Jeroen Roose

Jeroen Roose is a tenured Professor and Vice Chair of Anatomy at the University of California San Francisco (UCSF). He co-founded the Bakar ImmunoX Immunology Program, co-leads the AutoIPI (AutoImmunoProfiler) initiative, and serves as co-lead of the UCSF Endeavor program. His lab connects to UCSF's CoLabs, and he advises the Mark Foundation for Cancer Research.

• Education:
  • MS, Medical Biology (1993), University of Utrecht
  • PhD, Immunology/Transcription (1999), University of Utrecht
  • Postdoctoral Fellowship, Immunology/Signaling (1997–1999), University of Utrecht
  • Postdoctoral Fellowship, Immunology/Signaling (1999–2004), UCSF

Roose’s research explores cell fate decisions and cell fitness governed by signaling pathways and cell-cell interactions in cancer, autoimmune diseases, and COVID-19. Key areas include Wnt signaling, Ras signaling, organoid models, and tumor microenvironment dynamics. Collaborations with biophysicists, computational engineers, and clinicians bridge fundamental and pre-clinical science.

His recent publications highlight exosome-mediated tumor microenvironment reprogramming, myeloid cell responses to SARS-CoV-2, and signaling pathway integration in leukemia.

• Scientific Awards:
  • Gabrielle's Angel Foundation Award (2012)
  • UCSF PSA Mentoring Award (2013)
  • R01 Awards (NIH/NIAID 2014, NIH/NCI 2015, NIH/NHLBI 2016)
  • Alex's Lemonade Stand Innovator Award (2015)
  • Renewal P01 Award (2020, NIH/NIAID)
  • Endeavor Award (2021, Mark Foundation)
  • Renewal R01 Awards (2022, NIH/NCI)

Roose secures substantial funding from NIH, DoD, Mark Foundation, and industry partners. His lab offers a multidisciplinary training environment for staff, students, and fellows through partnerships with biobanked organoids and clinical collaborators.