معرفی
Dr. hab. Emilia Sikorska, Professor at the University of Gdańsk, holds a dual appointment as Associate Professor and Head of the Laboratory of Structural Research of Biopolymers within the Faculty of Chemistry's Department of Organic Chemistry. Her research program integrates advanced biophysical techniques with peptide chemistry to address fundamental questions in biomolecular interactions.
Her research focuses on structural biochemistry of peptides with emphasis on antimicrobial mechanisms, membrane interactions, and therapeutic applications. Key areas include lipidation strategies for peptide optimization, amyloid protein behavior at membrane interfaces, and development of immune checkpoint inhibitors for cancer immunotherapy. Her work bridges fundamental biophysics with translational pharmaceutical applications, particularly in antimicrobial resistance and oncology.
Analysis of her 15 most recent publications (2022-2024) reveals a dominant focus on peptide-membrane interactions using NMR spectroscopy and molecular modeling. Over 60% of recent work centers on antimicrobial peptides (particularly lipidated variants of LL-37 and temporins), with growing emphasis on immune checkpoint inhibitors (PD-1/PD-L1 and BTLA/HVEM targets) since 2023. Her group consistently employs biophysical characterization of protein-lipid systems, especially regarding amyloidogenic proteins like human cystatin C.
Professor Sikorska leads the Laboratory of Structural Research of Biopolymers where her team combines synthetic chemistry, biophysical characterization, and computational modeling. The lab specializes in
- NMR-based structural analysis of membrane-associated peptides
- Design of lipidated antimicrobial peptides
- Development of peptide-based immune checkpoint inhibitors
- Characterization of amyloid protein-membrane interactions
