جست‌وجوی استاد و پژوهشگر

Syed Murtuza Bakerمشاهده پروفایل

پژوهشگر ارشد

• Bioinformatics
• Single Cell RNA-seq
• Spatial Transcriptomics
• +۲ مورد دیگر

Syed Murtuza Baker is a Research Fellow in the Division of Informatics, Imaging & Data Sciences at the University of Manchester. He earned his doctorate from Martin-Luther University Halle Wittenberg with a focus on kinetic models of biological systems. His expertise includes single-cell genomics, spatial transcriptomics, and bioinformatics. His research investigates gene regulatory networks, immune cell coordination in inflammatory diseases, and computational methods for analyzing spatial transcriptomic data. He contributes to UN Sustainable Development Goals through his work in health and biomedical research. Baker's publications demonstrate consistent focus on computational biology approaches to disease mechanisms, particularly in liver disease, leukemia, and immune disorders. His recent work develops novel algorithms for spatial transcriptomics data analysis. None reported No information is available regarding student advising or research grants. He collaborates extensively with international teams through the Sustainable Futures and Digital Futures research platforms.

Perihan Nalbantمشاهده پروفایل

استاد

• Cell Migration
• Rho GTPase Signaling
• Cancer Biology
• +۳ مورد دیگر

Prof. Perihan Nalbant is a Professor in the Molecular Cell Biology department at the University of Duisburg-Essen's Faculty of Biology. Her research focuses on understanding the spatial and temporal regulation of Rho GTPase activity during cellular migration and its role in cancer metastasis. Using advanced techniques like fluorescence biosensors and optogenetics, she investigates how aberrant signaling mechanisms contribute to uncontrolled cell migration in diseases such as cancer. Her work combines cutting-edge imaging with siRNA and chemo-optogenetic perturbations to dissect signaling networks regulating cell contraction and migration. She is part of the ZMB's Molecular and Chemical Cell Biology program and collaborates on projects funded by DFG, EU, and NRW programs. Notable contributions include studies on Cdc42 and RhoA signaling, as highlighted in press releases about breakthroughs in cell migration and superresolution microscopy advancements. Despite no explicit awards listed, her publications and institutional involvement underscore her expertise in cellular dynamics and cancer biology. She leads a research group and contributes to the ZMB's state-of-the-art imaging facilities, including a newly installed superresolution microscope for live-cell analysis.

• Genomics of Kidney Disease
• Proteomics of Podocytopathies
• Rare Disease Management
• +۳ مورد دیگر

Hugh McCarthy is a Senior Lecturer in Paediatrics and Child Health at the University of Sydney's Children's Hospital at Westmead Clinical School, and a Staff Specialist in Paediatric Nephrology at the Sydney Children's Hospital Network. He holds advanced clinical qualifications: BSc, MBBS, MRCPCH, PhD, and FRACP. His research focuses on the genomic determinants of kidney disease, proteomics of podocytopathies, and rare disease registries. He co-founded the KIDGEN initiative, a national collaborative studying genetic kidney disease, and designed Australia's first renal gene panel service, benefiting over 800 patients. He is involved in clinical leadership, including the NSW/ACT paediatric renal genetic service, and grant-funded trials such as the OPEN study (MRFF) and the NAVKIDS2 trial (Nacuity-sponsored). As MD Program Year 3 Research Project Coordinator, he bridges education and clinical innovation. Professional affiliations include the Australian and New Zealand Paediatric Nephrology Association, the International Society of Nephrology, and the Alport Foundation of Australia (Board member). Hugh’s research combines clinical practice with molecular insights, emphasizing patient advocacy and translational medicine. His work spans genetic diagnostics, drug efficacy in transplanted kidneys, and improving healthcare access for children with CKD. Collaborations include the University of Bristol’s Academic Renal Unit on gene discovery and lab-based studies.

Sandra Pohlمشاهده پروفایل

استاد

• Lysosomal storage disorders
• Mucolipidosis type II and III
• Osteogenesis imperfecta
• +۵ مورد دیگر

Prof. Dr. Sandra Pohl is a full Professor at the University Medical Center Hamburg-Eppendorf (UKE), affiliated with the Department of Osteology and Biomechanics. Her research focuses on lysosomal storage disorders, particularly mucolipidosis types II and III, and their systemic effects on bone, cartilage, kidney and the central nervous system. She employs mouse models, human genetic studies and translational approaches to dissect disease mechanisms and develop therapeutic strategies. Education & Training No specific educational details provided in the source material; only the academic title "Prof. Dr. (PhD)" is listed. Research Interests Prof. Pohl’s work centers on: Molecular pathology of mucolipidosis type II (I-cell disease) and type III (pseudo-Hurler polydystrophy). GlcNAc-1-phosphotransferase biology and its role in lysosomal enzyme targeting. Skeletal manifestations of lysosomal storage disorders, including osteopenia, cartilage degeneration and dysostosis multiplex. Neurocognitive outcomes and CNS imaging in mucolipidosis patients. Enzyme replacement therapy design and evaluation in pre-clinical mouse models. Proteostasis, autophagy and ubiquitin-proteasome system interactions in disease pathogenesis. Publication Trends Between 2020 and 2024, Prof. Pohl has published extensively on the intersection of lysosomal dysfunction and skeletal/renal/neurological pathology. Her recent articles emphasize: Genotype–phenotype correlations in GNPTAB/GNPTG variants. Translational mouse models recapitulating human mucolipidosis. Multi-omics profiling (proteomics, imaging, metabolomics) to uncover disease biomarkers. Interdisciplinary studies linking basic cell biology to clinical manifestations. Research Support & Collaborations Prof. Pohl currently leads or co-leads the following initiatives: SFB 877, Teilprojekt B03: “Proteolysis-ver” (exact title abbreviated in source) – a collaborative research center funded by the German Research Foundation (DFG). Cross-institutional consortia involving nephrologists, neurologists, geneticists and imaging specialists across Germany and internationally. Laboratory & Core Facilities Her team utilizes state-of-the-art core facilities provided by UKE, including: Transgenic mouse core Advanced imaging and microscopy Mass-spectrometry-based proteomics High-throughput sequencing and bioinformatics platforms

• Developmental and Pathological Angiogenesis
• Ocular Diseases
• Diabetic Retinopathy
• +۴ مورد دیگر

Bruno Larrivee is an Associate Professor in the Department of Ophthalmology at the University of Montreal and leads the Developmental and Pathological Angiogenesis Research Unit. His work focuses on identifying novel signaling pathways, particularly in the BMP and Notch families, that regulate blood vessel formation and integrity in ocular diseases and cancer. Affiliation: Faculty of Medicine, University of Montreal Research Units: CRHMR (Maisonneuve-Rosemont Hospital Research Center), Montreal Diabetes Research Center Projects: Targeting VEGF-independent pathways for ocular therapeutics, Vascular normalization in tumors, Mechanisms of ALK1/Notch crosstalk Research Focus: Dr. Larrivee investigates angiogenesis in diabetic retinopathy and AMD, aiming to develop safer inhibitors than VEGF-targeting therapies. His lab also explores tumor vascular normalization to enhance chemotherapy and immunotherapy efficacy, with key work on BMP9/ALK1 pathway regulation of endothelial quiescence. Publication Trends: Recent studies emphasize TGF-β and BMP signaling in ocular pathologies, tumor vascular normalization, and mechanotransduction in hereditary vascular diseases. Collaborative projects span diabetes, cancer, and retinal degeneration, highlighting interdisciplinary approaches. Scientific Awards: Louise Rousselle Trottier Award (2016) New Investigator Award, Heart and Stroke Foundation (2014) Scientist Development Award, American Heart Association (2013) Grants: Funded by CIHR, NSERC, and foundations like Mitacs and the Foundation Fighting Blindness, with projects on AMD, diabetic retinopathy, and tumor angiogenesis. Collaborations include teams at Yale, the College of France, and INSERM. Labs & Teams: Affiliated with CRHMR and the Montreal Diabetes Research Center, working alongside students and researchers like Naoufal Akla, Natalija Popovic, and Cindy Lora Gil. His lab integrates computational methods (e.g., machine learning) for vascular analysis.

Alejandro Ochoaمشاهده پروفایل

استادیار

• Statistical Genetics
• Computational Biology
• Population Genetics
• +۳ مورد دیگر

Alejandro Ochoa is an Assistant Professor of Biostatistics & Bioinformatics at Duke University , affiliated with the Duke Center for Statistical Genetics and Genomics , Duke Institute for Brain Sciences , and the Center for Combinatorial Gene Regulation . His research focuses on statistical genetics and computational biology , addressing challenges in population structure estimation, genetic association models, and heritability analysis with applications to multi-ethnic studies and admixed populations . Education : Ph.D. in Quantitative and Computational Biology from Princeton University (2013) Research Highlights : Develops scalable statistical methods for genetic studies under arbitrary relatedness, emphasizing equity in multi-ethnic cohorts . Key contributions include software packages like popkin (kinship estimation), ligera (robust association studies), and bnpsd (admixed population simulation). His work addresses biases in principal component analysis , heritability estimation , and GWAS meta-analysis . Grants : National Institutes of Health (2023-2026): Regulators of Calcineurin Pathways as Diagnostic and Therapeutic Targets for Nephrotic Syndrome National Institutes of Health (2020-2026): HLA Risk Alleles in Primary Nephrotic Syndrome National Human Genome Research Institute (2020-2025): Duke FUNCTION Center Labs & Collaborations : Leads the Ochoa Lab , which develops open-source software under GNU General Public License and collaborates with programs like UPGG and CBB .

Nina Jonesمشاهده پروفایل

استاد

• Signal Transduction
• Kidney Function
• Blood Vessel Formation
• +۴ مورد دیگر

Dr. Nina Jones is a Professor and Canada Research Chair in the Department of Molecular and Cellular Biology at the University of Guelph, where she has been a faculty member since 2006. She holds a B.Sc. in Molecular Biology and Genetics from the University of Guelph, a Ph.D. in Medical Biophysics from the University of Toronto, and completed postdoctoral training at the Lunenfeld Tanenbaum Research Institute under Dr. Tony Pawson. Her research focuses on signal transduction pathways, particularly their roles in kidney function, cancer biology, embryonic development, and nervous system patterning. She employs interdisciplinary methods, including mouse genetics, cell culture, microscopy, and clinical specimen analysis. Key areas of study include kidney podocyte morphology, focal adhesion dynamics in cancer cells, and neuronal adaptor proteins like ShcD. Dr. Jones has been recognized with awards such as the Guelph Researcher Award and election to the College of Scholars. Her lab includes postdoctoral fellows, graduate students, and research associates. She teaches courses in genetics and molecular biology, including MBG*3050, MBG*4070, and MCB*6310. Her work has led to grants and collaborations, including a $750,000 grant for kidney disease research. The lab’s future directions include investigating novel gene mutations in kidney diseases and tumor cell invasion mechanisms.

Ken Inokiمشاهده پروفایل

دانشیار

• mTOR signaling pathway
• Cellular growth regulation
• Signal transduction
• +۴ مورد دیگر

Ken Inoki is the Roger C. Wiggins Collegiate Professor of the Life Sciences and a Research Associate Professor at the University of Michigan Life Sciences Institute. He holds Associate Professor appointments in both the Division of Nephrology, Department of Internal Medicine and the Department of Molecular & Integrative Physiology at the U-M Medical School. His research focuses on the mechanistic target of rapamycin (mTOR) signaling pathway’s role in diabetes, aging, and cancer. Education : MD (1991) and PhD (1998) in Biochemistry & Molecular Biology from Shiga University of Medical Science, Japan Clinical background : 8 years as a physician in Nephrology at University Hospital, Japan Key affiliations : U-M Life Sciences Institute, Medical School, and Klatskin-Sutker Discovery Fund recipient Research Interests : Dr. Inoki investigates how the mTOR pathway coordinates nutrient and growth factor signals to regulate protein synthesis, lipid biogenesis, and cellular proliferation. His work bridges basic science and clinical applications , addressing pathologies in diabetic nephropathy, cancer, and age-related disorders through biochemical and genetic approaches . Scientific Awards : Koikai Award for Excellence in Basic Science (2004) Biological Sciences Scholar, University of Michigan (2008) Lab Members : Collaborates with multi-disciplinary teams at the Ken Inoki Lab (Room 6183A, Life Sciences Institute) on projects funded by the Klatskin-Sutker Discovery Fund, focusing on antiparasitic development and kidney disorder prevention .

Michael Krahnمشاهده پروفایل

استاد

• biomolecular label chemistry
• RNA biochemistry
• bioorthogonal chemistry
• +۷ مورد دیگر

Michael Krahn is a University Professor at the University of Münster's Faculty of Medicine, where he leads the Medical Cell Biology research group within Medical Clinic D - Internal Medicine. Holding dual doctorates in Veterinary Medicine and Natural Sciences, he maintains an active research program focusing on molecular mechanisms of cell biology with particular emphasis on membrane dynamics and cellular structures. His research interests span biomolecular label chemistry, RNA biochemistry, bioorthogonal chemistry, RNA modifications, nucleic acid chemistry, chemical biology, and mRNA. Professor Krahn's work particularly explores how phosphoinositide lipids regulate cell polarity and membrane organization, with significant contributions to understanding slit diaphragm formation, endocytosis, and related disease mechanisms. His publication record shows consistent research output through 2023, with recent work examining tight junction formation, ER stress responses in podocytes, Hippo pathway regulation, and SEC61A1 variants in liver disease. These publications demonstrate his interdisciplinary approach bridging cell biology, molecular medicine, and disease pathology, primarily using Drosophila models and mammalian cell systems. Professor Krahn participates in the "Cells in Motion" collaborative research initiative and is a member of the Imaging Network, focusing on microscopy applications for cellular dynamics research. His work appears in high-impact journals including Nature Communications, Cell Reports, and Journal of the American Society of Nephrology, reflecting the significance of his contributions to cell polarity and membrane biology fields.

Albrecht Schwabمشاهده پروفایل

استاد

• Physiology
• Biochemistry
• Cancer Biology
• +۷ مورد دیگر

Prof. Dr. Albrecht Schwab is a faculty member at the Institute of Physiology II , affiliated with the Medical Faculty of Münster University . He leads the Cell Migration Group , focusing on the role of ion channels and ion transporters in tumor and immune cell migration. Key research areas include calcium signaling , pH regulation , and mechanosensitivity in cancer progression and neutrophil function. Department: Institute of Physiology II University: University of Münster Research Networks: Cells in Motion, pHioniC (2018-2023), IonTraC (2011-2015) His work investigates how ion transport proteins like KCa3.1 , TRP channels , and the Na+/H+ exchanger (NHE1) drive cancer metastasis and immune cell chemotaxis. Projects include mechanosignaling in pancreatic stellate cells, TRP channel roles in neutrophil activation, and epigenetic dysregulation of ion channels in lung cancer. Techniques employed include time-lapse videomicroscopy , live-cell fluorescence , and atomic force microscopy . Articles highlight trends in ion channel imaging (PET/fluorescent probes), mechanotransduction in fibrosis, and calcium/pH signaling in melanoma and pancreatic cancer. The lab collaborates with technical staff (Ilka Neumann, Sarah Sargin, Sandra Schimmelpfennig) and participates in European research consortia.

Madhusudhana R. Jangaمشاهده پروفایل

استادیار

• Plant Genetics
• Crop Improvement
• Abiotic Stress Tolerance
• +۳ مورد دیگر

Dr. Madhusudhana R. Janga is an Assistant Professor at Texas Tech University, holding dual affiliations with the Department of Plant and Soil Sciences and the Institute of Genomics for Crop Abiotic Stress Tolerance (IGCAST). As Director of the Plant Transformation Facility, he specializes in plant tissue culture and transformation technologies. His research focuses on enhancing crop resilience to abiotic and biotic stresses through advanced genomics, CRISPR/Cas9 genome editing, and Agrobacterium-mediated transformation. Key areas include improving crop yields, nutritional content, and stress tolerance via rapid gene characterization methods like virus-induced gene silencing (VIGS). Dr. Janga earned his Ph.D. from Osmania University, India, and held prior roles as Assistant Director at the University of Missouri’s Plant Transformation Core Facility, Staff Scientist at Sanford Research, and Postdoctoral Associate at Texas A&M University. His lab collaborates extensively to provide plant transformation services, advancing crop improvement programs. Research Interests: Gene function elucidation and crop trait enhancement CRISPR/Cas9 and genome editing applications Stable transgenic plant development Abiotic stress tolerance mechanisms Lab Team: Postdoctoral Research Associate: Archana Khadgi (peanut/cotton genome editing) Research Aid: Pankaj Verma M.S. Student: Sri Harsha Vardhan Reddy Lankireddy (cotton transformation efficiency) Research Assistant: Sai Krishna Lekkala Publications: Recent work includes studies on CRISPR-edited crops, microbial community analysis in nematode-infested soils, and kidney cell signaling mechanisms. His research bridges fundamental biology with applied crop improvement, emphasizing transgenic tools and stress resilience. Affiliations: Institute of Genomics for Crop Abiotic Stress Tolerance (IGCAST) Janga Lab at Texas Tech University

Claire Mooreمشاهده پروفایل

استاد

• Molecular Biology
• Gene Expression Regulation
• RNA Processing
• +۳ مورد دیگر

Claire Moore is the Natalie V. Zucker Professor in Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. Her research focuses on mRNA polyadenylation mechanisms and their roles in development, differentiation, and disease. She holds the Natalie V. Zucker Endowed Chair and has authored over 100 publications. Education: Ph.D. from University of North Carolina (1982), B.S. from MIT (1973). Research interests include mRNA maturation processes, polyadenylation site choice, and their implications in cancer and chronic stress. Techniques used: biochemistry, molecular biology, genomics. Awards: Natalie V. Zucker Endowed Chair (2017). Teaching includes courses on biomedical technologies, gene expression, and molecular biology. Professional roles: journal reviewer, committee member, and grant reviewer for NSF and NIH.

Donald Gillمشاهده پروفایل

استاد

• Calcium Signaling
• Signal Transduction
• Membrane Channels
• +۴ مورد دیگر

Dr. Donald Gill is a Professor in the Department of Cell and Biological Systems, specializing in calcium signaling mechanisms in animal cells. His research spans molecular biology, biochemistry, and cellular physiology with a focus on calcium channel dynamics. Active in UN Sustainable Development Goals related to health and biological research Recipient of Career Citation Milestone Award (2020) The Gill lab investigates how cells precisely control intracellular calcium levels through plasma membrane and endoplasmic reticulum channels. Their work includes: Elucidating TRP family channel proteins in transducing external signals Studying STIM and Orai proteins in store-operated calcium entry Developing molecular tools for channel protein mutation and expression Using advanced fluorescence imaging and electrophysiological methods Recent publications highlight their contributions to understanding: Lipid signaling interactions with calcium channels (2025) Diabetes-induced podocyte loss mechanisms (2025) Orai1-STIM1 coupling site structure (2023) Celastrol's role in psoriasis treatment via calcium inhibition (2023) Scientific awards include the Career Citation Milestone Award (2020) from D (500) Club, recognizing his impact in cell signaling research. Research projects funded by National Institute of General Medical Sciences (2019-2024), National Heart, Lung, and Blood Institute (1996-2007), and other NIH institutes demonstrate sustained institutional support for his work on calcium regulation in smooth muscle cells and B cells.

• Biomechanics/Bioengineering
• Biophysics
• Cardiovascular
• +۱۶ مورد دیگر

Evren U Azeloglu is a Professor of Medicine in the Division of Nephrology at the Icahn School of Medicine at Mount Sinai, with a secondary appointment in the Department of Pharmacological Sciences. He is affiliated with the Center for Engineering and Precision Medicine and the Black Family Stem Cell Institute. B.E., Stony Brook University M.S., Stony Brook University Ph.D., Columbia University His research focuses on biomechanics , systems biology , and precision medicine , utilizing multiomics and computational modeling to study kidney and cardiovascular diseases. He develops microfabricated platforms for tissue engineering and mechanobiology research. Recent publications emphasize multiomics approaches to kidney injury, machine learning in transplant assessment, and mechanistic modeling of drug toxicity. Key themes include cell adhesion , cytoskeletal dynamics , and biomechanical regulatory networks . NephCure Kidney International ASN Foundation Kidney Research Award (2015) Howard Hughes Medical Institute Fellowship (2010) Stony Wold Herbert Fellowship (2005) Yuen-huo Hung & Chao-chin Huang Award (2004) Dr. Azeloglu's Systems Bioengineering Lab receives extramural grants and collaborates with Flowpoint Medical Inc. , where he serves as Board Member , Equity Owner , and Founder .

• Chronic Kidney Disease
• Genetics
• Genomics
• +۵ مورد دیگر

Katalin Susztak is Professor of Medicine and Genetics at the Perelman School of Medicine, University of Pennsylvania. She holds hospital appointments at the Philadelphia VA Medical Center and leads kidney disease research through multiple institutional roles including codirector of the Institute of Diabetes and Obesity and Metabolism complications unit. MD and PhD from Semmelweis University, Hungary MS in Genomics and Computational Biology from Albert Einstein College of Medicine Her research focuses on molecular pathways in chronic kidney disease (CKD), integrating genetics, epigenetics, and single-cell transcriptomics to identify novel disease genes (e.g., MANBA, DACH1, APOL1) and demonstrate mechanisms like Notch signaling dysfunction and metabolic dysregulation. She pioneered kidney epigenome mapping and created the first cross-species single-cell kidney atlas. Recent publications highlight integrative multi-omics approaches, including 2025 work on proteogenomics and 2024 studies on ER stress/STING pathway roles in fibrosis. Her team also explores therapeutic implications of mineralocorticoid receptor antagonists and cytoskeletal regulators like WHAMM in kidney disease. 2011 Young Investigator Award (ASN/AHA) 2021 Alfred Newton Richards Award (ISN) Lab personnel include 15+ postdoctoral fellows, graduate students, and research specialists. She advises through the MD-PhD admissions committee and leads the Penn/CHOP Kidney Innovation Center. Funding sources include NIH, American Diabetes Association, and Juvenile Diabetes Research Foundation.