معرفی
Daniela Rotin is a Professor at the Department of Biochemistry, University of Toronto, and a Senior Scientist at the Cell Biology Program of the Hospital for Sick Children since 1992. Her research focuses on the ubiquitin system, particularly the Nedd4 family of E3 ubiquitin ligases, and their roles in regulating membrane proteins linked to diseases like cystic fibrosis, hypertension, and cancer.
- 1992–Present: Independent Investigator, Cell Biology Program, Hospital for Sick Children, Toronto
- Professor: Department of Biochemistry, University of Toronto
Research Interests: Her lab investigates the biochemistry, structure, and function of Nedd4 ubiquitin ligases, their physiological roles in cellular processes, and the development of proteomic methodologies to identify ligase substrates. Key projects involve studying disease-relevant membrane proteins such as ENaC, CFTR, and PTPsigma.
Scientific Awards:
- Canada Research Chair, Tier I (2004–2011, 2011–2018)
- Woman of Action (WOA) Scientist Award (2011)
- Zeller’s Senior Scientist Award (2003)
- CIHR Investigator (1999–2004)
- Premier’s Research Excellence Award (1999)
Advising: Mentored recent graduates Ruth Milkereit and Avinash Persaud, who published in Nature Communications. Her lab has trained multiple trainees working on ubiquitin ligases and membrane protein regulation.
Labs & Teams: Rotin’s lab at the Hospital for Sick Children collaborates with interdisciplinary teams in biochemistry, cell biology, and proteomics to study ubiquitin-mediated protein regulation and develop therapeutic strategies for cystic fibrosis and related diseases.
