Brian Hendrich

Dr Brian Hendrich is a Principal Research Fellow at the Cambridge Stem Cell Institute, affiliated with the Department of Biochemistry at the University of Cambridge. His research focuses on the transcriptional control of stem cell fate, particularly the role of chromatin-modifying proteins like the NuRD complex in gene expression dynamics during pluripotency and differentiation.

Education

• PhD in Genetics, Stanford University (1995)

Research Interests

Dr. Hendrich investigates how chromatin structure and epigenetic regulators influence developmental decisions in pluripotent cells. His work bridges stem cell biology, molecular genetics, and chromatin remodeling, aiming to understand mechanisms linking gene regulation to diseases like cancer.

Publications Trends

His recent studies highlight the NuRD complex’s role in transcriptional noise suppression, lineage commitment, and 3D genome organization during stem cell differentiation, often using advanced techniques like single-cell Hi-C and live-cell imaging.

Grants & Collaborations

• Wellcome Trust
• Medical Research Council (MRC)
• Wolfson College
• AstraZeneca

Laboratory & Team

Based at the Jeffrey Cheah Biomedical Centre, his group includes researchers India Baker, Jennifer Balmer, Prajakta Gade, Kateryna Kravchenko, Xiaoyan Ma, Seun Ogundele, Ramy Ragheb, and Nicola Reynolds. The lab integrates biochemical, genomic, and imaging approaches to decode stem cell fate determination.