معرفی
Sylvie Garcia is a Group Leader and Head of the 'Humanized mice and in vivo analysis of human Plasmodium infections' group at the Institut Pasteur, Paris. Her research focuses on developing humanized mouse models to study malaria (Plasmodium species) and other human diseases, with an emphasis on immune system reconstitution and host-pathogen interactions. She leads projects on Plasmodium vivax blood-stage infections, innate CD8 T cell responses during Salmonella infections, and the creation of novel humanized mouse models (e.g., CH1-2hSa mice). Her work bridges fundamental immunology, parasitology, and translational medicine, aiming to improve therapies and vaccines.
Her group collaborates with the Institut Pasteur's Drug Discovery & Screening platform and has contributed to studies on HIV replication dynamics, T cell memory, and humanized stem cell-derived cardiac progenitors. Key achievements include establishing models for sustained Plasmodium vivax infections and demonstrating the role of Bcl-2 in regulating non-cognate CD8 T cell survival during Salmonella infections.
Garcia's research also explores the mechanisms of immune responses in chronic diseases and the use of humanized mice to study human-specific pathogens. Her lab is part of the Biology of Plasmodium Infection and Transmission department, with a focus on advancing in vivo models for malaria transmission and immune evasion studies.
Her team includes PhD students (Barbara Mouyama, Dorenda Schoorl) and collaborators like Sabine Thiberge (co-author on key malaria studies). The group has published extensively in high-impact journals like Nature Communications and PLoS One, with a focus on translational immunology and parasitology.
