جست‌وجوی استاد و پژوهشگر

Hermann Pavenstädtمشاهده پروفایل

استاد

• Nephrology
• Cell Biology
• Medical Imaging
• +۳ مورد دیگر

Prof. Hermann Pavenstädt is a faculty member at the University of Münster within the Department of Nephrology and Rheumatology , leading the Pavenstädt Lab . His research focuses on cell dynamics and imaging , particularly in renal and immunological contexts. He has contributed to understanding podocyte biology, endothelial dysfunction, and novel diagnostic imaging techniques for kidney diseases and transplant rejection. Key research areas include nephrology , cell biology , and medical imaging , with a focus on molecular mechanisms underlying kidney disease progression and therapeutic interventions. His work integrates experimental models, molecular biology, and advanced imaging technologies. Notable contributions include studies on Lasp1's role in arthritis, PET imaging for transplant rejection, and the impact of aldosterone antagonists on endothelial health. His articles highlight interdisciplinary approaches to kidney-related pathologies and translational medicine. Prof. Pavenstädt's team collaborates across departments in the Medical Faculty and participates in the Multiscale Imaging Centre , emphasizing innovative imaging solutions for clinical challenges. His lab's work bridges basic science and clinical applications, aiming to improve diagnostic and therapeutic strategies for renal and immunological disorders.

• Extracellular Vesicles
• Mitochondrial Dysfunction
• Oxidative Stress
• +۷ مورد دیگر

Elena Grossini is an Associate Professor at the Department of Translational Medicine, Università degli Studi del Piemonte Orientale Amedeo Avogadro. Her research focuses on extracellular vesicles, mitochondrial dysfunction, oxidative stress, and their roles in cardiovascular disease, pregnancy-related disorders, and liver pathologies. She has published extensively on topics such as systemic sclerosis, preeclampsia, and neurovascular unit interactions. Key projects include investigating NAFLD-associated aging and the role of oxidative stress in depression among breast cancer patients. Her work bridges basic science and clinical applications, with a particular emphasis on translational medicine. Recent studies highlight the therapeutic potential of extracellular vesicles and dietary agents like genistein in managing metabolic and cardiovascular conditions. Collaborations span Italy and involve multidisciplinary teams addressing endothelial dysfunction, renal protection, and biomarker development. Her research aligns with UN Sustainable Development Goals related to health and well-being.

Haiqi Chenمشاهده پروفایل

استادیار

• Gene Regulation
• Reproductive Biology
• Spatial Genomics
• +۵ مورد دیگر

Haiqi Chen is an Assistant Professor at the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Department of Obstetrics and Gynecology at UT Southwestern Medical Center. His research focuses on gene regulation in mammalian reproductive systems, leveraging spatial and functional genomics technologies. He leads the Chen Lab, which develops cutting-edge methods such as spatial transcriptomics and machine learning approaches to study chromatin remodeling and tissue microenvironment dynamics in reproductive biology. Dr. Chen holds a Ph.D. in Molecular Endocrinology from a joint program between the University of Hong Kong and the Rockefeller University (2017), followed by postdoctoral training at the Broad Institute of MIT and Harvard. In 2021, he established his independent lab at UT Southwestern. His research interests span advanced genomic technologies, including next-generation spatial genomics and functional genomics tools, combined with computational methods to dissect gene regulation in male reproduction. Key areas include the mechanistic study of blood-testis barrier dynamics, sperm maturation, and the application of spatial transcriptomics to map cellular interactions in reproductive tissues. Awards: Lalor Foundation Fellowship (202X), 2024 Rising Star Award in Reproductive Biology Publications highlight breakthroughs in spatial genomics, such as PHOTON technology for subcellular resolution, and investigations into spermatogenesis and contraceptive mechanisms. The lab actively collaborates on topics like chromatin organization and extrachromosomal DNA in the germline.

Djillali Sahaliمشاهده پروفایل

استاد

• Glomerulopathies
• Nephro-oncology
• Renal immunopathology
• +۳ مورد دیگر

Djillali Sahali is a Professor and Team Leader at the Université Paris-Est Créteil, working within the Faculty of Medicine at the Mondor Institute for Biomedical Research (IMRB - Inserm U955). He leads the Pathophysiology of glomerular diseases research team, focusing on the study of human glomerular diseases, which are leading causes of renal failure worldwide. Dr. Sahali's research centers on two main axes: idiopathic nephrotic syndrome (axis 1) and nephro-oncology (axis 2). His work investigates immunopathological mechanisms of glomerulopathies, exploring the link between environmental stress and disease flare-ups, as well as developing innovative therapeutic approaches using nano-interference for experimental podocytopathies. His team coordinates the National Reference Center for Idiopathic Nephrotic Syndrome, granting access to valuable cohorts and biobanks. Analysis of Dr. Sahali's recent publications reveals a strong focus on molecular mechanisms underlying glomerular diseases, particularly examining podocyte biology, CMIP protein function, and immune dysregulation in nephrotic syndrome. His research increasingly incorporates nanotechnology for kidney-targeted drug delivery systems, reflecting a trend toward developing novel therapeutic approaches for renal conditions. Dr. Sahali leads a substantial research team comprising 9 teacher-researchers and hospital-university staff, 1 researcher, 4 hospital staff, 1 post-doc, 3 doctoral students, and 2 administrative and technical staff members. His team benefits from coordination of the National Reference Center for Idiopathic Nephrotic Syndrome, providing access to clinical cohorts and biobanks essential for translational research. The Pathophysiology of glomerular diseases team operates within the PHYDES department (Pathophysiology of cardiovascular and respiratory diseases, Development and Senescence) at the Hôpital Henri Mondor in Créteil. The team maintains strong collaborations with other research units within the IMRB, particularly in immunology and molecular biology, to advance understanding of renal pathologies and develop innovative treatments.

• Hypoxia Biology
• Erythropoiesis Regulation
• Globin Proteins
• +۳ مورد دیگر

David Hoogewijs is a Professor at the Faculty of Science and Medicine of the University of Fribourg. His research focuses on oxygen sensing mechanisms, erythropoiesis regulation, and globin protein biology, with significant contributions to understanding hypoxia-induced pathologies and metabolic adaptations. Primary Affiliation: University of Fribourg, Faculty of Science and Medicine Contact: david.hoogewijs@unifr.ch Location: PER 09 bu. 2.107, Ch. du Musée 5, 1700 Fribourg Research Interests: Professor Hoogewijs investigates the molecular mechanisms underlying hypoxia responses, particularly focusing on erythropoietin (EPO) regulation, globin protein functions (including cytoglobin and androglobin), and their roles in chronic kidney disease, melanoma progression, and male fertility. His work bridges basic oxygen physiology with clinical applications in hematology and nephrology. Publication Trends: Recent articles highlight his expertise in hypoxia-inducible factor (HIF) signaling, genetic variants in erythrocytosis, and the dual roles of globins in oxidative stress and cancer biology. Studies span from molecular mechanisms to translational applications in disease models. Teaching Activities: He contributes to courses in medical and physiological research domains, including seminars on regenerative medicine and cardio-metabolic research, primarily at the Faculty of Science and Medicine.

• Biotechnology
• Cancer Biology
• Virology
• +۶ مورد دیگر

Dr. Michał Rychłowski is a Researcher affiliated with the Intercollegiate Faculty of Biotechnology at the University of Gdańsk and Medical University of Gdańsk, Department of Recombinant Vaccines. His work focuses on biotechnological innovations in cancer biology, virology, and photodynamic therapy, with an emphasis on protein-nanoparticle interactions and cellular mechanisms of disease. Key research areas include molecular chaperones, targeted protein degradation (LYTACs), and drug delivery systems. He explores host-pathogen interactions in skin infections and cancer metastasis, particularly involving Staphylococcus aureus and prostate cancer cell invasiveness. His studies incorporate advanced techniques like proteomic profiling, in vitro infection models, and light-activated therapies. Notable contributions include gallium porphyrin-based photodynamic approaches against antibiotic-resistant bacteria and mechanistic insights into Hsp70/Hsp110 chaperone networks. Collaborations bridge biotechnology, molecular biology, and clinical applications, aiming to develop novel therapeutic strategies. Research also addresses podocyte dysfunction in kidney disease, focusing on signaling pathways like AMPK/PKGIα and their roles in albumin permeability under diabetic conditions. His work on extracellular vesicles highlights their dual role in cellular homeostasis and pathogen exploitation. Despite prolific publication output, no formal awards or student advisement records are explicitly mentioned.

• Endocrinology
• Diabetes Metabolism
• Cardiovascular Research
• +۳ مورد دیگر

Armando Mendez is an Associate Professor in the Department of Medicine, specializing in Endocrinology, Diabetes, and Metabolism. His research integrates molecular mechanisms of metabolic diseases with clinical translation, focusing on diabetes complications, cardiovascular comorbidities in HIV, stem cell therapies, and neuroendocrine regulation. Research domains include: Stem cell-derived extracellular vesicles for tissue regeneration Metabolic pathophysiology in spinal cord injury Cardiovascular sequelae of viral infections Oxytocin signaling in pancreatic β-cell function Psychoneuroendocrine interactions in chronic disease His recent publications demonstrate strong emphasis on: Translational applications of mesenchymal stem cells Multi-system complications of HIV/SARS-CoV-2 co-exposure Metabolic interventions for spinal cord injury Intersectional health disparities Awards: None reported Research involves interdisciplinary collaborations across endocrinology, virology, and rehabilitation medicine, with investigations spanning molecular mechanisms to clinical interventions.

Denise Inmanمشاهده پروفایل

دانشیار

• Neurodegeneration
• Glaucoma
• Metabolism
• +۲ مورد دیگر

Denise Inman, PhD is an Associate Professor in Pharmaceutical Sciences at the UNT System College of Pharmacy, University of North Texas Health Science Center. Her laboratory focuses on glaucoma mechanisms, particularly the interaction between neurons and glial cells during neurodegeneration. Key research topics include metabolic dysfunction, mitochondrial dysfunction, and energy substrate transfer in glaucoma pathogenesis. Education: BS in Biology, Drexel University PhD in Neuroscience, University of Virginia Research Interests: Neurodegeneration mechanisms Glaucoma pathogenesis Metabolism and mitochondrial biology Therapeutic development for optic nerve protection Funding: Active NIH grants include projects on optic nerve metabolic changes and metabolic vulnerability in glaucoma. Recent grants total 13 sponsored projects with funding from agencies like the National Eye Institute. Publications: Over 49 peer-reviewed articles, with recent work focusing on transcorneal electrical stimulation, Sigma-2 modulators, and metabolic interventions in glaucoma. Research spans mouse models, retinal ganglion cells, and mitochondrial dysfunction. Labs/Teams: Leads the Inman Lab, investigating glaucoma mechanisms and therapeutic targets. Collaborates on projects involving retinal ganglion cells and optic nerve metabolism.

Abigail Layمشاهده پروفایل

پژوهشگر ارشد

• Diabetic Vascular Disease
• Kidney Disease
• Molecular Biology
• +۴ مورد دیگر

Dr. Abigail Lay is a Research Fellow in the Division of Cardiovascular Sciences at The University of Manchester. She holds BHF Accelerator and Kidney Research UK Fellowships, focusing on diabetic vascular disease, particularly diabetic kidney disease. Her research integrates laboratory models and computational methods to identify therapeutic targets. She completed her BSc in Microbiology with Immunology (University of Leeds, 2011) and PhD in 2015 at the University of Bristol. Research interests include molecular mechanisms of kidney disease and therapeutic target discovery. She has authored 23 publications and leads a project on DNA methylation in Diabetic Kidney Disease. Current advisees include Nancy A Smart (PhD) and Kim Godinho/Yao Lu (MSc). She serves on BMC Nephrology’s editorial board and multiple professional committees. Key awards: BHF Accelerator Fellowship (2021), Kidney Research UK Fellowship (2022). Her work contributes to Sustainable Development Goals related to health and well-being.

Charlie Hindmarchمشاهده پروفایل

استادیار

• Genetics
• Genomics
• Molecular genetics
• +۱۱ مورد دیگر

Dr. Charlie Hindmarch is an Assistant Professor in the Department of Medicine at Queen's University, affiliated with the School of Medicine and Faculty of Health Sciences. He holds cross-appointments as Director of the Genomics, Transcriptomics, and Molecular Medicine laboratory at the Queen's CardioPulmonary Unit (QCPU) and Scientific Operations Director for the Translational Institute of Medicine (TIME). His research focuses on pulmonary arterial hypertension (PAH), genomic/transcriptomic profiling, and the role of biological sex in cardiovascular diseases. He employs cutting-edge tools like next-generation sequencing and mass cytometry (CyTOF). Dr. Hindmarch holds a PhD in Neuroscience and Endocrinology from the University of Bristol (2009), with prior postdoctoral training there and visiting professorships at the University of Malay and Federal Rural University of Rio de Janeiro. His work spans over 43 publications with an h-index of 17. Research Interests: Genetics, Genomics, Molecular genetics, Analytical biochemistry, Pulmonary Hypertension, Cardiology, Translational Medicine, DNA computing, and Animal Models of Disease. His lab specializes in transcriptomics, proteomics, and bioinformatics. Key roles include leading the TIME Institute's strategic plan and managing advanced equipment (e.g., mass cytometer) at QCPU. Current supervision includes a Master's student, Abhishek Shastry. His work integrates genomic, proteomic, and clinical data to bridge basic and translational research in cardiovascular diseases.

Georgina Gyarmatiمشاهده پروفایل

استادیار

• Cardiovascular Diseases
• Renal Physiology
• Intravital Microscopy
• +۳ مورد دیگر

Georgina Gyarmati, MD, PhD is an Assistant Professor of Research in the Department of Physiology and Neuroscience at the Keck School of Medicine, University of Southern California. She serves as Assistant Director of the Confocal Microscopy Core and maintains an active research profile in cardiovascular and renal physiology. Her work bridges basic science discovery with therapeutic translation through advanced imaging technologies. Her educational background includes an MD from Semmelweis University Medical School (Budapest), an MPH from Johns Hopkins University, and postdoctoral training in renal physiology at USC. Her research focuses on neuro-endothelial cells (NECs) and macula densa cell functionality, revealing novel neuron-like properties in renal sensory systems. She pioneered the concept of macula densa cells as "ganglion-like mini-brains" within nephrons, establishing a kidney-brain axis for systemic communication. Analysis of her 15 most recent publications (2020-2024) shows consistent focus on intravital multiphoton imaging to study glomerular dynamics, endothelial function, and cellular mechanisms in kidney disease. Key themes include NEC characterization, salt sensing pathways, nanomedicine delivery, and vascular remodeling in hypertension and genetic disorders. Her work frequently appears in high-impact journals like JCI Insight and Journal of the American Society of Nephrology. As Assistant Director of the Multiphoton Microscopy Core, she has advanced intravital imaging applications for quantitative visualization of physiological parameters across multiple organs including kidney, brain, liver, spleen, and skin. Her technical expertise enables single-cell resolution studies of endothelial remodeling, podocyte function, and immune cell interactions in disease models.

• Pharmacology
• Medical Sciences
• Diabetes Research
• +۳ مورد دیگر

Barbara Lewko is a retired Professor from the Faculty of Pharmacy at the Medical University of Gdańsk. She held her academic position until her retirement and has contributed significantly to medical sciences and pharmacology. Her research focuses on kidney physiology, diabetes, and cellular mechanisms in pharmacological contexts, including studies on glucose regulation, podocytes, and insulin effects. Education & Career: She obtained her doctoral degree in 1994 and was appointed Professor in 2008. Her career spanned roles culminating in her professorship until retirement. Research Interests: Her work integrates pharmacological agents with physiological studies, particularly in kidney diseases, diabetes pathophysiology, and cellular stress responses. Key topics include podocyte function, angiotensin signaling, and actin cytoskeleton dynamics in renal cells. Achievements: With 55 publications, 1 promoted thesis, and 2 notable achievements, her research has a substantial impact reflected in a MEiN Score of 679. Her studies often explore beta cells, calcium signaling, and stress pathways in kidney and diabetic contexts. Labs/Teams: Though specific lab names are not listed, her research aligns with pharmacology and renal biology groups at the Medical University of Gdańsk.

• Kidney Disease
• Nephrology
• Immunology
• +۵ مورد دیگر

Associate Professor Guoping Zheng is affiliated with the Westmead Clinical School at the University of Sydney, specializing in nephrology and immunology. His research focuses on kidney fibrosis, inflammation, and the roles of macrophages, TGF-β signaling, and β-catenin in renal pathologies. He collaborates with institutions like the Norris Comprehensive Cancer Research Center (University of Southern California) on Wnt/b-catenin inhibitor studies. Key research interests include the molecular mechanisms of kidney disease progression, particularly in chronic conditions and transplant fibrosis. He has secured grants from the National Health and Medical Research Council (NHMRC), including a Peter Doherty Fellowship (2006) and recent grants targeting β-catenin/FoxO pathways and kidney failure prevention. His work spans experimental models of kidney injury and translational therapies. Publications highlight contributions to understanding renal fibrosis, macrophage biology, and TGF-β's dual roles in inflammation/fibrosis. Recent studies investigate therapeutic strategies like Flt3 inhibitors and engineered macrophages. His team actively supervises research projects on MMPs, E-cadherin, and β-catenin in kidney disease pathogenesis. Grants : Over 10 NHMRC grants since 2006, including $2.5M+ for fibrosis research. Students : Advises Xutong HU on AKI-to-CKD transition mechanisms. Labs/Teams : Collaborates with multidisciplinary groups in nephrology and immunology.

Gerhard Schrattمشاهده پروفایل

استاد

• Molecular Neuroscience
• Synaptic Plasticity
• Non-coding RNAs
• +۱ مورد دیگر

Gerhard Schratt is Full Professor and Head of the Institute for Neuroscience at ETH Zürich. His laboratory investigates molecular mechanisms of synapse development and plasticity, with emphasis on non-coding RNA regulation in neurological disorders. Research integrates molecular neurobiology with computational approaches to study microRNA functions in neuronal development, synaptic homeostasis, and stress responses. Current projects examine RNA-based therapies for neurodegenerative conditions and computational pathology platforms for digital histology. Professor Schratt's group develops AI frameworks for neurological assessment including multimodal dementia diagnosis, voice-based cognitive testing with privacy protection, and digital pathology for kidney disease. Collaborative projects with the Chan Zuckerberg Initiative explore mitochondrial regulation by microRNAs. He teaches molecular neurophysiology and neuroscience courses, supervising doctoral candidates in systems neuroscience approaches.

• Kidney Diseases
• Pathology
• Podocyte Function
• +۴ مورد دیگر

David Cimbaluk is an Associate Professor in the Department of Pathology at Rush University's Rush Medical College, Chicago. His research focuses on kidney diseases, immunology, and molecular pathology, with a strong emphasis on podocyte function, inflammation pathways, and diagnostic methods for renal disorders. He has collaborated extensively on studies involving kidney disease mechanisms, autoimmune conditions like systemic lupus erythematosus, and novel therapeutic strategies for cancer and transplantation. His work spans experimental models (e.g., mouse studies) and clinical applications, including the development of diagnostic techniques like fine-needle aspiration and spatialomic profiling. Key areas include CD11b receptor modulation, miRNA regulation in diabetic nephropathy, and the role of SuPAR in viral-induced proteinuria. He has also contributed to understanding genetic syndromes like Alport Syndrome and X-linked conditions. Education: Not explicitly stated in text, inferred to include advanced training in pathology and molecular biology. Publications: Over 30 peer-reviewed articles since 2005, focusing on nephrology, immunology, and diagnostic pathology. His publications highlight interdisciplinary collaboration, with frequent co-authorship in journals like Nature Communications , JCI Insight , and Journal of Clinical Investigation . Research trends emphasize translational studies linking molecular mechanisms to clinical outcomes in renal and autoimmune diseases. Notable contributions include defining SuPAR's role in kidney disease, developing the SeqStain spatial profiling method, and investigating miR-146a's role in diabetic glomerulopathy. Collaborations with institutions like the University of Chicago and international teams underscore his global impact.