جستجوی استاد راهنمای دانشگاهی

Toni M. Antalisمشاهده پروفایل

استاد

• Vascular Biology
• Ovarian Cancer
• Inflammation
• +۶ مورد دیگر

Toni M. Antalis, PhD, is a Professor in the Department of Pharmacology & Physiology at the University of Maryland School of Medicine. She serves as Associate Director of Training and Education for the Marlene and Stewart Greenebaum Comprehensive Cancer Center and Director of the Program in Molecular Medicine. Her research bridges vascular biology and cancer, focusing on membrane-anchored serine proteases and their role in tumor metastasis, inflammation, and coagulation. Doctorate in Biochemistry from Rice University Postdoctoral training in Cell Biology at Baylor College of Medicine Her laboratory investigates how protease-activated receptors (PARs) and the plasminogen activation system influence vascular disease and ovarian cancer progression. Current projects include studying fibrinolysis in thrombus resolution and developing protease-targeted therapies for metastatic ovarian cancer. Recent publications highlight roles of matriptase, testisin, and PAI-2 in tumor dissemination and vascular permeability. Dr. Antalis' research is funded by the National Institutes of Health (NIH), the Department of Defense, and a VA Merit Award. She has previously received support from the Lance Armstrong Foundation and Rivkin Center. She co-directs NIH-funded T32 and PREP programs for cancer training. Mentored numerous PhD students and postdoctoral fellows Developed engineered anthrax toxin prodrugs for ovarian cancer therapy (patents 10,568,929 and 11,013,784)

• Bioactive compounds
• Antioxidant assays
• Food technology
• +۵ مورد دیگر

Wilfried Andlauer is a Professor at the Institute of Life Sciences within HES-SO Valais-Wallis School of Engineering. His research focuses on bioactive compounds , non-thermal food processing , and bioavailability studies , particularly in agricultural by-products like grape cane, walnut press cake, and Spirulina algae. He has developed advanced methods for solid-state fermentation , cold plasma decontamination , and bioactives fingerprinting . Key projects include optimizing microwave-assisted extraction for stilbenoids, analyzing iron absorption from insect flour , and developing microfluidic antioxidant assays . His work integrates nutraceutical research with practical applications in food safety and sustainable processing . Collaborations span Switzerland and Asia , with expertise in analytical chemistry and bioprocessing .

Heath MacMillanمشاهده پروفایل

دانشیار

• Insect physiology
• Thermal stress responses
• Cold tolerance mechanisms
• +۶ مورد دیگر

Heath MacMillan is an Associate Professor in the Department of Biology at Carleton University, Faculty of Science. His research focuses on integrative insect physiology, particularly how environmental stressors like extreme temperatures, microplastics, and dietary changes affect molecular, biochemical, and whole-organism performance. Research Themes: Cold tolerance mechanisms, ionoregulatory collapse, microplastic pollution impacts, thermal acclimation physiology, and nutritional ecology for edible insects. Model Systems: Drosophila melanogaster, Gryllodes sigillatus, Aedes aegypti, and tropical butterflies. Techniques: Transcriptomics, metabolomics, in vitro osmoregulation assays, thermal gradient devices, and fluorescent microplastic tracking. His lab collaborates with Environment and Climate Change Canada, Dr. Jennifer Provencher, and Entomo Farms to address both fundamental physiological questions and applied problems in sustainable insect protein production. Current work explores how thermal plasticity and cross-tolerance mechanisms interact with ecological stressors like hypoxia and desiccation. Publications highlight his team's development of the ionoregulatory collapse model for cold tolerance, discovery of microplastic impacts on cricket growth, and characterization of thermal acclimation's role in maintaining central nervous system function. Research integrates molecular mechanisms with ecological predictions about species distribution and abundance under climate change. Lab opportunities emphasize collaborative, interdisciplinary work across physiology, biochemistry, and ecology. Graduate students and postdocs are encouraged to develop independent projects within the lab's existing frameworks. Undergraduates gain hands-on experience through volunteer work and independent studies.

Yusuke Toyamaمشاهده پروفایل

دانشیار

• Tissue Mechanics
• Tissue Homeostasis
• Apoptosis
• +۳ مورد دیگر

Yusuke Toyama is an Associate Professor at the National University of Singapore (NUS) in the Department of Biological Sciences (Faculty of Science) and a Principal Investigator at the Mechanobiology Institute (MBI). His high-impact research earned him the Dean's Chair in the Faculty of Science in 2018. Education: PhD in Engineering, Osaka University, Japan (2003) Undergraduate studies, Hokkaido University, Japan Dr. Toyama investigates tissue mechanics and homeostasis, focusing on apoptotic cell extrusion from epithelial tissues. His lab discovered that actomyosin-driven cytoskeletal rearrangements in neighboring cells mechanically expel dying cells. Recent work reveals immune cells also provide critical mechanical force for apoptotic clearance. His interdisciplinary approach integrates super-resolution imaging, optogenetics, biophysical force measurements, and machine learning to decipher tissue dynamics. His 2021-2025 publications demonstrate consistent focus on epithelial mechanics, neural stem cell reactivation, and cell junction dynamics. Key themes include F-actin's role in tissue integrity, force transmission at adherens junctions, and immune cell mechanics in homeostasis. Studies frequently employ Drosophila and mammalian models with advanced biophysical techniques to uncover conserved tissue organization principles. Scientific Awards: Dean's Chair in the Faculty of Science, NUS (2018) Dr. Toyama mentors six PhD students including Le Thuy Truc Anh (2024) and Vinod S/O Prabhakaran (2023). His research is funded by NUS and MBI, supporting investigations into tissue mechanobiology and apoptotic clearance mechanisms through interdisciplinary collaborations. He leads the Mechanotransduction in Tissues Group at MBI, collaborating with the Ladoux Lab (cell adhesion), Kanchanawong Lab (super-resolution imaging), and Ravasio Lab (tissue mechanics). His team integrates physicists, biologists, and engineers to study mechanical regulation of tissue organization.

David Booneمشاهده پروفایل

استاد مدعو

• Microbiology & Immunology
• Cancer
• Cellular & Molecular Biology
• +۹ مورد دیگر

David Boone is an Adjunct Professor in the Department of Biology at the University of Notre Dame and a Professor of Microbiology and Immunology at Indiana University School of Medicine – South Bend. His research focuses on the molecular and immunological mechanisms underlying inflammatory bowel diseases (IBD), colon cancer, and obesity, with a strong emphasis on host-microbe interactions, autophagy, and intestinal barrier function. Adjunct Professor of Biology, University of Notre Dame (2021–Present) Professor of Microbiology and Immunology, Indiana University School of Medicine – South Bend (2021–Present) Adjunct Associate Professor, University of Notre Dame (2014–2021) Associate Professor, Indiana University School of Medicine – South Bend (2014–2021) Assistant Professor of Medicine, University of Chicago (2006–2013) Adjunct Assistant Professor, University of California, San Francisco (2004–2006) Education: Ph.D., University of Ottawa (1997) B.Sc., University of Waterloo (1989) Dr. Boone's research explores the role of key regulatory genes such as ATG16L1 and TNFAIP3 in intestinal inflammation and cancer. His lab uses genetically engineered mouse models to investigate how disruptions in autophagy, NF-kB signaling, and epithelial barrier integrity contribute to disease. A major focus is the protective effect of the ATG16L1 Thr300Ala variant in colorectal cancer through enhanced type I interferon production. His recent publications reveal a consistent trend in understanding immune regulation in the gut, particularly how genetic variants influence microbial interactions, epithelial cell function, and anti-tumor immunity. His work bridges molecular immunology, genetics, and microbiome science, contributing to translational insights in IBD and cancer. Scientific Awards: No awards explicitly mentioned in the text. Dr. Boone has advised numerous graduate students and postdoctoral researchers, many of whom have co-authored his publications. While specific grants are not listed, his sustained research output suggests active funding. His work involves collaboration across institutions, including the University of Chicago, UCSF, and various medical research centers. He leads a research lab focused on intestinal immunology, utilizing transgenic mouse models and human cell lines to dissect pathways involved in inflammation, autophagy, and cancer. The lab investigates microbial infiltration, mucus layer integrity, and immune cell responses in genetically susceptible hosts.

• Nephrology
• Renal Physiology
• Membrane Transport
• +۷ مورد دیگر

Peter S. Aronson is the C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular and Molecular Physiology at Yale School of Medicine. He holds primary appointments in the Department of Internal Medicine and secondary appointments in Cellular & Molecular Physiology and the MD-PhD Program. He has been a faculty member at Yale since 1977 and served as Chief of the Section of Nephrology from 1987 to 2002. Department: Internal Medicine (Nephrology) School: Yale School of Medicine University: Yale University Academic Rank: Professor Email: peter.aronson@yale.edu Dr. Aronson's research focuses on the molecular and physiological mechanisms regulating renal electrolyte transport, particularly sodium, acid-base, and oxalate excretion. His work centers on membrane transporters such as NHE isoforms (Na + -H + exchangers) and SLC26 anion exchangers. He employs approaches including isoform-specific antibody development and genetically modified mouse models to study transporter function in vivo. His investigations into SLC26A6 have elucidated its critical role in oxalate homeostasis and calcium oxalate kidney stone formation. His recent publications (2021–2024) emphasize oxalate metabolism, its systemic effects in dialysis patients, and genetic determinants of transporter function. Themes include the link between elevated oxalate and sudden cardiac death, the role of macrophages in oxalate release, and the physiological modeling of intestinal oxalate transport. These studies span molecular physiology, clinical nephrology, and translational research, reflecting a cohesive trajectory in understanding electrolyte and anion handling in health and disease. Dr. Aronson has received numerous scientific honors, including: Homer W. Smith Award, American Society of Nephrology (1994) Robert W. Berliner Award, American Physiological Society (2016) Walter B. Cannon Award, American Physiological Society (2019) Fellow, American Academy of Arts and Sciences (2009) Fellow, American Association for the Advancement of Science (1996) Young Investigator Award, ASN and AHA (1985) Charles W. Bohmfalk Teaching Prize (2005) Fund for Physician-Scientist Mentorship Award (2023) Dr. Aronson is deeply involved in academic leadership and education. He served as President of the American Society of Nephrology in 2008 and is currently an Associate Director of the Yale M.D.-Ph.D. Program. He has been recognized for excellence in teaching and mentorship, advising numerous students and trainees. His research is conducted in collaboration with a strong network of co-investigators, including Felix Knauf, Tong Wang, and Robert Thomson, and is supported by sustained funding in the field of renal physiology. His laboratory investigates ion transport mechanisms using molecular, cellular, and whole-animal models, with a particular focus on the kidney’s role in systemic electrolyte and acid-base balance. The team combines biochemical, immunological, and genetic techniques to dissect transporter function and regulation.

Klaus Ebnetمشاهده پروفایل

استاد

• Cell Adhesion
• Cell Polarity
• Junctional Adhesion Molecules (JAMs)
• +۵ مورد دیگر

Prof. Dr. Klaus Ebnet is a Full Professor at the University of Muenster, leading the Ebnet Lab: Cell Adhesion and Cell Polarity within the Center for Molecular Biology of Inflammation (ZMBE). His work focuses on understanding molecular mechanisms of cell-cell interactions, cell polarity establishment, and adhesion molecule functions such as Junctional Adhesion Molecules (JAMs) and integrins. He holds a position in the Institute of Medical Biochemistry and participates in the 'Cells in Motion' research initiative. Research Interests: Regulation of epithelial cell polarity via adhesion receptors JAM-A-integrin signaling complexes in cell migration Role of TMIGD1 in microvillus formation and mitochondrial interactions Mechanical regulation of tight junction assembly Cell adhesion dynamics in angiogenesis and cancer metastasis Publications (selected 2022-2012): Focus on molecular mechanisms of cell adhesion, polarity maintenance, and their disruption in disease contexts. Highlights include discoveries about JAM-A's role in spindle orientation during mitosis, integrin cross-talk in collective cell migration, and the TMIGD1-based adhesion complex in intestinal development. Labs/Teams: Leads the Ebnet Lab at ZMBE, collaborating in interdisciplinary imaging networks. Active in training graduate students through the 'Cells in Motion' graduate school program.

Charles Parkosمشاهده پروفایل

استاد

• Mucosal Inflammation
• Epithelial Pathobiology
• Leukocyte Trafficking
• +۳ مورد دیگر

Charles Parkos, MD, PhD is the Carl V. Weller Professor and Chair of the Department of Pathology at the University of Michigan Medical School. He trained at University of California at San Diego/Scripps Research Institute (MD/PhD, 1987), Brigham and Women’s Hospital (Pathology residency/fellowship), and Harvard Medical School before joining Emory University (1997–2014), where he served as Director of Experimental Pathology and full Professor. Research Focus : Dr. Parkos investigates Mucosal inflammation mechanisms in inflammatory bowel disease (IBD) Neutrophil trafficking across intestinal epithelium Epithelial barrier dysfunction and repair Role of CD11b/CD18, CD47, SIRPα, and JAM family proteins Molecular regulation of leukocyte-epithelial interactions In vivo/ex vivo inflammation models Scientific Contributions : His work has been instrumental in defining leukocyte migration dynamics across mucosal barriers, with over 189 publications in top journals (Nature, Cell, J Exp Med). He has held continuous NIH R01 funding since 1995 and served as President of the American Society for Investigative Pathology (2010–2011). Mentorship & Leadership : Dr. Parkos has trained numerous graduate students and postdocs, many of whom hold prominent academic positions. He directed Emory’s Medical Scientist Training Program (2001–2014), expanding it to 88 students, and chairs grant review committees for the Crohn’s and Colitis Foundation of America.

• Animal Physiology
• Endocrinology
• Environmental Biology
• +۴ مورد دیگر

Scott P. Kelly is a Full Professor in the Department of Biology at York University. His research focuses on the regulation of salt and water balance in aquatic animals, emphasizing the endocrine system's role in linking environmental changes to physiological responses, and the permeability properties of occluding junctions (tight junctions in vertebrates, septate junctions in invertebrates). He uses model organisms such as mayfly nymphs, sea lampreys, teleost fishes, and amphibians to study processes like epithelial permeability responses to environmental/systemic changes, endocrine regulation of paracellular permeability, and the impact of salinization on freshwater organisms. Dr. Kelly prioritizes trainee development in his research program, ensuring intellectual growth and involvement. His work bridges Animal Physiology, Endocrinology, and Environmental Biology, addressing critical ecological and physiological questions in aquatic systems.

• Blood-Brain Barrier Biology
• Neurovascular Biology
• Wnt/β-catenin Signaling
• +۵ مورد دیگر

Dritan Agalliu is an Associate Professor of Pathology and Cell Biology (in Neurology) at Columbia University Irving Medical Center, with a focus on neurovascular biology and blood-brain barrier (BBB) mechanisms. He has developed innovative mouse models to study BBB dynamics in diseases like stroke and multiple sclerosis, and investigates Wnt/β-catenin signaling in vascular development and repair. His work bridges molecular genetics, immunology, and clinical neuroscience. Research Highlights : Discovered roles for Wnt signaling in BBB formation and repair Developed live-animal imaging models for BBB structural components Linked neuroinflammation to vascular and behavioral deficits Pioneered studies on immune cell entry in psychiatric disorder models Scientific Recognition : 2020 Lamport Award for Basic Science Research 2016 PANDAS Network Research Innovator 2006 Doctoral Distinction in Genetics 1998 Cum Laude graduate Contact: da191@cumc.columbia.edu | Agalliu Lab

Salah Amashehمشاهده پروفایل

استاد

• Epithelial Barrier
• Tight Junction Proteins
• Claudins
• +۴ مورد دیگر

Salah Amasheh is a Professor at the Institute of Veterinary Physiology , Department of Veterinary Medicine, Free University of Berlin. He serves as Deputy Managing Director and Coordinator for International Relations at his institution. PhD from Justus-Liebig-University Gießen (1998) Habilitation in Experimental Biomedicine (2008) Key research areas: epithelial barrier function, claudin proteins, ion transport, and intestinal/renal physiology His work focuses on tight junction proteins (e.g., claudin-2, claudin-17) and their roles in epithelial permeability, inflammation, and drug delivery. Publications highlight claudin channel selectivity, barrier modulation in diseases like inflammatory bowel disease, and absorption enhancement strategies. Notable awards include the Forschungspreis des Fachbereichs Humanmedizin (2001) and Personal Research Funding (€75,000, 2007). He has contributed to 15+ seminal studies on tight junctions and barrier function, with citations in high-impact journals like Molecular Biology of the Cell and Biomaterials . Amasheh leads the Epithelial Barrier Research Group and collaborates with Charité’s doctoral committee. His grants and leadership roles reflect sustained influence in biomedical research and education since the 1990s.

Sian-eleri Owensمشاهده پروفایل

مدرس

• Cell Biology
• Pore-Forming Toxins
• Pathogen Tolerance
• +۳ مورد دیگر

Dr Sian-eleri Owens is a Lecturer in Biomedical Sciences at Swansea University Medical School, with a focus on Blood Sciences and Immunohaematology. Fluent in Welsh and English, she teaches courses such as cell biology and laboratory skills. Her research investigates enhancing innate defenses against pathogens, particularly mechanisms involving pore-forming toxins and cellular protection. She holds a BSc from the University of Wales Institute Cardiff and a PhD from Cardiff University School of Pharmacy and Pharmaceutical Sciences. Education: BSc (Hons) in Biomedical Science, University of Wales Institute Cardiff; PhD in Myosin Light Chain-Dependent Modulation of Tight Junctions, Cardiff University School of Pharmacy. Research Interests: Cell biology, pathogen tolerance, and innate immune responses. Her work explores glucocorticoids, oxysterols, and bisphosphonates as protective agents against pore-forming toxins from bacteria. Collaborations include the National Botanic Garden of Wales for bilingual science outreach. Publications: Over 20 peer-reviewed articles in journals such as Communications Biology, Frontiers in Immunology, and The FASEB Journal, focusing on cellular protection mechanisms and antimicrobial defense strategies. Supervision: Currently advising a PhD student on cholesterol-dependent cytolysin protection mechanisms, co-supervised with Dr James Cronin. Labs/Teams: Affiliated with the Institute of Life Science at Swansea University, contributing to interdisciplinary research in biomedical defense mechanisms.

Susanne M. Krugمشاهده پروفایل

استاد

• Tight Junctions
• Epithelial Barrier Function
• Inflammatory Bowel Diseases (IBD)
• +۵ مورد دیگر

Susanne M. Krug is a Professor at Charité - Universitätsmedizin Berlin, leading research in the Clinical Physiology/Nutritional Medicine division. Her work focuses on epithelial and endothelial barrier mechanisms, particularly tight junction biology in inflammatory bowel disease (IBD) and neuropathic pain. She coordinates multiple DFG-funded projects including TRR 241 (Immune-epithelial communication in IBD) and GRK 2318 (Tight junction proteins in health/disease). Her research integrates molecular physiology with translational models, employing techniques like organoid-based monolayers, impedance spectroscopy, and freeze-fracture EM. Key interests include: Tricellulin regulation in IBD and barrier defects Paracellular transport pathways for drug delivery Blood-nerve barrier dysfunction in pain Claudin channel biophysics Analysis of her recent articles reveals persistent themes: epithelial barrier repair mechanisms (45% of publications), neuro-immune interactions (30%), and molecular engineering of junction proteins (25%). Her lab frequently employs advanced microscopy and electrophysiology to quantify barrier properties. As Associate Editor for BMC Gastroenterology and Editorial Board member for IJMS , she shapes discourse in barrier pathophysiology. She holds leadership roles in doctoral training programs and maintains active collaborations across Europe and the US.

Andrew Doniniمشاهده پروفایل

دانشیار

• Insect Physiology
• Osmoregulation
• Aquatic Insect Biology
• +۴ مورد دیگر

Andrew Donini is an Associate Professor in the Department of Biology at York University, Canada. His research focuses on the physiological mechanisms enabling aquatic insect larvae to survive environmental challenges such as high ammonia levels and salinity changes. He leads the Donini Lab, which investigates ammonia excretion in mosquitoes (Aedes aegypti) living in ammonia-rich habitats and studies how freshwater insects cope with salination caused by rising sea levels and road salt runoff. Donini teaches courses on invertebrate physiology, comparative animal physiology, and epithelial physiology at both undergraduate and graduate levels. His lab uses molecular, cellular, and whole-organism approaches to study ion transporters, aquaporins, and septate junctions in osmoregulatory organs like Malpighian tubules and anal papillae. Recent work includes discoveries about AeAmt2's role in mosquito sperm fertility and Aedes aegypti's adaptation to high ammonia environments. Research highlights include studies on cold tolerance plasticity in Drosophila, salt stress effects on mayfly physiology, and the role of neuroendocrine factors in regulating epithelial transport. His work addresses global challenges like climate change impacts on freshwater ecosystems and disease vector persistence in non-traditional habitats. Donini has advised students such as Andrea Durant (PhD), Elia Grieco Guardian (MSc), and Fargol Nowghani (MSc), with notable achievements including high-impact publications in PNAS and Aquatic Toxicology. The lab is funded by NSERC Canada and other grants to study insect osmoregulation and environmental physiology.

• Food Chemistry
• Toxicology
• Nanoparticle Toxicology
• +۵ مورد دیگر

Janice Bergen is a researcher affiliated with the Faculty of Chemistry , working in the Department of Food Chemistry and Toxicology . She contributes to interdisciplinary projects at the Core Facility Multimodal Imaging, focusing on nanoparticle interactions with biological systems and chemical modulation of cellular processes. Research Focus: Nanoparticle toxicology, intestinal barrier function, and food constituent safety assessment Key Collaborations: Interactions with teams studying cancer mechanotransduction and endocrine disruptors Her work spans Nanotechnology , Toxicology , and Food Science , particularly investigating how engineered nanoparticles affect cellular compliance and tight junction proteins like claudin-4. Recent studies examine synergies between food contaminants (fumonisin B1, palmitic acid) and nanoparticle shape in modulating lipid metabolism. Publications highlight her contributions to: Mesoporous silica nanoparticle design for intestinal barrier studies Autophagy regulation in cancer cells under mechanical stress Development of nanoparticle-based tools for paracellular permeability analysis Her research aligns with UN Sustainable Development Goals related to health (SDG 3) and environmental sustainability (SDG 12).