معرفی
Peter S. Aronson is the C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular and Molecular Physiology at Yale School of Medicine. He holds primary appointments in the Department of Internal Medicine and secondary appointments in Cellular & Molecular Physiology and the MD-PhD Program. He has been a faculty member at Yale since 1977 and served as Chief of the Section of Nephrology from 1987 to 2002.
- Department: Internal Medicine (Nephrology)
- School: Yale School of Medicine
- University: Yale University
- Academic Rank: Professor
- Email: peter.aronson@yale.edu
Dr. Aronson's research focuses on the molecular and physiological mechanisms regulating renal electrolyte transport, particularly sodium, acid-base, and oxalate excretion. His work centers on membrane transporters such as NHE isoforms (Na+-H+ exchangers) and SLC26 anion exchangers. He employs approaches including isoform-specific antibody development and genetically modified mouse models to study transporter function in vivo. His investigations into SLC26A6 have elucidated its critical role in oxalate homeostasis and calcium oxalate kidney stone formation.
His recent publications (2021–2024) emphasize oxalate metabolism, its systemic effects in dialysis patients, and genetic determinants of transporter function. Themes include the link between elevated oxalate and sudden cardiac death, the role of macrophages in oxalate release, and the physiological modeling of intestinal oxalate transport. These studies span molecular physiology, clinical nephrology, and translational research, reflecting a cohesive trajectory in understanding electrolyte and anion handling in health and disease.
Dr. Aronson has received numerous scientific honors, including:
- Homer W. Smith Award, American Society of Nephrology (1994)
- Robert W. Berliner Award, American Physiological Society (2016)
- Walter B. Cannon Award, American Physiological Society (2019)
- Fellow, American Academy of Arts and Sciences (2009)
- Fellow, American Association for the Advancement of Science (1996)
- Young Investigator Award, ASN and AHA (1985)
- Charles W. Bohmfalk Teaching Prize (2005)
- Fund for Physician-Scientist Mentorship Award (2023)
Dr. Aronson is deeply involved in academic leadership and education. He served as President of the American Society of Nephrology in 2008 and is currently an Associate Director of the Yale M.D.-Ph.D. Program. He has been recognized for excellence in teaching and mentorship, advising numerous students and trainees. His research is conducted in collaboration with a strong network of co-investigators, including Felix Knauf, Tong Wang, and Robert Thomson, and is supported by sustained funding in the field of renal physiology.
His laboratory investigates ion transport mechanisms using molecular, cellular, and whole-animal models, with a particular focus on the kidney’s role in systemic electrolyte and acid-base balance. The team combines biochemical, immunological, and genetic techniques to dissect transporter function and regulation.
