معرفی
Dr. Agata Gitlin-Domagalska serves as an Adjunct Professor at the Faculty of Chemistry, University of Gdańsk, where she leads research in the Department of Molecular Biochemistry and Laboratory of Bioorganic Chemistry. Her work bridges peptide chemistry and bioorganic drug design, focusing on innovative synthetic strategies and therapeutic applications.
- Academic Affiliation: Faculty of Chemistry, University of Gdańsk
- Department: Department of Molecular Biochemistry
- Laboratory: Laboratory of Bioorganic Chemistry
Specializing in peptide synthesis and prodrug development, Dr. Gitlin-Domagalska investigates strategies to enhance oral bioavailability of charged peptides through lipophilic charge masking and non-covalent inhibition of serine proteases like matriptase and furin. Her research extends to antimicrobial peptide conjugates with dual therapeutic functions and Zika virus suppression via protease inhibition.
Recent publications highlight her expertise in peptide splicing mechanisms, solid-phase synthesis optimization, and nanoparticle-based delivery. She has developed cyclic RGD prodrugs for targeted intestinal permeability and bicyclic furin inhibitors using combinatorial chemistry approaches.
Her work contributes to antibiotic conjugates with leukemia-selective antifungal activity, neuroprotective humanin analogs, and vasopressin derivatives with expanded therapeutic potential. Current trends emphasize matriptase-selective inhibitors and earthworm-derived antimicrobial nanoparticles.
Dr. Gitlin-Domagalska employs model membrane biosensing for drug-membrane interaction studies and has pioneered high-shear mixing techniques to improve amide bond formation efficiency in peptide synthesis processes.