جست‌وجوی استاد و پژوهشگر

Simon Halegouaمشاهده پروفایل

استاد

• Neuronal Growth Factors
• Signal Transduction
• Endosomal Signaling
• +۴ مورد دیگر

Simon Halegoua is a Professor at Stony Brook University's Renaissance School of Medicine , Department of Neurobiology & Behavior. He earned his PhD in Molecular Biology from SUNY Stony Brook in 1978 and has held academic positions there since 1982, including Interim Chair (2006-2008) and Director of the Center for Nervous System Disorders since 2002. Education: B.S. in Biochemistry, Stony Brook University (1974) Ph.D. in Molecular Biology, Stony Brook University (1978) Postdoctoral Fellow, Salk Institute (1978-1982) His research focuses on neurotrophin signaling , particularly how Nerve Growth Factor (NGF) and Trk receptors regulate neuronal survival, axon growth, and synaptic strength through retrograde signaling endosomes . He pioneered the model of endosomal signaling and discovered the Pincher protein, critical for endosome formation and long-distance axonal transport. The 15 most recent publications highlight his work on retrograde signaling (via endosomes and Pincher), sodium channel regulation in peripheral neurons, and signal transduction dynamics involving Ras, Raf, and Trk receptors. Key subfields include endocytosis , neuronal growth cones , and phospholipid metabolism in signaling compartments. Professor Halegoua has served on editorial boards for Journal of Neuroscience and Journal of Biological Chemistry . His lab personnel include research technicians like Wendy Akmentin , though no formal advisees are listed in the provided texts.

Markus Sperandioمشاهده پروفایل

استاد

• Inflammation
• Neutrophil Recruitment
• Glycobiology
• +۳ مورد دیگر

Markus Sperandio is a Professor at the Biomedical Center Munich , Ludwig-Maximilians-Universität München (LMU Munich). His research focuses on neutrophil recruitment during inflammation and its molecular regulation, with a particular interest in fetal immune ontogeny , glyco-structures , and circadian rhythms in immunity . Email: markus.sperandio@med.uni-muenchen.de Research Interests : His work explores how sialylation, alarmins (e.g., S100A8/A9), and ion channels (e.g., KV1.3, TRPM7) modulate leukocyte trafficking. Recent projects investigate the interplay between circadian clocks and inflammatory responses, as well as pathways like the non-canonical NF-κB pathway in fetal development. Article Trends : His publications emphasize neutrophil adhesion , selectin ligands , and magnesium-dependent signaling in inflammation. Contributions span in vivo models of sepsis, murine fetal immunity, and nanoparticle-induced pulmonary inflammation. Grants & Collaborations : Dr. Sperandio leads projects within collaborative networks like TRR 359 PILOT and TRR 332 - Neutrophils , funded by institutions such as the German Research Foundation (DFG) .

Nghia Duongمشاهده پروفایل

پژوهشگر ارشد

• Solid-State NMR
• Structural Characterization
• Methodological Development
• +۳ مورد دیگر

Dr. Nghia Duong is a Research Fellow at the Université d'Aix-Marseille (UNIV-AMU) within the Applied Spectrometry for Structural Characterization (SACS) team. His work focuses on methodological developments in solid-state NMR experiments for structural determination of biological and chemical solids, emphasizing efficiency, robustness, and faster acquisition techniques. Email: tuan-nghia.DUONG@univ-amu.fr Phone: 04 13 94 58 01 Research interests include: Advanced solid-state NMR methodologies Structural characterization of crystalline and amorphous solids Dynamic nuclear polarization (DNP) applications Design of covalent organic frameworks and coordination polymers Electrocatalytic water splitting materials Development of high-resolution micro-MAS probes for metabolomics His publications highlight trends in structural NMR spectroscopy , materials science , and methodological innovation for fast MAS applications. Collaborative projects span pharmaceutical solid characterization , hydrogen storage systems , and supramolecular chemistry . Duong actively contributes to micro-MAS NMR developments for mass-limited samples. The Applied Spectrometry for Structural Characterization (SACS) team provides a multidisciplinary platform for his research, integrating NMR with electron diffraction and materials synthesis approaches.

Isabella Marinelliمشاهده پروفایل

پژوهشگر ارشد

• Mathematical Modeling
• Biomedical Sciences
• Physiology
• +۳ مورد دیگر

Dr Isabella Marinelli is a Research Fellow at the Centre for Systems Modelling and Quantitative Biomedicine (University of Birmingham), specializing in mathematical biomedicine. Her work bridges Mathematics, Biology, and Medicine through computational modeling of biological systems. Education: PhD (cum laude) in Mathematics and Statistics (University of the Basque Country, 2019) MSc in Mathematics (University of Trento, 2015) BSc in Mathematics (University of Pisa, 2012) Research focuses on hormone dynamics in physiological and pathological contexts, particularly exploring: Stress hormone cortisol's impact on epileptiform activity rhythms Hypothalamic corticotrope responses to CRH and AVP Biomarker identification for endocrine disorders Pancreatic β-cell oscillatory insulin secretion mechanisms Her recent publications analyze β-cell networks, circadian epilepsy patterns, and glycolytic oscillations. Scientific Achievements: Developed age-structured epidemiological models for hepatitis C Created computational frameworks for Varicella-Zoster Virus transmission Recipient of PhD (cum laude) award Actively supervises MSc projects in Applied Mathematics and contributes to patient/public engagement through the Community Action Team (CAT). She also serves as a STEM ambassador since 2022.

Ben Engelمشاهده پروفایل

استادیار

• Structural Biology
• Cell Biology
• Photosynthesis
• +۷ مورد دیگر

Dr. Ben Engel is an Assistant Professor at the Biozentrum, University of Basel, Switzerland, since 2022. His research focuses on structural cell biology using cryo-electron tomography (cryo-ET) to study organelle architecture and function. Investigates correlations between organelle morphology and function Researches photosynthesis in marine algae and its response to climate change Studies cilia structure and disease implications His laboratory has made significant discoveries in mitochondrial and chloroplast architecture, particularly in carbon dioxide fixation mechanisms in diatoms. Awards include the ERC Consolidator Grant (2022), Human Frontier Research Grant (2021), and EMBO Young Investigator (2020). Develops advanced cryo-ET methodologies for in situ structural analysis Collaborates on mitochondrial evolution across eukaryotes Focuses on interorganelle interactions (mitochondria-chloroplast coordination)

Anna Bogdanovaمشاهده پروفایل

استاد

• Molecular Biology
• Cell Biochemistry
• Neurodegenerative Diseases
• +۳ مورد دیگر

Anna Bogdanova is a Professor at the University of Zurich , leading the Department of Molecular Life Sciences research group. Her work spans molecular biology, cell biochemistry, and translational medicine, with a focus on red blood cell physiology, neurodegenerative disease mechanisms, and probiotic microbiology. Current research interests include: Hypoxia signaling via mitochondrial ion transporters Phosphatidylserine flippase in hereditary anemias TSPO modulation in prion disease neuroinflammation Antimutagenic probiotics Beta-amyloid receptor mechanisms via Na,K-ATPase Recent publications highlight: 2024 Cells editorial on red blood cell imaging 2023 Am J Hematol study on ATP11C mutations 2022 Cells work on amyloid-Src kinase interactions 2021 Neuropsychopharmacology clinical trial with minocycline 2022 Microorganisms review on quorum-sensing inhibition

Nicholas W Bellonoمشاهده پروفایل

دانشیار

• Signal Transduction
• Ion Channel Biophysics
• Sensory Biology
• +۳ مورد دیگر

Nicholas W Bellono is an Associate Professor in the Department of Molecular and Cellular Biology at Harvard University's Faculty of Arts and Sciences. His research investigates how organisms adapt to environmental signals through specialized systems, focusing on signal transduction, ion channel biophysics, and evolutionary mechanisms that shape sensory physiology and behavior. Key Research Areas: Sensory neuroscience, ion channel function, evolutionary physiology Techniques: Electrophysiology, structural biology, comparative genomics Recent work examines chemotactile sensation in octopuses and sensory organ evolution in sea robins , revealing molecular pathways for microbiome-driven behavior and leg-like appendage specialization. The lab maintains a diverse aquatic species facility to study unconventional systems.

• Neuroscience
• Cognitive Neuroscience
• Molecular Neuroscience
• +۳ مورد دیگر

Mark F. Yeckel, Ph.D., serves as Professor of Medical Sciences at Quinnipiac University within the School of Medicine. His academic appointment is based in the Medicine, Nursing, and Health Sciences building (room 307L) with institutional mail directed to NH-MED. With over three decades of neuroscience research, Dr. Yeckel maintains an active laboratory investigating fundamental mechanisms of cognitive function and neural disorders. His educational foundation includes: BA from University of California, San Diego PhD from University of Southern California Dr. Yeckel's research program centers on ion channel physiology and calcium signaling dynamics in cortical and subcortical circuits. He employs electrophysiological, molecular, and behavioral approaches to investigate how KCNQ potassium channels, TRPC channels, and intracellular calcium waves regulate neuronal excitability in prefrontal cortex, hippocampus, and nucleus accumbens. His work specifically addresses mechanisms underlying working memory deficits in stress conditions, schizophrenia-related cognitive impairments, and addiction pathways, with significant translational implications for neuropsychiatric disorders. Analysis of his publication history reveals a cohesive research trajectory focused on the intersection of molecular neurobiology and cognitive neuroscience. His work consistently demonstrates how ion channel modulation (particularly SK, TRPC, and KCNQ channels) and calcium signaling cascades influence synaptic plasticity and information processing in neural circuits governing executive function and reward. A critical contribution includes identifying KCNQ channels as therapeutic targets for stress-induced working memory impairment, bridging basic science with potential clinical applications. No scientific awards or honors were documented in the available materials. Information regarding Dr. Yeckel's advisory roles for graduate students, research grant funding, or laboratory team composition was not provided in the source materials. His research appears to be conducted through independent investigation with extensive publication output spanning multiple neuroscience subdisciplines.

• Self-Healing Materials
• Porous Materials
• Inorganic-Organic Hybrid Nanomaterials
• +۵ مورد دیگر

Atsushi Shimojima is a Professor at Waseda University's School of Advanced Science and Engineering , specializing in siloxane-based nanomaterials and self-healing materials . His research focuses on molecular-scale assembly of inorganic-organic hybrids, pore structure engineering, and photomechanical systems. He has published extensively in journals like Chemistry – A European Journal and ACS Nano . Education: PhD in Engineering from Waseda University Research Areas: Self-healing materials, porous materials, sol-gel methods Research Interests encompass designing siloxane networks for intrinsic self-healing, creating ordered nanoporous structures through cage siloxane assembly, and developing photoresponsive hybrids. His work bridges zeolite chemistry and dense silica polymorphs through framework density optimization. Scientific Awards include the Waseda Research Award (2017) Japan Ceramic Society Progress Award (2006) . He is a member of multiple chemical societies like the International Sol-Gel Society and American Chemical Society. His publications demonstrate expertise in siloxane bond dynamics, cage-type germoxanes, and hierarchical nanoporous material synthesis. Recent studies highlight mesoscale structural control and fluoride ion encapsulation strategies.

Claire M. Doerschukمشاهده پروفایل

استاد

• Pulmonary Immunology
• Host Defense Mechanisms
• Inflammatory Processes
• +۷ مورد دیگر

Claire M. Doerschuk, MD is a Professor of Medicine and Pathology at the University of North Carolina at Chapel Hill School of Medicine. She serves as Director of the Center for Airways Disease and is a member of the UNC Lineberger Comprehensive Cancer Center. Her academic career has focused on pulmonary immunology and host defense mechanisms in the lungs. Dr. Doerschuk's research addresses host defense mechanisms in the lungs, particularly the inflammatory and innate immune processes that are important in the pathogenesis of bacterial pneumonia, acute lung injury/acute respiratory distress syndrome, and lung disease induced by environmental toxins. Her work employs in vivo, translational, imaging, cell biological, immunological, molecular and multi-omic approaches to investigate leukocyte recruitment, edema, and lung injury. She studies pathogens causing community-acquired and nosocomial pneumonias, particularly in immunocompromised cancer patients, with the goal of developing therapies that can enhance beneficial inflammatory responses while dampening harmful ones. Analysis of her recent publications reveals a continued focus on neutrophil biology, inflammatory signaling pathways, and lung injury mechanisms. Her work spans from basic molecular mechanisms to clinical applications, with increasing attention to environmental lung disease and translational approaches to treat inflammatory lung conditions. The research shows consistent investigation of leukocyte-endothelial interactions, cytokine signaling, and the cellular mechanisms underlying pulmonary inflammation. Dr. Doerschuk has received numerous prestigious awards including the Distinguished Achievement Award from the American Thoracic Society (2016), the Parker B. Francis Lectureship (2006), the Elizabeth Rich MD Award (2003), and Fellowship in the American Association for the Advancement of Science (1999). She has also been recognized with the American Thoracic Society Recognition Award for Scientific Accomplishment (1998) and the American Lung Association Career Investigator Award (1990-1995). She has served as Principal Investigator on multiple NIH R01 grants investigating lung microenvironment and neutrophil responses during pneumonia and acute lung injury. Dr. Doerschuk also served as Chair of the NIH Study Section on Lung Injury, Resolution and Repair (2008-2010) and as Multi-PI of the UNC Research Training Program in Respiratory Diseases and Critical Care. Her grant portfolio demonstrates sustained NIH funding for innovative research in pulmonary inflammation and host defense. As Director of the Center for Airways Disease, Dr. Doerschuk leads a collaborative research effort focused on understanding the conceptual and mechanistic basis of airway diseases. The center brings together investigators studying various aspects of airway biology, inflammation, and disease pathogenesis to advance knowledge and develop new therapeutic approaches for patients with airway disorders.

Sandra Schickمشاهده پروفایل

پژوهشگر

• Epigenetics
• Chromatin Remodeling
• Genome Stability
• +۷ مورد دیگر

Sandra Schick is a researcher at the Institute of Molecular Biology (IMB) in Mainz, Germany, with leadership roles since 2020. She holds a PhD in Molecular Biology (2016) and a Master's in Biomedicine from Johannes Gutenberg University. Her research focuses on chromatin regulation through BAF complexes, including their role in epigenetics , genome stability , and disease mechanisms . She employs genomics , proteomics , and CRISPR/Cas9 in mouse and human models. Scientific awards include the Life Science Research Award (2019) and scholarships from the Bayer Foundation (2009) and Keystone Meeting (2018). Her recent publications investigate chromatin remodeling in cancer and aging.

• Sarcopenia
• Aging
• Skeletal Muscle Biology
• +۳ مورد دیگر

Tyesha N Burks serves as an Assistant Professor in the Department of Natural Sciences at Bowie State University, teaching foundational biology courses including BIOL 102: Introductory Biology and BIOL 209: General Genetics, with plans to instruct BIOL 301: Human Hereditary. Her academic home within the university structure centers on natural sciences education and research. Her educational trajectory includes a BS from University of Maryland Eastern Shore (2006), PhD from Johns Hopkins School of Medicine (2011), and post-doctoral training at Johns Hopkins School of Medicine (2016). This rigorous training established her expertise in aging biology and muscle physiology. Dr. Burks' research program fundamentally investigates sarcopenia —the age-related loss of skeletal muscle mass and function affecting all demographics. She pioneers work identifying pre-phenotypic molecular signaling modulations and discovering compounds that alter sarcopenia progression . Her approach integrates molecular pathway analysis , therapeutic intervention studies , and comparative physiology models to address critical gaps in understanding muscle aging mechanisms. Publication trends from 2011-2016 reveal consistent focus on renin-angiotensin system modulation, TGF-β signaling in muscle atrophy, and pharmacological interventions (losartan/rapamycin). Her work bridges basic molecular mechanisms with translational applications, predominantly using rodent models to explore functional outcomes like grip strength and running capacity in aging contexts. Her exceptional contributions have earned significant recognition: Diverse Issues in Higher Education 2017 Emerging Scholars Recognition (2016) National Institutes on Aging Butler-Williams Scholar (2013) Multiple Gerontological Society of America travel awards (2010-2015) American Aging Association travel fellowships (2010, 2013) World Muscle Society international awards (2010, 2012) While specific grant details aren't documented, her award portfolio demonstrates sustained competitive funding for aging research. Professional affiliations with the Council on Undergraduate Research, American Aging Association, and Gerontology Society of America facilitate collaborative networks advancing her sarcopenia investigations. Though lab specifics aren't detailed, her publication patterns indicate active collaboration with Johns Hopkins researchers on muscle physiology projects.

Thomas P. Flaggمشاهده پروفایل

استاد

• Ion Channel Structure & Function
• Cardiac Electrophysiology
• Potassium Channels
• +۵ مورد دیگر

Dr. Thomas P. Flagg is a Professor in the Department of Anatomy, Physiology and Genetics at the Uniformed Services University of the Health Sciences (USUHS) School of Medicine in Bethesda, MD. He serves as Co-Module Director for the Foundation in Medicine Module, demonstrating significant leadership in medical education curriculum development. With over two decades of research experience, Dr. Flagg has established himself as a leading expert in cardiac ion channel physiology, particularly focusing on KATP channels and their role in cardiac function and disease. Dr. Flagg's educational background includes: B.S. in Chemical Biology (minor in History) from Stevens Institute of Technology (1989-1993) M.S. in Physiology from University of Maryland, Baltimore (1994-1996) Ph.D. in Physiology from University of Maryland, Baltimore (1996-2001) under mentor Paul A. Welling, M.D. Postdoctoral training at Washington University School of Medicine, St. Louis (2001-2004) with Colin G. Nichols, Ph.D. His research primarily investigates the structure and function of cardiac ion channels, with particular emphasis on KATP channels and their role in cardiac electrophysiology, arrhythmogenesis, and response to metabolic stress. Dr. Flagg's work bridges basic molecular mechanisms with clinical implications, exploring how ion channel dysfunction contributes to cardiac disorders and how therapeutic interventions might target these pathways. His laboratory employs diverse techniques including molecular biology, electrophysiology, transgenic models, and human iPSC-derived cardiomyocytes. Analysis of Dr. Flagg's recent publications (2017-2023) reveals evolving research trajectories. While maintaining his core focus on cardiac ion channels, his work has expanded to include connections with spinal muscular atrophy (SMA), where he investigates how SMN protein deficiency affects cardiac calcium signaling. More recently, his research has branched into nutritional approaches for warfighter health optimization, examining how flavonoids and berry extracts might provide cardioprotective and neuroprotective benefits. This represents a strategic expansion from pure cardiac electrophysiology toward translational applications with military relevance. Dr. Flagg maintains an active research program with consistent publication output across high-impact journals including Circulation, Journal of Molecular and Cellular Cardiology, and Journal of the American Heart Association. His collaborative network spans multiple institutions, with frequent co-authorship with experts in cardiology, electrophysiology, and neuromuscular disorders. While specific grant information isn't provided in the available materials, his sustained research productivity suggests successful funding history from agencies supporting cardiovascular and military-relevant medical research.

Jürgen Klingaufمشاهده پروفایل

استاد

• Synaptic transmission
• Biophysics
• Imaging Technology
• +۶ مورد دیگر

Prof. Dr. Jürgen Klingauf is Professor and Chair of Medical Biophysics at the Institute of Medical Physics and Biophysics, University of Münster, where he leads the Cell Biophysics research group within the Medical Faculty. His laboratory is part of the Medical Faculty of Münster University Hospital and maintains close ties with the Fluorescence Microscopy Facility Münster (FM)². His educational background includes: Studies in Biology and Physics at Universities of Hamburg and Bonn (1984-1988) Dr. rer. nat. (Physics) from University of Göttingen (1999) Postdoctoral research with Prof. Erwin Neher at MPI Biophysical Chemistry, Göttingen (1999-2001) Prof. Klingauf's research focuses on synaptic transmission mechanisms, particularly presynaptic processes involving neurotransmitter release and vesicle recycling. His laboratory develops specialized neuronal culture systems and employs cutting-edge imaging techniques including TIRFM, STED, STORM, and electron microscopy to visualize single synaptic vesicles and proteins. Key research areas include molecular coupling of exo- and endocytosis, organization of active zones, and vesicle pool dynamics. His team utilizes CRISPR/Cas-mediated knock-down and molecular biology approaches to investigate proteins critical for synaptic function. Analysis of his publication record reveals consistent contributions to understanding synaptic vesicle dynamics, with recent work emphasizing high-resolution imaging of presynaptic mechanisms. His research bridges neuroscience, biophysics, and cell biology, with particular focus on molecular organization at synaptic sites and vesicle recycling pathways. Key themes across his work include the relationship between vesicle pools, molecular mechanisms of neurotransmitter release, and the structural organization of presynaptic compartments. Prof. Klingauf actively mentors numerous doctoral students and has trained researchers who now hold positions at institutions worldwide including Utrecht University, University of Bordeaux, and Scripps Research. His laboratory maintains state-of-the-art microscopy facilities and collaborates extensively with other neuroscience research groups. The Cell Biophysics group operates advanced imaging systems including dual-objective 3D dSTORM setups and specialized neuronal culture platforms that enable precise investigation of presynaptic mechanisms. Their work continues to advance fundamental understanding of synaptic transmission with implications for neurological disorders involving synaptic dysfunction.

Lawrence Salkoffمشاهده پروفایل

استاد

• Neuroscience
• Molecular Biology
• Genetics
• +۵ مورد دیگر

Lawrence Salkoff is a full Professor of Neuroscience at Washington University in St. Louis School of Medicine, where he has maintained an active research laboratory since 1984. His work focuses on potassium channels, particularly their role in electrical signaling in the brain, heart, and other excitable tissues. As a neurogeneticist by training, his research bridges molecular biology, electrophysiology, and systems physiology. Dr. Salkoff's research interests center on high-conductance potassium channels of the SLO family, which control and shape electrical activity throughout the body. His laboratory employs a comparative genomic approach, studying channels across species from humans to C. elegans to understand fundamental principles of channel structure, function, and evolution. His work has significant implications for understanding neurological disorders including epilepsy, cardiac arrhythmias, and learning and memory deficits. Analysis of his recent publications reveals consistent focus on BK (Slo1) channels, sodium-activated potassium channels, and sperm-specific SLO3 channels. His research spans structural biology, channel biophysics, and physiological implications across multiple organ systems including the nervous system, cardiovascular system, and reproductive system. Selected Awards and Recognition: Klingenstein Research Fellowship (1985-1988) Cornerstone Faculty Mentor of the Year (2015) Dr. Salkoff has trained numerous researchers throughout his career and maintains an active laboratory studying the fundamental mechanisms of potassium channel function. His work continues to provide critical insights into how ion channels shape electrical signaling in biological systems, with implications for understanding both normal physiology and disease states.