Dmitri Kudryashov

Dr. Dmitri Kudryashov is a Professor in the Department of Chemistry and Biochemistry at The Ohio State University (OSU), part of the College of Arts and Sciences. He joined OSU in 2011 and was promoted to Associate Professor in 2017, later becoming a full Professor. His research focuses on actin cytoskeleton dynamics, bacterial toxins, and their roles in health and disease.

Education and Background: Kudryashov received his MD from the Russian Medical State University (Moscow) and a PhD from the Russian Academy of Medical Sciences. He completed postdoctoral research at UCLA under Prof. Emil Reisler, earning awards for his work on actin and myosin cytoskeletons, including the Paul Boyer Award and Herbert Newby McCoy Award.

Research Interests: Key areas include:

• Actin cytoskeleton in health/disease: cancer metastasis, bacterial/viral pathogenesis, and osteogenesis
• Actin-specific bacterial toxins (e.g., ACD, TccC3) and their mechanisms
• Selective cancer cell ablation using split toxins
• Defensin-mediated neutralization of pathogens

His lab uses interdisciplinary approaches like fluorescence spectroscopy, cryo-EM, and X-ray crystallography, collaborating with experts in NMR, microbiology, and structural biology.

Awards and Grants: NIH grants (IGMS R01, NCI R21), Pelotonia funding, and patents for split toxin technology. Notable publications in Science, Nature Structural & Molecular Biology, and PNAS.

Lab and Team: The Kudryashov Group recruits undergraduates, graduates, and postdocs. Current projects explore toxin-based tools for studying actin roles in inflammation, apoptosis, and DNA repair. Collaborations span institutions like University of Delaware, Stanford, and University of Virginia.