Dynamic ligation screening Professors and Supervisors | ApplySharif

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استاد راهنما، استاد دانشگاه یا پژوهشگر مناسب برای مسیر پژوهشی‌تان را پیدا کنید و با او ارتباط بگیرید.

نمایش ۱-۱۵ از ۳۹ استاد راهنما

اطلاعات این پروفایل‌ها از صفحات عمومی دانشگاه‌ها جمع‌آوری شده و ممکن است به‌روز نباشد.

Bradley D. Olsenمشاهده پروفایل

استاد

Massachusetts Institute of TechnologyUnited States

Bradley D. Olsen is a full professor in the Department of Chemical Engineering at the Massachusetts Institute of Technology (MIT), where he leads research at the intersection of polymer science, soft matter physics, and bioengineering. His work focuses on designing materials for critical applications in biotechnology, hemostasis, and sustainable polymer development while advancing fundamental understanding of polymer network mechanics and self-assembly. Education: Ph.D. in Chemical Engineering, University of California Berkeley (2007) S.B. in Chemical Engineering, Massachusetts Institute of Technology (2003) Olsen's research spans protein-based materials, block copolymer phase behavior, and mechanochemical hydrogels. He has pioneered methods for quantifying polymer network topology, developing hemostatic nanoparticles, and creating bio-inspired materials for selective biomolecular transport and medical applications. His recent publications emphasize data-driven approaches to polymer characterization and educational outreach in materials science. Scientific Awards: American Physical Society (APS) Fellow (2023) Fulbright Amazonia Scholar (2023) Alexander and I. Michael Kasser Chair in Chemical Engineering (2021) ACS Macro Letters Young Investigator Award (2021) MIT Committed to Caring Honor (2019) AIChE Owens Corning Early Career Award (2019) APS Dillon Medal (2018) Kavli Emerging Leader in Chemistry (2017) ACS Polymer Division Fellow (2016) Camille Dreyfus-Teacher Scholar (2015) Alfred P. Sloan Research Fellow (2014) NSF Career Grant (2013) NIH Postdoctoral Fellowship (2008-2009) Hertz Fellow (2003-2007) Barry M. Goldwater Scholarship (2002) Olsen has received significant grant support including NSF Career (2013) and AFOSR (2012) awards. His teaching activities include innovative international outreach like the 2025 soccer-themed science camp in Brazil. The Olsen Group at MIT explores advanced materials with applications ranging from trauma care to sustainable polymers.

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Urs F. Greberمشاهده پروفایل

استاد

University of ZurichSwitzerland

Prof. Dr. Urs F. Greber is an Ordinary Professor of Molecular Cell Biology at the Department of Molecular Life Sciences, Faculty of Mathematics and Natural Sciences, University of Zurich. His research focuses on understanding how viruses interact with host cells, particularly adenoviruses and rhinoviruses that cause human respiratory diseases. He leads the Greber Lab, which investigates viral entry mechanisms, replication processes, and the cellular responses to infection. Greber's research interests span virology, molecular cell biology, and infection mechanisms. His lab explores how viruses take control over membrane and lipid functions, cytoplasmic transport processes, and cellular metabolism to support their gene expression and progeny formation. They employ system-wide profiling, molecular cell biology approaches, light microscopy, and machine learning for image analysis to map the cell state underlying viral infections of cultured and primary human cells, including lung organoids and iPSC-derived macrophages. A key focus is understanding cell-to-cell variability in infection phenotypes and the mode-of-action of antiviral compounds. The Greber Lab has published extensively on adenovirus biology, including viral entry, uncoating, nuclear import, and assembly mechanisms. Their recent work has identified broad-spectrum antiviral compounds, elucidated alternative virus entry pathways, and developed innovative imaging and AI-based approaches for quantifying virus infectivity. Their research contributes to understanding how viruses break down host defense barriers and has implications for antiviral therapy development. Greber has supervised numerous PhD and Master's students including Cornelia Bircher, Alessandro Savi, Franziska Tomas, Alfonso Gomez-Gonzalez, Anthony Petkidis, and Dominik Olszewski. His lab has received funding from the Swiss National Science Foundation, including a grant for coronavirus research during the pandemic. The lab actively collaborates with other research groups at University of Zurich, ETH Zurich, and international institutions. Current projects include exploring how viral DNA interactions contribute to infection outcome variability, investigating adenovirus egress mechanisms, and developing high-throughput screening methods for antiviral compounds.

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David Ackerleyمشاهده پروفایل

استاد

Victoria University of WellingtonNew Zealand

Enzymes
Synthetic biology
Microbiology
+۴ مورد دیگر

Professor David Ackerley (Victoria University of Wellington) is a leading microbiologist and enzyme engineer specializing in directed evolution of bacterial enzymes for biotechnological applications. As Biotechnology Programme Director since 2006, he lectures in foundational courses like BTEC101 and BTEC201. Academic rank: Professor of Biotechnology Institutional affiliation: Victoria University of Wellington Research focus areas: Microbial Biotechnology, Drug Discovery, Synthetic Biology His research employs Darwinian evolutionary principles to engineer enzymes with enhanced activities, particularly targeting non-ribosomal peptide synthetases and nitroreductases for antibiotic development and cancer therapy. Recent work explores metagenomic domain substitution in pyoverdine biosynthesis and Purpuramine R from marine sponges. Key publications demonstrate innovations in metagenomic library construction , CRISPR screening for regeneration genes, and structural characterization of engineered enzymes. His team has developed NTR 2.0 , a high-efficacy nitroreductase for targeted cell ablation. Current research projects include: Clean solutions from dirty genes: Plastic-degrading enzyme discovery Engineering enzymes for CAR T-cell-chemotherapy synergy Repurposing niclosamide against Gram-negative superbugs Grants from the Health Research Council of New Zealand, Royal Society of New Zealand, and Cancer Society of NZ support his work. Collaborations span biomedical research, synthetic biology, and environmental applications.

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Aaron Hoskinsمشاهده پروفایل

استاد

University of Wisconsin-MadisonUnited States

Aaron Hoskins is a full-time Professor of Biochemistry and Chemistry at the University of Wisconsin–Madison, where he leads an active research program focused on pre-mRNA splicing, spliceosome assembly, and single-molecule biophysics. He is affiliated with the Department of Biochemistry and the Hoskins Group laboratory, located in the Biochemical Sciences Building. Education: B.S., 2000 – Purdue University Ph.D., 2006 – Massachusetts Institute of Technology Postdoctoral Fellow, 2006–2011 – Brandeis University and UMass Medical School His research centers on understanding the molecular mechanisms of pre-mRNA splicing and spliceosome assembly in eukaryotes. Using single-molecule fluorescence microscopy, his lab investigates how the spliceosome recognizes RNA targets, how ribonucleoproteins are assembled, and how splicing fidelity is maintained or disrupted in disease. His work integrates genetics, chemical biology, and biophysical approaches to dissect spliceosome dynamics and to develop new tools for studying RNA processing. Aaron Hoskins has published over 80 peer-reviewed articles since 2004, with recent work appearing in RNA , eLife , Structure , and Cell Chemical Biology . His research trends include the structural dynamics of spliceosomal snRNPs, cancer-associated mutations in splicing factors, and the development of splicing inhibitors as potential therapeutics. His lab also explores translational applications, including the use of humanized yeast strains for drug screening. He is supported by multiple NIH grants (R01 GM053007, R01 GM112735, R01 GM081648) and has collaborated extensively with UW-Madison colleagues David Brow and Samuel Butcher. His lab is equipped with custom-built fluorescence microscopes for single-molecule imaging and is actively training the next generation of scientists in RNA biology and biophysics.

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M. (Mike) Boxemمشاهده پروفایل

استاد

Utrecht UniversityNetherlands

Prof. Mike Boxem is a Professor in the Department of Biology at Utrecht University's Faculty of Science, specializing in Developmental Biology. His research focuses on epithelial polarity, cell polarity complexes, and C. elegans genetics. He holds a PhD from Utrecht University (2002) and completed postdoctoral work at the Dana-Farber Cancer Institute. Notable honors include the NWO Vici (2016), NWO Vidi (2010), and ECHO grants. He leads the PolarNet Marie Curie ITN network and has supervised 8 research projects. His work contributes to understanding cell polarity mechanisms and developmental processes in C. elegans. Educations: BSc Medical Biology, VU University Amsterdam PhD in Biology, Utrecht University (2002) Research Interests: Boxem’s lab investigates how cell polarity complexes regulate epithelial tissue organization in C. elegans. Key topics include Crumbs polarity proteins, intermediate filaments, and signaling pathways controlling lumen formation and germline development. His work integrates genetic, biochemical, and imaging approaches to dissect molecular mechanisms underlying polarity establishment and maintenance. Grants & Awards: NWO Vici Grant (2016) - Supports long-term research NWO Vidi Grant (2010) - Established his independent lab ECHO Grant (2014) - European funding for collaborative projects Labs/Teams: His group is part of the Biodynamics and Biocomplexity research division. Collaborations span global networks, including the PolarNet consortium focusing on epithelial polarity.

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Richard J. Payneمشاهده پروفایل

استاد

University of SydneyAustralia

Professor Richard J. Payne (FAA, FRSC, FRSN, FRACI) is the NHMRC Investigator Leadership Fellow and Deputy Director of the ARC Centre of Excellence for Innovations in Peptide and Protein Science at The University of Sydney. He earned a BSc (1st class honours) from the University of Canterbury (2002) and a PhD from the University of Cambridge under the late Professor Chris Abell (2003-2007). After postdoctoral work at The Scripps Research Institute with Professor Chi-Huey Wong (2007-2008), he joined The University of Sydney as a Lecturer in Organic Chemistry. His research focuses on chemical synthesis of biomolecules to address biological and medical challenges, particularly in anti-infectives , vaccine development , and glycopeptide engineering . His lab pioneered diselenide-selenoester ligation and selenocysteine-based modification techniques for constructing complex peptides and proteins. Current projects target pathogens like Mycobacterium tuberculosis , Plasmodium falciparum , and SARS-CoV-2 through inhibitor design , anticoagulant discovery , and LYTAC development . His 15 most recent publications span 2025-2021 and reflect multidisciplinary work at the chemistry-biology interface , including antiviral peptides , glycoprotein assembly , and supramolecular anticoagulants . Notably, 2025 articles address C-terminal bromodomain inhibitors and on-demand reversible anticoagulants , while 2024 studies focus on PROTAC-based proteostasis disruption and mycobacterial chaperone targeting . Awards & Honors 2016 Malcolm McIntosh Prime Minister's Prize 2023 Australian Academy of Science Fellowship 2014 Le Fèvre Memorial Prize & Edgeworth David Medal 2018 A.J. Birch Medal He supervises 8 active research students and leads collaborations with The Payne Research Group , Charles Perkins Centre , and Sydney Nano Institute . His work aligns with the University of Sydney's research strengths in Molecules to Materials and Next Generation Therapeutics .

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Agata Gitlin-Domagalskaمشاهده پروفایل

استاد مدعو

University of GdańskPoland

Dr. Agata Gitlin-Domagalska serves as an Adjunct Professor at the Faculty of Chemistry, University of Gdańsk, where she leads research in the Department of Molecular Biochemistry and Laboratory of Bioorganic Chemistry. Her work bridges peptide chemistry and bioorganic drug design, focusing on innovative synthetic strategies and therapeutic applications. Academic Affiliation: Faculty of Chemistry, University of Gdańsk Department: Department of Molecular Biochemistry Laboratory: Laboratory of Bioorganic Chemistry Specializing in peptide synthesis and prodrug development , Dr. Gitlin-Domagalska investigates strategies to enhance oral bioavailability of charged peptides through lipophilic charge masking and non-covalent inhibition of serine proteases like matriptase and furin . Her research extends to antimicrobial peptide conjugates with dual therapeutic functions and Zika virus suppression via protease inhibition. Recent publications highlight her expertise in peptide splicing mechanisms , solid-phase synthesis optimization , and nanoparticle-based delivery . She has developed cyclic RGD prodrugs for targeted intestinal permeability and bicyclic furin inhibitors using combinatorial chemistry approaches. Her work contributes to antibiotic conjugates with leukemia-selective antifungal activity , neuroprotective humanin analogs , and vasopressin derivatives with expanded therapeutic potential. Current trends emphasize matriptase-selective inhibitors and earthworm-derived antimicrobial nanoparticles . Dr. Gitlin-Domagalska employs model membrane biosensing for drug-membrane interaction studies and has pioneered high-shear mixing techniques to improve amide bond formation efficiency in peptide synthesis processes.

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Gaurav Bhardwajمشاهده پروفایل

استادیار

University of WashingtonUnited States

Gaurav Bhardwaj is an Assistant Professor in the Department of Medicinal Chemistry at the University of Washington School of Pharmacy. He is affiliated with the Institute for Protein Design and leads the Bhardwaj Lab, focusing on computational and experimental tools for peptide-based therapeutics. Education: B.Tech in Biotechnology, GGS Indraprastha University, Delhi PhD in Integrative Biosciences, Pennsylvania State University Postdoctoral work at University of California, Davis and University of Washington, Seattle His research spans computational peptide design , structural biology , and drug discovery , targeting challenges in membrane permeability , oral bioavailability , and blood-brain barrier traversal . Current projects address antibiotic resistance, chronic pain, and neurodegenerative disorders. Recent publications highlight de novo macrocycle design , AlphaFold-based modeling , and cyclic peptide libraries , emphasizing computational methods and deep learning applications in drug design. His work integrates molecular biophysics and structural validation to enhance therapeutic efficacy. The Bhardwaj Lab promotes diversity and offers opportunities for undergraduate researchers, graduate students, postdoctoral fellows, and technicians, with a focus on interdisciplinary collaboration at the interface of chemistry, biology, and computational sciences.

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Gary Honمشاهده پروفایل

استادیار

Southwestern UniversityUnited States

Gary Hon is an Assistant Professor at the University of Texas Southwestern Medical Center (UTSW), jointly affiliated with the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Lyda Hill Department of Bioinformatics. His research lies at the intersection of genomics, epigenetics, and systems biology, with a focus on decoding the regulatory complexity of the human genome. His research interests include: Understanding the molecular basis of cell state for applications in regenerative medicine Elucidating how non-coding genetic variants contribute to development and disease Developing integrative techniques combining gene regulation, epigenetics, genome engineering, and single-cell genomics Advancing bioinformatics tools for analyzing chromatin and transcriptional regulation The trends across his recent publications reveal a strong emphasis on enhancer biology, epigenetic modifications (especially 5mC and 5hmC), single-cell functional genomics, and the development of novel molecular tools such as in situ chromatin capture and combinatorial perturbation assays. His work frequently leverages CRISPR-based technologies and high-throughput sequencing to dissect gene regulatory networks. Dr. Hon has received significant recognition for his innovative research, including: CPRIT Scholar NIH Director’s New Innovator Award Dr. Hon leads the Hon Lab, which actively develops and applies systems-level approaches to study genome regulation. His collaborative research involves advising graduate students and postdoctoral fellows, many of whom appear as co-authors on his publications. While specific grant details are not listed, his prestigious awards suggest substantial federal and state funding support for his high-impact, interdisciplinary research program.

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Jörg Rademannمشاهده پروفایل

استاد

Free University of BerlinGermany

Prof. Jörg Rademann is a Professor of Pharmaceutical/Medicinal Chemistry at Freie Universität Berlin since 2013. His research group specializes in fragment-based drug discovery and chemical biology , focusing on protein-ligand interactions for disease-related targets in cancer , Alzheimer's , tuberculosis , and viral infections (SARS, Zika, dengue, West Nile). The group integrates synthetic organic chemistry with bioanalytical , biochemical , and biophysical techniques , operating within the Department of Pharmacy at Freie Universität Berlin. B.Sc., M.Sc., and Ph.D. teaching: Inorganic and organic drug chemistry, pharmaceutical analysis Co-initiator of national ChemBioNet for chemical biology collaboration Developed Dynamic Ligation Screening (DLS) for fragment identification Research Interests include: Fragment-based ligand discovery for proteases, phosphatases, and protein-protein interactions Chemical probe development for structural and functional protein studies Solid-phase synthesis of peptides, peptidomimetics, and carbohydrates Multivalent constructs for enhanced binding and pharmacological properties Glycosaminoglycan (GAG) interactions in disease mechanisms Synthetic methodology for C-acylation and phosphorus/sulfur ylides Scientific Awards : Innovation Award in Medicinal Chemistry (GDCh/DPhG) (2002) Thieme Journal Award (2002) DFG Junior Research Group (2002) Landesgraduiertenförderung Baden-Württemberg (1994-97) Rutgers exchange fellowship (1990) Jugend forscht award (1986) Email : joerg.rademann@fu-berlin.de

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Sabrina Leslieمشاهده پروفایل

دانشیار

McGill UniversityCanada

Sabrina Leslie is an Associate Professor at the University of British Columbia (UBC) in the Michael Smith Laboratories and Department of Physics. Her research focuses on developing single-molecule microscopy tools to study biomolecular interactions in biologically relevant environments. She leads the Leslie Lab, which bridges physics, engineering, and biology to advance genetic medicines and vaccines. Education BSc (Honours Physics and Mathematics), University of British Columbia (2002) PhD in Optical and Atomic Physics, UC Berkeley (2008) Postdoctoral Fellowship, Harvard University (2009–2011) Research Interests Dr. Leslie pioneers the Convex Lens-induced Confinement (CLiC) imaging platform to visualize single molecules (DNA, RNA, proteins) and lipid nanoparticles in realistic cellular conditions. Her lab investigates nucleic acid dynamics, nanoparticle formulation for drug delivery, and single-cell analysis. Applications include improving mRNA vaccines and oligonucleotide therapeutics. Key Awards Member of Royal Society of Canada’s College of New Scholars (2020) NSERC Accelerator Award (2017–2020) Young Investigator Award, Canadian Biophysical Society (2019) Advising & Collaborations Her lab has trained over 50 students and postdocs. Collaborators include industry partners in biotechnology and nanotechnology. She co-founded ScopeSys to commercialize CLiC technology. Labs & Teams Based at UBC’s Michael Smith Laboratories, the Leslie Lab integrates interdisciplinary expertise. Ongoing projects include lipid nanoparticle characterization, single-molecule RNA studies, and CLiC-based diagnostics.

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Savas Tayمشاهده پروفایل

استاد

University of ChicagoUnited States

Savas Tay is a Professor of Molecular Engineering and Director of the Biological and Immuno Engineering Research Theme at the University of Chicago Pritzker School of Molecular Engineering. His research focuses on immune signaling, single-cell analysis, microfluidics, infectious diseases, and microbiome dynamics. He directs the Tay Lab and is affiliated with the Institute for Genomics and Systems Biology. He holds a PhD in Optical Sciences from the University of Arizona and conducted postdoctoral research at Stanford University. His research integrates experimental and computational approaches to study cellular communication networks, developing innovative technologies like microfluidic devices and proximity sequencing for high-throughput biological analysis. Key projects include studying herpesvirus replication mechanisms, SARS-CoV-2 pathogenesis, and drug repurposing strategies for viral infections. Education: PhD in Optical Sciences, University of Arizona Postdoctoral Research, Stanford University Bioengineering Prof. Tay has secured major grants including the ERC Starting Grant (2013) and Paul G. Allen Distinguished Investigator Award (2019). His work has been featured in Nature , Science , Cell , and media outlets like BBC and National Geographic. Awards: ERC Starting Grant (2013) Paul G. Allen Distinguished Investigator Award (2019) Labs/Teams: Tay Lab at UChicago Pritzker School of Molecular Engineering His recent work emphasizes high-throughput systems for analyzing cell signaling dynamics, including microfluidic platforms for studying metastasis and viral replication. Collaborations span engineering, immunology, and computational biology to address complex biological questions.

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Anne Conibearمشاهده پروفایل

پژوهشگر ارشد

University of QueenslandAustralia

Dr. Anne Conibear is an Honorary Research Fellow at the School of Biomedical Sciences , University of Queensland . Her research focuses on understanding the role of post-translational modifications (PTMs) in regulating protein structure and function using chemical synthesis , NMR spectroscopy , and protein semi-synthesis techniques. PhD in Chemistry/Biochemistry, University of Queensland Postdoctoral fellowship in Vienna Current UQ Development Fellowship for independent research Her work leverages chemical biology tools to study PTMs like phosphorylation, sulfation, and palmitoylation, providing atomic-resolution insights into how cells dynamically respond to environmental cues. Recent publications highlight structural analysis of PTMs in Hsp90 , HMGN1 , and CD44 , alongside methodological advances in isotope labeling and ligation techniques . She has also contributed to venom peptide research and antimicrobial mechanisms . 2022: Australian Peptide Display Facility (ARC LIEF) 2020-2021: UQ Early Career Researcher Grant 2019-2022: CIL Research Grant 2019-2021: UQ Development Fellowship Dr. Conibear collaborates with industry partners like Syntab Therapeutics and CIL Research Program , while supervising research projects such as the 2024 Master Philosophy thesis on µ-Conotoxins . She actively participates in scientific outreach, including INDICAR cancer research initiatives .

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Todd O. Yeatesمشاهده پروفایل

استاد پژوهشی

University of California, Los AngelesUnited States

Todd O. Yeates serves as a Research Professor in the Department of Chemistry and Biochemistry at the University of California, Los Angeles (UCLA), where he leads an active laboratory at the UCLA-DOE Institute for Genomics and Proteomics. His research program integrates molecular, structural, and computational biology to address fundamental questions in protein architecture and function, with significant implications for nanotechnology and bioenergy applications. Professor Yeates' primary research interests include: Bacterial Microcompartments : Pioneering structural studies of protein-based metabolic organelles in bacteria, providing the first 3D views of shell proteins and mechanistic insights into substrate transport across microcompartments Synthetic Protein Design : Developing innovative strategies for engineering self-assembling protein cages, arrays, and nanomaterials with applications in nanotechnology and biomaterials Computational Genomics : Creating genomic context methods to infer protein function, including the discovery of disulfide bonding as a key stability mechanism in thermophilic archaea Protein Crystallography : Solving theoretical challenges in macromolecular crystallization, including space group preferences and racemic crystallography approaches Analysis of recent publications (2023-2025) reveals a dominant research trajectory toward engineered protein scaffolds for cryo-EM applications, with significant focus on overcoming resolution barriers for small proteins. Concurrently, his group continues advancing bacterial microcompartment research while integrating computational tools like AlphaFold for hybrid structure determination. The work demonstrates a consistent theme of bridging fundamental structural biology with practical nanotechnology applications through rational protein design. No scientific awards were documented in the available source materials. The Yeates laboratory maintains an active research program supported by institutional resources at UCLA, though specific grant details and advisee information are not provided in the source text. The laboratory's extensive publication record and methodological innovations suggest robust research infrastructure and mentorship activities within the department. Based at the UCLA-DOE Institute, the laboratory employs interdisciplinary approaches combining X-ray crystallography, cryo-EM, computational modeling, and synthetic biology. Current priorities include refining imaging scaffolds for structural biology, exploring fundamental principles of protein self-assembly, and applying genomic context methods to discover novel biological mechanisms, with ongoing emphasis on translating basic research into nanotechnology applications.

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Michael G. Kharasمشاهده پروفایل

استاد

Cornell UniversityUnited States

Michael G. Kharas is a Professor at Weill Cornell Medicine's Pharmacology Graduate Program and an Investigator at Memorial Sloan-Kettering Cancer Center's Molecular Pharmacology Program. His research focuses on RNA regulators in hematopoietic stem cells and leukemia pathogenesis, particularly Musashi-2 and m6A methylation mechanisms. Dr. Kharas investigates how post-transcriptional RNA regulation affects symmetric/asymmetric cell division balance in HSCs and leukemic stem cells. His lab develops small molecules targeting RNA-binding proteins and studies metabolic adaptations in leukemia, including fructose utilization and serine synthesis pathways. Current projects explore RNA methylation, chromatin regulation, and screening approaches for self-renewal modulation. His publications reveal trends in RNA biology, epigenetics, and leukemic stem cell targeting. Key subfields include m6A-dependent differentiation control, Musashi-2 networks, metabolic dependencies, chromatin maintenance, and therapeutic strategies against RNA regulators. Leukemia and Lymphoma Society Career Development Award Alex Lemonade Stand Foundation ‘A’ Award American Society of Hematology Junior Faculty Scholar Award Kimmel and V-Scholar Awards Louis V. Gerstner Young Investigator Award As lab head, he mentors researchers and collaborates across institutions. His work spans basic HSC biology, translational leukemia models, and drug discovery platforms targeting RNA-protein interactions.

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