معرفی
Anne-Marie Lauzon is a Professor in the Department of Medicine at McGill University's Faculty of Medicine and Health Sciences, and a Senior Scientist at the Research Institute of the McGill University Health Centre (RI-MUHC), Glen site. She leads research within the Translational Research in Respiratory Diseases Program at the Centre for Translational Biology, with her clinical departmental affiliation in the Division of Respiratory Medicine at the MUHC.
Her research focuses on understanding the molecular mechanisms underlying airway smooth muscle function in asthma, particularly examining how specific proteins determine contractile properties related to airway hyperresponsiveness. Dr. Lauzon has established a specialized tissue and molecular mechanics laboratory featuring in vitro motility and laser trap assays to investigate contractile protein expression and function in both normal and asthmatic airways.
Her work spans both fundamental molecular investigations of myosin and actin interactions and translational studies examining airway smooth muscle in disease contexts. This dual approach has yielded significant insights into the structural and functional alterations in contractile proteins that contribute to asthma pathophysiology, with numerous publications demonstrating how molecular changes translate to tissue-level dysfunction.
Dr. Lauzon's research program has identified key mechanisms involving caldesmon, tropomyosin, and myosin phosphorylation states in regulating smooth muscle contraction. Her laboratory's sophisticated biomechanical approaches have provided molecular-level evidence for phenomena previously only observed at the tissue level, bridging critical gaps between basic science and clinical respiratory medicine.
