جست‌وجوی استاد و پژوهشگر

Dmitri Kudryashovمشاهده پروفایل

استاد

• Biochemistry
• Cell Biology
• Molecular Biology
• +۶ مورد دیگر

Dr. Dmitri Kudryashov is a Professor in the Department of Chemistry and Biochemistry at The Ohio State University (OSU), part of the College of Arts and Sciences. He joined OSU in 2011 and was promoted to Associate Professor in 2017, later becoming a full Professor. His research focuses on actin cytoskeleton dynamics, bacterial toxins, and their roles in health and disease. Education and Background: Kudryashov received his MD from the Russian Medical State University (Moscow) and a PhD from the Russian Academy of Medical Sciences. He completed postdoctoral research at UCLA under Prof. Emil Reisler, earning awards for his work on actin and myosin cytoskeletons, including the Paul Boyer Award and Herbert Newby McCoy Award. Research Interests: Key areas include: Actin cytoskeleton in health/disease: cancer metastasis, bacterial/viral pathogenesis, and osteogenesis Actin-specific bacterial toxins (e.g., ACD, TccC3) and their mechanisms Selective cancer cell ablation using split toxins Defensin-mediated neutralization of pathogens His lab uses interdisciplinary approaches like fluorescence spectroscopy, cryo-EM, and X-ray crystallography, collaborating with experts in NMR, microbiology, and structural biology. Awards and Grants: NIH grants (IGMS R01, NCI R21), Pelotonia funding, and patents for split toxin technology. Notable publications in Science , Nature Structural & Molecular Biology , and PNAS . Lab and Team: The Kudryashov Group recruits undergraduates, graduates, and postdocs. Current projects explore toxin-based tools for studying actin roles in inflammation, apoptosis, and DNA repair. Collaborations span institutions like University of Delaware, Stanford, and University of Virginia.

James Sherryمشاهده پروفایل

استاد بالینی

• Immigrant/Refugee Health Policy
• Global Health
• Community Health Care
• +۵ مورد دیگر

James Sherry, MD, PhD, is a Clinical Professor and Director of the CUNY Center for Immigrant, Refugee, and Global Health at the City University of New York (CUNY) Graduate School of Public Health and Health Policy. He holds leadership roles in global health initiatives, including directing the USAID Health Research and Applied Research Development Project (HEARD) and its successor, the Implementation Science Collaborative. His expertise spans reproductive, maternal, child, and adolescent health, with over three decades of experience in program design, implementation, and evaluation across low- and middle-income countries. Dr. Sherry earned his MD from the University of Michigan, PhD in Biochemistry from Carnegie-Mellon University, and residency training in Pediatrics at Children’s Hospital of Michigan. He also holds an MBBCH from Cairo University. His career includes roles as Professor and Chair of Global Health at George Washington University, Chief Science Officer at PEPFAR/OGAC, and leadership positions at UNAIDS, UNICEF, and the World Food Program. His research focuses on immigrant/refugee health policy, rural health systems, global health organizational development, and implementation science. Current projects emphasize multi-country collaborations to strengthen evidence-based health policies. He serves on boards for the United Way of Chautauqua County and the Chautauqua Integrated Delivery Systems, and directs the Chautauqua Health Network. Dr. Sherry’s academic contributions span biochemistry to global health systems, with notable work on Guinea worm eradication, mHealth innovations, and health diplomacy strategies. His recent publications highlight frameworks for implementation science and maternal/newborn health interventions across diverse settings.

• Keratinocyte and melanocyte biology
• Ultraviolet radiation induced skin carcinogenesis
• Protein kinase C signaling

Mitchell Denning, PhD, is the Associate Dean for Graduate Education and a Professor in the Department of Cancer Biology and Pharmacology & Neuroscience at Loyola University Chicago's Stritch School of Medicine. His research focuses on keratinocyte and melanocyte biology, ultraviolet radiation-induced skin carcinogenesis, and the role of protein kinase C (PKC) signaling pathways in epidermal biology. His work investigates cellular responses to UV radiation, including DNA damage repair, inflammation, and cell death mechanisms, with applications in developing preventive and therapeutic strategies against skin cancers. Education: BS in Biochemistry, University of Arizona PhD in Human Cancer Biology, University of Wisconsin-Madison Postdoctoral Fellowships: Skin Carcinogenesis (NIH/NCI) and Cell-Cell Adhesion (Northwestern University) Research Interests: Dr. Denning’s lab explores how PKC signaling regulates epidermal cell fate decisions (proliferation, differentiation, death) and how UV radiation disrupts these processes, leading to skin carcinogenesis. Key topics include UV-induced inflammation, DNA repair mechanisms, and the development of novel therapeutics targeting these pathways. Publications: His recent work spans cancer biology, hepatocellular carcinoma, and signaling pathways, with a focus on translating molecular mechanisms into clinical applications. Notable studies include investigations into RIPK3 signaling in leukemia, EphA2 inhibition in liver cancer, and PKCα’s role in breast cancer drug resistance. Labs/Teams: His laboratory integrates molecular, biochemical, and cell biological approaches to study epidermal biology and skin cancer pathogenesis.

William Jacksonمشاهده پروفایل

استاد

• Cardiovascular Pharmacology
• Ion Channel Biology
• Vascular Physiology
• +۵ مورد دیگر

Dr. William Jackson is a Professor in the Department of Pharmacology & Toxicology at Michigan State University (MSU), affiliated with the College of Osteopathic Medicine. He completed his B.S. (Zoology, 1974), M.S. (Physiology, 1976), and Ph.D. (Physiology, 1979) at MSU, followed by postdoctoral training at the University of Virginia. His career includes academic roles at Western Michigan University (1989–2005) and the Medical College of Georgia (1983–1989). He leads the online Professional Science Master’s program in Integrative Pharmacology since 2005. Research focuses on ion channel regulation of vascular tone, particularly myogenic responses and oxygen signaling in microcirculation. Key areas include hypertension, aging effects, and disease impacts on arteriolar function. Notable contributions include identifying TRPV4 and K+ channel roles in cerebrovascular health and cognitive function. Teaching responsibilities include courses like PHM 830 (Experimental Design & Data Analysis) and PHM 802 (Cellular/Molecular Pharmacology). Awards include the Distinguished Faculty Scholar from WMU (1998). His work bridges pharmacology, physiology, and computational biology, with over 150 peer-reviewed articles addressing vascular pathophysiology mechanisms. Education: B.S. Zoology, MSU (1970–1974) M.S. Physiology, MSU (1974–1976) Ph.D. Physiology, MSU (1976–1979) Affiliations: Director, Online PSM Integrative Pharmacology Program Member, MSU Pharmacology & Toxicology faculty since 2005 Grants & Labs: NIH-funded studies on cerebral microvasculature Focus on translational research linking ion channels to clinical outcomes Publications emphasize mechanisms of vascular dysfunction in hypertension, aging, and neurodegenerative diseases, with recent work exploring sex-based differences in vascular resilience.

• Chemical Biology
• Cancer Biology
• Signal Transduction
• +۱۰ مورد دیگر

Kevan Shokat is a Professor in the Department of Cellular and Molecular Pharmacology at the University of California San Francisco (UCSF), where he leads a research group focused on chemical biology, kinase signaling, and targeted cancer therapies. His work bridges pharmacology, biochemistry, and oncology, with a strong emphasis on developing novel inhibitors for previously 'undruggable' targets like KRAS. His research interests center on signal transduction pathways in cancer, particularly the roles of Ras, mTOR, and kinase networks. He pioneered chemical genetic approaches using analog-sensitive kinases to map substrate networks and identify drug targets. His lab investigates mechanisms of drug resistance, oncogenic signaling, and the development of covalent inhibitors for mutant KRAS variants (e.g., G12C, G12D). He also explores mTOR modulation in cancer and neurodegeneration, and has contributed significantly to understanding kinase regulation and proteome dynamics. His recent publications highlight a strong trend in targeting oncogenic GTPases, developing chemical probes for spatial signaling, and uncovering resistance mechanisms in kinase inhibitors. The work spans structural biology, chemical probe design, and systems-level proteomics, often in collaboration with clinical and translational teams. Dr. Shokat has received numerous scientific honors, though specific awards are not listed in the text. His editorial roles and high-impact publications suggest recognition as a leader in chemical biology. He advises numerous students and postdoctoral researchers, as evidenced by his extensive co-authorship network. His lab also secures significant research grants, particularly in cancer drug discovery and kinase biology, though specific grants are not detailed. His laboratory is part of the UCSF academic and research ecosystem, collaborating across departments and institutions to advance chemical biology and therapeutic development.

Joffre Mercierمشاهده پروفایل

استاد

• Neuroethology
• Comparative Neurobiology
• Endocrinology
• +۷ مورد دیگر

Joffre Mercier is a Professor in the Department of Biological Sciences within the Faculty of Mathematics and Science at Brock University. His research focuses on understanding how hormones and neurotransmitters modulate animal behavior through actions on the central nervous system, neuromuscular junctions, and visceral organs. He employs invertebrate model systems such as crayfish, fruit flies (Drosophila melanogaster), and freshwater prawns to investigate these mechanisms at multiple levels, from whole-animal behavior to cellular and molecular processes. His research interests center on neuroethology and the physiological basis of behavior, particularly how neuropeptides like proctolin and biogenic amines such as dopamine and octopamine influence synaptic transmission and muscle function. Using genetically tractable models like Drosophila, his lab explores the roles of specific genes and proteins in neural and muscular activity, combining electrophysiology, pharmacology, and behavioral assays. A key focus is on how neuropeptides act as co-transmitters to modulate glutamate-induced muscle contractions and how these modulatory effects translate into changes in locomotion and other behaviors. The recent publication record shows a strong trend in invertebrate neurobiology, with emphasis on neuromodulation, synaptic plasticity, and the intersection of endocrinology with behavior. Work spans molecular mechanisms of peptide action, G-protein coupled receptor signaling, and the physiological roles of biogenic amines in both neural and reproductive systems. Studies frequently involve detailed physiological experimentation on model organisms, often with implications for broader principles in neuroscience and comparative physiology. While no formal scientific awards are listed in the provided text, his research has been published in high-impact journals such as Journal of Neurophysiology , Journal of Experimental Biology , and PLoS One . He actively mentors students, as evidenced by numerous co-authored publications with graduate and undergraduate researchers. His lab engages in both basic research and pedagogical innovation, having developed laboratory exercises for student training in physiological experimentation. Current work continues to probe intracellular signaling pathways mediating the effects of neuropeptides and amines, with ongoing projects on proctolin’s role in larval crawling behavior and its dual function as hormone and co-transmitter. Dr. Mercier’s laboratory functions as an integrative research team focused on cellular and systems-level neuroscience in invertebrates. The group utilizes a multidisciplinary approach combining genetics, physiology, and behavior to uncover fundamental mechanisms of neuromodulation. Though no formal lab name is provided, the research environment supports collaborative student-faculty projects and contributes to both scientific knowledge and educational advancement in biological sciences.

Christian Aalkjærمشاهده پروفایل

استاد

• Physiology
• Vascular Physiology
• Cardiovascular Physiology
• +۹ مورد دیگر

Christian Aalkjær is a Professor in the Department of Biomedicine at Aarhus University, Denmark. His research is centered on vascular and cardiovascular physiology, with a focus on hypertension, blood vessel function, and ion transport mechanisms. He has led major interdisciplinary projects, including the Danish Cardiovascular Giraffe Research Programme, investigating extreme physiological adaptations in giraffes to inform human cardiovascular disease. Research Interests: Physiology of resistance arteries and vascular tone Intracellular pH and ion transport (NBCn1, V-ATPase) Hypertension and cardiovascular remodeling Smooth muscle cell function Acid-base balance and water-salt metabolism Comparative physiology using giraffe models His recent publications (2023–2025) reflect a continued focus on vascular reactivity, small artery structure-function relationships, and molecular mechanisms in hypertension. Articles span topics from prorenin effects on mesenteric arteries to genetic causes of arrhythmia syndromes. Scientific Engagement: Active contributor to peer-reviewed journals such as Acta Physiologica , FASEB Journal , and Heart Rhythm Frequent invited speaker and lecturer on vascular physiology Public science communicator through media appearances on giraffe physiology and hypertension Advising and Research Leadership: While specific students are not listed, Aalkjær has supervised academic theses and mentored early-career researchers. He has been a project manager on major grants, including the DaGIR programme, and has secured long-term funding for cardiovascular research. He leads a research team focused on vascular mechanisms and collaborates extensively across disciplines. Laboratory and Research Environment: Based in the Skou Building at Aarhus University, his lab investigates vascular function using isolated vessel myography, molecular techniques, and in vivo models. The research environment emphasizes translational physiology, integrating basic science with clinical insights.

Michelle Peckhamمشاهده پروفایل

استاد

• Cell Biology
• Molecular Biology
• Cytoskeleton
• +۱۰ مورد دیگر

Professor Michelle Peckham is a leading cell biologist at the University of Leeds, affiliated with the Faculty of Biological Sciences and the School of Molecular and Cellular Biology. She holds the position of Professor of Cell Biology and leads a dynamic research group focused on the molecular motors myosin and actin, cytoskeletal organization, and muscle function. Her research program integrates structural biology , biochemistry , and advanced imaging to understand how myosins function and are regulated in health and disease. Her lab investigates mutations in cardiac, skeletal, and non-muscle myosin 2 that lead to heart disease, myopathies, and bleeding disorders. A key focus is on elucidating how these mutations alter protein structure and cellular integration. The lab pioneers the use of super-resolution microscopy (PALM, dSTORM, STED, iSIM) to visualize the nanoscale organization of cytoskeletal proteins, particularly in dense structures like the Z-disc. They have developed a custom 3D PALM/STORM microscope and novel software (PERPL) for data analysis. They also employ Cryo-EM , negative stain EM, protein expression, and live-cell imaging. Affimer reagents are used for precise labeling with minimal linkage error. Recent research trends show a strong emphasis on structural mechanisms of disease , nanoscale imaging , and interdisciplinary collaboration with experts in NMR, crystallography, and optical tweezers. Her most notable recent publication in Nature (2020) revealed the Cryo-EM structure of shutdown smooth muscle myosin. She actively supervises PhD students working on muscle differentiation on engineered surfaces and the function of IQ repeats in the microcephaly-linked protein ASPM. Research group develops custom super-resolution imaging systems Active collaborations across structural biology and biophysics Focus on translating molecular findings into disease mechanisms

• Microbiology
• Immunology
• Cell Biology
• +۳ مورد دیگر

Christina E Baer is an Associate Professor at UMass Chan Medical School, affiliated with the Department of Microbiology, T.H. Chan School of Medicine, and Morningside Graduate School of Biomedical Sciences. She directs the Sanderson Center for Optics Experimentation (SCOPE) and contributes to interdisciplinary research across the RNA Therapeutics Institute and Neuroscience. Education: BA in Physics & English from Wellesley College, PhD in Biophysics from University of California, Berkeley Her research spans Microbiology , Immunology , and Cell Biology , focusing on host-pathogen interactions in Mycobacterium tuberculosis infections, immune signaling pathways, and cellular mechanisms in neurodegenerative and metabolic diseases. Recent work includes studies on interferon signaling, oligodendrocyte renewal, and spatial transcriptomics. Key institutional roles include cross-departmental collaboration in Immunology and Microbiology Program and NeuroNexus Institute . Her publications reflect expertise in Cell Biology , Neurology , and Biochemistry , with significant contributions to understanding TB pathogenesis and precision medicine technologies. She leads interdisciplinary teams in SCOPE and works with co-authors like Christopher Sassetti and Arthur Mercurio on translational research projects. Her citations indicate impact in PubMed Central and Mendeley community engagement.

• Cell Biology
• Molecular Biology
• Physiology
• +۷ مورد دیگر

Mark Abe is a Professor at the University of Chicago, specializing in mitogen-activated protein kinases (MAPKs) and their roles in lung biology and cell signaling . His research focuses on ERK8 and ERK7, novel MAPKs involved in oxidative stress responses , apoptosis , and airway disease mechanisms . NIH Funding : R01HL073132 (2003-2008), K08HL003867 (1998-2003), F32HL009074 (1994) Key Collaborators : Marsha Rosner, Julian Solway, Michael Hershenson Research Themes : Dr. Abe’s work explores MAPK signaling pathways in lung epithelial cells and airway smooth muscle , particularly how oxygen intermediates and mitogen-activated kinases contribute to respiratory diseases . His publications highlight apoptosis regulation , cytokine production , and calcium signaling in airway injury models. Publication Trends : His 15 most recent articles (1996-2009) span Biochemistry , Cell Biology , and Pulmonary Medicine , with subfields including MAP Kinase Pathways , Lung Development , Ion Channel Regulation , Angiogenesis , Signal Transduction , and Reactive Oxygen Species . Department Affiliation : Dr. Abe collaborates with colleagues in the Department of Medicine (e.g., Fatima Ajmal, Romeen Lavani ) and interacts with researchers in Pulmonary and Critical Care domains.

• Pharmacology
• Cellular Signalling
• Free Fatty Acid Receptors
• +۴ مورد دیگر

Dr. Kenneth Watterson is a Lecturer in Molecular Biosciences at the University of Glasgow. He is affiliated with the Molecular Pharmacology & Cellular Signalling research group, focusing on lipid signaling and metabolic regulation. Research Interests Pharmacology of free fatty acid receptors (FFA1, FFA4, GPR120) Role of sphingosine-1-phosphate (S1P) in smooth muscle contraction and wound healing AMPK signaling in glucose and lipid metabolism Neuroendocrine regulation of energy balance Development of pharmacological tools for metabolic disease research Article Trends Dr. Watterson's publications (2000-2017) demonstrate expertise in S1P signaling , FFA receptor pharmacology , and metabolic disease mechanisms . His work spans diabetes research , smooth muscle physiology , and lipid mediator biology , with recent emphasis on drug discovery for metabolic disorders. Labs & Teams Active member of the Molecular Pharmacology & Cellular Signalling group at University of Glasgow, collaborating on lipid signaling projects. His research involves interdisciplinary teams in pharmacology, endocrinology, and cell biology.

• Aortic Dissection
• Biomechanics
• Computational Modeling
• +۳ مورد دیگر

Malte Rolf is a researcher at the Institute of Biomechanics at Graz University of Technology, specializing in computational modeling of cardiovascular mechanics and biomaterials. His work bridges engineering principles with medical device development , focusing on aortic dissection pathophysiology, biodegradable scaffolds, and fluid-structure interaction simulations. Key Research Areas: Aortic dissection mechanics, patient-specific computational models, biodegradable implant design, and uncertainty quantification in material properties. Academic Contributions: 18 research outputs since 2020, including peer-reviewed journals and conference proceedings. Collaborations with experts in cardiovascular medicine, computational mechanics, and materials science. Award: Recipient of the Marshall Plan Scholarship (2022) for outstanding research. Activities: Regular participation in international conferences (e.g., ECCOMAS 2024), with invited talks on smooth muscle function and scaffold modeling. His research employs advanced finite element analysis , Bayesian frameworks , and polynomial chaos expansion to address clinical challenges in aortic disease and tissue engineering. Current projects focus on developing predictive models for implant integration and aortic remodeling.

Jennifer L. Youngمشاهده پروفایل

عضو هیئت علمی

• Lung Injury Mechanisms
• Extracellular Matrix Signaling
• Cell Death and Survival
• +۴ مورد دیگر

Jennifer L. Young, Ph.D., is a Research Assistant Professor in the Department of Pediatrics, Neonatology at the University of Rochester School of Medicine and Dentistry. Her research investigates molecular mechanisms of lung injury, focusing on extracellular matrix signaling (CCN1/Cyr61), TNFα-mediated cell death, and inflammatory responses in diseases like ARDS and COPD. She aims to develop novel therapies by elucidating pathways of alveolar epithelial cell and fibroblast apoptosis. Education: Ph.D. in Molecular Biology and Genetics, Northwestern University (2004) B.S. in Biomedical Sciences, University of South Alabama (1998) Postdoctoral Fellowship: Biochemistry and Molecular Genetics, University of Illinois at Chicago (2004–2007) Awards: American Society for Cell Biology Pre-doctoral Travel Award (1999) Biomedical Sciences Distinguished Achievement in Medical Microbiology (1998) Alpha Chi National College Honor Scholarship Society (1996)

• Respiratory Diseases
• Smooth Muscle Physiology
• Asthma Pathophysiology
• +۳ مورد دیگر

Anne-Marie Lauzon is a Professor in the Department of Medicine at McGill University's Faculty of Medicine and Health Sciences, and a Senior Scientist at the Research Institute of the McGill University Health Centre (RI-MUHC), Glen site. She leads research within the Translational Research in Respiratory Diseases Program at the Centre for Translational Biology, with her clinical departmental affiliation in the Division of Respiratory Medicine at the MUHC. Her research focuses on understanding the molecular mechanisms underlying airway smooth muscle function in asthma, particularly examining how specific proteins determine contractile properties related to airway hyperresponsiveness. Dr. Lauzon has established a specialized tissue and molecular mechanics laboratory featuring in vitro motility and laser trap assays to investigate contractile protein expression and function in both normal and asthmatic airways. Her work spans both fundamental molecular investigations of myosin and actin interactions and translational studies examining airway smooth muscle in disease contexts. This dual approach has yielded significant insights into the structural and functional alterations in contractile proteins that contribute to asthma pathophysiology, with numerous publications demonstrating how molecular changes translate to tissue-level dysfunction. Dr. Lauzon's research program has identified key mechanisms involving caldesmon, tropomyosin, and myosin phosphorylation states in regulating smooth muscle contraction. Her laboratory's sophisticated biomechanical approaches have provided molecular-level evidence for phenomena previously only observed at the tissue level, bridging critical gaps between basic science and clinical respiratory medicine.

Dean Sheppardمشاهده پروفایل

استاد

• Molecular mechanisms of fibrosis
• Pulmonary diseases
• Integrin biology
• +۴ مورد دیگر

Dean Sheppard is a Professor of Medicine at the University of California San Francisco (UCSF) School of Medicine , specializing in molecular mechanisms underlying pulmonary fibrosis, acute lung injury, and immune responses to solid tumors . His lab investigates integrin family proteins (e.g., αvβ6, α5β1, α9β1, αvβ5, αvβ8) and their roles in TGFβ activation, with implications for fibrosis, cancer immunosuppression, and post-natal brain development. Education: Harvard College (A.B., 1972), SUNY at Stony Brook (M.D., 1975), University of Washington (Residency, 1975–78), UCSF (Fellowship, 1978–80) Research Interests focus on integrin-mediated cellular responses to extracellular matrix cues, fibrosis pathogenesis, and engineering cell-based therapies for fibrotic diseases and cancer. Current work leverages single-cell RNA sequencing to map fibroblast heterogeneity and develop novel murine models for lineage tracing and therapeutic interventions. Recent Publications highlight integrins in TGFβ activation, fibroblast-immune interactions, and applications of single-cell genomics to fibrosis and neuroimmunology. Collaborations with Wendell Lim explore genetically encoded therapeutics and enhanced cell therapies for solid tumors. Scientific Awards: Elected Member, American Society for Clinical Investigation (1992) Elected Member, Association of American Physicians (1995) NIH Merit Award (2004–2014) Top 20 Translational Scientists, Nature Biotechnology (2013) UCSF Faculty Research Lecture in Translational Science (2016) Research Funding includes 18 NIH grants spanning 1976–2025, with active projects like Induction, fate and function of inflammatory fibroblasts (RO1HL171159, 2024–2025) and Fibroblast heterogeneity in pulmonary fibrosis (R01HL142568, 2020–2024). Grants emphasize integrin biology, TGFβ signaling, and lung disease mechanisms.