معرفی
Mitchell Denning, PhD, is the Associate Dean for Graduate Education and a Professor in the Department of Cancer Biology and Pharmacology & Neuroscience at Loyola University Chicago's Stritch School of Medicine. His research focuses on keratinocyte and melanocyte biology, ultraviolet radiation-induced skin carcinogenesis, and the role of protein kinase C (PKC) signaling pathways in epidermal biology. His work investigates cellular responses to UV radiation, including DNA damage repair, inflammation, and cell death mechanisms, with applications in developing preventive and therapeutic strategies against skin cancers.
Education:
- BS in Biochemistry, University of Arizona
- PhD in Human Cancer Biology, University of Wisconsin-Madison
- Postdoctoral Fellowships: Skin Carcinogenesis (NIH/NCI) and Cell-Cell Adhesion (Northwestern University)
Research Interests: Dr. Denning’s lab explores how PKC signaling regulates epidermal cell fate decisions (proliferation, differentiation, death) and how UV radiation disrupts these processes, leading to skin carcinogenesis. Key topics include UV-induced inflammation, DNA repair mechanisms, and the development of novel therapeutics targeting these pathways.
Publications: His recent work spans cancer biology, hepatocellular carcinoma, and signaling pathways, with a focus on translating molecular mechanisms into clinical applications. Notable studies include investigations into RIPK3 signaling in leukemia, EphA2 inhibition in liver cancer, and PKCα’s role in breast cancer drug resistance.
Labs/Teams: His laboratory integrates molecular, biochemical, and cell biological approaches to study epidermal biology and skin cancer pathogenesis.
