جست‌وجوی استاد و پژوهشگر

• Immunology
• Signal Transduction
• Molecular Biology
• +۴ مورد دیگر

Bing Su, PhD, MPH is the KC Wong Endowed Professor and Director of the Shanghai Institute of Immunology at Shanghai Jiao Tong University (SJTU). He holds an adjunct appointment at Yale University in the Department of Immunobiology. His research focuses on signal transduction pathways, particularly MAPK and mTOR pathways, in immune and cardiovascular systems. He earned a B.S. in Cell Biology from Peking University, and MPH and PhD from Yale University. He leads the SJTUSM-Yale Institute of Immune Metabolism and has pioneered studies on kinase signaling in immune responses and vascular development. Notable achievements include elucidating roles of MEKK2/3 and Sin1 in immune cell function and cardiovascular biology. Dr. Su has been recognized as a Distinguished Professor at SJTU and holds the KC Wong Chair. His lab uses genetic and biochemical approaches to study kinase pathways in health and disease. Collaborations include work with Yale faculty like Lei Shen and David Schatz. Recent studies address T cell ferroptosis regulation, intestinal fibrosis mechanisms, and evolutionary adaptations in placental and neural development. His publications span Cell Genomics, Journal of Clinical Investigation, and Developmental Cell, highlighting his contributions to immunology, cancer biology, and evolutionary medicine. Key research themes include: 1) Molecular mechanisms of MAPK/mTOR signaling in immunity and vascular systems, 2) Evolutionary genetics of human traits (e.g., skin pigmentation, high-altitude adaptation), and 3) Translational studies in cancer immunotherapy and fibrotic diseases. His work bridges basic science with clinical applications through interdisciplinary collaborations.

David Heidaryمشاهده پروفایل

استاد پژوهشی

• Photodynamic Therapy
• Metal-Based Anticancer Agents
• Enzyme Inhibition (Cytochrome P450)
• +۳ مورد دیگر

David Heidary is a Research Professor at North Carolina State University, specializing in inorganic chemistry with a focus on photoactive metal complexes and their applications in cancer therapy. His work bridges medicinal chemistry, enzymology, and molecular biology, particularly targeting cytochrome P450 enzymes and developing light-activated anticancer agents. Key research areas include: Design of ruthenium-based anticancer drugs with photodynamic properties Structure-activity relationships of metal complexes for targeted therapies Enzyme inhibition strategies for cancer treatment Development of fluorescent probes for cellular imaging Recent studies emphasize dual-action compounds combining enzyme inhibition and DNA/RNA targeting. His work has advanced light-activated drug delivery systems and improved understanding of hypoxic tumor responses. Dr. Heidary collaborates extensively with biochemists and clinicians to translate fundamental discoveries into clinical applications. Publications (2021-2025) highlight advancements in: Photocaged enzyme regulators Mitochondrial dysfunction mechanisms Subcellular localization of molecular rotors CYP1B1/P450 inhibition strategies No specific awards or grants are explicitly mentioned in the provided text.

Song Liمشاهده پروفایل

استاد

• Drug Delivery Systems
• Cancer Therapy
• Immunology
• +۳ مورد دیگر

Dr. Song Li is the David and Betty Brenneman Professor in the Department of Pharmaceutical Sciences at the University of Pittsburgh School of Pharmacy and Director of the Center for Pharmacogenetics. He holds an MD and PhD from the Fourth Military Medical University, Xi’an, China, and completed postdoctoral training with Dr. Leaf Huang. His research focuses on drug/gene delivery systems, cancer therapy, and immunology, with over 179 peer-reviewed articles and 35 reviews. Dr. Li leads NIH-funded projects on nanocarrier development, tumor immune microenvironment modulation, and overcoming chemoresistance. Education: MD and PhD, Fourth Military Medical University (China), Postdoctoral training at University of Pittsburgh. Research Interests: Dr. Li’s lab develops ultrasmall nanocarriers (e.g., 15 nm systems) for improved tumor targeting, CD44-targeted delivery, and overcoming immune resistance via Xkr8 inhibition. Key breakthroughs include 'new amphiphilic surfactants' for hard-to-formulate drugs and GRM4/Xkr8 mechanisms in antitumor immunity. Recent work addresses non-cancer diseases like cardiovascular and liver conditions through novel delivery systems. Grants: Active NIH grants include R01CA278608 (breast cancer combination therapy) and R01CA295774 (iRhom1 targeting in colon cancer). Collaborates on lung cancer immunotherapy (R01CA239716). Labs/Teams: Directs the Center for Pharmacogenetics and leads interdisciplinary teams in nanomedicine, immunotherapy, and drug delivery.

Wilbert Zwartمشاهده پروفایل

استاد

• Biomedical Engineering
• Molecular Biology
• Cancer Research
• +۳ مورد دیگر

Wilbert Zwart is a Part-time Full Professor in the Department of Biomedical Engineering at Eindhoven University of Technology (TU/e). His research focuses on molecular mechanisms underlying cancer progression, epigenetic regulation, and computational modeling of tumor microenvironments. He collaborates actively with interdisciplinary teams in chemical biology and systems biology. Key research interests include chromatin dynamics, CRISPR-Cas9 editing efficiency modulation, and agent-based modeling of tumor growth. Recent work addresses epigenetic drug effects on gene editing tools and genomic heterogeneity in breast tumors. His studies integrate computational approaches with experimental biology to uncover cancer vulnerabilities. Publications span high-impact journals like Genome Biology, Nucleic Acids Research, and npj Systems Biology and Applications. No ancillary activities are listed, and no scientific awards are mentioned. Collaborations include co-authors from TU/e and international institutions, though formal student advisees are unspecified. Wilbert Zwart contributes to TU/e's Biomedical Engineering research ecosystem without noted lab-specific details or grant mentions in the provided text.

• Chronic Myeloid Leukemia
• Leukemic Stem Cell Biology
• Cancer Metabolism
• +۳ مورد دیگر

Dr. Mary Scott is a Research Fellow at the Paul O'Gorman Leukaemia Research Centre within the Wolfson Wohl Cancer Research Centre at the University of Glasgow, focusing on chronic myeloid leukemia (CML) stem cell biology and therapeutic resistance mechanisms. Her research centers on: Metabolic vulnerabilities in leukemic stem cells (arginine dependency, pyruvate anaplerosis) Epigenetic reprogramming and EZH2 inhibition strategies p53-mediated self-renewal pathways in residual CML disease Microenvironment interactions in the bone marrow niche Recent publications reveal a strong trend toward targeting persistent leukemic stem cells through dual metabolic-epigenetic approaches, with increasing emphasis on mitochondrial metabolism and transcriptional reprogramming as therapeutic avenues. Dr. Scott's research is supported by active grants: 2024-2025: Identification of biomarkers predictive of TKI response in CML (Tenovus Scotland) 2023-2026: Functional analysis of leukemia stem cell subtypes in CML (Leukaemia UK) 2014-2017: H3K27 methylation modulation for eradicating TKI-persistent CML stem cells (Blood Cancer UK) She operates within the Paul O'Gorman Leukaemia Research Centre team, utilizing advanced molecular profiling techniques to investigate therapy-resistant CML populations and develop novel eradication strategies.

Jiou Wangمشاهده پروفایل

استاد

• Neurodegeneration
• Protein Homeostasis
• RNA Homeostasis
• +۵ مورد دیگر

Jiou Wang is the Walder Distinguished Professor of Biochemistry and Molecular Biology at Johns Hopkins University. He holds primary appointments in the School of Medicine and secondary affiliations with the Bloomberg School of Public Health. His research focuses on protein and RNA homeostasis in neurodegenerative diseases, particularly Alzheimer’s, Parkinson’s, ALS, and FTD. He investigates mechanisms linking protein misfolding and RNA dysregulation to disease pathology, with a focus on the C9orf72 gene’s role in ALS/FTD. Dr. Wang leads a lab at Johns Hopkins, and postdoctoral positions are available. Education: MD from Peking University Health Sciences Center (1997), PhD from Johns Hopkins School of Medicine (2002). Research Interests: Protein/RNA quality control, repeat expansion diseases, stress granules, and energy metabolism in neurodegeneration. Key Achievements: Elected to the American Society for Clinical Investigation (ASCI) in 2020. His lab has uncovered novel pathways in protein and RNA regulation, including C9orf72’s role in mitochondrial function and energy homeostasis. Students/Advising: Advises current student Zhiyuan (Paul) Huang. Former lab members include researchers contributing to ALS/FTD studies. Labs/Teams: The Wang Lab focuses on translational research bridging basic mechanisms and therapeutic interventions for neurodegenerative disorders.

• Neuroscience
• Pharmacology
• Addiction Studies
• +۳ مورد دیگر

Jesse Schank leads the Schank Lab focusing on the neurobiological mechanisms linking stress, neuropeptides, and drug-seeking behavior. The lab specializes in the neurokinin-1 receptor (NK1R) and its role in the extended amygdala circuitry, particularly in stress-induced alcohol seeking, depression, and anxiety. Key projects include studying NK1R neurocircuitry in social defeat stress, oxycodone self-administration, and sex differences in alcohol consumption. Research interests emphasize translational studies on substance use disorders, leveraging rodent models to investigate how stress and neuropeptides modulate addictive behaviors. Collaborative work explores inflammatory mediators like interleukin-6 and epigenetic factors influencing alcohol intake. Publications highlight themes such as stress-alcohol interactions, aversion-resistant drinking, and neurokinin receptor antagonists as therapeutic targets. No scientific awards are explicitly listed in the provided texts. Lab activities include studies on pharmacological interventions (e.g., NK1R antagonists), behavioral assays for stress response, and neuroanatomical mapping of substance P pathways. The lab collaborates on projects involving opioid and alcohol co-use, with a focus on sex differences and neuroinflammatory processes.

• Nutritional Genetics
• Molecular Biology
• Genetics of Disease Processes
• +۵ مورد دیگر

Zoe Yates is a Lecturer in the School of Biomedical Sciences and Pharmacy at the University of Newcastle. She holds a PhD from the University of Leeds and has expertise in nutritional biochemistry, molecular biology, and genetics of disease processes, particularly focusing on folate bioavailability, B-vitamin metabolism, and their roles in conditions like heart disease, cancer, and neural tube defects. Her research also addresses the implications of mandatory folic acid fortification and fetal programming of adult diseases. Her career includes a Research Fellowship at the University of Newcastle (2007–2012) and postdoctoral roles at the University of Nottingham and University of Leeds. She has authored over 35 peer-reviewed publications in journals like Nature Reviews Genetics, Lancet, and Journal of the National Cancer Institute, and secured grants including the Ramaciotti Foundation Establishment Grant and University of Newcastle Strategic Pilot Grant. Teaching expertise includes research methods and ethics, while administrative roles involve laboratory management and health & safety. Collaborations focus on nutrigenomics, vitamin D-folate interactions, and epigenetic mechanisms. Awards include invitations to speak at the Asia Pacific Nutrigenomics Conference and Nutrition Society Australia events. Key research themes: Folate metabolism's role in health/disease, vitamin D-folate interactions, genetic polymorphisms' impacts, and mandatory fortification's dual effects. Active in professional bodies like the Nutrition Society of Australia and University of Newcastle's Institutional Biosafety Committee.

• Epigenetics
• Cancer Biology
• DNA Methylation
• +۳ مورد دیگر

Dr. Heather Lee is an Associate Professor at the University of Newcastle, affiliated with the School of Biomedical Sciences and Pharmacy. Her research focuses on epigenetic mechanisms in cancer, particularly acute myeloid leukaemia (AML), leveraging single-cell sequencing technologies to study cellular heterogeneity and therapeutic resistance. She completed her PhD at the Garvan Institute of Medical Research and postdoctoral training at the Babraham Institute (UK), where she pioneered single-cell epigenomics techniques. Education: PhD in Biomedical Sciences from the University of New South Wales, BSc (Honours) in Biochemistry from the University of Sydney. Research Interests: Epigenetic regulation in cancer, DNA methylation dynamics, single-cell genomic approaches, and translational therapies targeting epigenetic drivers of disease. She collaborates with clinical haematologists and patient advocates to bridge laboratory findings with clinical applications. Awards: 2018 Metcalf Prize for Stem Cell Research, multiple grants from the National Health and Medical Research Council and Cancer Institute NSW. Grants/Funding: NHMRC Research Fellowships, Cure Cancer Australia grants, and industry partnerships. Her team investigates cholesterol biosynthesis pathways in AML and develops biomarkers for treatment response. Labs/Teams: Leads a research group at the Hunter Medical Research Institute, collaborating with the Australasian Leukaemia and Lymphoma Group and Calvary Mater Hospital (Newcastle).

Monia Saviمشاهده پروفایل

دانشیار

• Diabetic cardiomyopathy
• Cardiovascular diseases
• Cardiac regeneration
• +۳ مورد دیگر

Monia Savi is a Associate Professor in the Department of Chemistry, Life Sciences and Environmental Sustainability at the University of Parma. With a PhD in Systemic Physiopathology (2009), she has held various academic positions since 2009, including Fixed-term research assistant (RTDa) (2018–present) and multiple Postdoctoral research fellow roles. Research Focus : Diabetic cardiomyopathy, cardiac regeneration, nanoparticle cardiotoxicity, and antiarrhythmic drug mechanisms. Collaborations : Works with experts in cardiology, stem cell research, and nanotoxicology across Italy and Europe. Awards : National Scientific Qualification as Associate Professor (2017). She serves as a journal referee for multiple high-impact publications and contributes to European Society of Cardiology working groups. Her work emphasizes translational biomedical sciences , with teaching appointments in physiology courses since 2018.

Helen M. Blauمشاهده پروفایل

استاد

• Stem Cell Biology
• Regenerative Medicine
• Cellular Reprogramming
• +۱۲ مورد دیگر

Helen M. Blau is the Donald E. and Delia B. Baxter Foundation Professor and Professor in the Department of Microbiology & Immunology at Stanford University, with a courtesy appointment in Psychiatry and Behavioral Sciences. She serves as Director of the Baxter Laboratory for Stem Cell Biology and is a member of multiple interdisciplinary institutes, including Bio-X, the Cardiovascular Institute, Wu Tsai Neurosciences Institute, Stanford Cancer Institute, and the Wu Tsai Human Performance Alliance. Her research focuses on stem cell biology, cellular reprogramming, muscle regeneration, and aging. Key areas include the role of mechanical and biochemical cues in cell fate decisions, the discovery of 'gerozymes' such as 15-PGDH as drivers of aging, and the development of therapeutic strategies for muscle wasting disorders and fibrosis. Her lab integrates single-cell multiomics, bioengineering, and advanced imaging to study rejuvenation and regenerative mechanisms. Her recent publications (2023–2025) highlight innovative work in reversing muscle aging with prostaglandin E2, suppressing cardiac fibrosis via mechanosensing inhibition, mapping sex-biased thymic niches, and developing tools for hiPSC-cardiomyocyte analysis. These studies reflect a strong trend toward translational, interdisciplinary research combining molecular biology, computational modeling, and regenerative medicine. Honors include: National Medal of Science (2025) Member, Royal Society (2024) Member, Austrian Academy of Sciences (2024) Member, National Academy of Sciences (2016) Member, National Academy of Medicine (1995) FASEB Excellence in Science Award (1999) She mentors postdoctoral fellows and graduate students across Bioengineering, Cancer Biology, Genetics, Microbiology & Immunology, Neurosciences, and Stem Cell Biology and Regenerative Medicine programs. Her lab receives major grants from foundations and federal agencies, supporting high-impact research in regenerative medicine. The Blau Lab fosters collaboration among biologists, bioengineers, and computational scientists, with a mission to translate basic discoveries into therapies that improve human health.

Andrea Ablasserمشاهده پروفایل

استاد

• Innate Immunity
• Molecular Immunology
• Cellular Biology
• +۷ مورد دیگر

Andrea Ablasser is a Full Professor at École polytechnique fédérale de Lausanne (EPFL), affiliated with the School of Life Sciences, the Global Health Institute (GHI), and the Department of Molecular and Cellular Biology. She leads the Ablasser Lab, focusing on innate immunity and host defense mechanisms. Her research centers on the molecular basis of pathogen detection, particularly the cGAS-STING signaling pathway, which is crucial in immunity against infections and cancer. Her work spans nucleic acid sensing, inflammatory regulation, aging-related inflammation, and autoimmune disorders. Recent studies explore mitochondrial DNA-driven inflammation, epigenetic regulation of immune responses, and the role of cGAS-STING in neurodegeneration. The trends in her recent publications show a strong focus on innate immune signaling, with recurring themes in cGAS/STING regulation, nucleic acid sensing, and immune homeostasis. Her work combines molecular biology, cell biology, and translational approaches, often published in high-impact journals like Nature , Science , and Nature Immunology . Andrea Ablasser has been honored with several prestigious awards, including: Paul Ehrlich and Ludwig Darmstaedter Prize 2025 Liliane Bettencourt Prize for Life Sciences Clarivate Highly Cited Researcher 2024 She mentors multiple PhD students and is actively involved in academic governance as a member of the EPFL Academic Strategic Committee and the Doctoral Program in Molecular Life Sciences. She contributes to teaching through courses such as Immunology - advances and therapeutic implications and practical lab instruction. Her lab is supported by competitive research funding, reflecting its impact in immunology and molecular medicine.

Teresa A. Milnerمشاهده پروفایل

استاد

• Neuroscience
• Neurobiology of Addiction
• Neuroplasticity
• +۷ مورد دیگر

Teresa A. Milner is a Professor of Neuroscience at Weill Cornell Medicine's Graduate School of Medical Sciences and a member of the Feil Family Brain & Mind Research Institute. She has been a dedicated faculty member since joining as a postdoctoral research fellow in 1982, rising through the ranks to become a full Professor in 2003. Her work bridges neuroscience, endocrinology, and cardiovascular research, with a particular focus on sex differences in brain function across the lifespan. Dr. Milner received her B.S. from the University of California, Irvine and her Ph.D. from the University of California, San Diego. She completed her postdoctoral training at Weill Cornell Medicine, where she has remained throughout her distinguished career. Dr. Milner's research program centers on understanding estrogen influences on brain function over the life cycle, with particular emphasis on two main systems: 1) cardiovascular circuitry in the hypothalamus, and 2) the learning and memory networks modulated by the hippocampus and its connections. Her laboratory employs multidisciplinary anatomical, molecular, and physiological approaches, including the technically sophisticated method of electron microscopic immunocytochemistry. Key areas of investigation include: Neural mechanisms of hypertension susceptibility in a mouse model of menopause Sex differences in the hippocampal opioid system and their implications for addiction Characterization of a novel "accelerated ovarian failure" mouse model of menopause Estrogen receptor distribution and function in various brain regions Neurobiological substrates underlying sex differences in hypertension during peri- and post-menopausal periods Analysis of Dr. Milner's recent publications (2022-2025) reveals a continued focus on the intersection of menopause, neuroinflammation, and neurodegenerative processes. Her work increasingly incorporates advanced genomic and single-cell techniques to examine how estrogen signaling affects brain function at the molecular level. There's a clear trajectory toward understanding the mechanisms linking hormonal changes during menopause to increased risk of Alzheimer's disease and hypertension, with particular attention to sex-specific neuroinflammatory responses in the hippocampus and hypothalamus. Dr. Milner has received numerous prestigious awards recognizing her excellence in mentoring and teaching: Excellence in Mentoring Award, Weill Cornell Medical College Postdoctoral Association (2008) Award for Teaching Excellence, Weill Cornell Medical College Medical School (for Brain and Mind) (2010) Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School of Medical Sciences (2012) Dean's Award for Excellence in Mentorship, Weill Cornell Medicine (2021) Forty Years of Service, Weill Cornell Medicine (2022) Throughout her career, Dr. Milner has mentored more than 160 individuals, ranging from high school students to senior faculty members. Her laboratory has been consistently supported by NIH grants and collaborative funding, with recent projects focusing on the effects of chronic opioid exposure in single-cell RNA expression in the non-human primate hippocampus following HIV, in collaboration with Drs. Tilgner and Ndhlovu. Her work bridges basic neuroscience with clinical implications, particularly regarding women's health issues related to menopause and addiction. The Milner Laboratory, housed within the Feil Family Brain & Mind Research Institute, maintains state-of-the-art facilities for electron microscopy, molecular biology, and physiological studies. Current lab members include graduate student Tracey Van Kempen and postdoctoral researcher Jose Da Silva Marques Lopes. The lab collaborates extensively with other researchers at Weill Cornell Medicine and beyond, including scientists at The Rockefeller University, where Dr. Milner holds an adjunct professorship.

• Microbiome
• Immunology
• Microbiology
• +۴ مورد دیگر

Jos Boekhorst is a Research Associate at Wageningen University & Research, affiliated with the Host-Microbe Interactomics group. His research focuses on microbiome dynamics in health and disease, with particular expertise in metagenomics, host-microbe interactions, and microbial culturomics. He holds a doctoral degree and actively contributes to both human and animal microbiome studies. Research Interests: Dr. Boekhorst investigates microbial ecosystems across diverse contexts including: Gut microbiome development in infants and piglets Streptococcus suis pathogenesis and translocation mechanisms Antimicrobial discovery from microbial communities Impact of diet and environmental factors on microbiome composition Resistome dynamics in disease-associated microbiomes His work integrates multi-omics approaches with in vitro and animal models. Publication Trends: Recent articles (2023-2025) demonstrate: Strong focus on Streptococcus suis pathogenesis mechanisms Innovative use of organoid models for infection studies Exploration of microbiome-based therapeutic interventions Geographical comparisons of microbial communities Integration of culturomics with metagenomic approaches Supervision & Projects: Currently co-supervising PhD candidates on: FIBERME: Microbiome-artificial intelligence integration Pesticide effects on human microbiome and organ function Microbiome fortification in pigs via metagenomics-driven culturomics

• Integrin Signaling
• Extracellular Matrix (ECM) Biology
• Tissue Remodeling
• +۴ مورد دیگر

C. Michael DiPersio is a Professor of Surgery and Molecular and Cellular Physiology at Albany Medical College . His research focuses on the roles of integrins, particularly α3β1 and α9β1, in regulating tissue remodeling during wound healing and cancer progression. Education: PhD, Brown University, 1991 BS, University of Massachusetts, Dartmouth, 1985 DiPersio’s work explores how integrin-mediated signaling controls extracellular matrix (ECM) dynamics , paracrine communication , and gene expression to modulate pathological processes such as chronic wounds, hypertrophic scars, and tumor metastasis. His lab employs genetic knockout models , transcriptomics , and cell biological approaches to identify therapeutic strategies targeting integrins. Recent publications highlight integrin α3β1’s role in regulating the tumor secretome (e.g., fibulin-2, CSF-1) and post-transcriptional gene regulation via alternative splicing and polyadenylation. These studies link integrin signaling to mRNA stability pathways in cancer cells and stromal-tumor crosstalk in skin and breast tumors. The DiPersio lab collaborates with Dr. Livingston Van De Water’s group to investigate integrin knockout models, emphasizing the antagonistic functions of α3β1 and α9β1 during wound healing and tumorigenesis. Current projects aim to translate these findings into therapies for cancer and pathological wound healing.