جست‌وجوی استاد و پژوهشگر

• Muscular Dystrophies
• Gene Therapy
• Fibrosis
• +۵ مورد دیگر

David W Hammers is an Assistant Professor in the Department of MD-PHARMACOLOGY / THERAPEUTICS at the University of Florida. His research focuses on understanding the physiological and pathophysiological mechanisms of skeletal and cardiac muscle, particularly in genetic diseases like muscular dystrophies. The Hammers Lab investigates therapeutic targets for muscle and heart diseases using small molecules and gene therapies, with recent work identifying repurposed drugs that reduce fibrosis and enhance muscle regeneration. Teaching includes courses such as GMS6476 Fundamentals of Skeletal Muscle (2020-2024) PAS5026 Pharmacotherapeutics I (2023-2024) Molecules to Man: Past, Present and Future Therapeutic Strategies for Disease (2024-2025) Research interests span Muscular dystrophy and cardiomyopathy Gene therapy development Regenerative medicine strategies Inflammation dynamics in muscle diseases Publications highlight advancements in Cardiac function modulation in dystrophin-deficient hearts Microdystrophin gene therapy limitations Lipidomic profiling in disease models Lab activities emphasize translational research with a focus on Remodeling therapeutics AAV-based gene delivery In vivo imaging technologies

• Peroxisome Biology
• Molecular Genetics
• Angelman Syndrome
• +۲ مورد دیگر

Ben Distel is an Associate Professor in Clinical Genetics at Erasmus University Rotterdam. His research focuses on molecular mechanisms underlying neurodevelopmental disorders, particularly Angelman syndrome and peroxisome biogenesis disorders. His laboratory utilizes cross-species approaches to identify UBE3A-dependent signaling pathways and develop therapeutic strategies. Distel's work integrates proteomics, genetic engineering, and behavioral analysis to investigate ubiquitin-proteasome system dysregulation. Recent studies examine hippocampal responses in Angelman syndrome models and FEM1B-related neurodevelopmental disorders. Collaborative projects span biochemistry, neurology, and clinical genetics to bridge molecular insights with therapeutic development.

Jinchao Guمشاهده پروفایل

پژوهشگر ارشد

• Neuroscience
• Stem Cell Biology
• Genetic Engineering
• +۳ مورد دیگر

Dr. Jinchao Gu is a Research Fellow in the Department of Neuroscience at Monash University, affiliated with the School of Translational Medicine. He holds a PhD in Biotechnology from Swinburne University of Technology (2018–2023), focusing on GABAA receptors in neuronal models. His research specializes in generating in vitro neuronal cell models using human pluripotent stem cells (hiPSCs) to study epilepsy and other neurological disorders. Key technical expertise includes molecular cloning, CRISPR/Cas9 genome editing, and rapid neural differentiation from hiPSCs. He contributes to UN Sustainable Development Goals through advancements in disease modeling and drug screening. Dr. Gu is a Chief Investigator in the 2022–2027 project "Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for drug-resistant epilepsy," collaborating with multiple institutions. His recent publications (2021–2024) emphasize stem cell differentiation, transposon systems, and CRISPR applications in neuroscience.

Stuart McDonaldمشاهده پروفایل

پژوهشگر ارشد

• Traumatic Brain Injury (TBI)
• Concussion
• Trauma Biomarkers
• +۳ مورد دیگر

Dr Stuart McDonald is a Senior Research Fellow and Director of Fluid Biomarker Research in the Department of Neuroscience at Monash University. He leads the Monash Trauma Group, focusing on improving clinical management of traumatic brain injuries (TBI) through blood biomarker research. His work explores interactions between injured brain systems and peripheral body systems, emphasizing translational research in mild TBI. Education: PhD in Neuroscience, La Trobe University (2012). External position: Honorary Associate at La Trobe University. Research focuses on concussion, TBI biomarkers, neuroinflammation, neurofilament light, and microRNAs. Key projects include INFORMED (concussion management in sports), biomarkers in alcohol/drug-influenced TBI, and head impact kinematics in Australian football. Collaborations span international teams and involve clinical and experimental studies. Labs/Teams: Monash Trauma Group and SIMOA facilities. Active in over 10 research projects (2021–2026) addressing biomarker development, injury mechanisms, and clinical applications. Publications emphasize blood-based biomarkers, neuroinflammation, and TBI outcomes.

Dörthe Katschinskiمشاهده پروفایل

استاد

• Hypoxia Sensing
• Cardiovascular Physiology
• Mitochondrial Function
• +۳ مورد دیگر

Prof. Dr. Dörthe Katschinski is a Professor of Physiology at the University of Göttingen Medical Center since 2006. Her research focuses on hypoxia sensing, signaling, and adaptation, particularly in cardiovascular systems. She leads the Department of Cardiovascular Physiology, with affiliations in Cardiovascular Science and Molecular Medicine. Her work integrates cellular and molecular mechanisms, including mitochondrial function, redox regulation, and ischemia-reperfusion injury. Key contributions include studies on HIF prolyl hydroxylase inhibitors for cardioprotection and the use of transgenic biosensor mice to monitor redox states in vivo. Education: MD Thesis (1994), University of Lübeck Postdoc at University of Lübeck, Wisconsin (USA), and Halle Habilitation (2001), University of Lübeck Research Interests: Hypoxia signaling pathways Myocardial ischemia and reperfusion Transgenic mouse models Redox biology and mitochondrial function Achievements: Developed redox-sensitive mouse lines for in vivo imaging Explored HIF-modulating therapies for cardiac protection Labs/Teams: Department of Cardiovascular Physiology at Göttingen University Medical Center Collaborations in renal erythropoietin research and melanoma biology

Sylvie Garciaمشاهده پروفایل

پژوهشگر

• Malaria Research
• Immunology
• Humanized Mice Models
• +۳ مورد دیگر

Sylvie Garcia is a Group Leader and Head of the 'Humanized mice and in vivo analysis of human Plasmodium infections' group at the Institut Pasteur, Paris. Her research focuses on developing humanized mouse models to study malaria (Plasmodium species) and other human diseases, with an emphasis on immune system reconstitution and host-pathogen interactions. She leads projects on Plasmodium vivax blood-stage infections, innate CD8 T cell responses during Salmonella infections, and the creation of novel humanized mouse models (e.g., CH1-2hSa mice). Her work bridges fundamental immunology, parasitology, and translational medicine, aiming to improve therapies and vaccines. Her group collaborates with the Institut Pasteur's Drug Discovery & Screening platform and has contributed to studies on HIV replication dynamics, T cell memory, and humanized stem cell-derived cardiac progenitors. Key achievements include establishing models for sustained Plasmodium vivax infections and demonstrating the role of Bcl-2 in regulating non-cognate CD8 T cell survival during Salmonella infections. Garcia's research also explores the mechanisms of immune responses in chronic diseases and the use of humanized mice to study human-specific pathogens. Her lab is part of the Biology of Plasmodium Infection and Transmission department, with a focus on advancing in vivo models for malaria transmission and immune evasion studies. Her team includes PhD students (Barbara Mouyama, Dorenda Schoorl) and collaborators like Sabine Thiberge (co-author on key malaria studies). The group has published extensively in high-impact journals like Nature Communications and PLoS One, with a focus on translational immunology and parasitology.

Lei Leiمشاهده پروفایل

استاد

• Origin of Life
• Evolution of the Genetic Code
• Transcriptional Regulation
• +۵ مورد دیگر

Professor Lei Lei is a faculty member at the University of New England's Graduate School of Biomedical Science and Engineering since 2010. He specializes in teaching undergraduate courses such as Cell and Molecular Biology and Developmental Neurobiology, earning the Debra J. Summers Memorial Award for Teaching Excellence in 2018. His research focuses on two core areas: transcriptional regulation in neural development and the evolutionary origins of life and genetic code. Lei holds a Ph.D. in Biochemistry from Michigan State University (1998) and a B.S. in Biology from Wuhan University (1991). He completed postdoctoral training in Developmental Biology at UT Southwestern Medical Center. His work has been supported by grants including NIH R01 awards and the COBRE interdisciplinary center for Pain and Sensory Function studies. Lei’s research integrates evolutionary biology with molecular mechanisms, exploring how genetic code evolution intersects with modern developmental biology. His lab investigates transcriptional networks controlling sensory neuron development and axon regeneration, with a focus on Sox11 and Klf7 transcription factors. He has presented at major conferences like the Society for Developmental Biology and the Gordon Research Conference on Neurotrophic Factors. Grants: NIH R01 (2020), COBRE P20GM103643 (2015), and multiple institutional partnerships. Labs/Teams: Collaborates across institutions including Mayo Clinic Arizona and Barrow Neurological Institute. Future Work: Expanding studies on genetic code evolution and neurotrophic factor pathways in chronic pain.

• Neurology
• Physiology
• Biophysics
• +۴ مورد دیگر

Stephen Caldwell Cannon is a Professor of Physiology and Neurology at the University of California Los Angeles (UCLA) School of Medicine, where he also serves as Act/Interim Department Chair for Molecular and Medical Pharmacology and Department Chair for Physiology. He holds an MD and PhD in Biomedical Engineering from Johns Hopkins University and a BS/MS in Mechanical Engineering from Washington University. His research focuses on the pathophysiology of myotonia and periodic paralysis, with a particular emphasis on ion channel dysfunction and genetic mutations in skeletal muscle diseases. His work has been supported by multiple NIH grants, including R01AR078198 and R01AR063182, and he leads the Cannon Lab at UCLA. His publications span top journals like Nature Communications , Proceedings of the National Academy of Sciences , and Brain , addressing mechanisms of voltage-gated ion channels, gating pore currents, and therapeutic strategies for muscle disorders. Recent studies highlight his contributions to understanding hypokalemic periodic paralysis and Andersen-Tawil syndrome. Cannon has received prestigious awards such as the Biophysical Society Award in the Biophysics of Health and Disease (2022), the Paul Horowicz Endowed Lecture (2019), and the MERIT Award from the NIH (2008-2018). He has also contributed to clinical guidelines for nondystrophic myotonias and mentored numerous researchers in molecular physiology and neurological diseases.

Robert Moyzisمشاهده پروفایل

استاد مهمان

• Human Genome Organization
• Complex Genetic Disorders
• Telomere Biology
• +۵ مورد دیگر

Robert Moyzis is a Visiting Distinguished Professor of Biological Chemistry at Soka University of America. He holds a PhD from Johns Hopkins University and has held prominent roles such as Director of the Center for Human Genome Studies at Los Alamos National Laboratory and Professor at the University of California, Irvine. His research focuses on human genome organization, telomere biology, and the genetic basis of complex disorders like ADHD and Alzheimer’s. Moyzis pioneered the discovery of human telomere sequences and contributed to the Human Genome Project. He has received prestigious awards, including the Los Alamos Medal (2018) and the E.O. Lawrence Presidential Award (1993). His work bridges molecular genetics with evolutionary studies, exploring how cultural factors influence human DNA evolution. Current projects include gene-environment interactions and the role of dopamine receptors in longevity. Education: PhD in Biophysics/Molecular Genetics from Johns Hopkins University. Research Interests: Human genome evolution, telomere biology, ADHD genetics, and cultural genomics. His lab’s work on Darwinian selection in humans challenges assumptions about modern human evolution, suggesting cultural influences shape genetic changes. Grants & Collaborations: Led NIH-funded studies on ADHD genetics and longevity, collaborated with institutions globally, including Beijing Normal University. Awards: Includes the Los Alamos Medal, AAAS Fellowship, and multiple NIH grants.

Allison Barryمشاهده پروفایل

استادیار

• Cardiorespiratory Fitness
• Physical Activity
• Tactical Populations
• +۳ مورد دیگر

Allison Barry is an Assistant Professor at the School of Health and Consumer Sciences, South Dakota State University. Her research focuses on enhancing cardiorespiratory fitness and physical activity levels in tactical populations such as firefighters and police officers, while developing wellness initiatives for these groups. She holds a Ph.D. in Exercise and Nutrition Sciences (North Dakota State University, 2018), an M.S. in Kinesiology (University of North Dakota, 2014), and a B.S. in Exercise Science (University of Montana, 2012). Educations: Ph.D., Exercise and Nutrition Sciences, North Dakota State University (2018) M.S., Kinesiology, University of North Dakota (2014) B.S., Exercise Science, University of Montana (2012) Dr. Barry’s research emphasizes translating physiological insights into practical wellness programs for emergency service workers. Her studies investigate physical activity patterns, nutrition, and muscle health, particularly in middle-aged populations. Recent work includes developing occupational-specific fitness protocols for firefighters and exploring the role of protein intake in muscle maintenance. Her scholarly contributions span topics like sensory neuron subpopulations, proteomic profiling, and the impact of dietary leucine on muscle quality. These studies reflect her interdisciplinary approach to improving health outcomes through exercise science and nutrition. Affiliations: National Strength and Conditioning Association, American College of Sports Medicine. Professional Experience: Assistant Professor, South Dakota State University (2022–present) Assistant Professor, Pittsburg State University (2018–2022)

David R. Entenbergمشاهده پروفایل

دانشیار

• Photonics-based assays
• Intravital imaging
• Quantitative digital pathology
• +۳ مورد دیگر

David R. Entenberg is an Associate Professor in the Department of Pathology at Albert Einstein College of Medicine. He also serves as Co-Director of the Gruss-Lipper Biophotonics Center and holds leadership roles in the Integrated Imaging Program, including Director of Technology Development and Leader of the Computational Analysis of Biomarkers Program. His research focuses on developing photonics-based assays to study cancer metastasis, with specialties in intravital imaging, quantitative digital pathology, and biomarker validation. He has pioneered surgical engineering techniques for imaging metastasis in live models, including lung and pancreatic imaging windows. Dr. Entenberg's work bridges physics and biology, leveraging expertise in optical and mechanical engineering to advance cancer research tools. His research interests include optimizing mouse models for real-time metastasis visualization, designing implantable microdevices to alter tumor microenvironments, and applying multiphoton microscopy to study tumor-cell interactions. He co-authored key primers on multiphoton imaging and teaches at Einstein's Quantitative Imaging of Cells course. His lab's innovations have led to breakthroughs in understanding metastatic pathways, macrophage roles in cancer progression, and racial disparities in breast cancer outcomes. Dr. Entenberg's publications highlight advancements in tumor microenvironment analysis, biomarker validation (e.g., TMEM scoring), and preclinical therapy testing using Listeria-based delivery systems. His collaborative projects span breast, pancreatic, and thyroid cancer models, with a focus on translating imaging technologies into clinical applications. His lab is actively developing novel imaging platforms and biomarker tools to improve metastasis prediction and therapeutic targeting. Current efforts include refining intravital imaging techniques for prolonged observation of metastatic processes and enhancing computational methods for analyzing tumor cell behavior in vivo.

David Shattuckمشاهده پروفایل

استاد مدعو

• Neuroimaging
• Computational Biology
• Brain Imaging
• +۲ مورد دیگر

David Shattuck is an Adjunct Professor in the Department of Neurology at the University of California Los Angeles (UCLA) School of Medicine. He specializes in neuroimaging and computational neuroscience , with a focus on developing advanced software tools for brain analysis. Academic Affiliation: University of California Los Angeles Department: Neurology Research Focus: Neuroimaging, Brain Segmentation, Cortical Thickness Analysis, Computational Biology Research Contributions: Dr. Shattuck is the principal investigator for NIH R01NS074980 , developing the BrainSuite software suite for multimodal brain imaging analysis and visualization. His work spans human connectome mapping , mouse brain atlases , and neurodegenerative disease imaging . Scientific Trends: His recent publications emphasize deep learning in neuroimaging (e.g., SwinUNETR for mouse brain segmentation), structure tensor analysis for brain tissue orientation, and VR environments for neuroimaging visualization. Keywords across his work include Neuroscience , Medical Informatics , Genetic Disorders , and Biomedical Imaging . Collaborations: Dr. Shattuck collaborates extensively with researchers in neuroimaging genetics , clinical neuroscience , and computational biology , including Arthur Toga, Paul Thompson, and Richard Leahy.

Owen N. Witteمشاهده پروفایل

استاد

• Prostate Cancer
• Neuroendocrine Cancer
• T Cell Receptor Engineering
• +۶ مورد دیگر

Owen N. Witte is a Professor at the David Geffen School of Medicine , University of California Los Angeles (UCLA) , with dual appointments in Microbiology, Immunology & Molecular Genetics and Molecular and Medical Pharmacology . His research focuses on prostate cancer , neuroendocrine cancer , T cell receptor engineering , and molecular pharmacology . Research Highlights: Identified PGC-1α's role in neuroendocrine cancer progression Developed nanovial-based TCR screening for cancer immunopeptidomics Explored MYC-dependent RNA splicing in prostate cancer Mapped genomic/epigenomic landscapes of aggressive prostate cancer Scientific Awards: NIH U01CA233074 NIH R01CA222877 NIH R01CA220238 NIH U01CA164188 Collaborative Work includes immunotherapy development , cancer stem cell characterization , and precision medicine strategies for lethal neuroendocrine prostate cancer.

Annette Allenمشاهده پروفایل

پژوهشگر ارشد

• Circadian Rhythms
• Neuroscience
• Vision Science
• +۳ مورد دیگر

Annette Allen is a Research Fellow specializing in circadian rhythms and visual systems. Her lab investigates how biological clocks modulate neural circuits, physiology, and behavior, particularly in rodents. She explores retinal and brain adaptations to light cycles, and redesigns visual displays to control photoreceptors like melanopsin. Research focuses on circadian specializations in retinal cells, consequences of circadian disruption on vision, and ecological niches influencing visual systems. Techniques include in vivo/ex vivo electrophysiology and circuit manipulation in nocturnal/diurnal rodents. Key contributions include advancing understanding of melanopsin's role in vision and developing lighting standards for health and animal welfare. Projects span biological timing, sensory systems, and interdisciplinary collaborations. Awards : Sir Henry Dale Fellow (202X) Impacts : International lighting standards, healthy lighting guidelines, and re-designed artificial lights for biological needs. Labs/Teams : Lab focuses on visual systems as models for neural flexibility, with emphasis on circadian and ecological adaptations.

Valia Bravo-Eganaمشاهده پروفایل

دانشیار

• Immunogenetics
• Transplantation Medicine
• Molecular Biology
• +۳ مورد دیگر

Valia Bravo-Egana is an Associate Professor at the Department of Surgery (Tissue Typing Unit), Medical College of Georgia. She holds a Ph.D. in Molecular Biology from the University of Brasilia (2009) and is a Fellow of the American College of Histocompatibility and Immunogenetics (2021). Her research focuses on immunogenetics, HLA typing, transplantation medicine, and molecular biology, with a particular emphasis on advancing diagnostic techniques like next-generation sequencing (NGS). She has contributed to the development of humanized mouse models for studying allogeneic responses in organ transplantation and has explored NGS applications in HLA gene analysis. Key awards include the 2023 AU/MCG Woman Who Inspires and the 2019 E3 Award. Her work bridges clinical and translational research, addressing challenges in organ transplantation and immunogenetics. She has also received grants such as the American Diabetes Association Postdoctoral Fellowship (2009). Her publications highlight innovations in laboratory medicine for transplantation, NGS impact on immunogenetics, and HLA allele characterization. She collaborates within her department’s Tissue Typing Unit to advance precision medicine in transplant outcomes.