Gary Hon

Gary Hon is an Assistant Professor at the University of Texas Southwestern Medical Center (UTSW), jointly affiliated with the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Lyda Hill Department of Bioinformatics. His research lies at the intersection of genomics, epigenetics, and systems biology, with a focus on decoding the regulatory complexity of the human genome.

His research interests include:

• Understanding the molecular basis of cell state for applications in regenerative medicine
• Elucidating how non-coding genetic variants contribute to development and disease
• Developing integrative techniques combining gene regulation, epigenetics, genome engineering, and single-cell genomics
• Advancing bioinformatics tools for analyzing chromatin and transcriptional regulation

The trends across his recent publications reveal a strong emphasis on enhancer biology, epigenetic modifications (especially 5mC and 5hmC), single-cell functional genomics, and the development of novel molecular tools such as in situ chromatin capture and combinatorial perturbation assays. His work frequently leverages CRISPR-based technologies and high-throughput sequencing to dissect gene regulatory networks.

Dr. Hon has received significant recognition for his innovative research, including:

• CPRIT Scholar
• NIH Director’s New Innovator Award

Dr. Hon leads the Hon Lab, which actively develops and applies systems-level approaches to study genome regulation. His collaborative research involves advising graduate students and postdoctoral fellows, many of whom appear as co-authors on his publications. While specific grant details are not listed, his prestigious awards suggest substantial federal and state funding support for his high-impact, interdisciplinary research program.