جست‌وجوی استاد و پژوهشگر

Fenghua Huمشاهده پروفایل

دانشیار

• Neurodegeneration
• Amyotrophic Lateral Sclerosis (ALS)
• Frontotemporal Lobar Degeneration (FTLD)
• +۴ مورد دیگر

Fenghua Hu is an Associate Professor in the Department of Molecular Biology and Genetics at Cornell University, and a member of the Weill Institute for Cell and Molecular Biology. She holds affiliations with the Biochemistry, Molecular, and Cell Biology (BMCB), Genetics, Genomics and Development (GGD), and Biological and Biomedical Sciences (BBS) graduate programs. Dr. Hu earned her B.S. in Biochemistry from Peking University (1997) and her Ph.D. from Baylor College of Medicine (2002), followed by postdoctoral training at Yale University. Her research focuses on molecular mechanisms of neurodegenerative diseases, particularly ALS and FTLD, with emphasis on progranulin, TMEM106B, C9orf72, and TDP-43. Her lab investigates lysosomal dysfunction links to neurodegeneration, exploring therapeutic avenues for these diseases. Key findings include the role of progranulin in lysosomal pathways and TMEM106B in myelination and inflammation. Dr. Hu has been recognized with awards such as the Rosalinde and Arthur Gilbert Foundation/AFAR New Investigator Award (2010), Platform Speaker Award (2001), and the Trentin Award for Scholastic Excellence (1998). She teaches BIOMG 6360: Functional Organization of Eukaryotic Cells and actively collaborates with interdisciplinary teams in neuroscience and cell biology. Her lab’s work spans from basic molecular mechanisms to translational research, with recent studies highlighting TMEM106B’s role in SARS-CoV-2 cell entry and C9ORF72’s regulation of inflammation. Ongoing projects address lysosomal dysfunction in aging and neurodegeneration, leveraging mouse models and biochemical approaches.

Xin Guمشاهده پروفایل

استادیار

• Cell Biology
• Molecular Biology
• Cancer Biology
• +۳ مورد دیگر

Xin Gu, Ph.D., is an Assistant Professor of Cancer Biology at Dana-Farber Cancer Institute and Assistant Professor of Cell Biology at Harvard Medical School (HMS). Her research focuses on elucidating ubiquitin-independent protein degradation mechanisms, particularly the midnolin-proteasome pathway, which selectively degrades transcription factors critical for cellular responses. The Gu Lab employs biochemical, structural, and genetic approaches to study these pathways' roles in physiology and disease, with long-term goals of developing therapeutic strategies for cancer, immune disorders, and neurological conditions. Education: Bachelor of Science in Biology, Peking University Ph.D. in Biology, Massachusetts Institute of Technology (MIT) Postdoctoral Research, Department of Neurobiology, HMS Research Interests: The lab investigates mechanisms of protein homeostasis, focusing on midnolin-mediated proteasomal degradation. Key areas include understanding how this pathway regulates stimulus-responsive transcription factors, its crosstalk with chromatin biology and metabolism, and its role in organismal health. The lab also seeks to identify novel ubiquitin-independent degradation pathways. Publications: Recent work highlights structural insights into midnolin-proteasome interactions, nutrient-sensing pathways (e.g., mTORC1), and the role of Sestrin in dietary adaptation. These studies underscore the lab’s interdisciplinary approach to cellular mechanisms. Lab & Collaborations: The Gu Lab is recruiting postdocs, graduate students, and research assistants with expertise in biochemistry, structural biology, and mouse models. The team emphasizes inclusivity and collaboration, fostering an environment for innovative research. The lab’s future directions include developing pharmacological tools to target midnolin pathways and exploring their therapeutic potential.

Steven Gygiمشاهده پروفایل

استاد

• Proteomics
• Mass Spectrometry
• Cell Biology
• +۳ مورد دیگر

Steven Gygi, Ph.D., is a Professor of Cell Biology at Harvard Medical School (HMS) and the faculty director of two mass spectrometry (MS) core facilities: the Taplin Biological MS Facility and the Thermo Fisher Center for Multiplexed Proteomics (TCMP@HMS). His research focuses on developing and applying mass spectrometry-based proteomics technologies to study protein expression, modifications, interactions, and functional dynamics. Key initiatives include the BioPlex project, mapping the human protein-protein interactome, and advancing sample multiplexing techniques like Tandem Mass Tags (TMT) for high-throughput proteomics analysis. Dr. Gygi received his Ph.D. in Pharmacology and Toxicology from the University of Utah and completed postdoctoral work with Ruedi Aebersold at the University of Washington. His work has been supported by NIH grants, including roles as Principal Investigator (PI) on projects like 'Systematic Exploration of the Human Interactome IV' and co-PI on cancer signaling studies. Research interests span proteomic profiling of cellular processes, disease mechanisms, and drug discovery. Recent work includes studies on mitochondrial function, lysosomal storage diseases, and Alzheimer’s disease proteostasis deficits. The Gygi Lab collaborates extensively, publishing in top journals like Nature , Cell , and Nature Biotechnology . Grants and Funding: Gygi leads NIH-funded projects exploring interactome mapping, proteomic profiling, and signaling pathways. His lab also develops cutting-edge mass spectrometry tools for multiplexed analysis, enabling high-resolution biological insights. Labs/Teams: Directs the TCMP@HMS and Taplin Facility, providing proteomics resources to the scientific community. Active in training students and postdocs in proteomics technology and application.

Chun Guoمشاهده پروفایل

مدرس

• Protein SUMOylation
• Cell Biology
• Neurodegenerative Diseases
• +۳ مورد دیگر

Dr. Chun Guo is a Lecturer in the School of Biosciences at the University of Sheffield, with a career spanning over two decades in academia and research. He holds a PhD from De Montfort University (2002) and an MBBS from Soochow University (1991). His research focuses on protein SUMOylation and deSUMOylation in health and disease, particularly in ischemia and age-related conditions like neurodegeneration and cancer. He employs molecular biology, biochemistry, and pharmacology to study mitochondrial dynamics and stress responses. Education History: MBBS, Medical College of Soochow University (1986–1991) PhD in Leicester School of Pharmacy, De Montfort University (1999–2002) Research Interests: His work examines SUMOylation's role in mitochondrial fission/fusion, autophagy, and cellular survival under stress. Key topics include SENP3-mediated deSUMOylation pathways and their implications for ischemic injury and neurodegenerative diseases. Publications Trends: Over 30 peer-reviewed articles since 2001, with recent focus on mitochondrial dynamics, SUMOylation in stress responses, and neuroprotective mechanisms. Collaborations span institutions globally, addressing translational applications in disease treatment. Scientific Awards: Fellow of the Higher Education Academy (2018). Teaching & Advising: Supervises undergraduate and postgraduate students in Molecular Biology, Neuroanatomy, and Cell Biology. Oversees PhD projects on autophagy regulation and cancer chemoprevention. Active in grant reviews for BBSRC, British Heart Foundation, and others. Research Group: Leads projects on SUMOylation pathways, mitochondrial biology, and translational medicine within Sheffield's Biosciences School. Collaborates with the University of Bristol, Manchester, and international partners.

Andrew Pedenمشاهده پروفایل

استاد

• Cell Biology
• Molecular Biology
• Membrane Trafficking
• +۷ مورد دیگر

Professor Andrew Peden is a faculty member in the School of Biosciences at the University of Sheffield, specializing in cell biology and molecular mechanisms of protein secretion. He holds a PhD in Molecular Biology from the University of Cambridge (1995–1999) and a BSc from the University of Edinburgh (1991–1995). His academic career includes roles as Lecturer (2012–2018), Senior Lecturer (2019–2023), and currently Professor (2023–present). Research: Peden's lab focuses on constitutive secretion pathways, post-Golgi trafficking, and SNARE protein functions. Key interests include antibody secretion in plasma cells, cytokine release in inflammation, and diseases linked to secretion defects (e.g., amyloidosis, monoclonal gammopathies). Recent work explores SARS-CoV-2 pathogenesis and antiviral mechanisms, including viral evasion of tetherin restriction. Awards & Grants: Funded by BBSRC, MRC, Medimmune, and UCB. Recognized by the NC3Rs (2024) for ethical research practices. Professional roles include BBSRC Committee D member (2023–present) and WHO COVID-19 assays group member (2021–present). Teaching & Mentorship: Leads courses on membrane dynamics (BMS376), molecular cell biology (BIS225), and supervises undergraduate, Masters, and PhD students. Recent advisees include Sam, Ola, and Dan. Active in lab collaborations with groups at UCL, Strathclyde, and Stanford. Labs & Facilities: Based in the Florey Building, his lab uses advanced imaging, proteomics, and functional genomics. Collaborates with the Luzio and Faundez labs on SNARE interactions and secretion assays.

Lisiane Meiraمشاهده پروفایل

مدرس

• Cellular Stress Responses
• Cancer Therapeutics
• DNA Damage and Repair
• +۳ مورد دیگر

Dr. Lisiane Meira is a Lecturer in DNA Damage and Ageing at the University of Surrey's School of Biosciences. Her research focuses on cellular responses to stress, particularly in cancer and chronic disease contexts, with emphasis on alkylating agents and their clinical applications. She holds a Postgraduate Certificate in Academic Practice from the University of Surrey. Her research investigates mechanisms linking DNA repair pathways to disease progression, including studies on glioblastoma, endometrial cancer, and cardiovascular conditions. She has supervised three postgraduate students: Dr. Eirini Martinou (PhD), Thomas Cox (PhD), and Abbey Pearson (MSci in Biochemistry). Her teaching portfolio includes modules on Cell Biology, Cancer Therapeutics, and Mechanistic Toxicology. Key publications highlight her work on unfolded protein response in glioblastoma, adipocytokines in endometrial cancer, and NUDT5 inhibition in glioma. She has contributed to understanding DNA repair's role in atherosclerosis and coronary artery disease through collaborations with cardiology research groups. Dr. Meira's research integrates molecular biology, genetics, and clinical data to advance therapeutic strategies for cancer and cardiovascular diseases. Her interdisciplinary approach spans from basic science to translational medicine, addressing unmet needs in precision oncology and personalized treatment regimens.

Lianne Willemsمشاهده پروفایل

مدرس ارشد

• Chemical Biology
• Glycobiology
• Enzymology
• +۳ مورد دیگر

Dr. Lianne Willems is a Senior Lecturer in the Department of Chemistry at the University of York. Her research focuses on the chemical biology of carbohydrates and carbohydrate-processing enzymes, with a particular interest in developing tools to study O-glycosylation and its role in diseases like muscular dystrophies. She holds an ERC Starting Grant for her work on ribitol-phosphate-based chemical tools. Education: PhD (2014) from Leiden University, followed by postdoctoral research at Simon Fraser University (Canada), where she received a Banting Postdoctoral Fellowship and a Rubicon Fellowship. Her research spans organic chemistry, biochemistry, and cell biology to understand glycobiological processes. Research Interests: Development of chemical probes for enzyme activity, synthesis of glycoconjugates, O-glycosylated proteome characterization, and mechanistic studies of glycosyltransferases. Her work integrates bioorthogonal chemistry and activity-based protein profiling to uncover cellular mechanisms. Key Awards: ERC Starting Grant (2020–2025), Banting Fellowship (Canada), Rubicon Fellowship (NWO). Current projects include the RibiTool initiative exploring ribitol-phosphate biology. Grants and Collaborations: Leads the ERC-funded RibiTool project and collaborates internationally on glycobiology and enzymology. Engages in educational innovation, including flipped classroom approaches in chemistry teaching. Labs/Teams: Heads a research group focused on chemical biology and glycobiology within the Department of Chemistry at York.

• Biochemistry
• Genetics and Molecular Biology
• Cancer Research
• +۶ مورد دیگر

Asst Prof Alexander Ludwig is an Assistant Professor at the School of Biological Sciences, Nanyang Technological University (NTU), Singapore. His research focuses on epithelial cell biology, cell polarity, and membrane organization, with a particular interest in understanding the molecular mechanisms underlying tight junction regulation and cellular polarity establishment. He employs advanced techniques such as proximity proteomics, correlative light-electron microscopy, and live-cell imaging to investigate these processes. Ludwig holds a PhD in Biochemistry from the University of Zurich (2003–2008) and has held significant research positions, including Senior Research Fellow at NTU (2013–2018) and Career Development Fellow at the MRC Laboratory of Molecular Biology, Cambridge, UK (2008–2013). His work integrates biochemistry, cell biology, and structural biology to explore topics such as chromatin mechanics, caveolar membrane environments, and bacterial pathogenesis within host cells. Key research themes include the role of protein phase separation in sealing tight junctions, the mechanobiology of epithelial barriers, and the regulation of primary cilia signaling via PALS1 and KIF13B interactions. His lab (ALab) investigates mechanisms of epithelial cell polarization and cell-cell junction dynamics, with recent advancements in proteomic approaches to map interactomes under membrane tension. Ludwig’s publications highlight contributions to understanding nuclear architecture, bacterial endo-lysosomal trafficking, and the biophysical properties of chromatin in epithelial contexts. His research has been featured in high-impact journals such as Advanced Science , Frontiers in Cell and Developmental Biology , and Journal of Cell Biology . The lab actively explores translational applications of their findings in fields like nanomedicine and infectious disease pathogenesis.

Eric Hastieمشاهده پروفایل

استادیار

• Cell Biology
• Cancer Biology
• Molecular Biology
• +۳ مورد دیگر

Eric Hastie is a Teaching Assistant Professor in the Department of Biology at the University of North Carolina at Chapel Hill. He co-advises oSTEM (Out in Science, Technology, Engineering, and Mathematics) and co-directs the Carolina Biology Education Research Lab (CBER Lab). His teaching portfolio includes foundational biology courses (BIOL 101), research skills development (BIOL 105), and advanced physiology (BIOL 253). He also mentors undergraduate research through BIOL 395 and explores pedagogical strategies in courses like BIOL 295. His research focuses on both cell biology—particularly basement membrane dynamics, invadopodia function, and cancer invasion mechanisms—and innovative educational practices, including team-based learning and scalable undergraduate research experiences. Hastie collaborates with medical students to integrate clinical vignettes into physiology education and advocates for accessible, inclusive science education through initiatives like CURE programs. His publications span molecular biology, cancer therapy (e.g., oncolytic virotherapy), and educational interventions for pre-health students. The CBER Lab emphasizes improving biology education through evidence-based strategies. No specific scientific awards are listed, though his contributions to teaching and research are evident through his active course development and mentorship roles.

• Developmental Neurobiology
• Synaptic Development
• Cannabinoid Neurobiology
• +۴ مورد دیگر

Declan Ali serves as Dean of the Faculty of Science and Professor in the Department of Biological Sciences at the University of Alberta. His dual role combines administrative leadership with active research in developmental neurobiology. Contact details include two email addresses and phone numbers associated with his administrative and academic positions. Research focuses on synaptic development mechanisms, particularly presynaptic and postsynaptic receptor modulation during synapse formation. Key models include zebrafish embryology to study cannabinoid impacts on neurodevelopment and cancer signaling pathways like Wnt/β-catenin. Recent work examines cannabinoid teratogenicity, TRP channel roles in carcinogenesis, and autophagy regulatory networks. Publications (2023-2025) highlight intergenerational THC effects, miRNA regulation in lung cancer, and autophagy-lysosomal pathway modulation. No scientific awards explicitly mentioned, though research contributions are substantial. Advising details and grants remain unspecified. Laboratory work emphasizes in vivo zebrafish models and molecular oncology approaches.

• Autophagy
• Cell Biology
• Molecular Biology
• +۳ مورد دیگر

Prof. Dr. Tassula Proikas-Cezanne is an Adjunct Professor for Molecular Biology and Cell Biology at the University of Tuebingen, Germany. She leads the independent research group 'Autophagy' within the Department of Molecular Biology and the Interfaculty Institute for Cell Biology. Her work focuses on autophagy mechanisms, cellular biology, and their implications in neurodegeneration and liver disease. She is affiliated with the Proikas-Cezanne laboratory and collaborates with institutions like the Nordheim laboratory. Her research emphasizes the role of autophagy in health and disease, particularly exploring pathways involving WIPI proteins and lifespan regulation. She has contributed to major reviews on autophagy guidelines and co-authored studies on lipid droplet interactions and liver disease. Her work bridges basic molecular mechanisms with translational applications in medicine. Prof. Proikas-Cezanne actively promotes academic initiatives such as 'Women in Autophagy' to enhance gender equity in science. Her laboratory is a hub for advanced research in cellular and molecular biology, attracting international collaborations.

Kyle Cunninghamمشاهده پروفایل

استاد

• Drug Resistance Mechanisms
• Pathogenic Yeasts
• Calcium Signaling
• +۳ مورد دیگر

Kyle Cunningham is a Professor in the Department of Biology at Johns Hopkins University's Krieger School of Arts & Sciences. He specializes in drug resistance mechanisms and virulence pathways in pathogenic yeasts. Previously, he earned his PhD from UCLA and conducted postdoctoral research at the University of Basel and MIT's Whitehead Institute. His research integrates molecular biology, cell biology, and genetics to elucidate fungal pathogenesis and cellular stress responses. Education: PhD in Membrane Biochemistry, UCLA (1994); Postdoctoral training at University of Basel (mitochondrial biogenesis) and MIT Whitehead Institute (yeast genetics). Research Focus: Investigates calcium signaling pathways, fungal programmed cell death, and mechanisms of antifungal resistance in Candida species. Recent work emphasizes transposon sequencing (Tn-seq) to map genetic determinants of drug resistance and virulence. His lab also explores host-parasite interactions and immune modulation by helminth-derived proteins. Awards/Grants: While specific awards aren't listed, his extensive publication record indicates sustained NIH/NSF grant support for studies on fungal pathogenesis and traumatic injury biomarkers. Labs/Teams: Leads a research group in the Department of Biology's Molecular Microbiology division, collaborating with clinical teams on translational projects linking fungal genetics to human health.

• Partial Differential Equations
• Geometric Analysis
• Mathematical Analysis
• +۳ مورد دیگر

Yang Yang is currently a J.J. Sylvester Assistant Professor in the Department of Mathematics at Johns Hopkins University, mentored by Jacob Bernstein. Previously, they completed their PhD at UC Irvine under the supervision of Connor Mooney. Their research focuses on Partial Differential Equations and Geometric Analysis, particularly exploring regularity and classification of solutions to geometric variational problems. Education: PhD in Mathematics from UC Irvine (advisor: Connor Mooney). Research Interests Yang Yang investigates advanced mathematical frameworks addressing geometric variational problems. Their work emphasizes understanding solution regularity and structural properties within PDEs and geometric analysis. Recent studies bridge mathematical models with applications in neuroscience, including neuroimaging biomarkers for psychosis, olfactory system dysfunction, and tumor microenvironment dynamics in gliomas. Key Contributions Developed novel methods for analyzing white matter connectivity in psychiatric disorders Explored autophagy pathways in neuronal cells of psychosis patients Pioneered metabolomic studies of cerebrospinal fluid in schizophrenia Notable Awards No specific awards mentioned in the provided text. Grants & Advising No grant information or student advising records explicitly listed. Research activities focus on collaborative projects in mathematical neuroscience. Labs & Teams Active participation in neuroimaging and psychiatric research initiatives at JHU, though specific lab affiliations not detailed in text.

Konrad Zinsmaierمشاهده پروفایل

استاد

• Neuroscience
• Neurodegenerative Diseases
• Molecular Biology
• +۳ مورد دیگر

Konrad Zinsmaier is a Professor and Department Head at the University of Arizona, where he leads research on synaptic function and neurodegenerative mechanisms. His work combines molecular biology and genetics in Drosophila models to study synaptic plasticity, mitochondrial dynamics, and neuroprotective pathways. His research focuses on mechanisms maintaining synaptic integrity, including roles of cysteine-string protein (CSP) in preventing neurodegeneration and DCAF12’s involvement in ubiquitination pathways. Key projects include modeling neuronal ceroid lipofuscinosis (CLN4) and investigating mitochondrial transport via Miro GTPases. Publications highlight contributions to understanding ALS, Parkinson’s disease mechanisms, and synaptic vesicle recycling. His studies bridge basic neuroscience with disease modeling, emphasizing translational potential for neuroprotective therapies. Teaching responsibilities include courses on neurogenetics, cellular neurobiology, and neuroscience methodology. Research also extends to cryopreservation techniques for primary neurons and olfactory receptor function in Drosophila . Labs: Automated Analysis of Mitochondrial x-y-t Tracks focuses on real-time mitochondrial dynamics and signaling.

Roger Geigerمشاهده پروفایل

دانشیار

• Adaptive Immunity
• Immune Oncology
• Systems Immunology
• +۳ مورد دیگر

Roger Geiger is an Associate Professor at the Università della Svizzera italiana (USI) and Group Leader at the Institute for Research in Biomedicine (IRB) in Bellinzona, Switzerland. His research focuses on T cell responses to tumors using systems biology approaches, with emphasis on metabolic regulation and proteomics. He holds an ERC Starting grant and an ERC Consolidator grant, and is an EMBO Young Investigator. Education: Master’s and PhD in Biochemistry from ETH Zürich (2007, 2011). Postdoctoral training at IRB (2011–2016) and the Max Planck Institute of Biochemistry (2016). His work integrates immunology, oncology, and systems biology to identify therapeutic targets in cancer immunotherapy. Key research areas include immune oncology, metabolic reprogramming of T cells, and engineered bacteria for tumor modulation. His lab employs advanced proteomics and metabolic profiling techniques to dissect tumor immune interactions. Scientific awards: EMBO Young Investigator (2018), ERC Starting Grant (2017), ERC Consolidator Grant (2021). Grants and collaborations: Focus on translational research bridging basic immunology and clinical oncology. Active in mentoring early-career researchers through training programs at USI and IRB.