جستجوی استاد راهنمای دانشگاهی

Sophie Lanone is a researcher and team leader of the Genetic-environment Interactions in COPD, Cystic Fibrosis, and Respiratory Pathologies (GEIC2O) team at the Mondor Institute of Biomedical Research (IMRB), affiliated with Université Paris-Est Créteil. Her work focuses on understanding the interplay between genetic and environmental factors in respiratory diseases, particularly COPD, cystic fibrosis, and surfactant-related pathologies. She leads a multidisciplinary team of clinicians and scientists investigating molecular mechanisms, inflammation resolution, and environmental impacts on pulmonary health. Key research themes include the molecular basis of cigarette smoke-induced COPD, genetic and cellular aspects of cystic fibrosis, and the role of specialized pro-resolving mediators in disease. Funding sources include EU programs (e.g., H2020 REMEDIA), ANR, and patient associations like Vaincre la Mucoviscidose. Recent advances include identifying lipid mediator defects in CF patients and demonstrating resolvin E1’s efficacy in correcting ciliary dysfunction. Team members have received awards, such as Khadeeja Adam Sy’s 2024 prize for active participation in CF research. Collaborations span in vitro/ex vivo models, patient cohort studies, and translational approaches toward personalized therapies. The team also explores environmental exposures (e.g., asbestos, nanoparticles) and their long-term respiratory health impacts.

• Genetic-Environment Interactions
• Cystic Fibrosis
• Respiratory Pathologies
• +۳ مورد دیگر

R.-A. Lavergne serves as an Assistant Professor and Hospital Practitioner at the University of Nantes, specializing in medical mycology with a focus on antifungal resistance mechanisms and environmental drivers of resistance. Their work bridges clinical practice and environmental microbiology through the One Health framework, investigating azole resistance in Aspergillus species and diagnostic innovations for fungal pathogens. Educational background includes a PhD on Aspergillus fumigatus resistance mechanisms defended at the University of Nantes in July 2018. Advanced training encompasses molecular diagnostics, antifungal susceptibility testing, and environmental sampling methodologies. Research centers on azole resistance evolution in Aspergillus , particularly TR-mutation pathways (TR34/L98H, TR46/Y121F/T289A), and agricultural fungicide impacts on clinical resistance. Key projects examine sterol biosynthesis alterations under drug pressure, environmental reservoirs in crop fields, and novel antifungal compounds like CIN-102. Diagnostic work includes Mucorales DNA detection in serum and MALDI-TOF optimization for cryptic Candida species. Recent publications reveal three dominant research axes: (1) Environmental origins of resistance (Colombian crop studies); (2) Molecular mechanisms of TR-mutation-mediated resistance; (3) Diagnostic innovations for mucormycosis and rare fungal pathogens. This integrated approach spans genomic, biochemical, and epidemiological methodologies. Active involvement in national research initiatives includes ANR TEILEISH, ANR AspergillusOne-Health, ANR Chair INSERM COMBINE, ANR OTARI, ANR AspergIs, ANR FungiSol, and ANR INTERLUDE. Collaborative networks span French cystic fibrosis centers, transplant units, and international agricultural health projects. As part of the Department of Medical Mycology and Parasitology, Dr. Lavergne contributes to clinical diagnostics for immunocompromised patients while leading environmental resistance surveillance. The research group maintains active collaborations with Prof. Le Pape's team on resistance mechanisms and Prof. Morio's diagnostics unit.

• Antifungal Resistance
• Medical Mycology
• Aspergillus fumigatus
• +۳ مورد دیگر

Véronique Stoven is a Professor at Mines Paris Tech and holds a research position within the Curie Institute as a Research Teacher. She leads work in the Cancer Systems Biology team (Unit: Computational Oncology U1331). Research Focus: Computational biology, protein-ligand interactions, and machine learning for drug candidate design. Applies systems biology approaches to study triple-negative breast tumors (TNBC) and cystic fibrosis in respiratory epithelial cells. Publications highlight trends in: Omics data integration for disease modeling (2024) Benchmarking machine learning techniques in molecular informatics (2023) SLC transporter analysis in cystic fibrosis research (2022)

• Computational Biology
• Machine Learning
• Protein-Ligand Interactions
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Katy JEANNOT is a Clinical Professor affiliated with the University of Bourgogne Franche-Comté and the CHU Besançon Hospital. Her research focuses on antibiotic resistance mechanisms in Pseudomonas aeruginosa and Acinetobacter baumannii, including efflux pumps, genetic determinants of resistance, and adaptations to antimicrobial peptides. She investigates clinical isolates from cystic fibrosis patients, analyzing their phenotypic and genotypic evolution. Her work spans epidemiological studies of antibiotic resistance, such as the 2023–24 Mycoplasma pneumoniae outbreak in France, and evaluates new antimicrobial agents like cefiderocol and murepavadin. She collaborates on projects involving rapid diagnostic tests for carbapenemases and genomic studies of high-risk bacterial clones. Key research areas include multidrug resistance mechanisms, envelope stress responses, and the development of novel antimicrobial strategies. She has contributed to clinical trials assessing compassionate use of antibiotics and has authored/co-authored over 80 peer-reviewed articles, emphasizing global antibiotic resistance surveillance and molecular epidemiology. Affiliations: CHU Besançon, UMR 6249 Chrono-Environnement, University of Bourgogne Franche-Comté Labs/Teams: Involved in multidisciplinary teams studying microbial pathogenesis and antimicrobial resistance.

• Bacteriology
• Molecular Biology
• Antibiotic Resistance
• +۷ مورد دیگر

Daniela Rotin is a Professor at the University of Toronto, affiliated with the Temerty Faculty of Medicine, and holds appointments in the Department of Biochemistry and the Department of Physiology. She is a senior scientist in the Cell Biology Program at The Hospital for Sick Children (SickKids) in Toronto, where her research focuses on ubiquitin ligases, particularly the Nedd4 family, and their roles in cellular regulation, epithelial physiology, and disease. Her research interests include cell biology, physiology, ubiquitylation, endocytosis, cystic fibrosis, autophagy, epithelial biology, ion channel regulation, and protein trafficking. She has made significant contributions to understanding the regulation of the epithelial sodium channel (ENaC) by ubiquitin ligases such as Nedd4-2, and the discovery of primate-specific splice isoforms like Nedd4-1(NE), which regulates autophagy in response to nutrient availability. Her recent publications highlight a strong trend in molecular mechanisms of ubiquitin ligase activity, stress signaling (e.g., p38-MAPK, WNK kinases), and cellular responses to osmolarity and ion imbalances. Her work integrates cell biology, biochemistry, and physiology to uncover novel regulatory pathways in health and disease, with implications for cystic fibrosis, hypertension, epilepsy, and cancer. Dr. Rotin has not been noted to have received specific scientific awards in the provided text, but her high citation metrics (h-index 33, i10-index 48, over 4,700 citations) reflect significant scholarly impact. She collaborates extensively with researchers at SickKids, the University of Toronto, and international institutions. She advises a research team studying ubiquitin-mediated proteostasis, and her lab has secured funding for projects on ENaC regulation, autophagy, and organoid models of epithelial disease. She leads a research group that utilizes advanced techniques including CRISPR-Cas9, proteomics, and iPSC-derived organoids. Dr. Rotin is actively involved in research through her laboratory at SickKids, where she investigates the molecular basis of protein trafficking, cellular stress responses, and the pathophysiology of epithelial disorders. Her team includes postdoctoral fellows, graduate students, and research associates working on ubiquitin ligases and their roles in development and disease.

• Cell Biology
• Physiology
• Ubiquitylation
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Christophe D'Enfert is a Professor at the Institut Pasteur in Paris and Head of the Fungal Biology and Pathogenicity Unit, which is part of the Department of Mycology. He also holds affiliations with the Department of Genomes and Genetics at Institut Pasteur and the Department of Microbiology and Food Chain at INRAE (USC 2019). His research focuses on the molecular mechanisms of fungal pathogenesis, particularly in Candida albicans , a leading cause of hospital-acquired fungal infections. His research interests include medical mycology , fungal pathogenesis , host-pathogen interactions , microbial genomics , biofilm biology , and antifungal resistance . He investigates three main areas: genomic diversity in C. albicans , colonization of surfaces by biofilms, and regulation of morphogenesis. His work aims to improve the clinical management of invasive candidiasis through better understanding of fungal virulence and host interactions. The recent articles published by his team reflect a strong emphasis on functional and population genomics, transcriptional regulation, fungal cell wall biology, host-microbiota interactions, and the molecular basis of fungal virulence. These studies frequently involve collaborations across Europe and utilize cutting-edge techniques such as RNAseq, whole-genome sequencing, and high-throughput screening. Coordinator of the FunHoMic Marie Skłodowska-Curie Innovative Training Network Recipient of EU funding (Marie Curie ITN) Recipient of Swiss National Science Foundation funding (Sinergia program) Christophe D'Enfert supervises several PhD students and postdoctoral researchers. He leads multiple funded research projects including studies on C. albicans genomic diversity, biofilm formation, morphogenesis regulation, and the fungus-host-microbiota interplay. He is also involved in teaching, notably the Pasteur Course on Molecular Genetics and Epigenetics and the Medical Mycology MOOC. His laboratory benefits from advanced equipment such as plate readers, colony counters, flow cytometers, and robotic colony pickers.

• Medical Mycology
• Fungal Pathogenesis
• Host-Pathogen Interactions
• +۹ مورد دیگر

Virginie Loizeau is a Research Fellow at the French School of Public Health (EHESP), affiliated with the Department of Human and Social Sciences and the UMR 6051 ARENES research unit. She holds a Doctorate in Sociology (2022), a Master of Research in Planning and Urbanism (2015), and is a licensed architect (DPLG, 2004). Her research bridges social/medical sciences and spatial planning, focusing on health promotion through living environment design. Key areas include environmental health interactions, reduction of territorial health inequalities, chronic disease prevention (particularly respiratory conditions and cancer), and climate change impacts on public health. Her work examines how private/public spaces influence risk mitigation for conditions like cystic fibrosis and asthma. Dr. Loizeau's doctoral research (funded by Vaincre la Mucoviscidose and Brittany Region) analyzed domestic respiratory risk prevention strategies, while her current Greencan project (INCA-funded) investigates urban green spaces' relationship to cancer risk through interdisciplinary epidemiology-environmental-social science collaboration. She has secured competitive funding from major health research bodies including the French National Cancer Institute (INCA) and patient advocacy organizations. Her work operates within the UMR 6051 ARENES framework, leveraging cross-institutional resources from CNRS, EHESP, and Rennes academic partners. Her research methodology integrates qualitative sociological analysis with environmental health metrics, emphasizing practical spatial interventions for vulnerable populations facing air quality challenges and chronic disease burdens.

• Health Promotion
• Disease Prevention
• Environmental Health
• +۳ مورد دیگر

Christelle Routelous is a Lecturer and researcher at the French School of Public Health (EHESP), where she has been working since June 2006. She is affiliated with the Institute of Management (IdM) and the Research team on health services and management (ARENES, UMR 6051 and INSERM 1309). Her work focuses on organizational theory and behavior within healthcare systems, particularly examining management practices in hospitals and elderly care facilities. Dr. Routelous earned her Doctorate in socio-economics of innovation from Ecole des Mines Paris Tech in 2008, with a thesis titled "Health democracy put to the test by medical practices: Sociology of a participatory model in medicine," supervised by M. Akrich (Mines) and N. Dodier (EHESS). She received qualification for the position of lecturer from CNU section 19 in 2011. Her research interests span strategic management and human resources management in public healthcare settings, public management, and organizational behavior theories. She has extensively studied coordination mechanisms in healthcare, quality of life at work in nursing homes (EHPADs), hospital management, and the integration of medical and social care services. Analysis of her publications reveals consistent focus on workplace conditions in healthcare settings, particularly examining job crafting strategies during the pandemic, salutogenic management approaches to reduce workplace hardship in nursing homes, and the role of practice communities in improving quality of work life. She has also contributed significantly to understanding healthcare coordination models and the implementation of antimicrobial stewardship programs in French hospitals. Dr. Routelous was awarded the "Prix de la meilleure communication thématique" (best thematic communication award) on June 17, 2022, for her work on job crafting strategies among healthcare workers during the Covid crisis. She actively supervises student work and participates annually in juries for the appointment of directors of public health and medico-social establishments. Her research has been supported by numerous grants including DIREES funding for multiple projects examining 4-day work experiments, workplace time reconciliation strategies, and quality of life at work in EHPADs. She has also secured funding from the National Solidarity Fund for Autonomy (CNSA), European Partnership Transforming Health and Care Systems (THCS), and other national and European sources. Dr. Routelous collaborates with several research teams including the ARENES research unit (UMR 6051) and INSERM 1309. She works closely with researchers from IAE Rennes, Rennes 2 University, and international partners from UQAM in Montreal. Her current projects include MUSICALISE (focusing on care integration for multiple sclerosis patients) and SPACE (examining nomadic managers and teleworkers in third places).

• Organizational Behavior
• Healthcare Management
• Public Management
• +۶ مورد دیگر

Laurence MILLON is a Professor (PU-PH) at the University of Franche-Comté, affiliated with the Medical School of Besançon and the Department of Parasitology-Mycology at CHU Besançon. She leads the Parasitology-Mycology Laboratory and the National Echinococcosis Reference Centre. Her research focuses on invasive fungal infections, parasitic diseases like echinococcosis, and diagnostic methodologies. She has held leadership roles in European initiatives, including the European Fungal PCR working group and the World Health Organization Collaborating Centre for Echinococcosis prevention. Key responsibilities include standardizing PCR diagnostics for fungal infections and managing national and international references centers. Research interests: Molecular biology of fungal and parasitic pathogens, epidemiology of infections, diagnostic innovation, and hypersensitivity pneumonitis. Publications span 2025–2023, emphasizing fungal diagnostics, echinococcosis genetics, and public health interventions. Grants and advising: Supervises students like Julie Rousselot. Collaborates on projects funded by national and international bodies, including the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). No explicit awards are listed, though her roles imply significant recognition in parasitology and mycology. Labs/teams: Head of Parasitology-Mycology Lab, collaborates with teams on fungal PCR standardization and echinococcosis control.

• Molecular Biology
• Immunology
• Epidemiology
• +۷ مورد دیگر

Roland Brosch is the Head of the Integrated Mycobacterial Pathogenomics Unit at the Institut Pasteur in Paris, France. He leads a dynamic research team focused on understanding the genomics, evolution, and pathogenicity of mycobacteria, particularly Mycobacterium tuberculosis . His work is central to uncovering the mechanisms behind the emergence of one of humanity's most persistent pathogens. His research interests span mycobacterial genomics , the evolution of M. tuberculosis from ancestral forms like M. canettii , the function of ESX secretion systems , host-pathogen interactions , and the development of novel anti-tuberculosis vaccines . His unit's work integrates cutting-edge genomic, phenotypic, and functional analyses to identify virulence factors and drug targets. The recent publications from his group, including high-impact reviews and original research in journals like PLoS Pathogens , PLoS Biology , and FEMS Microbiology Reviews , reveal a strong focus on the evolutionary trajectory of TB, the discovery of novel environmental mycobacteria as evolutionary 'missing links', the development of rapid diagnostics like TRACeR-TB, and the exploration of host-directed therapies. This indicates a research program at the forefront of both basic mycobacterial biology and translational applications. Roland Brosch is the Principal Investigator (PI) for major international research consortia, including PreDiCT-TB (focused on drug combination discovery) and TBVAC2020 (focused on next-generation TB vaccines). His unit also participates in the Labex IBEID initiative on emerging infectious diseases, highlighting the broad impact of his work. He mentors a diverse team of PhD students, postdoctoral researchers, and engineers, fostering the next generation of scientists in the field of infectious diseases. His laboratory, located at 25-28 Rue du Docteur Roux, is a hub for research on mycobacterial pathogenesis, contributing significantly to the global effort to combat tuberculosis through fundamental scientific discovery.

• Mycobacterial genomics
• Pathogenicity of Mycobacteria
• Evolution of Mycobacterium tuberculosis
• +۷ مورد دیگر

Milena Maglio, PhD, serves as an associate researcher at CESP (Inserm/Université Paris-Saclay) and heads the Observatory of Ethical Practices at the Espace de réflexion éthique d'Ile-de-France. Her academic foundation includes a doctorate in philosophy and postdoctoral work on sickle cell disease and cystic fibrosis at the Institut La Personne en médecine. Her research spans bioethics, clinical ethics, and moral philosophy with concentrated focus on end-of-life issues, life-value ethics, and psychosocial dimensions of genetic disorders. She examines ethical, historical, and political frameworks governing medical decision-making in terminal care and chronic illness management. Publications reveal interdisciplinary trends connecting philosophical theory to clinical practice, particularly in pain perception in sickle cell disease and non-human animal cognition. Her work bridges continental philosophy with healthcare ethics, emphasizing real-world applications in medical settings. Scientific awards: None documented in source materials. Advising and grant activities: No details available regarding student mentorship or research funding. She directs the Ethics Reflection Space of Ile-de-France, facilitating institutional ethical deliberation, and contributes to CESP's population health research through philosophical analysis of medical practices.

• Bioethics
• Clinical Ethics
• Moral Philosophy
• +۳ مورد دیگر

Anne-Cécile Begot is a Lecturer in Sociology at Paris-Est University Créteil Val de Marne (UPEC). Her research focuses on health sociology, particularly social inequalities in health, and the implementation of sexuality education in schools, analyzing intersections between national policies, academic frameworks, and local practices. Coordinates sexuality education research Coordinated MUCONFIN survey on cystic fibrosis during the 2020 lockdown Educational director of UPEC's Master's program in Educational Sciences Her work combines qualitative methodologies with social policy analysis, addressing themes like pandemic impacts on chronic disease management, ethics in health education, and the role of religious minorities in healthcare. She actively contributes to academic discourse through publications on public health, sexuality education, and social integration. While her publications span public health, educational sociology, and qualitative research, her recent work emphasizes pandemic-related health disparities and institutional dynamics in sexuality education. She also engages in knowledge dissemination through seminars and interviews, including collaborations with organizations like Sidaction on HIV/AIDS awareness.

• Health Sociology
• Social Inequalities in Health
• Sexuality Education
• +۳ مورد دیگر

Sophie Bachellier-Bassi is a Research Fellow at the Institut Pasteur in Paris, France, where she conducts research on fungal biology and pathogenicity, with a specific focus on Candida albicans . She is affiliated with the Fungal Biology and Pathogenicity Unit and serves as Head of Research for the Molecular Genetics and Epigenetics course at the Pasteur Institute since 2010. Dr. Bachellier-Bassi obtained her PhD at the Institut Pasteur studying repeated sequences of the bacterial genome in the laboratory of Prof. Maurice Hofnung under the supervision of Prof. Eric Gilson. She then completed a postdoctoral fellowship at the University of Dundee (UK) in the laboratory of Prof. David Lilley, investigating the regulation of transcription by DNA supercoiling in Escherichia coli . Her research focuses on the regulatory mechanisms of morphogenesis and biofilm formation in the pathogenic yeast Candida albicans . She has made significant contributions to understanding the molecular mechanisms underlying C. albicans pathogenicity, including studies on cell wall structure, metabolic reprogramming during biofilm formation, transcription factor regulation, and host-pathogen interactions. Her work bridges molecular microbiology, fungal genetics, and host immune responses. Analysis of her recent publications reveals a consistent focus on C. albicans pathogenesis, with particular attention to biofilm formation, morphological transitions, and the molecular mechanisms that enable this opportunistic pathogen to thrive in diverse host environments. Her research increasingly incorporates advanced imaging techniques, genetic approaches, and metabolic profiling to unravel the complex regulatory networks governing fungal virulence. Dr. Bachellier-Bassi serves as Principal Investigator for the HelPath project and contributes to several other research initiatives at the Institut Pasteur, including studies on C. albicans colonization of surfaces, regulation of morphogenesis, and the CANDIHUB project focused on Candida species responsible for invasive fungal infections.

• Fungal Biology
• Pathogenicity
• Morphogenesis
• +۵ مورد دیگر

Catherine LLANES is a Professor at the Université Bourgogne Franche-Comté, associated with the PATHOGENES department. Her research focuses on Pseudomonas aeruginosa, particularly antibiotic resistance mechanisms induced by essential oils and bacterial defense strategies such as efflux pumps and gene expression regulation. She investigates how compounds like cinnamaldehyde trigger multidrug resistance in pathogens. Her work merges microbiology, molecular biology, and bacterial physiology to combat antibiotic resistance in clinical settings. Her studies emphasize the unintended consequences of essential oil usage, revealing how components like cinnamaldehyde can select for drug-resistant mutants or induce efflux systems that reduce antibiotic efficacy. Key projects include analyzing transcriptional regulators (e.g., AmgRS, CmrA) mediating resistance and understanding the interplay between environmental stressors and bacterial pathogenicity. Publications highlight her expertise in efflux pump regulation (MexEF-OprN, MexT), amino acid substitution effects on resistance, and proteomic approaches to quantify resistance mechanisms in clinical isolates. Her research bridges fundamental biology and applied antimicrobial strategies, addressing urgent global health challenges like multidrug-resistant infections.

• Microbiology
• Bacterial physiology
• Molecular biology
• +۳ مورد دیگر

Philippe Poncet is a Professor at the Université de Pau et des Pays de l'Adour (UPPA) and Vice-President for Digital Environment. He leads the Numerical Methods and Complex Fluids team at the Laboratory of Mathematics and their Applications (LMAP). His expertise spans particle/vortex methods, high-performance computing, and applications in geoscience, microfluidics, and biomathematics, with a focus on reactive flows and porous media. Poncet's research integrates numerical analysis with practical challenges in environmental and biomedical engineering. Key interests include Lagrangian methods for fluid dynamics, optimization algorithms, pore-scale modeling, and cystic fibrosis biomechanics. His work bridges theoretical mathematics and industrial-scale simulations. Recent publications demonstrate advances in pore-scale dissolution modeling, Bayesian neural networks for inverse problems, and viscous flow simulations. His articles consistently address multi-scale challenges in geosciences and biomedicine using innovative computational frameworks. He has led significant projects including the ANR-funded MucoReaDy (mucus dynamics in respiratory diseases) and MicroMineral (CO₂ mineral storage). These collaborations involve multidisciplinary teams addressing environmental and health-related fluid dynamics.

• Numerical Analysis
• High Performance Computing
• Fluid Dynamics
• +۵ مورد دیگر