Nicholas Zorko

Nicholas Zorko, MD, PhD, is an Assistant Professor of Medicine at the University of Minnesota. His work centers on advancing NK cell-based immunotherapies for prostate and other solid tumors, with a focus on B7-H3 and PSMA-targeted tri-specific killer engagers (TriKEs).

Research Interests

• Targeting B7-H3 and PSMA in prostate cancer immunotherapy
• Enhancing NK cell function in "cold" tumor microenvironments
• Development of off-the-shelf CAR NK cell therapies
• Investigating HLA class I expression and immune evasion mechanisms

Scientific Contributions
The 15 most recent publications (2025-2023) demonstrate expertise in tumor immunology, tri-specific antibody engineering, and pan-cancer therapeutic strategies. Key trends include optimizing radioligand therapy for prostate cancer, characterizing immune cell infiltration in solid tumors, and addressing adverse events in T-cell and NK cell therapies.