Daniela Rotin

Daniela Rotin is a Professor at the University of Toronto, affiliated with the Temerty Faculty of Medicine, and holds appointments in the Department of Biochemistry and the Department of Physiology. She is a senior scientist in the Cell Biology Program at The Hospital for Sick Children (SickKids) in Toronto, where her research focuses on ubiquitin ligases, particularly the Nedd4 family, and their roles in cellular regulation, epithelial physiology, and disease.

Her research interests include cell biology, physiology, ubiquitylation, endocytosis, cystic fibrosis, autophagy, epithelial biology, ion channel regulation, and protein trafficking. She has made significant contributions to understanding the regulation of the epithelial sodium channel (ENaC) by ubiquitin ligases such as Nedd4-2, and the discovery of primate-specific splice isoforms like Nedd4-1(NE), which regulates autophagy in response to nutrient availability.

Her recent publications highlight a strong trend in molecular mechanisms of ubiquitin ligase activity, stress signaling (e.g., p38-MAPK, WNK kinases), and cellular responses to osmolarity and ion imbalances. Her work integrates cell biology, biochemistry, and physiology to uncover novel regulatory pathways in health and disease, with implications for cystic fibrosis, hypertension, epilepsy, and cancer.

Dr. Rotin has not been noted to have received specific scientific awards in the provided text, but her high citation metrics (h-index 33, i10-index 48, over 4,700 citations) reflect significant scholarly impact. She collaborates extensively with researchers at SickKids, the University of Toronto, and international institutions.

She advises a research team studying ubiquitin-mediated proteostasis, and her lab has secured funding for projects on ENaC regulation, autophagy, and organoid models of epithelial disease. She leads a research group that utilizes advanced techniques including CRISPR-Cas9, proteomics, and iPSC-derived organoids.

Dr. Rotin is actively involved in research through her laboratory at SickKids, where she investigates the molecular basis of protein trafficking, cellular stress responses, and the pathophysiology of epithelial disorders. Her team includes postdoctoral fellows, graduate students, and research associates working on ubiquitin ligases and their roles in development and disease.