معرفی
David Nikolic-Paterson is an Adjunct Professor of Medicine at Monash University's Monash Health Centre for Inflammatory Disease. He leads a research laboratory focused on mechanisms of inflammation and fibrosis in kidney disease and transplant rejection, with particular emphasis on signaling pathways in leukocytes, kidney cells, and fibroblasts. His work combines experimental models (human and animal) with clinical trials, including studies on ASK1 inhibitors for diabetic kidney disease. He has collaborated extensively with international researchers and pharmaceutical companies.
Current research projects include engineering anti-fibrotic therapies for chronic kidney disease, dissecting cystogenic pathways in polycystic kidney disease, and developing human kidney organoid models to replace mouse studies. He has led or co-led 25+ research projects since 2009, securing funding for initiatives like biomarker identification for therapy response and improving outcomes in cardiac surgery-induced kidney injury.
His publications (264+) span experimental kidney disease, clinical trials, and pre-clinical studies. Key areas include cellular senescence, PAR2 signaling, podocyte biology, and anti-fibrotic drug discovery. He currently supervises 4 PhD students and maintains active collaborations through Monash Health and international networks.
- Key Projects: ASK1 inhibitor trials, kidney organoid modeling, biomarker development
- Grants/Support: Multiple ARC and NHMRC grants since 2016
- Labs/Teams: Head of Research Lab at Monash Health, collaborating with Polo (STEM cell), Combes (fibrosis), and Tesch (clinical trials)
