معرفی
R.-A. Lavergne serves as an Assistant Professor and Hospital Practitioner at the University of Nantes, specializing in medical mycology with a focus on antifungal resistance mechanisms and environmental drivers of resistance. Their work bridges clinical practice and environmental microbiology through the One Health framework, investigating azole resistance in Aspergillus species and diagnostic innovations for fungal pathogens.
Educational background includes a PhD on Aspergillus fumigatus resistance mechanisms defended at the University of Nantes in July 2018. Advanced training encompasses molecular diagnostics, antifungal susceptibility testing, and environmental sampling methodologies.
Research centers on azole resistance evolution in Aspergillus, particularly TR-mutation pathways (TR34/L98H, TR46/Y121F/T289A), and agricultural fungicide impacts on clinical resistance. Key projects examine sterol biosynthesis alterations under drug pressure, environmental reservoirs in crop fields, and novel antifungal compounds like CIN-102. Diagnostic work includes Mucorales DNA detection in serum and MALDI-TOF optimization for cryptic Candida species.
Recent publications reveal three dominant research axes: (1) Environmental origins of resistance (Colombian crop studies); (2) Molecular mechanisms of TR-mutation-mediated resistance; (3) Diagnostic innovations for mucormycosis and rare fungal pathogens. This integrated approach spans genomic, biochemical, and epidemiological methodologies.
Active involvement in national research initiatives includes ANR TEILEISH, ANR AspergillusOne-Health, ANR Chair INSERM COMBINE, ANR OTARI, ANR AspergIs, ANR FungiSol, and ANR INTERLUDE. Collaborative networks span French cystic fibrosis centers, transplant units, and international agricultural health projects.
As part of the Department of Medical Mycology and Parasitology, Dr. Lavergne contributes to clinical diagnostics for immunocompromised patients while leading environmental resistance surveillance. The research group maintains active collaborations with Prof. Le Pape's team on resistance mechanisms and Prof. Morio's diagnostics unit.
