معرفی
Asst Prof Alexander Ludwig is an Assistant Professor at the School of Biological Sciences, Nanyang Technological University (NTU), Singapore. His research focuses on epithelial cell biology, cell polarity, and membrane organization, with a particular interest in understanding the molecular mechanisms underlying tight junction regulation and cellular polarity establishment. He employs advanced techniques such as proximity proteomics, correlative light-electron microscopy, and live-cell imaging to investigate these processes.
Ludwig holds a PhD in Biochemistry from the University of Zurich (2003–2008) and has held significant research positions, including Senior Research Fellow at NTU (2013–2018) and Career Development Fellow at the MRC Laboratory of Molecular Biology, Cambridge, UK (2008–2013). His work integrates biochemistry, cell biology, and structural biology to explore topics such as chromatin mechanics, caveolar membrane environments, and bacterial pathogenesis within host cells.
Key research themes include the role of protein phase separation in sealing tight junctions, the mechanobiology of epithelial barriers, and the regulation of primary cilia signaling via PALS1 and KIF13B interactions. His lab (ALab) investigates mechanisms of epithelial cell polarization and cell-cell junction dynamics, with recent advancements in proteomic approaches to map interactomes under membrane tension. Ludwig’s publications highlight contributions to understanding nuclear architecture, bacterial endo-lysosomal trafficking, and the biophysical properties of chromatin in epithelial contexts.
His research has been featured in high-impact journals such as Advanced Science, Frontiers in Cell and Developmental Biology, and Journal of Cell Biology. The lab actively explores translational applications of their findings in fields like nanomedicine and infectious disease pathogenesis.
