Isabel Orriss

Dr. Isabel Orriss is a Senior Lecturer in the Department of Comparative Biomedical Sciences at the Royal Veterinary College (RVC), where she has worked since 2013. Her research focuses on bone cell regulation and vascular calcification through local signaling factors like extracellular nucleotides and purinergic pathways.

• University of Southampton, Biochemistry BSc (1st Class, 2001)
• University College London, PhD (2005, supervised by Professors Tim Arnett and Geoff Burnstock)

Her research examines how extracellular nucleotides, antioxidants, and pH levels influence skeletal mineralization and soft tissue calcification. She has published over 40 peer-reviewed articles and leads the Bone Biology, Biomineralisation and Purinergic Signalling research group within Skeletal Biology at RVC.

Recent studies highlight her work on:

• Mechanisms of NPP1 regulation by acidosis
• ATP-mediated inhibition of bone mineralization
• Effects of purinergic receptor antagonists
• Interactions between metabolic hormones and bone

She holds a Career Development Fellowship from Arthritis Research UK (2010) and serves on the editorial board of Frontiers in Endocrinology: Bone Research. Dr. Orriss teaches across the BVetMed and BSc Bioveterinary Science programs, leading modules like Cell Cycle and Advanced Skeletal Pathobiology.