Jianming Xie

Jianming Xie, PhD is an Associate Professor in the Department of Biotechnology and Pharmaceutical Sciences at the College of Pharmacy, Western University of Health Sciences. He holds a PhD in Chemical Biology from The Scripps Research Institute (2006) and completed postdoctoral training in Immunology at Stanford University (2014). His work focuses on engineering CAR-T and CAR-NK cells to combat cancer and HIV through innovative antigen recognition strategies.

Education includes:

• B.S. in Chemistry (Fudan University, 1997)
• M.S. in Organic Chemistry (Shanghai Institute of Organic Chemistry, 2000)
• PhD in Chemical Biology (The Scripps Research Institute, 2006)
• Postdoctoral research in Immunology (Stanford University, 2014)

Research emphasizes:

• HLA-DR loss targeting via inhibitory CARs
• Universal CAR-NK cells for HIV epitope targeting
• DNP-conjugated antibody systems
• CAR-T therapy for post-transplant leukemia

Grants include:

• R21 AI155117 (2020-2023): HIV-targeted CAR-NK development
• Ming Hsieh Institute (2021-2023): CAR-T for acute leukemia

His lab develops modular immune cell therapies to address cancer antigen escape and HIV diversity challenges.