoscience within the School of Food Science and Nutrition. Her research is conducted in the Chemistry Faculty Environment, with a focus on glycan-mediated immune regulation and receptor signaling. She leads a multidisciplinary research program integrating carbohydrate chemistry, molecular biology, and immunology to understand how cell surface lectins translate extracellular glycan binding into intracellular immune signals.
Research Interests: Professor Guo's work centers on glycobiology, particularly the mechanisms of multivalent interactions between glycan-binding receptors (C-type lectins) and their ligands. She investigates how receptor clustering induced by multivalent glycans regulates dendritic cell function and immune responses. Her research has significant implications for understanding immune evasion by pathogens and cancer, and for developing novel therapeutics.
Her research program includes three major strands: (1) elucidating thermodynamic and kinetic principles of high-affinity multivalent lectin-glycan binding using glycan-nanoparticles; (2) uncovering how multivalent glycan binding modulates dendritic cell signaling, cytokine production, and antigen presentation; and (3) exploring therapeutic applications of glycan-nanoparticles in allergy and autoimmune diseases. These studies combine synthetic glycobiology, protein biochemistry, biophysics, and cell-based assays.
No scientific awards or prizes were mentioned in the provided text.
Professor Guo collaborates with clinical researchers to evaluate the therapeutic potential of glycan-nanoparticles using patient-derived samples. She has not listed any advisees or grant funding details. Her laboratory utilizes advanced nanoparticle platforms to mimic viral glycan structures and dissect immune cell activation mechanisms.
