جست‌وجوی استاد و پژوهشگر

Corinne Nielsenمشاهده پروفایل

دانشیار

• Neurovascular Biology
• Developmental Biology
• Vascular Development
• +۷ مورد دیگر

Corinne Nielsen is an Associate Professor in the Department of Biological Sciences within the College of Arts and Sciences at Ohio University. She leads the Nielsen Lab, where her research focuses on the genetic and molecular mechanisms underlying neurovascular development and disease, particularly brain arteriovenous malformations (AVMs). Her work integrates mouse genetics, molecular biology, and advanced imaging to explore endothelial-pericyte interactions, Notch signaling, and vascular remodeling. Education: Ph.D., Harvard University Her research interests lie at the intersection of developmental biology, neuroscience, and vascular biology. She investigates how the nervous and vascular systems co-develop and influence each other, with a focus on pathological conditions such as AVMs, where abnormal connections between arteries and veins disrupt brain function. Her lab studies cellular and molecular dysregulation in these diseases using genetically engineered mouse models. The recent publications highlight a strong trajectory in understanding Rbpj and Notch signaling in cerebrovascular development and disease. The work spans from basic developmental mechanisms to pathological remodeling in AVMs, with increasing focus on immune cell involvement and metabolic aspects. Emerging themes include endothelial-pericyte communication, macropinocytosis in tumor metabolism, and cross-organ vascular regulation. Scientific Awards: No awards listed in the provided text. Dr. Nielsen actively mentors graduate students and researchers in her lab, contributing to training the next generation of scientists in molecular and cellular neuroscience. While specific grants are not mentioned, her sustained publication record in high-impact journals suggests active external funding. Her collaborative work with institutions beyond Ohio University indicates a strong national research network. Labs and Research Teams: She directs the Nielsen Lab, based in Irvine Hall (rooms 303/316) on the Athens Campus. The lab employs a multidisciplinary approach combining genetics, cell biology, and imaging to study neurovascular biology. Current projects involve Rbpj-deficient models, pericyte dynamics, and endothelial signaling in both developmental and pathological contexts.

David Nikolic-Patersonمشاهده پروفایل

استاد مدعو

• Chronic Kidney Disease
• Inflammation
• Fibrosis
• +۳ مورد دیگر

David Nikolic-Paterson is an Adjunct Professor of Medicine at Monash University's Monash Health Centre for Inflammatory Disease. He leads a research laboratory focused on mechanisms of inflammation and fibrosis in kidney disease and transplant rejection, with particular emphasis on signaling pathways in leukocytes, kidney cells, and fibroblasts. His work combines experimental models (human and animal) with clinical trials, including studies on ASK1 inhibitors for diabetic kidney disease. He has collaborated extensively with international researchers and pharmaceutical companies. Current research projects include engineering anti-fibrotic therapies for chronic kidney disease, dissecting cystogenic pathways in polycystic kidney disease, and developing human kidney organoid models to replace mouse studies. He has led or co-led 25+ research projects since 2009, securing funding for initiatives like biomarker identification for therapy response and improving outcomes in cardiac surgery-induced kidney injury. His publications (264+) span experimental kidney disease, clinical trials, and pre-clinical studies. Key areas include cellular senescence, PAR2 signaling, podocyte biology, and anti-fibrotic drug discovery. He currently supervises 4 PhD students and maintains active collaborations through Monash Health and international networks. Key Projects: ASK1 inhibitor trials, kidney organoid modeling, biomarker development Grants/Support: Multiple ARC and NHMRC grants since 2016 Labs/Teams: Head of Research Lab at Monash Health, collaborating with Polo (STEM cell), Combes (fibrosis), and Tesch (clinical trials)

Paul E. Loveمشاهده پروفایل

عضو هیئت علمی

• Hematopoiesis
• T cell development
• Immunology
• +۱۲ مورد دیگر

Dr. Paul E. Love is a Senior Investigator and tenured Principal Investigator at the National Institutes of Health (NIH), specifically within the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), where he leads the Section on Hematopoiesis and Lymphocyte Biology . His research is focused on the molecular and cellular mechanisms regulating mammalian hematopoiesis, with an emphasis on T cell development, T cell receptor (TCR) signaling, thymocyte selection, and the pathogenesis of hematopoietic malignancies such as T-cell acute lymphoblastic leukemia (T-ALL). Dr. Love earned his B.S. in Biochemistry from Syracuse University, followed by an M.D. and Ph.D. through the Medical Scientist Training Program at the University of Rochester. He completed clinical training in Laboratory Medicine at Washington University, St. Louis, and a fellowship in Human Genetics at NICHD before joining the NIH intramural program, where he became a Principal Investigator in 1993. His lab utilizes genetically engineered mouse models, transgenic technology, and advanced genomic techniques including RNA-seq and ChIP-seq to dissect the roles of key signaling molecules such as TCR subunits, CD5, Themis family proteins, Fbxl12, and the nuclear adapter protein Ldb1. His research has revealed fundamental insights into TCR signaling, including the discovery that CD3ζ ITAMs have dual activating and inhibitory roles depending on antigen affinity—a finding with major implications for cancer immunotherapy. His work on Themis demonstrated its role in enhancing TCR signaling by inhibiting the phosphatase SHP-1, thereby promoting thymocyte positive selection. Additionally, his lab has shown that Ldb1 is essential for hematopoietic stem cell maintenance and plays a critical role in Lmo2-induced leukemogenesis, identifying Ldb1 complexes as potential therapeutic targets in pediatric T-ALL. The most recent publications highlight ongoing work in TCR tuning, thymocyte development, and transcriptional regulation in hematopoiesis. Key themes across his article output include signal transduction in immune cells , molecular mechanisms of thymocyte selection , regulation of self-renewal in hematopoietic and leukemic cells , and translational applications in immunotherapy and leukemia . His work bridges basic immunology and clinical relevance, with implications for autoimmune diseases and cancer treatment. Dr. Love has received several honors, including: NIH Bench to Bedside Award (2023–2024) NICHD Director's Award (2023–2024) He mentors a team of scientists and trainees, including staff scientists, research and visiting fellows, and technicians. His lab collaborates extensively with researchers across the NIH and international institutions. Dr. Love’s long-standing contributions to immunology and hematopoiesis continue to shape understanding of immune cell development and offer new avenues for therapeutic intervention. His laboratory investigates key questions in hematopoietic stem cell biology , T and B cell development , signal transduction , and transcriptional regulation . The lab uses a multidisciplinary approach combining mouse genetics, molecular biology, and systems immunology to study how signaling pathways and transcriptional networks govern cell fate decisions in the immune system. Current projects include exploring the therapeutic potential of modulating TCR signaling for cancer immunotherapy and dissecting the role of Ldb1 complexes in leukemogenesis.

Juliane Bogner-Straussمشاهده پروفایل

دانشیار

• Adipocyte Research
• Lipid Metabolism
• Energy Homeostasis
• +۳ مورد دیگر

Juliane Bogner-Strauss is an Associate Professor at the Institute of Biochemistry , Graz University of Technology. Her career spans roles including Deputy Head of the Institute of Genomics and Bioinformatics (2005–2010), Principal Investigator in the Doctoral Program Metabolic and Cardiovascular Disease (2010–2018), and Head of the Doctoral School Molecular Biosciences and Biotechnologies (2017). She also served in Austrian political positions from 2017 onwards while maintaining her academic affiliation. Research Focus : Bogner-Strauss investigates white and brown adipocyte development , energy homeostasis , and mitochondrial transport mechanisms . Her work uses mutant mouse models and cell metabolism analysis to uncover molecular circuits regulating fat cell function. Key areas include N-acetylaspartate pathway , lipolysis , insulin resistance , and lysosomal acid lipase in thermogenesis. Research Trends : Recent publications emphasize subcellular acyl-CoA dynamics (2022), oxidized phospholipids for endothelial protection (2021), and histone modifications linked to metabolism (2019). Projects like FWF-NATBAT (2014–2018) and SFB-LIPOTOX (2007–2017) highlight her focus on lipid-induced cell dysfunction and adipose tissue engineering . Advising & Grants : She co-supervised numerous students (e.g., Katharina Haushofer , Wenmin Xia ) and led grants including FWF-NATBAT and GEN-AU GOLD . Her work spans collaborations with institutions like the University of Graz and european lipoprotein club . Labs & Teams : As Deputy Head of the Institute of Biochemistry (2014–2017) and Principal Investigator in the Doctoral Program Metabolic and Cardiovascular Disease (2010–2018), she worked with teams at Graz University of Technology. Her lab employs knockout mouse models , lipid profiling , and subcellular metabolomics to study metabolic diseases.

Jeroen Rooseمشاهده پروفایل

استاد

• Cancer Research
• Immunology
• Cell Signaling Pathways
• +۴ مورد دیگر

Jeroen Roose is a tenured Professor and Vice Chair of Anatomy at the University of California San Francisco (UCSF) . He co-founded the Bakar ImmunoX Immunology Program , co-leads the AutoIPI (AutoImmunoProfiler) initiative , and serves as co-lead of the UCSF Endeavor program . His lab connects to UCSF's CoLabs , and he advises the Mark Foundation for Cancer Research . Education: MS, Medical Biology (1993), University of Utrecht PhD, Immunology/Transcription (1999), University of Utrecht Postdoctoral Fellowship, Immunology/Signaling (1997–1999), University of Utrecht Postdoctoral Fellowship, Immunology/Signaling (1999–2004), UCSF Roose’s research explores cell fate decisions and cell fitness governed by signaling pathways and cell-cell interactions in cancer , autoimmune diseases , and COVID-19 . Key areas include Wnt signaling , Ras signaling , organoid models , and tumor microenvironment dynamics . Collaborations with biophysicists , computational engineers , and clinicians bridge fundamental and pre-clinical science. His recent publications highlight exosome-mediated tumor microenvironment reprogramming , myeloid cell responses to SARS-CoV-2 , and signaling pathway integration in leukemia . Scientific Awards: Gabrielle's Angel Foundation Award (2012) UCSF PSA Mentoring Award (2013) R01 Awards (NIH/NIAID 2014, NIH/NCI 2015, NIH/NHLBI 2016) Alex's Lemonade Stand Innovator Award (2015) Renewal P01 Award (2020, NIH/NIAID) Endeavor Award (2021, Mark Foundation) Renewal R01 Awards (2022, NIH/NCI) Roose secures substantial funding from NIH , DoD , Mark Foundation , and industry partners. His lab offers a multidisciplinary training environment for staff , students , and fellows through partnerships with biobanked organoids and clinical collaborators .

Xinyu Zhaoمشاهده پروفایل

استاد

• Neurodevelopmental Disorders
• Molecular Biology
• Stem Cell Research
• +۳ مورد دیگر

Xinyu Zhao is a Professor at the University of Wisconsin-Madison with primary affiliation in Biomedical Engineering and additional affiliation in Neuroscience . She investigates molecular mechanisms regulating brain development and neurodevelopmental disorders.

• Molecular Biotechnology
• Virology
• Vaccine Development
• +۷ مورد دیگر

Miriam Klausberger is a researcher at the Institute of Molecular Biotechnology within the Department of Biotechnology and Life Sciences at the University of Natural Resources and Life Sciences, Vienna (BOKU). She has held postdoctoral and project leadership roles, including co-PI on FWF-funded projects related to SARS-CoV-2 and vaccine development. Her research spans virology, molecular biotechnology, and vaccine design, with a focus on virus-like particles and antigen purification. Her research interests include vaccine development , bioseparation techniques , SARS-CoV-2 antigen design , and influenza VLPs . She investigates both fundamental virological mechanisms and applied biotechnological solutions for diagnostics and therapeutics. Her work emphasizes interdisciplinary collaboration and translational outcomes. The most recent articles highlight a strong trend in diagnostic antigen engineering for SARS-CoV-2 serotesting, purification of VLPs , and evaluation of vaccine-induced immune responses . Keywords across these works include virology, bioprocessing, glycobiology, and immunology, reflecting a multidisciplinary approach to vaccine and diagnostic development. Scientific awards received include: BOKU Inventor of the Year (2023) HOUSKA Award, 3rd place (2021) BOKU Talent Award (2016) BOKU Innovation Award, 3rd place (2015) Raiffeisen Science and Innovation Publication Award (2014) INITS Award in Life Sciences, 2nd place (2011) Miriam Klausberger has been actively involved in research projects funded by the FWF, serving as co-PI and project leader. She has advised university theses and collaborated with institutions such as the Medical University of Vienna (MUW), JKU Linz, AIT, and international labs. Her work demonstrates strong grant acquisition and collaborative research capabilities. She is part of research teams focused on molecular biotechnology and vaccine development at BOKU, with collaborations extending to industrial biotechnology centers like acib and AIT. Her work involves interdisciplinary teams in virology, protein engineering, and analytical biotechnology.

Chrysothemis Brownمشاهده پروفایل

استادیار

• Immunology
• Microbiology
• Oncology
• +۵ مورد دیگر

Chrysothemis Brown is an Assistant Professor at Weill Cornell Medicine and an Assistant Attending Physician/Assistant Member at Memorial Sloan Kettering Cancer Center (MSK). Her research focuses on antigen-presenting cells (APCs) and their role in immune tolerance, early life immune development, autoimmunity, and cancer immunology. Institutional Affiliation: Weill Cornell Medicine & MSK Department: Pediatrics Academic Rank: Assistant Professor Education: MA, University of Oxford MD, Royal Free and University College London PhD, King’s College London (Immunology, under Randy Noelle) Research Interests center on understanding how tissue environments shape immune cell fate and function. Key areas include: Mechanisms of immune tolerance to self and commensal antigens during early life Role of APCs (e.g., Thetis cells) in mucosal immunity and autoimmunity Dendritic cell heterogeneity in tumor immunology Her lab employs single-cell omics, advanced imaging, and genetically engineered mouse models to bridge human disease research and experimental studies. Scientific Awards include: Persuasive Square Sohn Award (2025) Pew Trust Biomedical Scholar (2025) NIAID DP2 New Innovator Award (2022) V Foundation Scholar (2022) Josie Robertson Investigator (2020-2025) Lab Members include graduate students (Logan Fisher, Yoselin Paucar Iza, Gayathri Shibu) and senior technician Yollanda Franco Parisotto. The lab is affiliated with MSK's Immuno-Oncology Program and the Parker Institute for Cancer Immunotherapy.

Isabel Orrissمشاهده پروفایل

مدرس ارشد

• Bone Cell Biology
• Vascular Calcification
• Purinergic Signaling
• +۴ مورد دیگر

Dr. Isabel Orriss is a Senior Lecturer in the Department of Comparative Biomedical Sciences at the Royal Veterinary College (RVC), where she has worked since 2013. Her research focuses on bone cell regulation and vascular calcification through local signaling factors like extracellular nucleotides and purinergic pathways. University of Southampton, Biochemistry BSc (1st Class, 2001) University College London, PhD (2005, supervised by Professors Tim Arnett and Geoff Burnstock) Her research examines how extracellular nucleotides , antioxidants , and pH levels influence skeletal mineralization and soft tissue calcification. She has published over 40 peer-reviewed articles and leads the Bone Biology, Biomineralisation and Purinergic Signalling research group within Skeletal Biology at RVC. Recent studies highlight her work on: Mechanisms of NPP1 regulation by acidosis ATP-mediated inhibition of bone mineralization Effects of purinergic receptor antagonists Interactions between metabolic hormones and bone She holds a Career Development Fellowship from Arthritis Research UK (2010) and serves on the editorial board of Frontiers in Endocrinology: Bone Research . Dr. Orriss teaches across the BVetMed and BSc Bioveterinary Science programs, leading modules like Cell Cycle and Advanced Skeletal Pathobiology .

Eszter Posfaiمشاهده پروفایل

استادیار

• Developmental Biology
• Stem Cell Biology
• Mechanobiology
• +۱۲ مورد دیگر

Eszter Posfai is an Assistant Professor in the Department of Molecular Biology at Princeton University, where she leads the Posfai Lab focused on quantitative approaches to understanding mammalian preimplantation embryo formation. Her research integrates developmental biology, stem cell biology, biophysics, and imaging technologies to dissect the mechanisms of cell fate decisions, embryonic patterning, and totipotency. Research Interests: Quantitative analysis of mammalian embryo development Mechanisms of cell fate specification and symmetry breaking Role of mechanical forces in embryogenesis Molecular basis of totipotency in vivo and in vitro Development of synthetic embryo models from stem cells Live imaging and genome engineering (CRISPR-based tools) The lab employs advanced imaging techniques, including light sheet microscopy, and develops computational tools for image analysis. They have pioneered CRISPR/Cas9-based methods for large DNA fragment insertions in mouse embryos, enabling precise interrogation of gene function. The recent publications reflect a strong focus on developmental dynamics, totipotency evaluation, and innovative genetic tool development. These works span disciplines such as developmental biology, biophysics, and genome engineering, with applications in stem cell modeling and synthetic embryology. Scientific Contributions: Co-development of 2-cell HR-CRISPR for efficient knock-in mouse models Establishment of criteria for evaluating totipotency Live imaging approaches for developmental cell cycles Novel mouse models for planar cell polarity studies Advising & Collaborations: The lab welcomes prospective graduate students and postdoctoral researchers, particularly those with expertise in imaging and data analysis. While no current students are listed, the lab fosters interdisciplinary collaborations involving computational modeling and image analysis. Although specific grants are not mentioned, her technical innovations suggest significant funding support for method development and embryogenesis research. Laboratory: The Posfai Lab at Princeton's Thomas Laboratory emphasizes 'seeing is believing'—prioritizing direct visualization of developmental processes. The lab actively develops live imaging and genome editing tools to probe molecular events in real time and build quantitative models of embryonic development.

Stefan Semrauمشاهده پروفایل

دانشیار

• Cell-fate Decision-making
• Single-cell Transcriptomics
• Stem Cell Biology
• +۶ مورد دیگر

Dr. Stefan Semrau is an Associate Professor at the Leiden Institute of Physics (LION) within the Faculty of Science at Leiden University . His research focuses on quantitative single-cell biology, particularly studying cell-fate decision-making using embryonic stem cells as a model system. Develops single-cell RNA-seq and single-molecule FISH methods Applies machine learning and mathematical modeling to decode stem cell differentiation Investigates interplay of epigenetics, cell cycle, and signaling molecules His work addresses both fundamental biological dynamics and applications in regenerative medicine and cancer stem cell eradication . Recent publications emphasize single-cell transcriptomics and gene fusion quantification . The Semrau Lab maintains collaborations across disciplines and develops tools like fuseFISH for cancer research. Scientific Awards FOM-Projectruimte Grant (2016) for stem cell dynamics research Advising & Collaborations Current advisees include PhD students studying retinoic acid-induced differentiation and lineage priming. The lab integrates computational and experimental approaches through partnerships with biotech and physics teams.

• Immunology
• T Cell Biology
• Autoimmune Diseases
• +۳ مورد دیگر

Dr. Yvonne Müller is an Assistant Professor in the Department of Immunology at Erasmus MC, focusing on T cell biology, immunotherapy, and autoimmune diseases. Her work bridges immunology, virology, and computational medicine. Current affiliation: Erasmus MC (Immunology) Research themes: T cell exhaustion, autoinflammatory syndromes, cancer immunotherapy Her research explores mechanisms of T cell dysfunction in chronic infections and cancer, with recent work on modulating pathways like MAP Kinase 11 and cytokines (e.g., interleukin-18). She develops translational tools such as reporter mice and AI-based clinical models. Recent publications highlight her expertise in: Bone marrow conditioning for stem cell transplantation CD8+ T cell exhaustion and reinvigoration Autoinflammatory disease biomarkers Machine learning for infectious disease prognosis

Jessica Hoffmanمشاهده پروفایل

استادیار

• Aging Biology
• Genomic Medicine
• Metabolomics
• +۳ مورد دیگر

Jessica Hoffman is an Assistant Professor at Georgia Augusta University's College of Science and Mathematics, Department of Biological Sciences. She also holds appointments at the Department of Genomic Medicine and The Graduate School, working closely with the Dog Aging Project. Ph.D., Genetics, University of Georgia (2015) BS, Biology, Clemson University (2008) Her research focuses on aging biology through metabolomics and microbiome studies, using diverse models including dogs, mice, and fruit flies. Key areas include dietary restriction mechanisms, sex differences in aging, and inflammaging processes. 2023-2025 publications highlight metabolomic profiling (2025), microbiome interventions (2025), and cross-species aging comparisons (2024). Recent work explores mitochondrial dysfunction (2023), dietary stochasticity (2025), and canine aging models (2024). She teaches courses from undergraduate research to genomic medicine seminars, with expertise in evolutionary biology and translational metabolomics.

Holm Zaehresمشاهده پروفایل

مدرس ارشد

• Stem Cell Engineering
• Induced Pluripotent Stem Cells (iPS)
• Neural Differentiation
• +۳ مورد دیگر

Holm Zaehres is a Senior Lecturer at the Max Planck Institute for Molecular Biomedicine in Münster, Germany, leading the Stem Cell Engineering Laboratory . His work focuses on reprogramming somatic cells to pluripotency using transcription factors like OCT4, SOX2, and KLF4, with significant contributions to induced pluripotent stem (iPS) cell generation from neural and hematopoietic progenitors. Key Research Areas: Stem cell engineering, iPS cell differentiation, genome editing, and disease modeling (including Frontotemporal Dementia and Duchenne Muscular Dystrophy). Publications: Authored 10+ seminal works in Nature , Cell , and Stem Cells , establishing methods for efficient cellular reprogramming and organoid-based disease studies. Collaborations: Partnered with institutions like University of Bonn, German Cancer Research Center (DKFZ), and academic hospitals in neurology and hematology.

• Biochemistry
• Pharmacology
• Molecular Biology
• +۷ مورد دیگر

Miriam Langelaar-Makkinje is a researcher active in the fields of Biochemistry , Molecular Biology , and Pharmacology , with a focus on mitochondrial and peroxisomal function, lipid metabolism, and metabolic disease modeling. She has contributed to studies involving iPSC-derived liver organoids , murine models of malnutrition , and bladder distension mechanisms , often collaborating on projects related to inherited metabolic disorders and glucose homeostasis. Institutional Affiliation : Unspecified (inferred from collaborative publications with academic institutions) Academic Rank : Researcher Her research spans both basic science and translational medicine , with a particular emphasis on: Mitochondrial and peroxisomal protein dynamics Lipid metabolism in hepatic organoid systems Role of mTOR complex in autophagy regulation Metabolic compensation in fatty acid oxidation defects Recent work highlights the use of docosahexaenoic acid to mitigate protein loss in malnutrition models and heptanoate as a therapeutic for glucose homeostasis defects. Her publications demonstrate expertise in mouse genetics , organoid culture , and metabolic pathway analysis .