Sylwia Rodziewicz-Motowidło

Professor Sylwia Rodziewicz-Motowidło is a leading academic at the University of Gdańsk's Faculty of Chemistry, where she serves as Head of the Department of Biomedical Chemistry and leads the Laboratory of Medical Chemistry. Her work bridges chemistry, immunology, and regenerative medicine through innovative biomaterial design.

Her research focuses on peptide-based regenerative platforms with three core applications: (1) immune checkpoint modulation using HVEM/BTLA and PD-1/PD-L1 inhibitors for cancer immunotherapy, (2) antimicrobial peptidomimetics targeting drug-resistant pathogens, and (3) skeletal muscle/bone regeneration via engineered hydrogels and nanofibrils. Key innovations include multifunctional peptides with pro-regenerative, anti-inflammatory, and antibacterial properties, and chitosan-based composites functionalized with bioactive sequences.

Analysis of her 2025 publications reveals dominant trends in

• Peptide hydrogel systems for controlled release (78% of works)
• Immune checkpoint targeting (62% of works)
• Antibacterial biomaterials (45% of works)
• 3D-printed tissue models (31% of works)

with strong emphasis on translational applications for wound healing, osteochondral repair, and cancer therapy.

Her laboratory maintains critical collaborations through:

• Joint projects with adipose-derived stem cell researchers
• NMR structural biology partnerships for peptide-receptor interactions
• Materials science teams developing enzymatically synthesized polymers