Stefan Semrau

Dr. Stefan Semrau is an Associate Professor at the Leiden Institute of Physics (LION) within the Faculty of Science at Leiden University. His research focuses on quantitative single-cell biology, particularly studying cell-fate decision-making using embryonic stem cells as a model system.

• Develops single-cell RNA-seq and single-molecule FISH methods
• Applies machine learning and mathematical modeling to decode stem cell differentiation
• Investigates interplay of epigenetics, cell cycle, and signaling molecules

His work addresses both fundamental biological dynamics and applications in regenerative medicine and cancer stem cell eradication. Recent publications emphasize single-cell transcriptomics and gene fusion quantification. The Semrau Lab maintains collaborations across disciplines and develops tools like fuseFISH for cancer research.

Scientific Awards

• FOM-Projectruimte Grant (2016) for stem cell dynamics research

Advising & Collaborations

Current advisees include PhD students studying retinoic acid-induced differentiation and lineage priming. The lab integrates computational and experimental approaches through partnerships with biotech and physics teams.