جست‌وجوی استاد و پژوهشگر

• hypertension
• cardiovascular disease
• vascular biology
• +۶ مورد دیگر

Rhian Touyz is a Professor in the Department of Medicine at McGill University's Faculty of Medicine and Health Sciences. She serves as a Senior Scientist at the Research Institute of the McGill University Health Centre (RI-MUHC) at the Glen site, where she leads research within the Lifelong Cardiovascular Health Research Program at the Center for Translational Biology. Dr. Touyz's research focuses on elucidating the molecular and cellular processes that lead to vessel damage in hypertension. Her work specifically investigates reactive oxygen species, signaling molecules, hormones, and enzymes that cause damage to cells in the vascular wall. As evidenced by her extensive publication record, her laboratory has made significant contributions to understanding oxidative stress mechanisms in vascular biology, particularly related to NOX enzymes, ion channels, and signaling pathways in hypertension. Analysis of Dr. Touyz's recent publications (2019-2025) reveals a consistent research trajectory focused on molecular mechanisms of vascular dysfunction in hypertension. Her work spans multiple sub-disciplines including oxidative stress biology, ion channel physiology, vascular signaling pathways, and the intersection of cardiovascular disease with other conditions like obesity, cancer therapies, and viral infections. A significant portion of her recent work examines NOX enzymes (particularly NOX4 and NOX5) and their role in redox signaling in vascular cells. Her research has important clinical implications for understanding hypertension pathophysiology and developing novel therapeutic approaches. Dr. Touyz actively contributes to clinical guidelines and public health initiatives related to hypertension management, as demonstrated by her publications in CMAJ addressing Canadian hypertension practices. She also has a growing body of work in cardio-oncology, examining vascular complications of cancer therapies. Her research demonstrates strong translational potential, bridging basic molecular mechanisms with clinical applications in cardiovascular disease prevention and treatment.

• Biochemistry
• Molecular Biology
• Pharmacology
• +۷ مورد دیگر

Michael B. Jarstfer, PhD, is an Associate Professor at the University of North Carolina at Chapel Hill and a member of the UNC Lineberger Comprehensive Cancer Center . He is affiliated with the Eshelman School of Pharmacy , where his research focuses on the chemical basis and biochemical functions of cancer-related pathways . Research Interests : Enzyme function, ribonucleoprotein complex assemblage, telomere maintenance, telomerase mechanism, synthetic and physical organic chemistry, molecular biology, enzyme kinetics, and small-molecule design for anticancer therapy. Key Findings : His work reveals the A-form helix interaction in telomerase, rate-limiting steps in RNA-DNA unwinding, and template-dependent regulation of telomerase activity. Current Projects : Rational design of small molecules targeting telomerase assemblage and fidelity, aiming to induce telomere sequence alterations for apoptosis in cancer cells without relying on telomere erosion. Contact : Office phone 919-966-6422 , email jarstfer@unc.edu , lab at Beard Hall Room 326 . Research Trends : His publications (1994–2025) emphasize telomerase as a universal anticancer target, interdisciplinary methods (synthetic chemistry, structural biology), and educational innovations in pharmacy training.

• Translational Pathology
• Histopathology
• Multiplex Immunohistochemistry
• +۷ مورد دیگر

Michelle A. Wood-Trageser, PhD is an Assistant Professor in the Division of Translational Pathology at the University of Pittsburgh School of Medicine. She serves as co-director for the CAP/CLIA certified Research Histology Services Laboratory, working alongside Dr. A. Jake Demetris to advance the field of transplant pathology through innovative histological techniques. Dr. Wood-Trageser earned her BS from Elizabethtown College in 2004 and her PhD from the University of Pittsburgh in 2009, establishing a strong foundation for her career in translational research. Her research program focuses on integrating traditional histopathological approaches with multiplex immunohistochemistry and digital image analysis to enhance understanding of disease processes within tissue. The laboratory's primary focus is on characterizing the immune microenvironment within biopsy tissues, with recent expansion into genomic capabilities for developing novel clinical tests that correlate geographical information from biopsies with molecular signatures. This integrative approach bridges the gap between classical pathology and modern molecular diagnostics. Dr. Wood-Trageser's publication record demonstrates consistent productivity across two major research domains: reproductive genetics (particularly ovarian biology and infertility) and transplant pathology. Her recent work (2020-2023) shows an increasing emphasis on digital pathology applications in transplantation, including immune synapse detection and T cell monitoring in allografts. She has developed expertise in combining genomic data with spatial tissue information to create more comprehensive diagnostic tools. Dorothy Lyet Research Endowment, Summer Research Stipend, Elizabethtown College (2002, 2003) Beta Beta Beta, Biological Honors Society, Elizabethtown College (2003-2004) Stephen L. Phillips Scientific Achievement Award, University of Pittsburgh, School of Medicine (2008) Gary Betty Scholar, University of Michigan (2009) Trainee Day Travel Award, Endocrine Society (2009) Outstanding Abstract Award, Endocrine Society (2011) Lalor Foundation Travel Fellow, Society for the Study of Reproduction (2014) Cornelia Post Channing New Investigator Award, Society for the Study of Reproduction (2014) Dr. Paul M. Rike Fellowship Award, Magee-Womens Research Institute (2014) As co-director of the Research Histology Services Laboratory, Dr. Wood-Trageser oversees a CAP/CLIA certified facility that serves as a hub for advanced histological techniques applied to both clinical and research specimens. Her mentorship approach emphasizes technical excellence in histopathology while encouraging innovation in digital and genomic pathology applications. Current research directions include developing methods to correlate spatial tissue architecture with molecular signatures, creating more precise diagnostic frameworks for transplant pathology and reproductive disorders.

Praveen Thumbikatمشاهده پروفایل

استاد

• Immunology
• Urologic Diseases
• Chronic Pelvic Pain
• +۳ مورد دیگر

Praveen Thumbikat serves as the O'Connor Family Research Professor of Urology and Professor of Pathology at Northwestern University's Feinberg School of Medicine. His primary appointment resides in the Department of Urology with secondary affiliation in Pathology. His educational background includes a DVM from Kerala Agricultural University (1997), MS from G.B Pant University (1999), and PhD from the University of Minnesota (2004). Dr. Thumbikat's research centers on immune and neuronal dysfunction in urologic diseases, with specific focus on chronic pelvic pain, bacterial prostatitis, and benign prostatic hyperplasia. His laboratory investigates mast cells and T cells in autoimmunity, neuroinflammation, and fibrosis across prostate, dorsal root ganglia, and spinal cord systems. The lab also explores epigenetic mechanisms, commensal bacteria-derived molecules for immune modulation, and tumor microenvironment modification for prostate cancer immunotherapy. His recent publications (2021-2023) demonstrate consistent focus on mast cell inhibition therapies for chronic pelvic pain, prostate inflammation mechanisms, and translational applications for immunotherapy. Key themes include neuroimmunology, fibrosis pathways, and bacterial pathogenesis in urological disorders. Dr. Thumbikat actively leads clinical trials including 'Chemokine mechanisms in chronic pelvic pain' (IRB STU00030121) and 'MAST CELLS IN MALE CHRONIC PELVIC PAIN' (NCT03167216, IRB STU00202831), investigating biomarkers and mast cell-targeted treatments for chronic pelvic pain syndrome. He serves as Associate Editor for Frontiers in Pain Research (2025-present) and Editorial Board Member for PLOS ONE (2017-present), while maintaining professional memberships in the International Association for the Study of Pain, American Society for Microbiology, and Society for Basic Urologic Research. His laboratory maintains active industry collaborations through Dolor Therapeutics, LLC and Equilibrio Biosciences Inc, focusing on drug development for diagnostics, formulations, and novel therapeutics derived from clinically isolated bacterial strains.

Dritan Agalliuمشاهده پروفایل

دانشیار

• Blood-Brain Barrier Biology
• CNS and Retina Vascular Biology
• Dynamic Imaging of the CNS Vasculature
• +۲ مورد دیگر

Dritan Agalliu is an Associate Professor of Pathology and Cell Biology at Columbia University Irving Medical Center . He is also a CTNI Scholar and affiliated with societies like the Society for Neuroscience and the International Brain Barriers Society. PhD in Genetics and Development (2006, Columbia University) Postdoctoral training at Stanford University (2011) Research focuses on blood-brain barrier (BBB) mechanisms in CNS diseases like stroke and autoimmune disorders. His lab uses genetic, molecular, and imaging tools to study BBB tight junctions, caveolae, and Wnt/β-catenin signaling for barrier repair. They also investigate immune cell entry in psychiatric disorder models post-Streptococcus infections. Recent publications emphasize BBB dynamics in 2024-2023, including studies on Norrin/β-catenin in retinal barriers and VEGF-A-driven neuroinflammatory angiogenesis. Earlier work (2016-2021) explores Th17 cell mechanisms, extracellular vesicles in BBB disruption, and Wnt signaling in CNS repair. Scientific accolades include the 2020 Lamport Award, 2016 PANDAS Network Innovator, and distinctions in his 2006 PhD and 1998 B.S. Advises graduate students: Connor Monahan, Mary Claire Tuohy Laboratory: Agalliu Lab at Columbia University Black Building, Room 3-310

• Vascular Physiology
• Ion Channel Regulation
• Hypertension Research
• +۶ مورد دیگر

Thomas Andrew Qvistgaard Jepps is an Associate Professor in the Department of Biomedical Sciences at the University of Copenhagen's Faculty of Health and Medical Sciences, where he leads research on vascular physiology with a focus on circulation, kidney, and lung systems. He also holds a Guest Researcher position in the Department of Drug Design and Pharmacology within the Molecular and Cellular Pharmacology section. Dr. Jepps received his BSc (Hons.) in Biomedical Sciences from St. George's University of London (2005-2008), followed by a PhD from the same institution funded by the Biotechnology and Biological Sciences Research Council (2009-2013). His academic journey includes postdoctoral research at the University of Copenhagen and prestigious fellowships including a Marie Curie Independent Research Fellowship and a Carlsberg Foundation Research Fellowship. His research program centers on understanding vascular ion channel regulation, particularly potassium channels, and their role in hypertension and vascular diseases. Dr. Jepps investigates two primary areas: KCNE ancillary subunits and microtubules in smooth muscle cells, with additional projects on smooth muscle proliferation in atherosclerosis, novel ion channels in angiogenesis, and functional sympatholysis mechanisms. His laboratory employs advanced techniques including isometric tension recordings, electrophysiology, immunostaining, proximity ligation assays, and molecular biology approaches. Analysis of his recent publications reveals a strong focus on vascular tone regulation, with particular emphasis on microtubule function in hypertension, potassium channel modulation by novel compounds, and translational research connecting basic mechanisms to clinical applications such as colchicine for hypertension treatment and understanding drug-induced hypotension. Scientific Recognition: Selected for the 68th Lindau Nobel Laureate Meeting (2018) Multiple best presentation awards at international symposia (2009-2014) Widdicombe Prize in Physiology from St. George's University of London (2009) Regular invitations to present at international conferences and departmental seminars Dr. Jepps has supervised 2 ERASMUS students, 9 bachelor's project students, and 3 Master's students. His research is supported by significant grants including the Carlsberg Foundation Research Fellowship (1,178,053DKK), Lundbeck Foundation Postdoctoral Fellowship (700,000DKK), and a Marie Curie Postdoctoral Fellowship (€199,809). He has organized numerous scientific events including the First International Kv7 Channels Symposium and Cardiovascular Seminar Series at the University of Copenhagen. His laboratory maintains active collaborations with researchers across multiple institutions including Prof. Geoffrey Abbott at UC Irvine (KCNE subunits), Prof. Christian Aalkjær at Aarhus University (microtubules in arteries), and Prof. Anthony Heagerty at the University of Manchester (colchicine for hypertension treatment).

Alexei Tumanovمشاهده پروفایل

دانشیار

• Immunology
• Molecular Immunology
• Cancer Immunology
• +۳ مورد دیگر

Alexei Tumanov, M.D., Ph.D., serves as an Associate Professor in the Department of Microbiology, Immunology & Molecular Genetics at the University of Texas Health Science Center at San Antonio (UTHSCSA) School of Medicine. Recruited in Fall 2016 after establishing his research lab at Trudeau Institute (NY) in 2011, he maintains laboratory space in the MED building (5.018V). His academic journey began at Russian State Medical University (M.D.), followed by Ph.D. training at Engelhardt Institute of Molecular Biology, and postdoctoral work with Dr. Yang-Xin Fu at University of Chicago. Russian State Medical University: M.D. Engelhardt Institute of Molecular Biology: Ph.D. in Molecular Biology University of Chicago: Postdoctoral Training Dr. Tumanov's research program investigates immune system regulation of protective immunity versus immunopathology, combining molecular data with in vivo models to develop immunotherapies. His work spans lymphoid organ development, cytokine networks (particularly lymphotoxin pathways), neuro-immune interactions, and cancer immunology. The lab demonstrates consistent productivity with publications in high-impact journals including Nature, Science Immunology, and Cancer Cell. Analysis of his recent publications reveals a strong focus on lymphotoxin signaling pathways across multiple disease contexts - from pancreatic cancer tertiary lymphoid structures to asthma pathogenesis and lymph node development. His work consistently bridges fundamental immunology with translational applications, particularly in inflammation regulation and immune cell trafficking mechanisms. Dr. Tumanov maintains active collaborations across immunology research centers, evidenced by co-authorships with institutions including Jackson Laboratory, NCI-Frederick (NIH), and multiple European research groups. His lab appears to focus on both innate lymphoid cell biology and stromal-immune interactions within tissue microenvironments.

• Vascular Biology
• Cardiovascular Physiology
• Endothelial Function
• +۵ مورد دیگر

Dr. David X. Zhang is an Associate Professor in the Department of Medicine, Division of Cardiology at the Medical College of Wisconsin, where he is also a member of the Cardiovascular Research Center. His academic career bridges clinical medicine (MD) and basic science research (PhD), positioning him at the forefront of translational cardiovascular research. Dr. Zhang's research focuses on the molecular mechanisms of vascular function, with particular emphasis on endothelial physiology, ion channel regulation (especially TRP channels), and the signaling pathways that control vasodilation and vascular tone. His laboratory investigates how reactive oxygen species (NO, H2O2), calcium signaling, and various mediators regulate human microvascular function in both health and disease states. Key areas of investigation include the role of TRPV4 channels in vascular signaling, mechanisms of endothelial dysfunction in coronary artery disease, and the vascular consequences of inflammatory conditions including SARS-CoV-2 infection. Analysis of Dr. Zhang's recent publication record (2019-2025) reveals a consistent research trajectory focused on molecular vascular mechanisms with direct clinical relevance. His work frequently employs human tissue models, providing translational significance to his findings. The publications demonstrate expertise in multiple methodologies including human microvessel physiology, molecular signaling analysis, and structural biology approaches. His research has made significant contributions to understanding alternative vasodilator mechanisms, ion channel regulation in vascular tissue, and the molecular basis of endothelial dysfunction. Dr. Zhang maintains an active collaborative network, as evidenced by his numerous multi-institutional publications. His work has been published in high-impact journals including Nature Communications, Journal of Biological Chemistry, Arteriosclerosis Thrombosis and Vascular Biology, and Basic Research in Cardiology. While specific grant details aren't provided, the sustained productivity and sophisticated nature of the research suggest substantial ongoing funding support. For students and researchers interested in vascular biology, Dr. Zhang's laboratory offers opportunities to work at the intersection of basic science and clinical cardiovascular research, with emphasis on human vascular physiology and molecular signaling mechanisms that have direct relevance to cardiovascular disease pathogenesis and potential therapeutic targets.

• Cardiac physiology
• Inflammatory cardiovascular disease
• Drug-induced cardiotoxicity
• +۵ مورد دیگر

Professor David Greensmith serves as Professor of Cardiac Physiology and Associate Dean for International Development at The University of Salford's School of Science, Engineering & Environment. He is an active researcher, educator, and leader in cardiovascular science with significant contributions to understanding cardiac physiology, inflammatory cardiovascular disease, and drug-induced cardiotoxicity. Greensmith earned his undergraduate degree in Biological Sciences from The University of Salford in 2005, followed by a PhD and two post-doctoral positions in cardiac physiology at The University of Manchester under Professors David Eisner, Mahesh Nirmalan and Andrew Trafford. He returned to Salford in 2014 as a lecturer in Biomedical Science and has since risen to his current professorship. His research focuses on the cellular basis of normal and dysfunctional heart function, with particular emphasis on calcium signaling and oxidative stress mechanisms. Current projects investigate why anti-cancer drugs cause heart failure and how abnormal heart cell function contributes to coronary artery disease. His lab also explores natural product derivatives for cancer treatment, particularly against medulloblastoma and leukemia. Greensmith's recent publications demonstrate his dual focus on cardiac physiology and cancer therapeutics, with significant work on cytokines in coronary artery disease, calcium signaling mechanisms, and natural compounds like Tripterygium wilfordii derivatives. His research spans basic physiological mechanisms to potential clinical applications. The Physiological Society's Otto Hutter Teaching Prize (2023) Associate Editor for Current Research in Physiology President of the British Society for Cardiovascular Research (starting January 2025) Scientific Director of KidsCan (starting January 2025) Physiological Society representative for The University of Salford (since 2017) As an educator, Greensmith has led physiology modules and the Human Biology & Infectious Diseases degree programme. He co-leads initiatives to enhance widening participation in research careers, particularly for students from disadvantaged socioeconomic backgrounds. His 2023 Otto Hutter Teaching Prize recognized his excellence in physiology education. He accepts self-funded PhD students interested in cardiac physiology, drug-induced cardiotoxicity, and natural product-based cancer therapeutics.

• Vascular Physiology
• Exercise Physiology
• Hypertension Research
• +۳ مورد دیگر

Dr. Seher Ülker is a Lecturer in the Department of Physiotherapy and Rehabilitation at Alanya Alaaddin Keykubat University's Faculty of Health Sciences. She holds a PhD in Physiology from Akdeniz University (2018) and previously served as Research Assistant at Akdeniz University's Department of Physiology (2010-2018). Her academic appointments include multiple administrative roles: Deputy Head of Department (2021), Director of Research and Application Center (2020), and General Coordinator for Disabled Students (2019). Her research focuses on vascular physiology mechanisms , particularly carbon monoxide pathways in vascular tone regulation, exercise-induced vascular adaptations, and hypertension models. She investigates how aging, exercise training, magnesium supplementation, and 20-HETE inhibition affect vascular reactivity in resistance/conduction arteries using rodent models. Recent publications (2020-2024) demonstrate continued productivity in journals like Journal of Surgical Research and Turkish Bulletin of Hygiene . Dr. Ülker actively supervises graduate students with four recent theses (2023-2025) on rehabilitation topics including knee osteoarthritis, archery performance, temporomandibular dysfunction, and multiple sclerosis frailty. She teaches 8+ courses annually across undergraduate and graduate programs, covering physiology fundamentals, exercise physiology, and rehabilitation science. Key research contributions: Parabiosis effects on vascular aging (2022) Carbon monoxide regulation in hypertensive models (2020) Exercise adaptations in vascular tone (2019) Magnesium therapy mechanisms in hypertension (2015-2016) 20-HETE pathway in trained vasculature (2018) She has led 6 nationally funded research projects (2009-2018) including TÜBİTAK 1002 support. Dr. Ülker also contributes to rehabilitation literature through book chapters on temporomandibular dysfunction, sarcopenia, and exercise modalities.

• Vascular Biology
• Endothelial Cell Biology
• Macrophage Biology
• +۹ مورد دیگر

Dr. Yajaira Suarez is the Anthony N. Brady Professor of Comparative Medicine and Deputy Chair of the Department of Comparative Medicine at Yale School of Medicine. She also holds a secondary appointment as Professor of Pathology and is an active member of the Yale Cancer Center, Vascular Biology and Therapeutics Program, and Yale Center for Molecular and Systems Metabolism. Dr. Suarez earned her BS and PhD in Biochemistry and Molecular Biology from Universidad Autonoma de Madrid (1995, 2001), followed by postdoctoral training at Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (2002-2005) and Yale University School of Medicine (2005-2009). She began her independent research career at New York University School of Medicine in 2009 before joining Yale in 2013. Her research program focuses on understanding novel regulatory mechanisms in endothelial cell and macrophage functions, particularly examining non-coding RNAs, metabolic rewiring, immunometabolism, and cholesterol regulation. This work has significant implications for atherosclerosis, cancer, and metabolic diseases. Her publication record demonstrates consistent high-impact research in top-tier journals including Nature Communications, Journal of Clinical Investigation, and PNAS. Dr. Suarez's research output shows a clear focus on the intersection of vascular biology and metabolism, with recent publications (2021-2025) emphasizing endothelial cell metabolism, macrophage immunometabolism, and non-coding RNA regulation in cardiovascular and metabolic diseases. Her work has established her as a leader in understanding how metabolic pathways regulate vascular function and inflammation. Recipient of the 2025 Judah Folkman Award in Vascular Biology Elected member of Connecticut Academy of Science and Engineering (2022) Werner Risau New Investigator Award in Vascular Biology Kingsley Award in Medical Research from Yale School of Medicine Fellowship-Grant Award from CNIC P3+3 programme for Post-doctoral Careers in Biomedicine Dr. Suarez maintains active collaborations with numerous researchers at Yale and internationally. Her lab employs a multidisciplinary approach combining molecular and cellular biology, biochemistry, and genetically modified mouse models. Her recent work has significant translational potential for developing novel therapies for cardiovascular diseases, cancer, and metabolic disorders.

Dianna M. Milewiczمشاهده پروفایل

استاد

• Cardiovascular Medicine
• Medical Genetics
• Vascular Diseases
• +۵ مورد دیگر

Dr. Dianna M. Milewicz is a distinguished Professor, Vice-Chair of the Department of Internal Medicine, and Director of the Medical Genetics Division at the University of Texas Health Science Center at Houston (UTHealth) McGovern Medical School. She holds the prestigious President George H.W. Bush Chair of Cardiovascular Medicine and has directed the M.D./Ph.D. Program offered jointly between UTHealth and MD Anderson Cancer Center for over a decade. Dr. Milewicz's research focuses on the genetic basis of vascular diseases, particularly thoracic aortic aneurysms and dissections. Her work has significantly advanced the understanding of Marfan syndrome and other connective tissue disorders affecting the cardiovascular system. With over three decades of research productivity, her publication record demonstrates consistent contributions to the field of cardiovascular genetics. Analysis of Dr. Milewicz's recent publications reveals a strong emphasis on clinical guidelines for aortic disease management, genetic mechanisms of vascular pathology, and translational research connecting basic science discoveries to clinical applications. Her work spans from fundamental molecular mechanisms to large-scale consensus statements that shape clinical practice worldwide. Antoine Marfan Award Doris Duke Distinguished Clinical Scientist Award University of Texas Presidential Scholars Award for Excellence in Research Inducted into the American Society of Clinical Investigation Inducted into the Association of American Physicians As Director of the Medical Genetics Division and co-director of the MD/PhD program, Dr. Milewicz plays a pivotal role in training the next generation of physician-scientists. Her leadership extends to national guideline committees where she has helped shape standards of care for patients with aortic diseases. Her dual board certification in Internal Medicine and Medical Genetics enables her to bridge clinical care with cutting-edge genetic research, creating a comprehensive approach to patient management. Dr. Milewicz leads research efforts focused on identifying genetic markers for vascular diseases and understanding the molecular pathways that lead to aortic pathology. Her work has established critical connections between genetic mutations and clinical manifestations, enabling earlier diagnosis and more targeted interventions for patients at risk of aortic complications.

Michael E. DiSantoمشاهده پروفایل

دانشیار

• Urogenital Physiology
• Smooth Muscle Biology
• Sexual Medicine
• +۲ مورد دیگر

Michael E. DiSanto, PhD, serves as Associate Professor of Biomedical Sciences and Surgery and Director of Urology Research at Cooper Medical School of Rowan University (CMSRU), where he has been a core faculty member since the institution's founding in 2010. He co-directs the Uro-Renal course and plays a pivotal role in teaching the Fundamentals curriculum. Dr. DiSanto earned his PhD from Drexel University and completed postdoctoral training at Wyeth-Ayerst Laboratories and the University of Pennsylvania, where he was an NIH NRSA Postdoctoral Research Fellow and AFUD/NIH Research Scholar. He served on Penn's faculty until 2004 before directing Urology Research at Albert Einstein College of Medicine until joining CMSRU. His research program investigates smooth muscle physiology in the lower urogenital tract, with seminal contributions to understanding penile erection mechanisms and bladder dysfunction. Current work explores sphingolipid signaling pathways in urogenital tissues including the vagina, supported by continuous NIH R01 and program project funding. With over 60 publications in top-tier journals, his scientific impact is recognized through key professional roles: Associate Editor, Journal of Sexual Medicine Chair, Basic Science Committee of Sexual Medicine Society of North America Standing Member, NIH Urologic and Genitourinary Study Section Standing Member, American Diabetes Association Grant Review Panel His leadership extends to medical education through course directorship and curriculum development, while his research program provides critical infrastructure for urological discovery at CMSRU.

Lars Maegdefesselمشاهده پروفایل

استاد

• vascular disease
• atherosclerosis
• aortic aneurysm
• +۴ مورد دیگر

Lars Maegdefessel is a Professor of Molecular Vascular Medicine at the Technical University Munich (TUM), School of Medicine and Health. He leads the Experimental Vascular Medicine unit at Klinikum rechts der Isar and serves as a DZHK Junior Group Leader. His research focuses on the therapeutic and biomarker potential of non-coding RNAs in vascular diseases including atherosclerosis, aortic aneurysm, and related vascular pathologies. Dr. Maegdefessel's research interests center on the role of non-coding RNAs in vascular diseases, with particular focus on the vulnerability of atherosclerotic vascular lesions and the progression and rupture of abdominal aortic aneurysms. His laboratory utilizes unique human biobank materials and various pre-clinical experimental models to investigate novel molecular approaches for combating cardiovascular diseases. His work spans from basic research on microRNAs, long non-coding RNAs, and circular RNAs to translational applications in vascular medicine. Analysis of Dr. Maegdefessel's publication record reveals a strong focus on non-coding RNA mechanisms in vascular pathology, with particular emphasis on atherosclerosis stabilization, aneurysm development, and vascular inflammation. His research has evolved from basic miRNA characterization to sophisticated therapeutic applications including targeted delivery systems and novel biomarker discovery. The publications demonstrate a consistent trajectory toward clinical translation of RNA-based vascular therapeutics. ERC Consolidator Grant (2023) Russel Ross Award from American Heart Association (2023) Heisenberg Professorship of German Research Foundation (2016) Werner Risau Award of American Heart Association (2016) ERC Starting Grant (2015) Prince Daniel Research Award of Swedish Heart and Lung Foundation (2014) Ragnar Söderberg Fellowship in Medicine (2014) Dr. Maegdefessel's research program includes extensive collaboration with international teams and utilizes advanced methodologies including RNA sequencing, microarrays, proteomics, and epigenomic analyses. His laboratory investigates ncRNA function in human vascular tissues and pre-clinical models, with recent work focusing on artery-on-a-chip technology and novel therapeutic delivery systems for vascular applications.

Frances Planeمشاهده پروفایل

دانشیار

• Vascular Biology
• Cardiovascular Pharmacology
• Endothelial Dysfunction
• +۳ مورد دیگر

Frances Plane is an Associate Professor at the University of Alberta specializing in vascular biology and cardiovascular pharmacology. Her research targets endothelial dysfunction in metabolic diseases, focusing on endothelial-smooth muscle communication mechanisms critical for blood pressure regulation and tissue perfusion. Education: PhD Pharmacology, University of London, 1992 Her laboratory investigates how disruption of endothelial-derived factors like nitric oxide and myoendothelial gap junctions contributes to hypertension, atherosclerosis, and thrombosis in diabetes. Using functional, electrophysiological, and molecular approaches, her team identifies novel ion channel targets to restore vascular function. Current work emphasizes metabolic disease models and therapeutic strategies for endothelial repair. Recent publications (2018-2022) reveal strong thematic continuity in vascular pharmacology, with emphasis on endothelial ion channels, platelet-vascular interactions, and sex-specific responses. Key trends include oxidative stress mechanisms in metabolic disease, repurposing existing drugs for vascular conditions, and myoendothelial feedback pathways as therapeutic targets. Scientific Awards: NSERC Discovery Grant Research Grant from Marshall Eliuk Fund for Medical Research Dr. Plane actively mentors graduate students including MSc candidate Stephen Gust, while leading a research team with lab assistant Caleb McInroy. Her grants support investigations into vascular dysfunction biomarkers and novel interventions for diabetic vascular complications. She is affiliated with the Cardiovascular Research Institute and teaches PMCOL425 (Pharmacology). Her laboratory operates from the Medical Sciences Building (9-62), utilizing advanced techniques to study resistance artery physiology and endothelial signaling pathways in metabolic disease contexts.