جست‌وجوی استاد و پژوهشگر

Xiang Zhangمشاهده پروفایل

استاد

• Breast Cancer Metastasis
• Tumor Immunology
• Cancer Biology
• +۵ مورد دیگر

Xiang Zhang is a Professor in the Department of Molecular and Cellular Biology at Baylor College of Medicine (BCM), serving as Director of the Lester and Sue Smith Breast Center and holder of the William T. Butler, M.D., Endowed Chair. He also holds roles as a McNair Scholar and member of the Dan L. Duncan Comprehensive Cancer Center. Zhang’s research focuses on metastasis mechanisms and immunology, particularly in breast cancer bone metastasis. His work bridges tumor cell behavior with the tumor microenvironment, emphasizing spatiotemporal co-evolution and therapeutic development. Education: Ph.D. from Columbia University (2006), Postdoctoral Fellowship at Memorial Sloan Kettering Cancer Center (2011), and B.S. from Fudan University (2000). Honors include the Era of Hope Scholar Award (2016-2021) and NIH Pathway to Independence Award (2010-2014). Research Themes: 1) Breast cancer bone metastasis mechanisms, including niche interactions and osteogenic signaling. 2) Tumor immunology, focusing on immune suppression, myeloid cell dynamics, and therapy resistance. Recent breakthroughs include lipid-driven immune evasion in triple-negative breast cancer and single-cell profiling of metastatic ecosystems. Publications highlight discoveries in bone microenvironmental reprogramming, myeloid-B cell crosstalk, and therapeutic vulnerabilities. His lab actively explores biomarkers for therapy response and novel combination therapies. Grants and Awards: Over $15M in NIH/NCI grants, Department of Defense funding, and foundation support. Notable recognition includes the Michael E. DeBakey Award (2018) and Laura Zisken Prize (2020). Lab Team: Includes postdoctoral researchers (Noa Peled, Xuan Li) and students (Michael Dieffenbach). Current projects investigate lipid metabolism in therapy resistance and systemic immunosuppression mechanisms. Laboratory: Established in 2011, the Zhang Lab employs preclinical models, single-cell analysis, and translational approaches to combat metastasis. Active collaborations include work with the BCM Immunity Center and Stand Up To Cancer initiatives.

Dirk H. Buschمشاهده پروفایل

استاد

• Immunology
• Medical Microbiology
• T Cell Biology
• +۳ مورد دیگر

Prof. Dr. med. Dirk H. Busch serves as Professor at the Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), and holds the position of Vice Speaker for Collaborative Research Center SFB 1054. His academic affiliation centers on TUM's medical research infrastructure in Munich, Germany. His research specializes in Immunology with emphases on T cell developmental imprinting , polyclonal immune responses , and chronic infection dynamics . Through SFB 1054 Project B09, he investigates how early immune experiences shape long-term T cell functionality during persistent infections, bridging fundamental immunology with clinical applications in chronic disease management. Prof. Busch maintains active leadership in SFB 1054's research governance while directing laboratory investigations at TUM's Institute for Medical Microbiology, Immunology and Hygiene. His work integrates advanced cellular tracking methodologies to decode immune memory formation in chronic inflammatory conditions.

Tracey Lambمشاهده پروفایل

استاد

• Malaria Immunopathogenesis
• Plasmodium Parasites
• Vaccine Development
• +۳ مورد دیگر

Tracey Lamb is a Professor in the Department of Microbiology and Immunology at the University of Utah. Her research focuses on malaria immunopathogenesis, Plasmodium parasite interactions, and vaccine development. She holds a BSc from the University of Glasgow and a PhD from the University of Edinburgh. Education BSc, University of Glasgow, Scotland PhD, University of Edinburgh, Scotland Lamb's research spans four core areas: Eph receptor tyrosine kinases in malaria pathogenesis, ephrin ligand modulation of T cell responses, co-infection dynamics with pathogens like Epstein-Barr virus, and oral vaccine delivery systems using probiotic yeast. Her lab investigates how Eph receptors contribute to liver fibrosis and cerebral malaria, while exploring probiotic yeast-based vaccines for cost-effective mass distribution. The lab's recent publications highlight trends in malaria research, including molecular mechanisms of endothelial barrier disruption , immune evasion by Plasmodium, CD8+ T cell affinity in disease progression, and ephrin-Eph signaling in immunopathogenesis. Collaborations extend to the Center du Pasteur Cameroon and Emory University's Speck Lab. Labs & Affiliations Lamb Lab, University of Utah Collaborator, Center du Pasteur Cameroon Collaborator, Sam Speck Lab, Emory University Advising Thayer King Patrice Mimche Tuna Ortiz Georgia Veverka Palmer Netongo Pei-Yi Tai Taryn Stewart Scientific Awards

Lars Hangartnerمشاهده پروفایل

دانشیار

• Antibody Fc effector functions
• HIV vaccine development
• Polyclonal antibody analysis
• +۳ مورد دیگر

Lars Hangartner, PhD, is an Associate Professor in the Department of Immunology and Microbiology at Scripps Research. His research focuses on antibody Fc effector functions, polyclonal antibody response analysis, and IgA-mediated antiviral immunity. He leads efforts to develop technologies for rapid epitope mapping and investigates HIV vaccine strategies to enhance protective immune responses. Education : Ph.D. in Molecular Biology, ETH Zurich, Switzerland (2002) M.S. in Molecular Biology, University of Zurich (1997) Research Interests : Dr. Hangartner’s work spans three core areas: 1) molecular mechanisms of antibody-dependent effector functions (e.g., CDC, ADCC, ADCP) in HIV infection, 2) high-throughput methods to profile polyclonal antibody repertoires in vaccine trials, and 3) functional characterization of IgA antibodies in mucosal immunity. His lab collaborates extensively on HIV vaccine design, leveraging structural biology and systems immunology approaches. Awards : Gotz Preis from the Georg Friedrich Gotz Foundation (2010) Advising & Collaborations : His research integrates with the Ward Lab and other teams at Scripps Research. While no formal trainee names are listed, his work involves nonhuman primate models and clinical trial collaborations. Labs/Teams : Primary affiliation: Department of Immunology and Microbiology at Scripps Research. Collaborations include the Institute of Medical Virology (University of Zurich) and the NIH-funded HIV Vaccine Trials Network.

James M. Mathewمشاهده پروفایل

استاد پژوهشی

• Transplant Immunology
• Autoimmunity
• Transplant Tolerance
• +۳ مورد دیگر

Dr. James M. Mathew is a Research Professor of Surgery and Microbiology-Immunology at Northwestern University, and serves as Director of the Immune Monitoring Core at the Comprehensive Transplant Center (CTC). He earned his PhD in 1988 from Madurai Kamaraj University, India. Transplant Immunology Autoimmunity Transplant Tolerance Donor Stem Cells Regulatory T Cells Biomarkers Dr. Mathew has spent over 30 years investigating immune responsiveness and tolerance in clinical organ transplantation. His work focuses on the immunological effects of donor bone marrow and hematopoietic stem cell infusions, differential susceptibility of regulatory T cells (Tregs) to immunosuppressive drugs, and the development of polyclonally/antigen-specifically expanded autologous Tregs for tolerance induction in transplantation, autoimmunity, and allergic diseases. He also employs bionanotechnology to address challenges in ischemic injuries and tolerance induction. As Director of the Immune Monitoring Core, Dr. Mathew provides immune monitoring support for clinical trials across the CTC and other departments at Northwestern University. He is actively developing biomarkers for clinical transplant immunity and tolerance.

Jianming Xieمشاهده پروفایل

دانشیار

• Immunology
• Chemical Biology
• Pharmaceutical Biotechnology
• +۶ مورد دیگر

Jianming Xie, PhD is an Associate Professor in the Department of Biotechnology and Pharmaceutical Sciences at the College of Pharmacy, Western University of Health Sciences. He holds a PhD in Chemical Biology from The Scripps Research Institute (2006) and completed postdoctoral training in Immunology at Stanford University (2014). His work focuses on engineering CAR-T and CAR-NK cells to combat cancer and HIV through innovative antigen recognition strategies. Education includes: B.S. in Chemistry (Fudan University, 1997) M.S. in Organic Chemistry (Shanghai Institute of Organic Chemistry, 2000) PhD in Chemical Biology (The Scripps Research Institute, 2006) Postdoctoral research in Immunology (Stanford University, 2014) Research emphasizes: HLA-DR loss targeting via inhibitory CARs Universal CAR-NK cells for HIV epitope targeting DNP-conjugated antibody systems CAR-T therapy for post-transplant leukemia Grants include: R21 AI155117 (2020-2023): HIV-targeted CAR-NK development Ming Hsieh Institute (2021-2023): CAR-T for acute leukemia His lab develops modular immune cell therapies to address cancer antigen escape and HIV diversity challenges.

Dong Sung Anمشاهده پروفایل

استاد

• HIV/AIDS
• Gene Therapy
• Stem Cell Biology
• +۳ مورد دیگر

Dr. Dong Sung An is a Professor at the UCLA School of Nursing and Associate Dean of Research and Innovation, with an additional affiliation at the UCLA AIDS Institute. His research focuses on developing anti-HIV-1 gene therapy strategies using hematopoietic stem cells (HSCs). He aims to engineer HSCs to express protective genes against HIV, enabling lifelong immunity and targeting latent viral reservoirs. His work bridges basic science and clinical applications, with a focus on overcoming limitations of antiretroviral therapy (HAART). Dr. An earned his MD from Yamaguchi University School of Medicine (1993) and a PhD in Virology from Tokyo Medical and Dental University (1997). His research spans HIV pathogenesis, gene delivery systems, and humanized mouse models. Key contributions include the development of lentiviral vectors for CCR5 knockdown and RNA interference (RNAi) strategies to inhibit HIV entry. His scientific awards include the Soujinkan Award (2004). His publications highlight advancements in stem cell-based therapies, HIV resistance mechanisms, and translational research. Dr. An’s lab collaborates on projects such as engineering HIV-resistant T-cells and studying viral dissemination in bone marrow. Future work emphasizes clinical translation of gene therapy approaches to achieve HIV remission and cure.

• Immunology
• Cancer Biology
• Immunotherapy
• +۳ مورد دیگر

Weiwei Yu is an Associate Research Scientist at the Chen Lab within the Yale School of Medicine . His research focuses on immunology and cancer biology, particularly exploring T cell dynamics, immune checkpoint pathways (B7-H1/PD-L1 and PD-L2), and tumor microenvironment interactions. Collaborating with prominent scientists like Lieping Chen, his work has advanced understanding of T cell quiescence mechanisms, immunotherapy resistance, and molecular mechanisms regulating anti-tumor immunity. Key research areas include: Role of PLA2G10 in T cell infiltration suppression CD8α-PILRα signaling in maintaining T cell dormancy B7 family proteins in immune regulation Molecular pathways governing dendritic cell survival Notable contributions include 2024 Science Immunology work on cancer immune evasion and 2022 Science findings on T cell quiescence. His studies bridge fundamental immunology with translational cancer research.

Tom Cupedoمشاهده پروفایل

دانشیار

• Stromal Cell-Immune Cell Interactions
• Innate Lymphoid Cells
• Cancer Immunity
• +۳ مورد دیگر

Tom Cupedo is an Associate Professor of Hematology whose work focuses on the interactions between stromal cells, immune cells, and cancer in hematological malignancies. He investigates the bone marrow microenvironment's role in fostering multiple myeloma development and therapy resistance, with a goal to disrupt this niche for improved anti-cancer treatments. Research Expertise: Stromal cell-immune cell interactions, innate lymphoid cells, cancer immunity. Key Publications: His recent studies (2023–2025) explore inflammatory niche remodeling in AML , IL-1β-driven protumor microenvironments , and NK cell cytotoxicity enhancement in multiple myeloma. Collaborations: Works with institutions like the Cancer Institute, focusing on clinical trials and translational research in hematology and immunology.

• Immunology
• Vaccine Design
• Structural Biology
• +۲ مورد دیگر

William Schief is a Professor in the Department of Immunology and Microbiology conducting cutting-edge research in HIV vaccine development through structural biology and computational design approaches. Education: B.S. (Applied Mathematics), Yale University, 1989 Ph.D. (Physics), University of Washington, 1999 Sr. Fellow (Physiology & Biophysics), University of Washington, 2001 Sr. Fellow (Biochemistry), University of Washington, 2006 His research program integrates cryo-electron microscopy, computational protein modeling (Rosetta software), and immunology to design HIV immunogens that elicit broadly neutralizing antibodies. Key methodologies include structural analysis of antibody-antigen interactions and lymphatic-targeted vaccine delivery systems, with emphasis on guiding B-cell maturation through engineered immunogens. Recent publications (2021-2022) reveal a consistent focus on structural characterization of polyclonal antibody responses to HIV Env, leveraging cryoEM for immunogen design and PET imaging for vaccine distribution analysis. The work demonstrates interdisciplinary convergence of physics-based modeling, structural biology, and primate immunology. Scientific recognition: 1989 Cum Laude honors for B.S. degree, Yale University 1995 NIH Training Grant Fellowship in Molecular Biotechnology 1996 NIH Training Grant Fellowship in Molecular Biophysics 1999 Dahlstrom Prize for outstanding experimental physics graduate student 2002 NIH National Research Service Award Post-doctoral Fellowship Research is supported by NIH grants focusing on HIV vaccine development. While specific advisees aren't listed, his publications indicate mentorship of postdoctoral fellows and collaboration with immunology laboratories. Current work involves non-human primate models and structural vaccinology approaches. Laboratory operations feature cross-institutional teams utilizing cryoEM facilities and computational infrastructure for protein design, with active collaboration on HIV envelope trimer immunogens and lymphatic delivery systems.

• Cancer Genomics
• Multiple Myeloma
• Genomics
• +۳ مورد دیگر

Cody Ashby, PhD, is an Assistant Professor in the Department of Biomedical Informatics at the University of Arkansas for Medical Sciences (UAMS). He joined UAMS in 2014 as a post-doctoral fellow in the Myeloma Center and transitioned to his current role in 2015. Dr. Ashby holds a PhD in Molecular Biosciences and a Master’s in Computer Science from Arkansas State University. His research focuses on cancer genomics, particularly in multiple myeloma. He employs advanced sequencing technologies (e.g., whole-genome, RNA, single-cell, and long-read sequencing) to identify key genes and therapeutic targets in cancer progression. His work emphasizes understanding the molecular mechanisms underlying myeloma development, bone disease, and drug resistance, with a focus on translational applications. Recent studies highlight his exploration of biomarkers for disease progression, such as the Polyclonal Plasma Cell (PolyPC) signature and imaging-based prognostic factors. He also investigates signaling pathways (e.g., NOTCH3-CXCL12, CCL3-HMGB1) and epigenetic regulators (e.g., H3K4me3 domains) that drive tumor growth and microenvironment interactions. His work bridges computational methods with clinical data to improve risk stratification and treatment strategies. Dr. Ashby’s research has contributed to the development of targeted therapies, including CAR-T cell approaches and drug combinations that enhance both anti-tumor and bone-protective effects. He has managed multiple projects, including the Myeloma Genome Project Panel for molecular profiling and studies on race-related disparities in myeloma outcomes in Arkansas.

• Medical Parasitology
• Infectious Diseases
• Genomics
• +۳ مورد دیگر

Malgorzata Domagalska is a Research Professor and Unit Head of Experimental Parasitology at the Institute of Tropical Medicine Antwerp. She holds a Doctorate in Life Sciences and specializes in parasitic diseases, particularly Leishmania species. Her research focuses on genomic instability, drug resistance mechanisms, and pathogen adaptation in protozoan parasites. She leads multiple international projects funded by organizations like the Medical Research Council and Flemish Government. Education/Academic Qualification: Doctor (specific field unspecified). Research Interests: Investigating Leishmania's genetic diversity, drug resistance, and adaptation strategies. Key areas include aneuploidy's role in environmental stress responses and genomic plasticity in pathogen survival. Her work bridges molecular biology, genomics, and clinical parasitology. Recent Projects: MRC Cruzi Grant: Exploring genomic instability in Trypanosoma (2024–2027) LeishMAP: Molecular mechanisms of aneuploidy in Leishmania (2023–2026) LEISHCHROMAQ: Chromatin role in Leishmania quiescence (2021–2023) Labs/Teams: Leads the Experimental Parasitology Unit, collaborating with global researchers on Leishmania genomics and drug resistance.

• Gene Therapy
• Molecular Biology
• Genetic Therapeutics
• +۳ مورد دیگر

Qiushi Tang is an Instructor at UMass Chan Medical School, affiliated with the Department of Pediatrics and the Gene Therapy Center within the T.H. Chan School of Medicine. He holds a BS in Chemistry and MS in Biochemistry from Jilin University, China. His research focuses on gene therapy applications using adeno-associated viral (AAV) vectors, particularly addressing alpha-1 antitrypsin deficiency and liver-related genetic disorders. He has contributed to studies on AAV delivery optimization, immune response modulation, and preclinical models for therapeutic efficacy. Collaborations include work with leading researchers like Terence Flotte and Guangping Gao. His publications highlight advancements in vector design, protein quantification methods, and in vivo genome editing techniques. Education: Bachelor of Science (BS), Chemistry, Jilin University, China Master of Science (MS), Biochemistry, Jilin University, China Research Interests: Dr. Tang specializes in molecular and genetic therapies, with a focus on: Development of AAV vectors for disease treatment Optimization of gene delivery systems Genome editing for correcting genetic disorders Preclinical models for liver and pulmonary diseases Quantitative methods for protein expression analysis Key Contributions: His recent work includes: Safety evaluations of limb perfusion delivery for AAV vectors Advances in Z-AAT-specific ELISA assays Studies on immune modulation for AAV-based therapies Long-term efficacy of AAV9 for metabolic deficiencies Awards/Grants: No awards explicitly listed; however, his work has been cited in multiple patents and news outlets, reflecting its impact in the field. Collaborations with industry and academic partners likely involve grant-funded projects. Labs/Teams: Associated with the Gene Therapy Center and pediatric pulmonology division, contributing to interdisciplinary teams focused on translational research in genetic medicine.

Kilian Schoberمشاهده پروفایل

پژوهشگر

• Immunology
• T Cell Biology
• Chronic Immune Responses
• +۳ مورد دیگر

Kilian Schober is a Researcher affiliated with the Institute of Medical Microbiology, Immunology and Hygiene at the Technical University of Munich and Friedrich-Alexander-University Erlangen-Nürnberg . He is a project leader for SFB 1054 Project B09, focusing on tracking developmental imprinting of polyclonal T cell responses during chronic immune responses. His research lies at the intersection of immunology and microbiology, with specific emphasis on: T Cell Biology Chronic Immune Responses Developmental Immunology Clinical Microbiology Microbiology He is associated with the Universitätsklinikum Erlangen and maintains contact via the email address Kilian.Schober@uk-erlangen.de.

Richard Coicoمشاهده پروفایل

استاد

• Immunology
• Lymphocyte regulation
• Immunoglobulin D (IgD)
• +۷ مورد دیگر

Richard Coico is Professor of Cell Biology and Medicine at SUNY Downstate Health Sciences University, where he also serves as Vice Dean for Scientific Affairs and Director of the Clinical and Translational Science Center. With a PhD in immunology from New York University, Dr. Coico has established himself as a leading researcher at the intersection of basic immunology and translational medicine for over three decades. Dr. Coico's educational background includes: PhD in Immunology from New York University His research spans multiple areas of immunology with significant translational applications. Early in his career, Dr. Coico pioneered research on immunoglobulin D (IgD), being the first to identify IgD-receptors on helper T cells and demonstrate their role in enhancing immune responses through bi-directional regulatory consequences with IgD-expressing B cells. His work has since expanded to computational approaches for peptide vaccine development against hemorrhagic viruses like Ebola and Lassa, where his group was the first to identify immunogenic Lassa virus peptides capable of stimulating cytotoxic T cell responses in humanized mice. More recently, he has investigated immunotherapeutic approaches for Alzheimer's disease using beta-amyloid peptides in pre-clinical studies. Analysis of Dr. Coico's extensive publication record reveals an evolution from fundamental immunological mechanisms to increasingly translational applications. While maintaining his core expertise in lymphocyte regulation and IgD biology, he has successfully bridged into computational biology, viral immunology, and neuroimmunology. His 2023 publication on the kynurenine pathway demonstrates his ongoing engagement with cutting-edge intersections between nervous and immune systems in psychiatric illness, showing the breadth and adaptability of his research program over time. Dr. Coico has made significant methodological contributions to the field, with multiple publications in Current Protocols covering essential laboratory techniques including Gram staining and immunoglobulin purification. His leadership roles as Vice Dean for Scientific Affairs and Director of the Clinical and Translational Science Center reflect his commitment to advancing research infrastructure and fostering translational science at his institution.