جستجوی استاد راهنمای دانشگاهی

Nick Gilbertمشاهده پروفایل

استاد

• Chromatin Biology
• DNA Topology
• Genome Stability
• +۴ مورد دیگر

Nick Gilbert is a Professor at the Institute of Genetics and Cancer , University of Edinburgh , where he holds a Personal Chair of Chromatin Biology . He leads research projects at the MRC Human Genetics Unit , focusing on chromatin structure, DNA topology, and genome stability. Academic Qualifications: PhD in Chromatin Biology, University of Edinburgh (2000); BSc Biochemistry (1st Class), University of Edinburgh (1995) Research Interests: His work investigates how chromatin folding regulates gene transcription, DNA replication, and repair. Key areas include DNA supercoiling, common fragile sites in cancer genomes, and development of novel chromatin structure probes through collaborations with chemistry/engineering departments. Publication Trends: Recent studies focus on chromatin phase separation, 3D genome architecture, and the interplay between DNA topology and transcriptional noise. Collaborative work spans molecular biology, biophysics, and computational modeling. Scientific Awards: Wellcome Trust Career Development Fellowship (2006-2010) MRC Senior Fellowship (2012-present) Key Responsibilities: Director of Graduate Research and Training, Institute of Genetics and Cancer Principal Investigator in multiple projects including SARS-CoV-2 antibody development and mitotic chromosome folding

Martin Taylorمشاهده پروفایل

استاد

• Mutagenesis
• Genomics
• Bioinformatics
• +۱۱ مورد دیگر

Professor Martin Taylor is a Group Leader and Biomedical Genomics Section Head at the MRC Human Genetics Unit within the Institute of Genetics and Cancer at the University of Edinburgh. His research focuses on understanding mutational processes, interpreting genetic variation, and studying the evolution of gene regulation. Key Collaborations : Yale University, University of Trieste, The Jackson Laboratory, Institute for Basic Science (South Korea), IRB Barcelona, School of Mathematics (Edinburgh), DKFZ Heidelberg. Education : PhD from the University of Edinburgh (2002), BSc in Genetics from the University of Liverpool (1997). His work bridges population genetics, evolutionary genomics, and functional genomics to decode how mutations arise, their biomedical impacts (cancer, inherited diseases), and their role in evolutionary adaptation. He employs computational genomics, high-throughput sequencing, and molecular phylogenetics to analyze mutation patterns and gene regulation. Recent Trends : Articles highlight DNA damage repair dynamics, transcription-coupled mutagenesis, single-mitosis mutagenesis analysis, and regulatory element mutation hotspots. Keywords span biomedical genomics, evolutionary pressures, and computational techniques. Responsibilities : Served as Honorary Treasurer of The Genetics Society (2017-2021) and member of the Academic Steering Group for the Precision Medicine Doctoral Training Programme.

Carl Nathanمشاهده پروفایل

استاد

• Host-Pathogen Interactions
• Macrophage Biology
• Mycobacterium Tuberculosis
• +۶ مورد دیگر

Carl Nathan is a Professor of Medicine and Microbiology & Immunology at Weill Cornell Medical College, where he serves as Chair of the Department of Microbiology and Immunology. His lab at the Graduate School of Medical Sciences focuses on host-pathogen interactions, particularly with Mycobacterium tuberculosis (Mtb), and extends to drug development for TB, malaria, and inflammatory disorders. He has held prominent leadership roles, including founding director of the Tri-Institutional MD-PhD Program, acting dean of Weill Cornell Medical College, and dean of the Graduate School. Education: Harvard College, Harvard Medical School, internal medicine and oncology training at Massachusetts General Hospital, National Cancer Institute, and Yale. Collaborations: Sabine Ehrt, Dirk Schnappinger, Kyu Rhee (Weill Cornell), Jeremy Rock (Rockefeller), Michael Glickman (MSKCC), and the Gates Foundation’s TB Drug Accelerator. Research Interests: Nathan’s work spans innate immunity, macrophage biology, and Mtb’s mechanisms of survival in non-replicating states. His lab investigates enzymes like lipoamide dehydrogenase and phosphopantetheinyl transferase as drug targets, alongside proteostasis pathways in bacteria and immune cells. Projects emphasize interdisciplinary approaches, integrating immunology, biochemistry, and medicinal chemistry. Scientific Contributions: His lab pioneered the discovery of Mtb proteasome inhibitors and demonstrated interferon-gamma’s role in human macrophage activation. Key findings include cytokine-mediated macrophage deactivation, ROI/RNI effector systems, and Mtb’s UvrDNA repair pathways. Awards: National Academy of Sciences, National Academy of Medicine, Koch Prize, Sanofi-Institut Pasteur Senior International Scientist Award. Editorial Roles: Co-chair of the Journal of Experimental Medicine , board member of PNAS and Science Translational Medicine . Lab & Team: The Nathan Lab collaborates with multiple institutions and hosts trainees from immunology, microbiology, and chemistry backgrounds. The Global Health Floor in the Belfer Building includes labs of Sabine Ehrt, Dirk Schnappinger, and others, fostering a multi-disciplinary environment.

• Epigenetics
• Chromatin Structure and Function
• RNA Biology
• +۴ مورد دیگر

Oliver J Rando is a Professor in the Department of Biochemistry and Molecular Biotechnology at UMass Chan Medical School. His research focuses on epigenetic inheritance , chromatin structure , and genomic regulation . He holds an Endowed Chair in Biochemistry and Molecular Biotechnology and leads studies using genomic tools like DNA microarrays and high-throughput sequencing to analyze chromatin dynamics. His work explores histone modification patterns , nucleosome replacement mechanisms , and non-coding RNA roles in epigenetic transmission. Current projects investigate chromatin's role in yeast stress responses , stem cell pluripotency , and sperm RNA contributions to embryonic development. Key research questions include: How chromatin motifs are established by genomic sequences Mechanisms of replication-independent histone exchange Function of histone modification crosstalk Chromatin's role in filtering cellular signals Epigenetic packaging during gametogenesis

Zeynep Ozsoyمشاهده پروفایل

دانشیار

• Molecular Biology
• Genetics
• DNA Repair and Recombination
• +۷ مورد دیگر

Zeynep Ozsoy is an Associate Professor in the Department of Biology at Colorado Mesa University, where she contributes to both teaching and research. Her academic journey includes a PhD in Genetics and Molecular Biology from the University of North Carolina at Chapel Hill and postdoctoral training at the University of California - Davis. Her educational background includes: BS in Chemical Engineering, Bogazici University, Turkey PhD in Genetics and Molecular Biology, University of North Carolina at Chapel Hill (2002) Zeynep Ozsoy's research spans molecular biology and ecological genetics. Initially, her work focused on helicases—proteins involved in DNA strand separation—and their roles in DNA replication, repair, and recombination. Mutations in these proteins are linked to cancer predisposition and premature aging. Since joining Colorado Mesa University, her research has evolved to address regionally significant ecological issues, particularly the study of non-native insects that feed on tamarisk, an invasive plant dominating riparian zones in the western United States. Using DNA sequencing techniques, she and her students analyze species differentiation, population structure, and geographic origins of these insects. Although no specific publications are listed in the provided text, her ongoing research suggests active contributions in ecological genetics and molecular ecology, particularly through undergraduate-involved projects focusing on DNA barcoding and environmental analysis. She has not received any explicitly mentioned scientific awards. Zeynep Ozsoy is deeply committed to undergraduate education and mentoring. She teaches a wide array of courses, from introductory biology for majors and non-majors to advanced topics such as genetics, molecular cloning, and protein chemistry. She emphasizes making biological concepts relevant and engaging for students. Since 2010, she has mentored numerous undergraduates in structured research settings, guiding them in molecular techniques and scientific inquiry. While no grants are explicitly mentioned, her sustained research and student mentoring suggest involvement in funded or institutionally supported programs. Her laboratory work involves molecular analysis of insect DNA, likely conducted in collaboration with students at the university’s science facilities. She integrates research and teaching, creating a dynamic learning environment focused on real-world ecological and molecular problems.

• Cancer Immunology
• Tumor Microenvironment
• MicroRNA Diagnostics
• +۴ مورد دیگر

Kathrin Tyryshkin serves as an Adjunct Assistant Professor at Queen's University, holding a Ph.D. earned in 2014. Her academic affiliation centers within medical research domains though specific school or departmental structure isn't explicitly documented in available materials. Her research spans Cancer Immunology , Tumor Microenvironment , and MicroRNA Diagnostics , with significant focus on bladder cancer mechanisms, macrophage-T cell interactions, and liquid biopsy development. Recent work demonstrates expertise in machine learning applications for molecular classification and STING pathway immunotherapies. Publications reveal consistent investigation into sex differences in cancer models and epigenetic regulation of immune responses. Analysis of her 15 most recent publications (2022-2025) shows dominant themes in Macrophage-mediated tumor immunity (4 papers) MicroRNA-based cancer diagnostics (3 papers) Sex/age-related immune variations in bladder cancer (3 papers) STING pathway therapeutics (2 papers) Machine learning for molecular classification (2 papers) indicating a trajectory toward computational oncology integrated with wet-lab immunology. Her advising activities and grant funding aren't documented in available materials. No scientific awards or fellowships are mentioned in the provided texts.

Kristin Dittenhafer-Reedمشاهده پروفایل

دانشیار

• Biochemistry
• Mitochondrial function
• Molecular biology
• +۵ مورد دیگر

Dr. Kristin Dittenhafer-Reed is an Associate Professor of Chemistry at Hope College, where she joined the faculty in 2016. Her research and teaching are focused in biochemistry, specifically studying the biochemical mechanisms that control mitochondrial function. Dr. Dittenhafer-Reed earned her B.S. in Chemistry from Hope College (2009), followed by a Ph.D. in Biochemistry from the University of Wisconsin-Madison (2014), and completed postdoctoral training at the Center for Cancer and Cell Biology, Van Andel Research Institute (2014-2016). Her research focuses on understanding fundamental biochemical processes occurring in mitochondria, often considered the powerhouse of the cell. The Dittenhafer-Reed lab employs biochemistry, molecular biology and cell biology approaches to explore how processes within mitochondria work in a healthy context to enable avenues for the treatment of conditions caused when mitochondria are not functioning properly. Specifically, her lab investigates how the expression of mitochondrial DNA is regulated and how the mitochondria and nucleus communicate to meet varying energetic demands of a cell. Understanding mitochondrial function in human health and disease Mechanisms of control of mitochondrial DNA transcription Regulation of mitochondrial gene expression Post-translational modifications in mitochondrial regulation Analysis of Dr. Dittenhafer-Reed's publications reveals a consistent focus on mitochondrial biochemistry, particularly the role of sirtuins (especially SIRT3) in regulating mitochondrial metabolism through protein deacetylation. Her work bridges fundamental biochemical mechanisms with implications for metabolic diseases, aging, and neurological disorders. The research demonstrates increasing sophistication in techniques, moving from basic enzymology to systems-level approaches including proteomics and multi-tissue metabolic coordination. Dr. Dittenhafer-Reed has received significant recognition for her work: National Science Foundation CAREER Award (2022) Schaap Research Fellow (2020-2025) National Science Foundation Major Research Instrumentation Grant (2020-2023) Hope College 10 under 10 Alumni Award (2019) Towsley Research Scholar (2019) As an active researcher at an undergraduate institution, Dr. Dittenhafer-Reed maintains a robust research program that integrates undergraduate students into meaningful scientific discovery. Her laboratory has secured competitive external funding from the National Science Foundation and other sources, enabling state-of-the-art research while providing valuable training opportunities for students. Her work on mitochondrial transcription regulation represents a significant contribution to understanding how cells maintain energy homeostasis. The Dittenhafer-Reed Research Group operates within the Department of Chemistry at Hope College, utilizing biochemical, molecular, and cell biological approaches to investigate mitochondrial function. The lab's work on mitochondrial nucleoid proteins and transcriptional regulation has positioned it at the forefront of understanding how mitochondrial gene expression is controlled in response to cellular energy demands.

Eric T. Koolمشاهده پروفایل

استاد

• Organic Chemistry
• Chemical Biology
• Biophysics
• +۴ مورد دیگر

Eric T. Kool is a Professor in the Department of Chemistry at Stanford University , where he holds the George and Hilda Daubert Professorship. He is affiliated with interdisciplinary programs including Bio-X , Biophysics , Stanford Cancer Institute , and the Sarafan ChEM-H initiative. His research spans organic chemistry , chemical biology , and biophysics , focusing on designing molecular tools for nucleic acid analysis and manipulation. Key contributions include nonpolar nucleoside isosteres , rolling circle amplification , and fluorescent DNA/RNA probes . His work has enabled DNA replication studies without hydrogen bonding and RNA structure mapping in cellular environments. Recent publications emphasize RNA 2'-OH functionalization , oxidative DNA repair , and CRISPR-Cas9 regulation . His innovations in acylation chemistry and nucleic acid-based data storage highlight his interdisciplinary approach. Scientific Awards : Dreyfus Foundation Teacher-Scholar Award Alfred P. Sloan Foundation Fellowship ACS Arthur C. Cope Scholar Award ACS Pfizer Award Murray Goodman Prize ACS Breslow Award Fellow of AAAS Member of the American Academy of Arts and Sciences Kool has trained over 120 graduate students and postdoctoral researchers , with more than 35 securing academic positions. His lab’s 45 patents underpin five biotechnology companies, and he has delivered over 250 invited lectures globally. He is also an award-winning educator, twice receiving the Humanities & Sciences Dean's Award for Distinguished Teaching at Stanford for his sophomore organic chemistry courses.

Daitoku Sakamuroمشاهده پروفایل

دانشیار

• Cancer Biology
• Molecular Genetics
• Biochemistry
• +۲ مورد دیگر

Daitoku Sakamuro is an Associate Professor at the Medical College of Georgia , Augusta University, affiliated with the Department of Biochemistry and Molecular Biology . His research focuses on cancer cell resistance to genotoxic stresses and strategies to enhance chemotherapy efficacy. Ph.D. in Physiology (Osaka University, 1991) Postdoc in Molecular Genetics (Wistar Institute) Research interests include: Mechanisms of chemoresistance in cancer cells Role of tumor suppressors (BIN1, MYC, PARP1) in DNA repair Synthetic lethality approaches for cancer therapy Transcriptional regulation of apoptosis via E2F1 Recent publications highlight breakthroughs in: Overcoming glioblastoma resistance via SAMHD1 depletion Re-sensitizing platinum-refractory cancers using PARP/ATM inhibitors Molecular interplay between BIN1, MYC, and PARP1 in chemoresistance Scientific contributions recognized through awards such as: 2011 LCRC Special Award 2011 Best Grant Proposal Award 2011 Biotech Humanitarian Award nominee Active in academic service as a reviewer for journals including Cell Biology , BBA (Gene Structure & Expression) , and Cancer Research . Teaches courses in oncology, biochemistry, and medical sciences.

Nimrat Chatterjeeمشاهده پروفایل

استادیار

• Genome Instability Mechanisms
• Cancer Biology
• DNA Repair
• +۳ مورد دیگر

Nimrat Chatterjee is an Assistant Professor at the University of Vermont's Robert Larner, M.D. College of Medicine, Department of Microbiology and Molecular Genetics. Her research focuses on genome instability mechanisms in cancer and host-virus interactions, particularly studying the REV1 protein's role in DNA damage response and therapeutic targeting. Ph.D., Baylor College of Medicine (2014) Postdoctoral training at M.D. Anderson Cancer Center (2015) and MIT (2020) Kauffman Teaching Certification (2018) Her research explores how environmental stress affects DNA repair, mutagenesis pathways, and cancer therapy resistance. Recent work examines SARS-CoV-2's impact on genomic stability and small-molecule inhibitors targeting translesion synthesis. Publications demonstrate interdisciplinary approaches combining molecular biology, biochemical assays, and pharmacological interventions. The lab employs techniques like tissue culturing, DNA damage assays, PCR, western blotting, and microscopy. Key collaborations include Ragon Institute BSL3 training (2022) and expertise in bone marrow failure disorders (Shwachman-Diamond/Diamond-Blackfan anemias). Students: Aarzoo Grover, Sombodhi Bhattacharya, Brailey Buntin, Jessica Reich, Joshua Victor Email: nimrat.chatterjee@med.uvm.edu

• Biochemistry
• Cancer Biology
• Neuroscience
• +۶ مورد دیگر

Chandravanu Dash is a Professor and Interim Chair of the Department of Microbiology, Immunology and Physiology at Meharry Medical College, School of Medicine. He serves as Executive Director of the Center for AIDS Health Disparities Research, with affiliations to the Center for Molecular & Behavioral Neuroscience. His research focuses on the intersection of HIV, substance abuse, and neurodegenerative diseases. Education: PhD, MSc His research explores: HIV-1 integration mechanisms Role of miRNAs in viral replication Neurodegenerative effects of HIV and substance abuse Viral capsid-host interactions Key trends in his publications include: HIV-1 integration and capsid biology Neuroscience applications in substance abuse Molecular mechanisms of co-infections Current research projects funded by NIH Grants R01AI136740, U54 MD007586, R01DA042348, and R24DA021471 address: Role of viral capsid in HIV-1 integration Cellular miRNA regulation of HIV-1 HIV/cocaine interactions in semen exosomes Methamphetamine's impact on HIV research He leads the Center for AIDS Health Disparities Research , emphasizing precision HIV care and community engagement.

David B. Lewisمشاهده پروفایل

استاد

• Immunology
• Pediatric Allergy and Immunology
• Genetic Disorders
• +۶ مورد دیگر

David B. Lewis is a Professor at Stanford University School of Medicine in the Department of Pediatrics, Division of Allergy, Immunology & Rheumatology. He holds the Naddisy Foundation Professorship in Pediatric Food Allergy, Immunology, and Asthma and directs the Jeffrey Modell Primary Immunodeficiency Center at Stanford. Stanford University School of Medicine B.S. in Biology, Yale University His research focuses on human T-cell development, primary immunodeficiencies like Schimke Immuno-Osseous Dysplasia (SIOD), and CRISPR-based therapies for immune disorders and viral infections. Key projects include: CRISPR Cas13d RNAse for viral RNA degradation T-cell developmental transcriptional programs in neonates SMARCAL1 gene function in telomere maintenance Novel vaccine adjuvant development Recent publications highlight CRISPR antiviral strategies against coronaviruses, iNKT cell maturation, and clinical transplantation approaches for SIOD patients. The lab collaborates with Stanley Qi's CRISPR group and Matthew Porteus' genome editing laboratory. Scientific recognition includes two Henry J. Kaiser Awards for Excellence in Preclinical Teaching. He leads multidisciplinary programs at Stanford's Maternal & Child Health Research Institute and Cancer Institute. Current clinical focus: Primary Immunodeficiency disorders Teaching: Graduate and clinical immunology courses Labs: Core facility in Department of Pediatrics

Cristina Iftodeمشاهده پروفایل

استاد

• Stem cell differentiation
• Replication and transcription of DNA viruses
• Regenerative medicine
• +۲ مورد دیگر

Cristina Iftode is a Professor in the Department of Biological & Biomedical Sciences at Rowan University's College of Science & Mathematics. Her research spans stem cell differentiation, DNA virus replication, and biomaterials for regenerative medicine. BS in Biochemistry (Cell Biology and Genetics) from University of Bucharest, Romania PhD in Cellular and Molecular Biology from New York University Medical Center Postdoctoral work in Molecular Virology at Princeton University Her primary research focuses on: Adipose-derived mesenchymal stem cell (AD-MSC) differentiation for intervertebral disc regeneration using tissue engineering approaches with injectable scaffolds Protein-based biomaterials for medical applications in collaboration with Physics & Astronomy Secondary plant metabolite extraction for medicinal and cosmetological uses Key publication themes include biomaterials development , hydrogel engineering , stem cell applications , and plant-based metabolites . Scientific Awards : Rowan University Collaborative Innovation in Tissue Engineering Award (2016) Professional Memberships : American Society for Cell Biology American Society for Microbiology American Society for Virology

• Medical Microbiology
• Antimicrobial Agents
• Drug Development
• +۶ مورد دیگر

Fatma Kaynak Onurdağ is a Professor at Trakya University Faculty of Pharmacy, Department of Pharmaceutical Microbiology, since 2018. She previously served at Gazi University Faculty of Pharmacy from 2002 to 2013. Her academic journey includes a PhD in Medical Microbiology (2005) from Gazi University. PhD in Medical Microbiology (2005) Master's in Medical Microbiology (2002) BSc in Biology (2000) Her research focuses on antimicrobial agent development , drug resistance mechanisms , and pharmaceutical microbiology . She has extensively studied benzoxazole derivatives , efflux pump inhibition , and biofilm dynamics . Her work bridges synthetic chemistry , molecular modeling , and clinical microbiology , with applications in systemic fungal infections and nosocomial pathogens . Recent publications (2018–2021) highlight trends in drug design for resistant pathogens like Acinetobacter baumannii and Staphylococcus aureus , using molecular docking , QSAR analysis , and liposomal formulations . Her group explores antimicrobial synergy with adjuvants like N-acetylcysteine. Best 3rd Poster Award, XXXII. Turkish Microbiology Congress (2006) She has led and participated in over 15 research projects, including TUBITAK-funded studies on antimicrobial agents and efflux pump inhibitors . Her administrative roles include Head of Basic Pharmaceutical Sciences Department (2023–present) and Deputy Director of Gazi University Institute of Health Sciences (2016–2022).

Christopher Michael Grochowskiمشاهده پروفایل

استادیار

• Human Genetics
• Structural Variant Analysis
• Neurodevelopmental Disorders
• +۴ مورد دیگر

Christopher Michael Grochowski, PhD, is an Assistant Professor at Baylor College of Medicine's Human Genome Sequencing Center (HGSC) in Houston, Texas. His work focuses on structural variant analysis in human genetics, particularly mechanisms underlying genomic disorders and neurodevelopmental conditions. BS in Biology & Religious Studies (2011), American University MS in Biomedical Science (2014), Rowan University PhD in Human Genetics (2022), Baylor College of Medicine Dr. Grochowski's research integrates long-read sequencing, multiomics, and computational methods to resolve complex genomic rearrangements, including MECP2 duplication syndrome, chromosomal inversions, and biallelic variants in genes like SLC4A10. His work emphasizes genotype-phenotype correlations and developing tools such as HMZDupFinder for variant detection. His recent publications (2024-2025) span structural variant mechanisms, reference genome challenges, and applications to neurodevelopmental disorders. Key trends include analysis of ectopic recombination, allelic heterogeneity, and population-specific genomic architecture. While no formal awards are listed, his contributions to computational methods and disease mechanisms are prominent. Dr. Grochowski collaborates with clinical and research teams to advance genomic diagnostics and therapeutic approaches, with future work targeting personalized medicine applications and resolving reference genome gaps.