جست‌وجوی استاد و پژوهشگر

Annette Byrneمشاهده پروفایل

استاد

• Precision Medicine
• Molecular Imaging
• Angiogenesis
• +۷ مورد دیگر

Professor Annette Byrne is a leading academic at RCSI University of Medicine and Health Sciences , where she serves as Professor of Physiology and Head of the Precision Cancer Medicine (PCM) Group. She has held this position since 2019 after progressing through roles as Lecturer (2008), Senior Lecturer (2013), and Associate Professor (2017). Her research focuses on precision medicine approaches for colorectal and brain cancers , integrating multi-modality molecular imaging , Next Generation Sequencing , and patient-derived xenograft models . PhD in Cell Biology (University of York, 1999) John Kerner Fellowship in Gynaecologic Oncology (UCSF, 1999-2001) Scientist at Pharmacyclics Inc. (2001-2003) Senior Scientist at Angion Biomedica Corp. (2003-2005) Principal Investigator at UCD Conway Institute (2005-2008) Her research interest lies in precision cancer medicine , particularly elucidating predictive biomarkers (genomic, transcriptomic, proteomic) and identifying novel therapeutic targets . Key methodologies include radiomics , fluorescence-guided surgery , and systems modeling of apoptosis pathways. She has pioneered Ireland's first Tumour Xenograft Facility and Translational In Vivo Imaging Centre . Recent publications highlight her work on cross-species radiomics , cell-free DNA analysis , and glioblastoma microenvironment subtyping . Her Marie Curie networks (Gliotrain, Glioresolve) and COLOSSUS project have trained 25+ PhD researchers in brain cancer therapeutics. Over €45M in national/international grants Member of Royal Irish Academy (2025) Highly cited in Cancer Discovery , Annals of Oncology , and Nature journals She supervises multiple PhD candidates and leads the RCSI Precision Cancer Medicine Group , which utilizes computational approaches and molecular imaging to improve cancer treatment outcomes. Her GLIORESOLVE and EDIReX projects focus on tumor microenvironment manipulation and distributed PDX infrastructure.

George Barretoمشاهده پروفایل

دانشیار

• Neuroendocrinology
• Neurobiology
• Neurodegenerative Diseases
• +۷ مورد دیگر

George Barreto is an Associate Professor at the University of Limerick, affiliated with the Department of Biological Sciences, Bernal Institute, Health Research Institute, and Limerick Digital Cancer Research Centre. His research focuses on hormonal regulation of mitochondrial functions in the brain, neurodegenerative diseases, and drug development targeting mitochondria. He holds a PhD in Biological Sciences from Complutense University of Madrid (2009) and completed postdoctoral training at Stanford University (2009–present). His expertise spans neuroendocrinology, neurobiology, and neurodegenerative diseases, with a focus on sex differences in brain function. His research interests include the role of androgens/estrogens in neuroprotection, lipid metabolism in neuroimmune responses, and the therapeutic potential of synthetic hormones like tibolone. He has contributed to over 375 publications and actively reviews grants for national and international funding bodies. Key Research Themes: Mitochondrial dysfunction, neuroinflammation, traumatic brain injury, Alzheimer’s disease, and drug repurposing. Awards: Postdoctoral Fellowship and WERC/FENS PhD Fellowship. Collaborations: Global networks investigating glial cell biology, neuroprotective agents, and nutraceutical interventions.

Gary Brennanمشاهده پروفایل

استادیار

• Epigenetics
• RNA Biology
• Epilepsy
• +۲ مورد دیگر

Dr. Gary Brennan is an Assistant Professor at the School of Biomolecular and Biomedical Science, University College Dublin, and a member of the Conway Institute. He is a Funded Investigator at the FutureNeuro Research Center and has held affiliations with institutions including the Royal College of Surgeons in Ireland (RCSI) and the University of California-Irvine. His research focuses on the molecular mechanisms of epilepsy, particularly epigenetic and epitranscriptomic regulation, RNA modifications, and neuroinflammatory pathways. Education: PhD in Physiology & Medical Physics from RCSI (2015) Postdoctoral Training: University of California-Irvine (2012-2015) under Prof. Tallie Z. Baram; RCSI (2016-2018) under Prof. David Henshall His research program addresses three critical challenges: (1) understanding molecular reprogramming after brain insults, (2) developing RNA-based therapies targeting epigenetic processes, and (3) identifying peripheral biomarkers for epilepsy prediction. Key contributions include studies on microRNA regulation of seizure networks, m6A RNA methylation in temporal lobe epilepsy, and systemic delivery of antagomirs timed with blood-brain barrier disruption. His work has been published in journals like Nature Reviews Neurology , JCI Insight , and Molecular Brain . Recent funding includes grants from Science Foundation Ireland (SFI), Health Research Board (HRB), and the European Union. He has received awards such as the CURE Taking Flight Award and Marie Curie Fellowship. Dr. Brennan also supervises PhD students and coordinates modules on CNS diseases and multicellular systems.

• Non-coding RNAs
• Pulmonary Fibrosis
• Cystic Fibrosis
• +۴ مورد دیگر

Chiara De Santi is a Lecturer in Immunology at the School of Pharmacy and Biomolecular Sciences , Royal College of Surgeons in Ireland (RCSI), Dublin. She holds a PhD from the University of Siena and has held academic roles including Postdoctoral Researcher (2016–2020) and Research Fellow (2021–2022). Her research focuses on non-coding RNAs' therapeutic potential in lung diseases such as cystic fibrosis and pulmonary fibrosis, employing stem cell-derived organoids and ALI cultures for drug discovery. Education: BSc in Biological Sciences, University of Pisa (2007–2010) MSc in Molecular Biology, University of Pisa (2010–2012) PhD in Molecular Medicine, University of Siena (2012–2016) Research Interests: Non-coding RNAs (miRNAs, circRNAs) in lung pathologies Stem cell models for disease modeling Therapeutic modulation of inflammatory responses Cystic fibrosis and pulmonary fibrosis mechanisms Grants & Funding: RCSI Grant: The role of non-coding RNAs in alveolar epithelial damage (2023–2026) Vertex Pharmaceuticals: Target site blockers for CFTR mutation therapy (2024–2027) Irish Research Council: miRNA therapeutics in multiple sclerosis (2018–2020) Professional Activities: Athena Swan Champion for PBS (2023–present) RCSI EDI Committee and PPI in Research Committee member Chair of RCSI Postdoc Society (2021–2022) Teaching: Immunology modules for medical and biomedical science programs Leadership in Year 1 Prize Medal Dissertation Competition (Medicine) Contributions to MSc programs in Precision Medicine

• Cystic Fibrosis
• Lung Cancer
• Cancer Therapeutics
• +۷ مورد دیگر

Judith Coppinger is a Senior Lecturer at RCSI's School of Pharmacy and Biomolecular Sciences, with dual affiliation as Principal Investigator at the National Children’s Research Centre since 2017. Her academic journey includes a PhD in Pharmacology from RCSI (2004), postdoctoral training at the Scripps Research Institute (2005-2011), and faculty roles at UC San Diego (2011-2013) and University College Dublin (2013-2017). Her research focuses on omics-based approaches to uncover dysregulated protein interactions in diseases like cystic fibrosis and cancer, with a particular emphasis on exosome-mediated signaling, kinase inhibitors for CFTR restoration, and BAG3 as a cancer therapeutic target. Key research areas include cystic fibrosis pathophysiology, lung cancer signaling pathways, and translational therapeutics. Her work spans basic science to clinical translation, such as investigating exosomes as biomarkers for disease progression and targeting the PI3K/Akt/mTOR pathway in cystic fibrosis. She has secured major grants including Science Foundation Ireland funding for exosome-based therapies and the Cystic Fibrosis Foundation for EV biomarker studies in CF. Judith has received awards including the Career Development Award (2014), Isenberg Fellowship (2011), and New Investigators Travel Award (2010). Her lab at RCSI collaborates with Trinity College Dublin and the National Children’s Research Centre to advance research in respiratory medicine and cancer biology. Teaching and supervision activities are integral to her role, contributing to training future biomedical researchers.

• Biochemistry
• Molecular Biology
• Cancer Biology
• +۵ مورد دیگر

Kellie Dean is a College Lecturer, Principal Investigator, and Postgraduate Director at the School of Biochemistry & Cell Biology at University College Cork (UCC). A biochemist with expertise in RNA biology and cancer research, she leads a group focused on non-coding RNAs, RNA-binding proteins, and RNA-protein complexes in cancer pathology. Her academic journey includes a PhD from the University of North Carolina at Chapel Hill, postdoctoral work in Germany and the USA, and a transition to full-time academia in Ireland since 2015. Education : BSc in Chemistry (Indiana University of Pennsylvania), PhD in Biochemistry and Biophysics (UNC Chapel Hill) Key Collaborations : Howard Hughes Medical Institute, Science Foundation Ireland (SFI), Irish Research Council, University of California-Davis Her research spans RNA biology , cancer genomics , and bioinformatics , with a focus on long non-coding RNAs (lncRNAs) in ductal carcinoma in situ (DCIS) and ovarian cancer. She investigates their functional roles, diagnostic potential, and the phase separation of RNA-protein assemblies. Her work leverages ribosome profiling data to develop algorithms for micropeptide prediction in cancer immunotherapy vaccines. Her publications highlight trends in cancer RNA biology , including lncRNAs, translational regulation, and computational methods for RNA analysis. Key journals include Cancers , Frontiers in Cell and Developmental Biology , and BMC Cancer . Grants from the Science Foundation Ireland and Irish Research Council support her projects. Professional Affiliations : Member of Irish and European Associations for Cancer Research Member of the RNA Society and Biochemical Society Co-coordinator of UCC Cell EXPLORERS outreach program

• Epigenetics
• Genomics
• Cancer Research
• +۶ مورد دیگر

Dr. Sudipto Das is a Senior Lecturer at the Royal College of Surgeons in Ireland (RCSI), School of Pharmacy and Biomolecular Sciences, within the Department of Molecular and Cellular Therapeutics. He holds a PhD in Cancer Genetics from RCSI (2012) and has held academic positions including Honorary Lecturer (2017-2019) and StAR Research Lecturer (2019). His research focuses on epigenetics, genomics, and their applications in cancer, inflammatory bowel diseases, and heart failure. He leads the Epigenetics in Gastrointestinal Research Group, aiming to identify biomarkers and therapeutic targets. Dr. Das's education includes a B.Tech in Biotechnology (2007) from Yashwantrao Chavan Maharashtra Open University, a M.Res in Biomedical Sciences (2008) from the University of Glasgow, and a PhD in Cancer Genetics (2012) from RCSI. He has held post-doctoral roles as a Senior Post-doctoral Researcher (2015-2019) and Principal Investigator (2018-2023). He has secured funding from organizations like the Irish Cancer Society, British Heart Foundation, and Japan Society for Promotion of Science. His research interests include epigenetic modifications, non-coding RNAs, and multi-omic approaches to disease biomarkers. He teaches Pharmacology, Neuropharmacology, and Molecular Pathology at RCSI, Trinity College Dublin, and University College Cork. He is a member of professional organizations including the European Crohn's and Colitis Organisation and the American Association for Cancer Research. Key achievements include the Irish Cancer Society Fellowship and over 40 peer-reviewed publications in journals like Cancer Research and Nature Communications . His work emphasizes translational research to improve patient care through personalized medicine and precision oncology.

• Autoimmunity
• Immunology
• Ophthalmology
• +۷ مورد دیگر

Dr. Joan Ni Gabhann-Dromgoole is a Senior Lecturer at the Royal College of Surgeons in Ireland (RCSI), within the School of Pharmacy and Biomolecular Sciences and the Department of Molecular & Cellular Therapeutics. She holds academic positions in Ophthalmology and Immunology, with a focus on autoimmunity, particularly Sjögren's Syndrome, graft-versus-host disease (GVHD), and dry eye disease. Her research emphasizes identifying novel regulators of inflammation and developing microRNA-based therapeutics. Education: BSc (Hons) from Dublin Institute of Technology and PhD from University College Dublin. She began her postdoctoral fellowship in Molecular Immunology at RCSI in 2007, advancing to Honorary Lecturer in Biochemistry (2012–2015) before becoming a Lecturer in Ophthalmology and Immunology (2015–present). Research interests include immunology-driven ocular diseases, microRNA regulation of inflammation, and translational therapeutics. She has led multiple grants, including projects investigating ocular GVHD diagnostics and microRNA-based treatments for dry eye disease. Active in medical education, she teaches ophthalmology and immunology to medical students and contributes to programs like the Transition Year Mini Med Programme. Awards: While no specific honors are listed, her extensive publications and funded research reflect significant academic contributions. She collaborates with institutions like the Royal Victoria Eye & Ear Hospital and leads interdisciplinary research on systemic autoimmune complications and patient-centered care.

Cristina Ruedell Reschkeمشاهده پروفایل

مدرس

• Epilepsy Research
• Neuroscience
• Drug Delivery
• +۴ مورد دیگر

Cristina Ruedell Reschke is a Lecturer at RCSI University of Medicine and Health Sciences in the School of Pharmacy and Biomolecular Sciences, and a Funded Investigator at the FutureNeuro SFI Research Centre. She holds a PhD in Pharmacology from the Universidade Federal de Santa Maria (Brazil) and has extensive postdoctoral training at RCSI. Her research focuses on the interplay between circadian rhythms and epilepsy, with emphasis on microRNA-based therapies, drug delivery systems, and neuroinflammation mechanisms. She leads the Chrono-Epilepsy laboratory, established with the CURE Epilepsy Cameron Boyce Foundation award. Education: PhD in Pharmacology, Universidade Federal de Santa Maria (2013) MSc in Pharmacology, Universidade Federal de Santa Maria (2010) BPharm, Universidade Federal de Santa Maria (2006) Postgraduate Diploma in Health Professions Education (RCSI, 2018–2019) Postgraduate Certificate in Leadership (RCSI, 2015–2016) Research Interests: Epilepsy mechanisms and chronobiology MicroRNA-based therapies Targeted drug delivery systems Neuroinflammation and neuroprotection Clinical biomarker identification Grants & Collaborations: Lead investigator on multiple grants including CURE Epilepsy (2020), Enterprise Ireland (2024), and SFI funding Collaborations with UCBerkeley, UCSF, Stanford, and industry partners Member of the Irish Epilepsy League Academic Council Awards: Harinarayan Young Neuroscientist Award (2015) Grass Foundation Young Investigator Award (2017) Trailblazer Award (2019, shared) Teaching & Leadership: Academic Director of RCSI’s International Citizenship Programme Supports Equality, Diversity, and Inclusion (EDI) initiatives Active in public-patient involvement (PPI) with Epilepsy Ireland and Dravet Syndrome Ireland Labs & Teams: Chrono-Epilepsy Lab at RCSI FutureNeuro Research Centre collaborations

• Neurological Diseases
• Purinergic Signaling
• Epilepsy
• +۴ مورد دیگر

Dr. Tobias Engel is a Senior Lecturer in Physiology and Medical Physics at the Royal College of Surgeons in Ireland (RCSI). His research focuses on purinergic signaling pathways, particularly the P2X7 receptor's role in neurological conditions like epilepsy and Alzheimer's disease. He holds a B.Sc. in Biology from the Universidad Autónoma de Madrid and a Ph.D. in Neurobiology from the same institution's Centro de Biología Molecular 'Severo Ochoa.' Engel's work explores pathological changes post-brain injury leading to epileptic seizures, with emphasis on ATP-gated receptors and hyperexcitability mechanisms. He has secured grants from SFI, EU Horizon, and Enterprise Ireland for projects like 'EpiPrevent' and 'BrainPurinesNet,' aiming to develop diagnostics and therapies for brain disorders. His research clusters include Neurological and Psychiatric Disorders aligned with UN SDG 3 (Good Health). Prominent publications highlight P2X7 receptor modulation in epilepsy treatment, miRNA roles in neurodegeneration, and wearable biosensors for neurological monitoring. He has supervised two major theses on microRNA and P2X7-based therapies. Awards include the 2012 New Investigator Award. Engel collaborates internationally through initiatives like FutureNeuro and NeuroAdapt, fostering next-gen brain research leaders.

David Henshallمشاهده پروفایل

استاد

• Epilepsy
• Neuropharmacology
• MicroRNA research
• +۳ مورد دیگر

Professor David Henshall is a leading academic in neurology and molecular physiology at the Royal College of Surgeons in Ireland (RCSI). He holds the position of Professor of Molecular Physiology & Neuroscience and serves as Director of FutureNeuro, a Science Foundation Ireland Research Centre focused on neurological diseases. His research focuses on epilepsy mechanisms, neuroprotection pathways, and microRNA therapeutics. Henshall earned a BSc (First Class Honours in Pharmacology) from the University of Bristol and a PhD in Neuropharmacology from the University of Edinburgh. He has authored over 250 publications and co-authored Fine-Tuning Life: A guide to microRNAs (Cambridge University Press, 2024). Research Interests : - Epilepsy mechanisms and treatment development - Role of non-coding RNAs (microRNAs) in neurological disorders - ATP-gated ion channels as therapeutic targets - Circulating biomarkers of seizures and epilepsy progression Awards & Recognition : - Member of the Royal Irish Academy (2024) - Robert Bentley Todd Medal for Teaching and Research in Neuroscience (2014) - Principal Investigator Award (2008, 2004) Grants & Leadership : - Director, FutureNeuro SFI Research Centre (2017–present) - Coordinator, European FP7 project EpimiRNA (2013–2018) - Chair, International League Against Epilepsy’s Neurobiology Commission Lab & Collaborations : - FutureNeuro integrates multidisciplinary teams across RCSI, Trinity College Dublin, and other institutions to advance translational neuroscience. - Active collaborations in drug development, biomarker discovery, and AI-driven e-textile technologies for neurological monitoring.

• Cystic Fibrosis
• Alpha-1 Antitrypsin Deficiency
• Non-Coding RNA Biology
• +۵ مورد دیگر

Catherine Greene is an Associate Professor in the Department of Clinical Microbiology at the Royal College of Surgeons in Ireland (RCSI) and Deputy Head of the School of Postgraduate Studies overseeing PhD programs. She holds editorial roles including Editor-in-Chief of the Journal of Innate Immunity and Associate Editor of the European Respiratory Review . Her research focuses on innate immunity in cystic fibrosis (CF) and α-1 antitrypsin deficiency, with emphasis on non-coding RNA mechanisms and translational therapies. She has supervised 23 doctoral students and examined 25 PhD theses. Education: PhD and BA(Hons) in Microbiology from Trinity College Dublin (1995 and 1991), and a Postgraduate Diploma in Medical Education from RCSI (2018). Professional roles include serving on scientific review boards for the European Commission, US Alpha-1 Foundation, and Irish funding bodies. Recognitions include Fellowship of the European Respiratory Society and leadership in ERS Assembly 3 (2019–2022). Research interests span CF pathogenesis, sex dimorphism in lung disease, and nanomedicine applications. Her work addresses microRNA regulation, gene delivery systems, and precision medicine strategies for genetic respiratory disorders. Grants funded by Cystic Fibrosis Foundation, Horizon2020, and NIH support projects on lung disease mechanisms and therapeutic development.

Sinead Migginمشاهده پروفایل

استادیار

• Immunology
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Dr. Sinead Miggin is an Assistant Professor in the Department of Biology at Maynooth University, affiliated with the Human Health Institute and the Immune Signalling Lab. She holds a PhD in Biochemistry from University College Dublin (2000) and a Postgraduate Diploma in Higher Education (2015). Her research focuses on molecular mechanisms of innate immune responses via Toll-like receptors (TLRs), particularly their role in chronic inflammatory diseases like Rheumatoid Arthritis, Osteoarthritis, and Type 2 Diabetes. Her work employs proteomics and molecular immunology to identify novel TLR modulators. Key affiliations include Maynooth University’s Faculty of Science & Engineering and the Kathleen Lonsdale Institute for Human Health Research. Her publications span over two decades, with recent emphasis on cytokine profiling in pre-diabetic states, TLR-mediated inflammation, and non-coding RNA roles in cancer. She has contributed to conferences on TLR signaling and inflammation mechanisms. Advising and grants: No specific grants or student advisees listed, though her role as Principal Investigator suggests leadership in collaborative research projects. Her lab focuses on immune signaling pathways with implications for both inflammatory diseases and antiviral immunity.

Niall Barronمشاهده پروفایل

استاد

• Biomedical Engineering
• Biochemical Engineering
• Cellular and Molecular Biology
• +۵ مورد دیگر

Professor Niall Barron is a Professor of Biochemical Engineering at the School of Chemical and Bioprocess Engineering, University College Dublin (UCD), and a Principal Investigator at the National Institute for Bioprocessing Research and Training (NIBRT). He holds a BA (Mod) in Microbiology from Trinity College Dublin and a PhD in Applied Microbiology/Biochemistry from the University of Ulster (1997). His postdoctoral research at Baylor College of Medicine focused on nuclear steroid receptor function via genome engineering. He has held academic and research roles at Dublin City University (DCU), including Director of the National Institute for Cellular Biotechnology (NICB) from 2015–2017. His research focuses on genetic engineering strategies to improve recombinant protein production in CHO cells, AAV/LV vector manufacturing, and epigenetic regulation of bioprocess performance. He leads projects funded by industry and EU grants, including initiatives to enhance gene therapy vector production and mRNA methylation control. Education: BA (Mod) in Microbiology, Trinity College Dublin PhD in Applied Microbiology/Biochemistry, University of Ulster (1997) Research Interests: Targeted genome editing in CHO cells for improved biopharmaceutical production Optimization of AAV and LV vector systems for gene therapy miRNA and epitranscriptomic regulation of cellular processes Single-cell analysis to understand clonal variability and production instability Grants & Collaborations: Lead on grants from GSK, Enterprise Ireland, and Horizon 2020 (e.g., STACCATO, GeneClick) Focus on advancing bioprocess technologies and cell line engineering Teaching: Coordinates modules in biopharmaceutical manufacturing, biotechnology principles, and gene therapy processes Program Director for the MEngSc in Biopharmaceutical Manufacturing (Part-Time) Labs & Teams: Leads a multidisciplinary team at UCD and NIBRT focusing on biopharmaceutical engineering and cell line optimization

• Neuroscience
• Epilepsy
• Neuropharmacology
• +۵ مورد دیگر

Sean Quinlan is a Lecturer in Neuroscience at the School of Biomolecular and Biomedical Science, University College Dublin. His research focuses on the pathophysiology of early-life seizures and their role in epilepsy etiology, particularly examining calcium-activated potassium channels, intracellular calcium receptors, and hippocampal cellular dynamics. His work emphasizes neurotoxicity profiles of anti-seizure medications, transcriptomic alterations in the hippocampus, and the intersection of neuroinflammation with seizure pathology. Recent studies explore purinergic signaling, microRNA detection methods, and neurodevelopmental outcomes of drug interventions. Quinlan's publications span seizure suppression mechanisms (Padsevonil), comparative neurotoxicity analysis (phenobarbital vs. levetiracetam), and advanced diagnostic approaches for neonatal encephalopathy using purine nucleosides. His research integrates molecular neuroscience, pharmacology, and clinical translational models. Scientific awards include the Conway Fellow (University College Dublin, 2024) MSCA Research Fellow (2022-2024) Quinlan teaches Membrane Biology (Neur30080, 2024) and holds certifications in Bioinformatics and Data Analytics from University College Dublin.